Patents Assigned to State University
  • Patent number: 9452976
    Abstract: This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster from Streptomyces pactum ATCC 27456, characterization of individual genes in the gene cluster and the proteins encoded thereby as well as uses thereof. The pactamycin gene cluster is located within an 86.35 kilobases genetic locus and includes 53 open reading frames, 26 of which are considered to be the core cluster directly involved in the biosynthesis of pactamycin. The present disclosure also relates to the use of the pactamycin biosynthetic genes located within the identified gene cluster for drug design and development purposes, including the development of pactamycin analogs that are more efficacious and less toxic. Also provided are drugs and antibiotics so produced, as well as methods of their use.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: September 27, 2016
    Assignee: Oregon State University
    Inventors: Taifo Mahmud, Takuya Ito, Patricia M. Flatt, Niran Roongsawang, Norifumi Shirasaka
  • Patent number: 9453111
    Abstract: New methods for synthesizing boron-modified silazanes, their use as polymer-derived ceramic precursors, and polymer-derived ceramics and composites formed therefrom are disclosed. The polymeric ceramic precursors comprise a boron-modified silazane that is a room temperature liquid-phase polymer comprising a backbone having recurring monomeric repeat units comprising boron-nitrogen bonds. Nanocomposites comprising polymer-derived ceramics and carbon nanotubes are also disclosed.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: September 27, 2016
    Assignee: Kansas State University Research Foundation
    Inventors: Gurpreet Singh, Romil Bhandavat
  • Patent number: 9452205
    Abstract: The present disclosure relates generally to therapeutic compositions comprising recombinant bacteria. Further, the disclosure elaborates upon methods of utilizing the taught therapeutic compositions to treat autoimmune and inflammatory disease. The present teachings also relate to the disclosed recombinant bacteria and methods of producing the recombinant bacteria utilized in the compositions and methods. Further taught herein are dietary supplements and food additive compositions comprising the taught recombinant bacteria.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: September 27, 2016
    Assignee: Montana State University
    Inventors: David W. Pascual, Massimo Maddaloni
  • Patent number: 9453795
    Abstract: The present invention relates to a method for determining the amount of total phosphate in a body of water from reflected light, and also includes systems for the measurement, calculation and transmission of data relating to or carrying out that method. In addition, the invention relates to methods and systems for determining other parameters of water quality from reflected light, for example, turbidity, dissolved oxygen and/or nitrogen.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: September 27, 2016
    Assignee: Bowling Green State University
    Inventors: Teagan Loew, Robert K. Vincent
  • Patent number: 9453241
    Abstract: Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channel-rhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are expressed in retinal ganglion cells upon transduction using recombinant AAV vectors. Selective targeting of these transgenes for expression in discrete subcellular regions or sites is achieved by including a sorting motif in the vector that can target either the central area or surround (off-center) area of these cells. Nucleic acid molecules comprising nucleotide sequences encoding such rhodopsins and sorting motifs and their use in methods of differential expression of the transgene are disclosed. These compositions and methods provide significant improvements for restoring visual perception and various aspects of vision, particular in patients with retinal disease.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: September 27, 2016
    Assignee: Wayne State University
    Inventor: Zhuo-Hua Pan
  • Publication number: 20160271081
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: March 11, 2016
    Publication date: September 22, 2016
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Gifty A. Blankson, Ajit K. Parhi, Malvika Kaul, Daniel S. Pilch
  • Publication number: 20160272816
    Abstract: A composition for sealing defects in structural materials such as roads or paved surfaces, the composition preferably comprising one or more shape memory polymer (SMP) components capable of responding to increased temperature by decreasing in volume. Smart SMP-based sealants of the invention serve to avoid adhesion failure between a sealant and the repaired structure when the repaired structure is subjected to varied temperatures that cause thermal expansion and contraction.
