Patents Assigned to State University
  • THERAPEUTIC COMPOSITIONS AND METHODS FOR TREATMENT OF MUSCLE WASTING DISEASES
    Publication number: 20180303944
    Abstract: mRNA polymer complexes and drug delivery systems are disclosed herein that include a cationic polymer electrostatically complexed to an mRNA molecule that encodes a desired protein. Also disclosed herein are methods of treating as well as methods of slowing the loss of, increasing, and/or maintaining lean muscle mass in a subject, such as using mRNA polymer complexes and drug delivery systems.
    Type: Application
    Filed: May 18, 2018
    Publication date: October 25, 2018
    Applicant: Oregon State University
    Inventors: Oleh Taratula, Canan Schumann, Olena Taratula, Adam W.G. Alani
  • Method of using sonochemical activaction to form meta-stable substances
    Patent number: 10105299
    Abstract: A method for forming a coated particle having a core particle that is fully coated by a dual-layer coating that includes an inner layer formed of a hydrophilic composition and an outer layer formed of a hydrophobic polymer. The core particles are added to a hydrophilic solution and mixed together. The hydrophobic polymer is then added to form a mixture. The mixture is sonicated to coat the particles and the coated particles are separated and dried to form meta-stable coated particles.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: October 23, 2018
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY O F NEW YORK
    Inventors: Alexander Lee, Wilson Lee, Miriam Rafailovich
  • Tip enhanced laser assisted sample transfer for biomolecule mass spectrometry
    Patent number: 10107835
    Abstract: Disclosed are various embodiments for transferring molecules from a surface for mass spectrometry and other sample analysis methods, and the like. A laser is focused onto a tip of an atomic force microscope to remove and capture a quantity of molecules from the surface, so they can be transferred to a mass spectrometer or another instrument for analysis.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: October 23, 2018
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY
    Inventors: Kermit King Murray, Suman Ghorai, Chinthaka Aravinda Seneviratne
  • RNA hydrogel
    Patent number: 10106794
    Abstract: The disclosure relates to synthetic oligonucleotides that are unique in that they are RNA molecules that have the capacity to form a hydrogel. Also disclosed are DNA oligonucleotides that encode the RNA oligos so that the oligos can be prepared using in vitro transcription. The disclosure further pertains to pharmaceutical compositions comprising these hydrogels.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: October 23, 2018
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Li Niu, Zhen Huang
  • Carbazole-based gumbos for highly efficient blue OLEDs
    Patent number: 10109802
    Abstract: Various examples are provided for carbazole-based GUMBOS (group of uniform materials based on organic salts), and its application in organic light emitting diodes (OLEDs). In one example, a composition includes a solid phase carbazole-based GUMBOS (group of uniform materials based on organic salts) comprising a counterion such as, e.g., trifluoromethanesulfonate ([Otf]), bis-(trifluoromethanesulfonyl)imide ([NTf2]), bis-(pentafluoroethylsulfonyl)imide ([BETI]), tetrafluoroborate (BF4), hexafluorophosphate (PF6), and/or thiocyanate (SCN). The carbazole-based GUMBOS can include carbazoleimidazole-based GUMBOS or 3,6-diBDC carbazolium-based GUMBOS. In another example, a method includes preparing a biphasic solution; separating a layer of DCM from the biphasic solution after stirring; washing the DCM with water to remove byproducts; and evaporating the DCM to form a solid phase carbazoleimidazole-based GUMBOS.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: October 23, 2018
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventors: Noureen Siraj, Isiah Manuel Warner, Thenahandi Prasanthi Deepthika De Silva
  • Biocompatible polymer compositions for tissue void filling
    Patent number: 10105467
    Abstract: Biodegradable, bioabsorbable cross-linked polymer tissue scaffolds for filling a void in human or animal soft tissue, such as a surgical or other wound, are disclosed. Drugs incorporated into the polymer backbone and/or loaded into the matrix are released directly to the target site. Additional non-toxic chemical constituents can be used to tune the hydrophilio hydrophobic and other physical properties of the cross-linked polymer tissue scaffolds, and incorporating brominated or iodinated constituents provides radio-opacity. The radio-opaque cross-linked polymer tissue scaffolds can assist in the targeting of radiation therapy.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: October 23, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Atif J. Khan, Nava Shpaisman
