Abstract: This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.

Abstract: Fatigue failure in composite materials can be successfully modeled and predicted by monitoring irreversible gains in entropy. Permanent degradations in composites are marked by irreversible processes that are characterized by increases in entropy. By measuring changes in entropy, one can model and predict the deterioration and failure of composites. The technique may be used to predict the deterioration and failure of composites under essentially any type of loading—constant, variable, bending, torsion, tension, compression, or other.

Abstract: A point of use irrigation water fertigation system utilizes plasma production of nitrogen-bearing species. Soluble nitrogen-bearing species are generated using an atmospheric air plasma treatment of an irrigation water supply. A plasma is generated by a tube having an air intake. A high frequency generator generates atmospheric plasma. The end of the tube is placed above the surface of the irrigation water supply and the plasma emanating from the tube generates nitrogen species in the water. The non-thermal plasma discharge efficiently produces highly reactive radicals and NOx species that have impact on water chemistry including inactivation of microorganisms with high efficacy and accelerated removal of persistent organic pollutants such as perfluorinated compounds (PFCs) from water samples. Plasma ignition can be initiated with a low flow of helium gas injection. Upon ignition, the gas is transitioned to a helium/room air mix, immediately followed by a transition to ambient room air only.

Abstract: Alexandrian laurel (Danae racemosa L.) is a highly demanded evergreen shrub. However, seed germination often takes up to 12 to 18 months with a germination rate of only about 20%. Also, due to its slow-growth rate, it typically takes up to six years to produce a saleable one-gallon size plant. Germinating seeds in the presence of cytokinins and/or auxins increased in vitro shoot multiplication and seedling quality enhancement. Benzyladenine was found to balance seedling development by simultaneously accelerating shoot growth and slowing down root growth, whereas thidiazuron significantly promoted shoot multiplication and proliferation by producing 5-30 shoots per seed.

Abstract: Flexible electrical devices are provided that include a coated inner carbon nanotube electrode that has an exterior surface, an outer carbon nanotube electrode disposed on the exterior surface of the coated inner carbon nanotube electrode, and an overlap region in which the coated inner carbon nanotube electrode and the outer carbon nanotube electrode overlap one another, in which the device has a fiber-like geometry and first and second electrode ends. Methods are provided for fabricating an electrical component that includes a flexible electrical component having a fiber-like geometry and includes carbon nanotube electrodes.

Abstract: The present invention provides for separation of bacterial species and serotypes using electrophoretic methods.

Abstract: Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl ?-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.

Abstract: Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided.

Abstract: A system and method is provided which allows for the transfer of an image data file such as a medical image data file. Device scan slices of an object are acquired per time point. A portion of the device scan slices of the object, e.g., live body organ, per time point which illustrate a change in the object from a previous time point is selected. At least one optical temporal image in spiral fashion per time interval is formed from the selected portion. The at least one optical temporal image is transmittable as an image data file to a location.

Abstract: A photoepilation device including a compact hand piece applicator and a portable electronics module for use in a non-medical setting. The hand piece, which contains no electrical signals, allows the user to focus on individual hair follicles by observing a magnified image provided on a semiconductor display. The image from the hand piece is transported to a remote CCD through a coherent imaging fiber. which also delivers the therapeutic energy pulse from a remotely located source to the localized target. Destruction of pluripotential follicular stems cells found in the hair bulb and bulge regions is possible via a single low power laser diode. Control of pulse width and spot size attains a range of fluence levels up to 85 J·cm?2.

Abstract: A fiber grating device of low cost and arbitrary length is formed on a portion of a portion or the entirety of a highly elastic fiber optic core having a low Young's modulus of elasticity by causing elongation of the fiber optic core and forming or depositing a hard skin or cladding on the elongated fiber optic core. When the stress is then released, the hard skin or cladding buckles (including elastic or plastic deformation or both) to form wrinkles at the interface of the fiber optic core and the hard skin or cladding which are oriented circumferentially and highly uniform in height and spacing which can be varied at will by choice of materials, stretching, and thickness and composition of the cladding. Since the elastic elongation of the fiber optic core portion may be 200% or greater, an unprecedented measurement range is provided.

Abstract: A pH treatment and method for extraction of leachable resources and pollutants from sludge. A volume of wastewater sludge is initially dewatered followed by adding pH adjusting agents to the dewatered sludge to remove acid/base-soluble contaminants. The acid/base-soluble contaminants are flushed out or dewatered from the treated product. Treated sludge can then be sent to storage and held for beneficial uses.

Abstract: Disclosed herein are embodiments of a metallic composite that is made using embodiments of a facile, efficient method. Certain embodiments of the disclosed method of making the composite can comprise a one-step, room temperature synthetic procedure, and other embodiments can comprise a two-step synthetic procedure. Also disclosed herein are embodiments of a method of using the disclosed composite, such as for fluid purification via contaminant degradation, or in biological sensor applications.

Abstract: Methods and compositions for replication of threose nucleic acids (TNAs) are described. The described methods include a method for transcribing a DNA template into a TNA, and a method for reverse transcribing a threose nucleic acid into a cDNA.

Abstract: Compositions comprising therapeutic oligonucleotide miR-3151 compounds that target the expression of genes associated with tumorigenesis or cell transformation are provided.

Abstract: Certain exemplary embodiments can provide a system, machine, apparatus, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a process, method, and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, generating a gradient in an index of refraction of a material.

Abstract: Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided.

Abstract: Threshold logic elements and methods of operating the same are disclosed. In one embodiment, a threshold logic element includes a first input gate network configured to receive a first set of logical signals, a second input gate network configured to receive a second set of logical signals. The differential sense amplifier is operably associated with the first input gate network and the second input gate network such that the differential sense amplifier is configured to generate a differential logical output in accordance with a threshold logic function. In order to make the threshold logic element more robust, the differential sense amplifier is configured to feed back the differential logical output to the first input gate network and the second input gate network. By providing the differential logical output as feedback, floating node issues are avoided and the threshold logic element is more resistant to noise.

Abstract: ‘Von’ is a new and distinct blackberry (Rubus L. subgenus Rubus Watson) cultivar, which originated as an open-pollinated seedling from bulked seed collected from a population of F1 seedlings from the cross of NC 194 (non-patented)×Navaho (U.S. Plant Pat. No. 6,679, expired). This new blackberry cultivar can be distinguished by its high yields, large uniform fruit size, great fruit quality, mid- to late season fruit ripening, prolific fruiting row establishment, excellent shelf life and healthy plants.