Patents Assigned to Stanford University
  • Methods for treatment of multiple sclerosis using peptide analogues at position 91 of human myelin basic protein
    Patent number: 6489299
    Abstract: Peptide analogues of human myelin basic protein containing residues 87-99 are provided. Residue 91 of the peptide analogues is altered from the L-lysine residue found in the native protein to any other amino acid. Pharmaceutical compositions of the peptide analogues are provided. In addition, the peptide analogues are administered to patients with multiple sclerosis.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: December 3, 2002
    Assignees: Stanford University Medical Center, Neurocrine Biosciences, Inc.
    Inventors: Lawrence Steinman, Nicholas Ling, Paul J. Conlon, Amitabh Gaur
  • Methods and compositions for the inhibition of cancer metastasis mediated by endothelial adhesion molecules
    Patent number: 6465434
    Abstract: Methods and compositions are disclosed for the inhibition of cancer metastases mediated by endothelial adhesion molecules. The present invention discloses that sialyl Lea and di-sialyl Lea, which are expressed at the surface of cancer cells, function as a binding partner for LEC-CAMs, such as ELAM-1, which are expressed at the surface of endothelial cells. The present invention also discloses that LEC-CAMs, such as ELAM-1, involved in cancer metastasis share a carbohydrate domain common to both sialyl Lea and sialyl Lex. Antibodies, saccharides, glycoconjugates, enzyme inhibitors and other compounds may be used in the methods of the present invention to inhibit the binding of malignant cells to endothelial cells for a variety of purposes in vivo and in vitro.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: October 15, 2002
    Assignees: Stanford University
    Inventors: John L. Magnani, Eugene C. Butcher, Ellen L. Berg
  • Detection of polymorphisms by denaturing high-performance liquid chromatography
    Patent number: 6453244
    Abstract: The present invention provides a method for detecting polymorphisms in a nucleic acid by preconditioning a sample of nucleic acids to completely denature the nucleic acids, e.g., via heating and/or chemical treatment, and performing high-performance liquid chromatography (HPLC) on the nucleic acid under denaturing conditions to identify any polymorphisms. The nucleic acids to be analyzed are completely denatured prior to application of the sample to a stationary reverse-phase support and throughout the HPLC process. Sample elution is also carried out under completely denaturing conditions, and the sample mixture is eluted with a mobile phase containing an ion-pairing reagent and an organic solvent.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: September 17, 2002
    Assignee: Stanford University
    Inventor: Peter J. Oefner
  • Immunomodulating compounds comprising d-isomers of amino acids
    Patent number: 6436903
    Abstract: Compounds having immunomodulatory activity which are peptide-type compounds, or variants or fragments thereof, including the N-terminal acylated and C-terminal amidated or esterified forms of up to 30 amino acids wherein the peptide-type compound comprises the formula: (a) R aa76-77 L aa79-84 or (b) aa84-79 L aa77-76 R wherein: aa76 is E or V; aa77 is D, S or N; aa79 is R or G; aa80 is I or N; aa81 is a small or hydrophobic amino acid aa82 is R or L; aa83 is G or R; aa84 is a small or hydrophobic amino acid; wherein, in said compounds, at least one of the amino acids is the D isomer are used by themselves or in combination with immunosuppressant drugs, to reduce CTL activation, particularly in association with transplantation.
    Type: Grant
    Filed: May 22, 1996
    Date of Patent: August 20, 2002
    Assignee: Stanford University (Board of Trustees of the Leland Standford Junior University)
    Inventors: Carol A. Clayberger, Alan M. Krensky
  • Manufacture of semiconductor capacitively-coupled NDR device for applications such as high-density high-speed memories and power switches
    Publication number: 20020096690
    Abstract: A novel capacitively coupled NDR device can be used to implement a variety of semiconductor circuits, including high-density SRAM cells and power thyristor structures. In one example embodiment, the NDR device is used as a thin vertical PNPN structure with capacitively-coupled gate-assisted turn-off and turn-on mechanisms. An SRAM based on this new device is comparable in cell area, standby current, architecture, speed, and fabrication process to a DRAM of the same capacity. In one embodiment, an NDR-based SRAM cell consists of only two elements, has an 8 F2 footprint, can operate at high speeds and low voltages, has a good noise-margin, and is compatible in fabrication process with main-stream CMOS. This cell significantly reduces standby power consumption compared to other types of NDR-based SRAMs.
