Abstract: A system may be configured for implementing targeted attacks on deep reinforcement learning-based autonomous driving with learned visual patterns. In some examples, processing circuitry receives first input specifying an initial state for a driving environment and user configurable input specifying a target state. Processing circuitry may generate a representative dataset of the driving environment by performing multiple rollouts of the vehicle through the driving environment, including performing an action for the vehicle from the initial state with variable strength noise added to determine a next state for each rollout resulting from the action. Processing circuitry may train an artificial intelligence model to output a next predicted state based on the representative dataset as training input. In such an example, processing circuitry outputs from the artificial intelligence model, an attack plan against the autonomous driving agent to achieve the target state from the initial state.

Abstract: The present disclosure relates, in part, to soluble guanylyl cyclase (GC1) mimetic polypeptides comprising amino acid residues 581-635 of the ?-subunit of soluble guanylyl cyclase (GC1), or a fragment thereof, and at least one cell penetrating peptide (CPP). The present disclosure further relates to methods of treating, preventing, and/or ameliorating a disease or disorder in a subject, including but not limited to cancer, hypertension, hypotension, and cardiac dysfunction. In certain embodiments, the methods comprising administering to the subject the polypeptide of the present disclosure.

Abstract: Metal complexes with nitrile ligands of the type MO2X2L2, where M is molybdenum or tungsten, X is a halogen, each L is independently an organonitrile ligand with the general formula NCR, where each R is independently a C2-C18 group. Metal complexes with dinitrile bidentate ligands of the type MO2X2L?, where L? is a dintrile ligand, and dinitrile bridging ligands of the type (MO2X2)2L?, where L? is a dinitrile bridging ligand connecting the two metal atoms. Methods of making and using the metal complexes are described.

Abstract: Disclosed herein are compounds according to Formula A wherein the compound comprises at least one C6-30aliphatic moiety. Also disclosed are compositions comprising the compounds that may be useful for delivering agents such as therapeutic and/or prophylactic agents, for example, nucleic acids such as, but not limited to, DNA or RNA, small molecules, proteins, polypeptides or peptides. In some embodiments, the composition is a lipid nanoparticle. Also disclosed herein are lipid nanoparticles comprising the compounds and methods for making and using the nanoparticles.

Abstract: A system for testing sensors is disclosed. The system includes a platform having a plurality of mounting holes and a microcontroller, the microcontroller having a wireless network interface. The system also includes a mount releasably coupled to the platform through a mounting hole, the mount configured to hold a sensor. The system includes a motor operatively coupled to the platform, and a motor controller communicatively coupled to the motor and configured to drive the motor to rotate the platform about an axis of rotation at a target speed. The microcontroller is communicatively coupled to a sensor releasably coupled to the mount. The microcontroller is configured to receive a measurement from the sensor that is output by the sensor in response to the platform being rotated such that the mount is subjected to a constant centripetal force. The microcontroller is configured to wirelessly transmit the measurement to an external device.

Abstract: The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

Abstract: This invention is directed to compositions and methods for detecting proteinopathies.

Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.

Abstract: A method and system of operating a vehicle includes a first sensor generating first sensor data for an object comprising a first bounding box from a first sensor. The first sensor data comprising a first confidence score. A second sensor generates second sensor data for the object comprising a second bounding box from a second sensor different than the second sensor. The second sensor data comprises a second confidence score. A bounding box circuit is programmed to generate a third confidence score for the object based on the first sensor data and the second sensor data and utilize the first sensor data, the second sensor data and the third confidence score to control operation of a vehicle system.

Abstract: A system for measuring a membrane potential is disclosed. The system comprises a photoacoustic probe including a laser and an ultrasound transducer. The laser is configured to emit a light signal at one or more wavelengths to a neuronal cell. The neuronal cell may comprise a voltage-sensitive protein configured to absorb the light signal in a voltage-dependent manner. The ultrasound transducer is configured to receive a photoacoustic signal from the voltage-sensitive protein in response to absorbing the light signal. The system further comprises a processor configured to receive the photoacoustic signal from the ultrasound transducer and calculate a membrane potential of the neuron based on the photoacoustic signal. Methods of measuring a membrane potential and biomaterials related to the voltage-sensitive protein are also disclosed herein.