  • Drought-tolerance in plants
    Patent number: 10106813
    Abstract: Drought-inducible plant promoters are described herein that are useful for expressing drought tolerance factors in plants.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: October 23, 2018
    Assignee: Board of Trustees of Michigan State University
    Inventors: Kyung-Hwan Han, Won-Chan Kim, Joo-Yeol Kim, Jae-Heung Ko
  • Methods of applying polymers to surfaces and surfaces coated by polymers
    Patent number: 10109796
    Abstract: Disclosed herein, in certain embodiments, is a method of depositing a polymer onto a surface. In some embodiments, the method comprises using a high electric field and a high frequency vibratory motion to deposit a polymer solution onto the surface. Disclosed herein, in certain embodiments, is a method of manufacturing an electrode or diode. In some embodiments, the method comprises using a high electric field and a high frequency vibratory motion to deposit a polymer onto a surface. Further disclosed herein, in certain instances, is an electrode manufactured by any method disclosed herein. Further disclosed herein, in certain instances, is a diode manufactured by any method disclosed herein.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: October 23, 2018
    Assignee: San Diego State University Research Foundation
    Inventor: Kee Moon
  • Fluid purification system
    Patent number: 10105476
    Abstract: Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: October 23, 2018
    Assignees: Oregon State University, Outset Medical, Inc.
    Inventors: Richard B. Peterson, James R. Curtis
  • Hydrogel compositions and methods for electrochemical sensing
    Patent number: 10107736
    Abstract: Embodiments of hydrogels for electrochemical sensing, electrodes comprising the hydrogels, and methods of making and using the hydrogels are disclosed. The disclosed hydrogel electrodes comprise a cross-linked poly(acrylic acid-co-2-acrylamido-2-methyl-1-propanesulfonic acid (poly(AA-AMPS)) hydrogel and an electrical contact.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: October 23, 2018
    Assignee: Portland State University
    Inventors: Tami Lasseter Clare, Alice H. England
  • Direct inhibitors of Keap1-Nrf2 interaction as antioxidant inflammation modulators
    Patent number: 10106502
    Abstract: A method of identifying compounds as direct inhibitors of Keap1-Nrf2 interaction through high-throughput screening and lead development. The direct inhibitors of Keap1-Nrf2 interaction are more specific and free of various undesirable effects than existing indirect inhibitors, and are potential drug candidates of chemopreventive and therapeutic agents for treatment of various diseases or conditions involving oxidative stress and/or inflammation, including but not limited to cancers, diabetes, Alzheimer's, and Parkinson's. Novel compounds are identified and methods of preventing or treating diseases or conditions related to Keap1-Nrf2 interaction activity by use of the novel compounds identified or compositions containing such compounds are also disclosed.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: October 23, 2018
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, THE BROAD INSTITUTE, INC.
    Inventors: Longqin Hu, Sadagopan Magesh, Lin Chen, Timothy Lewis, Ben Munoz, Lili Wang
  • CHIMERIC OSPA GENES, PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20180296656
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Application
    Filed: January 19, 2018
    Publication date: October 18, 2018
    Applicants: BROOKHAVEN SCIENCE ASSOCIATE, LLC, RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK
    Inventors: Brian A. Crowe, Ian Livey, Maria O'rourke, Michael Schwendinger, John J Dunn, Benjamin J Luft
  • Explant Assay to Determine the Potential for Compositions to Promote or to Inhibit Neural Tube Defects
    Publication number: 20180299431
    Abstract: An explant assay based on embryonic tissue from laboratory animals may be used to identify substances that promote neural tube defects—teratogens to be avoided in pregnancy, and substances that inhibit neural tube defects—supplements that might be taken with benefit during pregnancy—to help reduce the incidence of birth defects. The assay screens for compounds that improve or impede mesodermal cell migration from an explant containing the primitive streak and parts of the lateral mesodermal wings that have been dissected from the embryo of a mouse or other experimental animal. Impaired migration of nascent mesodermal cells in the primitive streak is the morphogenetic basis underlying the pathogenesis of neural tube defects. We also hypothesize that maternal diabetes adversely affects mesoderm during gastrulation, before neurulation occurs.