    Type: Application
    Filed: March 20, 2002
    Publication date: July 25, 2002
    Applicant: Stanford University
    Inventors: Farid Nemati, James D. Plummer
  • Semiconductor capacitively-coupled NDR device and related applications in high-density high-speed memories and in power switches
    Publication number: 20020096689
    Abstract: A novel capacitively coupled NDR device can be used to implement a variety of semiconductor circuits, including high-density SRAM cells and power thyristor structures. In one example embodiment, the NDR device is used as a thin vertical PNPN structure with capacitively-coupled gate-assisted turn-off and turn-on mechanisms. An SRAM based on this new device is comparable in cell area, standby current, architecture, speed, and fabrication process to a DRAM of the same capacity. In one embodiment, an NDR-based SRAM cell consists of only two elements, has an 8 F2 footprint, can operate at high speeds and low voltages, has a good noise-margin, and is compatible in fabrication process with main-stream CMOS. This cell significantly reduces standby power consumption compared to other types of NDR-based SRAMs.
    Type: Application
    Filed: March 20, 2002
    Publication date: July 25, 2002
    Applicant: Stanford University
    Inventors: Farid Nemati, James D. Plummer
  • Methods and compositions for endothelial binding
    Patent number: 6391857
    Abstract: Novel methods and compositions are provided for modulating homing of leukocytes, particularly lympho-cytes, where the compounds are cross-reactive with Neu5Ac2-3Gal&bgr;1-X[Fuc&agr;1-y]GlcNAc, where one of x and y is three and the other is four. These compounds may be administered to a host associated with inflammation, to avoid the deleterious effects of leukocyte infiltration and for directing molecules to such sites.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: May 21, 2002
    Assignees: Stanford University
    Inventors: John L. Magnani, Eugene C. Butcher, Ellen L. Berg
  • Leukocyte homing modulation
    Patent number: 6387884
    Abstract: Novel methods and compositions are provided for modulating homing of leukocytes, particularly lymphocytes, where the compounds are cross-reactive with Neu5Ac2-3Gal&bgr;1−X[Fuc&agr;1−y]GlcNAc, where one of x and y is three and the other is four. These compounds may be administered to a host associated with inflammation, to avoid the deleterious effects of leukocyte infiltration.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: May 14, 2002
    Assignees: Stanford University
    Inventors: John L. Magnani, Eugene C. Butcher, Ellen L. Berg
  • Methods for treatment of multiple sclerosis using peptide analogues at position 91 of human myelin basic protein
    Patent number: 6369033
    Abstract: Peptide analogues of human myelin basic protein containing residues 87-99 are provided. Residue 91 of the peptide analogues is altered from the L-lysine residue found in the native protein to any other amino acid. Pharmaceutical compositions of the peptide analogues are provided. In addition, the peptide analogues are administered to patients with multiple sclerosis.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: April 9, 2002
    Assignees: Stanford University Medical Center, Neurocrine Biosciences, Inc.
    Inventors: Lawrence Steinman, Nicholas Ling, Paul J. Conlon, Amitabh Gaur
  • Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
    Patent number: 6329148
    Abstract: A synergistic combination of ligands that interact with death domain receptors, and diterpenoid triepoxides is used to increase tumor cell killing by induction of apoptosis. Ligands useful in the invention include TRAIL, TNF-&agr;, analogs thereof, stabilized multimers thereof, mimetics, etc. Of particular interest are combined therapy with the diterpenoid triepoxides triptolide and derivatives and analogs thereof.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: December 11, 2001
    Assignee: The Board of Trustees of the Leland Stanford University
    Inventors: Glenn D. Rosen, Peter Kao
  • Multi-genes expression profile
    Patent number: 6291170
    Abstract: This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase promoter region complement and then anti-sense RNA (aRNA) is transcribed from the cDNA by introducing an RNA polymerase capable of binding to the promoter region. Additional processes using the resulting aRNA are also described.