Abstract: Methods and systems for the detection and quantification of multiplicity of ionic analytes comprising CrO42?, AsO43?, SeO42?, and ClO4?, and optionally F?, Cl?, NO2?, NO3?, SO42?, using ion chromatography and suppressed ion conductivity. The method comprises loading a sample loop with a sample; injecting the sample from the sample loop into a column with an eluent, wherein the column comprises a guard column and an analytical column; separating, with the column, the injected sample at an effective separation temperature the injected sample in the presence of an organic modifier into a multiplicity of detectable ionic analytes; suppressing, with a suppressor, background signal; and detecting, with a detector, the multiplicity of ionic analytes.

Abstract: Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

Abstract: The present disclosure provides methods of treating a pathogen-induced lung inflammation in a subject are provided in which an anti-S100A9 antibody is administered to a subject. Methods of treating a respiratory virus infection by administering an anti-S100A9 antibody are also provided.

Abstract: An electrochemical cell is provided comprising a thin metal foil packaging made from at least one sheet of metal foil and having a perimeter extending around at least a portion of the electrochemical cell, as well as an electrochemical cell stack contained within the thin metal foil packaging, and a metal-to-metal welded seal around at least a portion of the perimeter of the thin metal foil packaging. The metal-to-metal welded seal is hermetic or nearly hermetic. Furthermore, the metal-to-metal welded seal is narrow, having a width of less than about 1 mm, and is less than about 5 mm away from the electrochemical cell stack. In some embodiments, the thin metal foil packaging functions not only as a hermetically or near hermetically sealed packaging, but also as either the negative or positive current collector, with one electrode of the cell bonded to the foil packaging.

Abstract: An apparatus, method, and system for post-processing a printed graphene ink pattern or other deposition on a substrate. A pulsed UV laser is tunable between various energy densities to selectively modify the printed ink or deposition in electrical or physical properties. In one example, radical improvements in electrical conductivity are achieved. In another example, controlled transformation from essentially 2D printed or deposited graphene to surface topology of 3D nanostructures are achieved. The 3D structures are beneficial in such applications as electrochemical sensors of different types and characteristics. In another example, hydrophobicity of the printed or deposited graphene can be manipulated starting from a hydrophilic to super hydrophobic surface.

Abstract: Various examples are provided related to transformer designs that offer very high isolation while maintaining high coupling between the windings. In one example, an isolation transformer includes a first excitation coil wound around a first core and a second excitation coil wound about a second core. The second core is electrically separated from the first core by a high resistivity magnetic material or a non-conductive material. The first and second cores can include corresponding core segments arranged in a trident geometry or a quindent geometry. The core segments can align when the first excitation coil is inserted into a void of the second excitation coil. The isolation transformer designs are mechanically separable which can result in safe, energized, plug operations.

Abstract: Described herein are quinoline compounds useful for, among other things, inhibition of the proteasome and for treatment of cancer and inflammation.

Abstract: Advancements in solid tumor (e.g., renal cell carcinoma) treatments and imaging are described. The advancements are based on nanoformulations that: (i) overcome deliverability issues associated with anti-cancer compounds; (ii) have increased targeted delivery to tumors, and hypoxic cores of tumors due to the presence of targeting ligands; (iii) have increased delivery to the hypoxic cores of tumors due to engineered shapes; (iv) provide synergistic treatment combinations; and/or (v) overcome cancer cell resistance to therapeutic treatments.

Abstract: Processes for conductive material nanogap formation have been developed that include: providing a base material, wherein the base material is either solid or comprises a micropore that extends through the first layered material, and wherein the micropore comprises a top opening, a bottom opening, and a volume boundary, applying a conductive material sheet to the first layered material, wherein the conductive material sheet covers the top opening of the micropore, applying two conducting electrodes to the conductive material sheet, so that each one of the conducting electrodes is positioned on either side of the micropore, applying an etch mask that covers at least a part of the conductive material sheet, the top opening of the micropore (if present), or a combination thereof, applying a passivation layer over at least the etch mask, fabricating a hole in the passivation layer directly above the top opening of the micropore, and applying at least one voltage pulse through the at least one conducting electrode

Abstract: The disclosure relates to a filtration system for harvesting microalgae. The filtration system includes a filter housing with modular filtration units each containing a fungal filter. The fungal filter includes a perforated support with a capture fungus on the support. The fungal filter is adapted to be removed and replaced from the modular filtration unit, for example during operation of the filtration system. The capture fungus is adapted to capture one or more types of microalgae upon contact of the capture fungus with the microalgae, for example via fungal mycelium. During use of the filtration system to treat an influent stream containing microalgae, microalgae are captured and coated on the fungal filters. The coated fungal filters can be easily removed and the microalgae is harvested directly from the perforated support. New replacement filters can be inserted into the filtration system for continuous operation.