    Type: Application
    Filed: October 26, 2016
    Publication date: October 18, 2018
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Johannes Michael Salbaum, Claudia Kappen
  • ANTIBODY BASED REAGENTS THAT SPECIFICALLY RECOGNIZE TOXIC OLIGOMERIC FORMS OF TAU
    Publication number: 20180298086
    Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.
    Type: Application
    Filed: January 26, 2018
    Publication date: October 18, 2018
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Michael SIERKS, Huilai TIAN
  • FRAMEWORK FOR SECURITY STRENGTH AND PERFORMANCE ANALYSIS OF MACHINE LEARNING BASED BIOMETRIC SYSTEMS
    Publication number: 20180300487
    Abstract: A framework for measuring the security strength of bio-metric security systems against spoofing attacks considering the adversary's knowledge about the system is disclosed.
    Type: Application
    Filed: April 10, 2018
    Publication date: October 18, 2018
    Applicant: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Sandeep K.S. Gupta, Ayan Banerjee, Seyed Koosha Sadeghi Oskooyee, Mohammad Javad Sohankar Esfahani
  • COMPOSITIONS FOR TREATING PERIODONTITIS AND DENTAL CALCULUS ACCUMULATION
    Publication number: 20180296454
    Abstract: Compositions comprising serine and an organic mono- or multi-phosphate salt and methods of using such compositions to treat and/or prevent periodontal disease and/or dental calculus are provided.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 18, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Israel Kleinberg, Robi Chatterjee
  • Molecular constructs for differentiating a target molecule from an off-target molecule
    Patent number: 10100350
    Abstract: Molecular constructs, populations thereof, arrays, compositions, methods and kits for differentiating a target molecule from an off-target molecule are provided.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: October 16, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kenneth J. Breslauer, William H. Braunlin, Leslie C. Beadling, Jens Volker
  • Fusion protein for HIV-1 gp120 antigen detection
    Patent number: 10100091
    Abstract: The present disclosure relates to novel fusion proteins that bind to the HIV-1 gp120 antigen. The present disclosure also relates to nucleic acids, plasmids and host cells that comprise a sequence that encodes the fusion proteins of the disclosure. The fusion proteins of the disclosure can be used in applications to detect the presence of HIV-1 gp120 protein, to detect an HIV-1 infection and to monitor treatment of an HIV-1 infection.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: October 16, 2018
    Assignee: ARIZONA BOARD OF REGENTS, for and on behalf of, ARIZONA STATE UNIVERSITY
    Inventor: Shengxi Chen
  • Reversible adhesive compositions and related methods
    Patent number: 10099458
    Abstract: The disclosure relates to reversible bonded structural joints using active adhesive compositions that can allow for dis-assembly, repair, and re-assembly. The disclosure is particularly directed to the adhesive composition material, irrespective of the type of the substrate(s) being joined. The adhesive composition can include any thermoplastic adhesive material that can be remotely activated for targeted heating of just the adhesive composition (e.g., and not the surrounding substrates being joined) via the inclusion of electromagnetically excitable particles in the adhesive composition. The substrates can be any metal material, any composite material, any hybrid material, or otherwise. The disclosed adhesive compositions allow for recyclability of parts at the end of their lifetime and repair/replacement of parts during their lifetime.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: October 16, 2018
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Mahmoodul Haq, Lawrence T. Drzal, Ermias G. Koricho
  • Facemask
    Patent number: D831895
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: October 23, 2018
    Assignee: Mississippi State University
    Inventors: Kyle Johnson, Mark F. Horstemeyer, Souma Chowdhury, Yuxiong Mao