    Type: Grant
    Filed: April 5, 1999
    Date of Patent: September 18, 2001
    Assignee: Board of Trustees of Leland Stanford University
    Inventors: Russell N. Van Gelder, Mark E. Von Zastrow, Jack D. Barchas, James D. Eberwine
  • Method to produce novel polyketides
    Patent number: 6261816
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: July 17, 2001
    Assignees: Stanford University, Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao
  • Polynucleotide encoding insect ecdysone receptor
    Patent number: 6245531
    Abstract: Polynucleotide sequences which encode ecdysone receptors have been isolated and expressed in host cells.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 12, 2001
    Assignee: Board of Trustees of Leland Stanford University
    Inventors: David S. Hogness, Michael R. Koelle, William A. Seagraves
  • Semiconductor capacitively-coupled NDR device and its applications in high-density high-speed memories and in power switches
    Patent number: 6229161
    Abstract: A novel capacitively coupled NDR device can be used to implement a variety of semiconductor circuits, including high-density SRAM cells and power thyristor structures. In one example embodiment, the NDR device is used as a thin vertical PNPN structure with capacitively-coupled gate-assisted turn-off and turn-on mechanisms. An SRAM based on this new device is comparable in cell area, standby current, architecture, speed, and fabrication process to a DRAM of the same capacity. In one embodiment, an NDR-based SRAM cell consists of only two elements, has an 8 F2 footprint, can operate at high speeds and low voltages, has a good noise-margin, and is compatible in fabrication process with main-stream CMOS. This cell significantly reduces standby power consumption compared to other types of NDR-based SRAMs.
    Type: Grant
    Filed: June 5, 1998
    Date of Patent: May 8, 2001
    Assignee: Stanford University
    Inventors: Farid Nemati, James D. Plummer
  • Manufacture of high-density pillar memory cell arrangement
    Patent number: 6204115
    Abstract: A fabrication process benefits high-density DRAM cells, including four-Gbit cells and beyond. In one embodiment, a poly-Si pillar transistor is formed on top of a trench capacitor with the top of the pillar transistor being directly connected to the bit line. To reduce the process steps, word line formation is achieved by a spacer etch process and a self-aligned process is used for formation of bit line contact using a CMP process. This embodiment reduces necessary layout area and provides improvements in overall device performance.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: March 20, 2001
    Assignee: Stanford University
    Inventor: Hyun-Jin Cho
  • Patched antibodies
    Patent number: 6172200
    Abstract: Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. The patched genes permit production of patched protein and production of antibodies that bind to patched proteins. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: January 9, 2001
    Assignee: The Board of Trustees of the Leland S. Stanford University
    Inventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson
  • Navigation data processing with filtering for refined position determination
    Patent number: 6144918
    Abstract: Consistent with one embodiment of the invention, a GPS signal processing system uses a behavior observer to monitor user dynamics and to aid a time-varying-gain filter arranged to perform continuous position and speed estimates. The behavior observer consists of a fast observer and a signal detector. The fast observer tacks user maneuvers. The signal detector compares outputs of the fast observer and the time-varying-gain filter to determine user dynamics and corrects operations of the time-varying-gain filter. Tracking ability is improved without degradation in steady-state position accuracy.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: November 7, 2000
    Assignee: Stanford University
    Inventors: Teresa M. Meng, Horng-Wen Lee
  • Synthesis of polyketides from diketides
    Patent number: 6080555
    Abstract: Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.
    Type: Grant
    Filed: July 5, 1996
    Date of Patent: June 27, 2000
    Assignees: Stanford University, Brown University
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane
  • Method to produce novel polyketides
    Patent number: 6066721
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: May 23, 2000
    Assignees: Stanford University, Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao
  • Method and system for automatic control of vehicles based on carrier phase differential GPS
    Patent number: 6052647
    Abstract: Described is an automatic control system for land (and possible marine) vehicles based on carrier phase differential GPS (CPGPS). The system relies on CPGPS to determine vehicle position and attitude very precisely (position to within 1 cm and attitude to within 0.1.degree.). A system incorporates a technique to calculate and compensate for antenna motion due to vehicle roll and pitch. One aspect of the system utilizes an intelligent vehicle controller that recognizes and adapts to changing conditions, such as vehicle speed, implements towed by the vehicle, soil conditions, and disturbance level. The system provides the capability to control the vehicle on various paths, including straight lines and arbitrary curves. Also described is a technique for initialization and vehicle control using only a single pseudolite.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: April 18, 2000
    Assignee: Stanford University
    Inventors: Bradford W. Parkinson, Michael L. O'Connor, Gabriel H. Elkaim, Thomas Bell