Abstract: An exoskeleton system is passively powered and pneumatically operated. The system may be a lower-limb system for walking gait restoration. The system may include a first linear actuator located in front of an upper leg section and a second linear actuator located behind a lower leg section.

Abstract: This invention relates to a new and distinct variety of red raspberry plant (Rubus idaeus L.) named ‘WSU 2166’ adapted to the raspberry production area of the Pacific Northwest. ‘WSU 2166’ is primarily characterized by suitability for machine harvestability, tolerance to root rot, early season production and large, conical fruit that is longer than it is broad.

Abstract: Methods of real-time emoji and emoticon production are disclosed that include: determining, by a computing device, at least one first emotional state of a user from information, wherein the at least one first emotional state is a presently-identified emotional state of the user; providing an emoji or emoticon production template system, wherein the template system includes at least one physical attribute of the user; and utilizing the emoji or emoticon production template system to: analyze the presently-identified emotional state of the user; determine a suitable map of the presently-identified state of the user; map the presently-identified state of the user on an emoji or emoticon production template; produce at least one unique emoji or emoticon based on the map; provide the at least one unique emoji or emoticon to the user, wherein the user selects the at least one unique emoji or emoticon and includes the at least one unique emoji or emoticon in a text message, a direct message, an electronic mail messa

Abstract: The present invention discloses systems for targeted gene editing and related uses.

Abstract: Synthesis of novel and unique PAMAM (poly-amidoamine) polymers. PAMAM polymers can be grown by systematic alternation between ethylenediamine (EDA) and methacrylate. By taking advantage of the alternating terminal ends, successive generations G1 and G0.5 were combined under acidic conditions with Pluronic P123 as a liquid-crystal template. The resulting polymer was imaged with TEM and the product was circular and amorphous of no characteristic size ranging between about 5 nm to about 600 nm, with remarkable electrochemical activity unseen in any of the generations of PAMAM. Applications of this electroactive poly-amidoamine organic polymer include use as a new electron transfer reagent for amperometric biosensors.

Abstract: Implementations described and claimed herein provide systems and methods for manufacturing customized cardiovascular devices. In one implementation, patient cardiovascular data for a patient is received at a controller. The patient cardiovascular data is captured using a patient interface. A printing profile for a cardiovascular medical device is received at the controller. A patient specific three-dimensional model of the cardiovascular medical device customized for the patient using the patient cardiovascular data and the printing profile is generated. The patient specific three-dimensional model of the cardiovascular medical device is sliced into a plurality of outlines using the controller. Print instructions based on the plurality of outlines are generated using the controller. A polymeric material is manipulated according to the print instructions into a customized polymeric cardiovascular medical device for the patient.

Abstract: The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment described here.

Abstract: Gallium nitride based devices and, more particularly to the generation of holes in gallium nitride based devices lacking p-type doping, and their use in light emitting diodes and lasers, both edge emitting and vertical emitting. By tailoring the intrinsic design, a wide range of wavelengths can be emitted from near-infrared to mid ultraviolet, depending upon the design of the adjacent cross-gap recombination zone. The innovation also provides for novel circuits and unique applications, particularly for water sterilization.

Abstract: A system, method, and apparatus for the fermentation of a beverage by use of continuous flow is provided. The fermented beverage can be any of a wine, beer, mead, ale, soda, cider, or other. The invention provides for small-scale fermentation that can be done in a much shorter time than previous batch fermentations. The small-scale and shortened time allows for variables to be introduced and tested to produce new varieties, flavors, qualities, and other combinations that are inputs of the fermented beverage.

Abstract: This invention relates to a wax composition comprising one or more fatty acid diester compounds having the formula of R1 and R2 are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; and n1 is an integer from 2 to 10. This invention also relates to a wax composition comprising: a) one or more fatty acid monoester or diester compounds having the formula of: and b) one or more hydroxylated fatty acid diester compounds having the formula of In these formulae, R is H or COR1?; R1? and R2? are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; n2 is an integer from 2 to 24; m is an integer from 2 to 12; and .(OH)m represents 2 to 12 hydroxyl groups substituting for 2 to 12 hydrogen atoms in the alkyl groups R1? and/or R2?. Uses of the compositions are also disclosed.