    Type: Application
    Filed: October 29, 2014
    Publication date: September 22, 2016
    Applicant: Board of Supervisors of Louisiana State University Agriculture And Mechanical College
    Inventor: Guoqiang LI
  • Publication number: 20160271082
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 22, 2016
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit K. Parhi, Gifty A. Blankson, Malvika Kaul, Daniel S. Pilch
  • Publication number: 20160270709
    Abstract: A method includes receiving multiple compound muscle action potential values (CMAPs), wherein each CMAP is an onset latency, a peak latency, a conduction velocity, or a response amplitude measured from a baseline; for each of the CMAPs and for each of a number parameters calculated from the CMAPs, determining a corresponding demyelinating boundary value using a normal value from a preselected population; determining whether each of the CMAPs and each of the parameters exceeds the corresponding demyelinating boundary value; determining one or more demyelinated nerve pathways based on which of the CMAPs and the parameters exceeds the corresponding demyelinating boundary value; indicating on a display which of the CMAPs and the parameters exceed the corresponding demyelinating boundary value; and displaying, in pictorial form, an anatomical diagram indicating the demyelinated nerve pathways.
    Type: Application
    Filed: November 4, 2014
    Publication date: September 22, 2016
    Applicant: The Research Foundation of State University of New York
    Inventors: Paul Jacob Maccabee, Lawrence Philip Eberle
  • Patent number: 9447429
    Abstract: A method to generate siRNAs in vivo is described, as are constructs and compositions useful in the method. The method does not depend on the use of DNA or synthetic constructs that contain inverted duplications or dual promoters so as to form perfect or largely double-stranded RNA. Rather, the method depends on constructs that yield single-stranded RNA transcripts, and exploits endogenous or in vivo-produced miRNAs or siRNAs to initiate production of siRNAs. The miRNAs or siRNAs guide cleavage of the transcript and set the register for production of siRNAs (usually 21 nucleotides in length) encoded adjacent to the initiation cleavage site within the construct. The method results in specific formation of siRNAs of predictable size and register (phase) relative to the initiation cleavage site. The method can be used to produce specific siRNAs in vivo for inactivation or suppression of one or more target genes or other entities, such as pathogens.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: September 20, 2016
    Assignee: Oregon State University
    Inventors: James C. Carrington, Edwards Allen
  • Patent number: 9446153
    Abstract: In a composition aspect of the invention, a nanoparticle coating comprises repeating polyacrylic acid monomers covalently bound together in an aliphatic chain having a plurality of carboxylic acid functional groups and modified carboxylic acid functional groups extending therefrom. A first portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having a terminal methoxy functional group and a second portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having at least one terminal catechol group.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: September 20, 2016
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Goutam Palui, Hyon Bin Na
  • Patent number: 9446255
    Abstract: A system for providing neurostimulation includes an external device (“external exciter”) and an implanted device. The external exciter includes an energy source which inductively powers the implanted device. Examples of such external exciters include devices having at least one of: ultrasonic transducers, Radio Frequency (RF) transmitters, and solar cells. The implanted device includes circuitry that limits its maximum energy output to a predetermined saturation threshold such that excess stimulation from the external exciter does not raise the output of the implanted device beyond the saturation threshold. The output signal of the external exciter is then pulse-width modulated in order to produce a desired amount of output stimulation from the implanted device to stimulate the bioelectrically excitable tissue at a desired level.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: September 20, 2016
    Assignee: Arizona Board of Regents on Behalf Arizona State University
    Inventors: Bruce C. Towe, Daniel Gulick
  • Patent number: 9450066
    Abstract: Methods for forming a vertically movable gate field effect transistor (VMGFET) on a silicon-on-insulator (SOI) wafer are described. The methods include providing a process of making VMGFET devices without critical alignment of masks between sequential etch and diffusion steps. The oxide layer of the SOI wafer is used for a self-limiting etch stop layer and for a sacrificial layer to form an insulating layer between a gate electrode and a substrate. The proper location of the gate electrode with respect to the source and drain junctions is insured by using a silicon gate structure as a mask layer for the diffusion process for defining the source and drain junctions.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: September 20, 2016
    Assignee: Texas State University
    Inventors: In-Hyouk Song, Byoung Hee You, Heung Seok Kang, Kang-Hee Lee
  • Patent number: 9450437