Abstract: Gait rehabilitation systems, methods, and apparatuses thereof are disclosed. In accordance with one aspect of the invention, a gait rehabilitation system may include a harness configured for attachment to an individual and at least one sensor configured to sense at least one parameter associated with gait of an individual, the individual having an affected leg and an unaffected leg. The system includes a braking system configured for attachment to the harness and in communication with the at least one sensor. The braking system is further configured for monitoring the at least one sensor to sense the at least one parameter associated with an individual's gait, determining when the affected leg is in a modification portion of the individual's gait from the sensed at least one parameter, and applying a braking force resisting movement of the harness during the determined modification portion.

Abstract: Cell penetrating peptides (CPPs) are established as a strategy to move cargoes into the interior of eukaryotic cells by engaging import machinery on the cell surface. In most cases the CPP is covalently linked to the cargo; it is common to express cargo proteins with a CPP extension. In some experiments a non-specific interactions (e.g., hydrophobic interactions) have been used to form CPP-cargo complexes, but this has numerous drawbacks. Transport is less efficient and the lack of specificity means that other macromolecules in the medium will also be internalized. This application describes the use of specific CPP labeled adaptor proteins that can be used to move a wide variety of cargoes into the cell interior. The prototype adaptor protein is calmodulin; it is small, stable and easily produced, and binds short (17 amino acid) targets with high affinity in the presence of calcium. A cargo produced with a calmodulin binding tag can be internalized efficiently by CPP tagged calmodulin.

Abstract: The present invention is directed to a method of producing a solid fuel which includes providing a bio-oil and thermally curing the bio-oil to form a carbonaceous solid. The present invention is also directed to a method of producing a solid fuel which includes providing a bio-oil; subjecting the bio-oil to an extraction procedure with an aqueous liquid to produce a concentrated pyrolytic sugar-containing extract and a water insoluble raffinate comprising a lignin-derived phenolic oil; and thermally curing the phenolic oil to form a carbonaceous solid.

Abstract: Compositions for increasing the thermal stability of optical absorbers are provided as well as methods of making and using the resulting compositions. The compositions or complexes of the present teachings generally include an optical absorber bound to a metal or a metal oxide through one or more linkers, which contain a metal binding moiety.

Abstract: Embodiments of a pricing solution system for product line pricing under discrete mixed multinomial logit demand are disclosed.

Abstract: An intervention for sleep disorders comprises collagen, a gelatin peptide, or the amino acid glycine; L-theanine; lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative; hyaluronic acid; epigallocatechin gallate; and quinic acid. The intervention helps regulate pro-inflammatory biomarkers that are often associated with insomnia development and progression. These biomarkers include cytokines and enzymes associated with tryptophan degradation. Inhibition of these enzymes and cytokines improves tryptophan availability and sleep quality, and allows individuals to sleep better with fewer side effects. The novel composition promotes high-quality, deep sleep.

Abstract: Modulation of inward potassium ion conductance with structurally diverse small-molecules in the arthropod salivary gland induces arthropod salivary gland failure that results in a reduction or elimination in the ability of the arthropod to feed. Administering Kir channel inhibitors reduces food intake, increases feeding time, reduces salivary gland secretion, induces mortality, and reduces transmission of vector-borne pathogens. Kir channel inhibitors induce these adverse effects in ticks, mosquitoes, horn flies, and aphids.

Abstract: A therapeutically effective composition for treating Alzheimer's disease includes a pharmaceutically acceptable dosage form comprising melatonin, resveratrol, EGCG, and vitamin B12 combined in a therapeutically effective amount. A combinatorial treatment method for Alzheimer's disease includes administering to a human having Alzheimer's disease a therapeutically effective combination of melatonin, resveratrol, EGCG, and vitamin B12. A method of treating Alzheimer's disease includes administering to a human having Alzheimer's disease a therapeutically effective amount of a pharmaceutically acceptable dosage form comprising melatonin, resveratrol, EGCG, and vitamin B12.

Abstract: This invention is directed to a method of diagnosing bladder cancer in dogs.

Abstract: This invention relates to a new and distinct variety of red raspberry plant (Rubus idaeus L.) named ‘WSU 2166’ adapted to the raspberry production area of the Pacific Northwest. ‘WSU 2166’ is primarily characterized by suitability for machine harvestability, tolerance to root rot, early season production and large, conical fruit that is longer than it is broad.