    Abstract: An electronic circuit to increase voltages from one or more energy sources. The electronic circuit can include a first set of capacitors and a second set of capacitors, and a first set of switches associated with the first set of capacitors and a second set of switches associated with the second set of capacitors. Also included is at least one energy source and an external load. The first and second set of capacitors, first and second set of switches, the at least one energy source, and the external load are arranged and connected such that the first set of capacitors is connected to the at least one energy source in parallel while the second set of capacitors is connected to the external load in series, and vice versa.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: September 20, 2016
    Assignee: The Penn State University
    Inventors: Younggy Kim, Bruce E. Logan, Marta Hatzell
  • Patent number: 9446045
    Abstract: A method for treating cancer tumors, particularly ovarian cancer tumors, is described, where fused cyclic pyrimidine having a cancer treating ability is selectively delivered to an FR expressing cancerous tumor.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: September 20, 2016
    Assignees: Duquesne University of the Holy Ghost, Wayne State University
    Inventors: Aleem Gangjee, Larry H. Matherly
  • Patent number: 9446147
    Abstract: A sugar-anchor polymer and methods of making and using the same to stabilize a lipid membrane. The sugar-anchor polymer includes a sugar covalently bound to a first anchor and a second anchor wherein the covalent bonds are selected from the group consisting essentially of an oxime bond, a hydrazone bond, an acylhydrazide bond, an aminothioacetal bond, an acetal bond, a thioacetal bond, a dithioacetal bond, a thioether bond and combinations thereof. The method includes reacting a sugar having at least two nucleophilic moieties with at least two anchors, each anchor having at least one electrophilic moiety, to form the polymer. Alternatively, the method includes reacting a sugar having at least two electrophilic moieties with at least two anchors, each anchor having at least one nucleophilic moiety, to form the polymer. The anchors may be lipids or peptides. The sugar-anchor polymers stabilize lipid membranes against serum proteins, dehydration, and cryopreservation.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: September 20, 2016
    Assignee: The Ohio State University
    Inventor: Dennis Bong
  • Patent number: 9447150
    Abstract: Described herein are small peptide domains and consensus sequences that bind small target molecules of industrial importance, e.g., metals such as nickel, ? carotene, and isoflavones such as genistein. Also described are fusion proteins containing such binding domains fused to proteins or to peptide domains like GST or CBD that bind other ligands and can be used to immobilize the target binding domain on a support. One class of fusion proteins that is useful in industrial settings are fusions that contain concatemers of target binding domains, which increases the binding equivalents per molecule.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: September 20, 2016
    Assignees: Iowa State University Research Foundation, Inc., Archer-Daniels-Midland Company
    Inventors: Thomas P. Binder, Aragula Gururaj Rao, Yasufumi Yamamoto, Paul D. Hanke
  • Patent number: 9446029
    Abstract: Methods for managing visceral pain in mammalian subjects are described, in which a NK-1 receptor antagonist is administered to the subject before, during or after administration of general anesthesia. The methods and uses of NK-1 receptor antagonists described herein provide improved visceral pain management and MAC reduction when used with volatile anesthetics for general anesthesia.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: September 20, 2016
    Assignee: Colorado State University Research Foundation
    Inventors: Pedro Boscan, David Twedt
  • Patent number: 9447075
    Abstract: Pyridazine derivatives that activate the excitatory amino acid transporter 2 (EAAT2), and methods use thereof for treating or preventing diseases, disorders, and conditions associated with glutamate excitotoxicity.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: September 20, 2016
    Assignees: The Brigham and Women's Hospital, Inc., The Ohio State University
    Inventors: Gregory D. Cuny, Marcie Glicksman, Xeuchao Xing, Chien-Liang Glenn Lin
  • Patent number: 9449381
    Abstract: Methods, systems, and media for generating and/or analyzing medical images having elongated structures are provided. In some embodiments, a method for analyzing medical images is provided, the method comprising: receiving a plurality of images, wherein each of the plurality of images includes a portion of an elongated structure; receiving a location of interest within a least one of the plurality of images; determining an orientation of the elongated structure in response to receiving the location of interest; adjusting image planes of each of the plurality of images to correspond with the orientation of the elongated structure; and causing the elongated structure to be displayed in the adjusted image planes.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: September 20, 2016
    Assignee: Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University
    Inventor: Jianming Liang