Abstract: The present invention relates to a method of increasing resistance against plant pathogens, particularly Phytophthora and Fusarium virguliforme in transgenic plants and/or plant cells, through the use of non host resistance nucleic acid molecules isolated from Arabidopsis. In these plants, at least one nonhost Arabidopsis resistance protein is introduced in comparison to the wild-type plants to confer resistance to plant pathogens. The invention relates to transgenic plants and/or plant cells having an increased resistance against plant pathogens particularly Phytophthora and Fusarium virguliforme to expression vectors, transformed plants and plant cells as well as the use of such plants in a plant breeding program.
Type:
Grant
Filed:
March 4, 2013
Date of Patent:
August 14, 2018
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Madan K. Bhattacharyya, Rishi Sumit, Binod B. Sahu
Abstract: A method to determine the distribution of non-reactive sulfur compounds and reactive sulfur compounds in petroleum samples by separating non-reactive sulfur compounds from reactive sulfur compounds in a petroleum composition includes the step of contacting the petroleum composition with a Ag-containing cation exchange media. The petroleum composition and the Ag-containing cation exchange media are contacted with a non-reactive sulfur compound solvent capable of eluting the non-reactive sulfur compounds in the presence of the Ag-containing cation exchange media and incapable of eluting the reactive sulfur compounds in the presence of the Ag-containing cation exchange media at the conditions of the exchange. The non-reactive sulfur compounds are eluted from the media with the non-reactive sulfur compound solvent to provide a first fraction. The amount of non-reactive sulfur compounds in the first fraction is then determined.
Type:
Grant
Filed:
March 13, 2014
Date of Patent:
August 14, 2018
Assignee:
FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Inventors:
Ryan P. Rodgers, Winston K. Robbins, Vladislav V. Lobodin
Abstract: Methods and systems for identifying blobs, for example kidney glomeruli, are disclosed. A raw image may be smoothed via a difference of Gaussians filter, and a Hessian analysis may be conducted on the smoothed image to mark glomeruli candidates. Exemplary candidate features are identified, such as average intensity AT, likelihood of blobness RT, and flatness ST. A clustering algorithm may be utilized to post prune the glomeruli candidates.
Type:
Grant
Filed:
March 28, 2016
Date of Patent:
August 14, 2018
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: Interactive visualizations of a convolutional neural network are provided. For example, a graphical user interface (GUI) can include a matrix having symbols indicating feature-map values that represent likelihoods of particular features being present or absent at various locations in an input to a convolutional neural network. Each column in the matrix can have feature-map values generated by convolving the input to the convolutional neural network with a respective filter for identifying a particular feature in the input. The GUI can detect, via an input device, an interaction indicating that that the columns in the matrix are to be combined into a particular number of groups. Based on the interaction, the columns can be clustered into the particular number of groups using a clustering method. The matrix in the GUI can then be updated to visually represent each respective group of columns as a single column of symbols within the matrix.
Type:
Grant
Filed:
October 3, 2017
Date of Patent:
August 14, 2018
Assignees:
SAS INSTITUTE INC., NORTH CAROLINA STATE UNIVERSITY
Inventors:
Samuel Paul Leeman-Munk, Saratendu Sethi, Christopher Graham Healey, Shaoliang Nie, Kalpesh Padia, Ravinder Devarajan, David James Caira, Jordan Riley Benson, James Allen Cox, Lawrence E. Lewis, Mustafa Onur Kabul
Abstract: The present invention relates to the administration of compositions comprising polyethylene glycol, for improving the general gastrointestinal health of an animal increasing growth performance and treating osteopenia, osteoporosis and other bone disorders.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
August 14, 2018
Assignees:
MIDWAY PHARMACEUTICALS, INC, BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
Abstract: The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs).
Type:
Grant
Filed:
December 14, 2013
Date of Patent:
August 14, 2018
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Abstract: An insect control composition and related methods of preparation and use are disclosed. The composition includes a mixture of non-Cannabaceae flour and an amount of Cannabaceae seed flour effective to mitigate a population of Insecta treated with the mixture.
Abstract: Disclosed herein are methods of treating diseases that exhibit over-activation of the ERBB4 pathway, such as breast cancer and lung cancer. The method comprises administering to a subject having a disease that exhibits over-activation of the ERBB4 pathway and a gene expression profile consistent with an ERBB4-sensitive profile a therapeutically effective amount of an ERBB4 inhibitor, wherein the disease is effectively treated. Gene expression profiles of ERBB4-sensitive cells and microarrays suitable for protein-tyrosine kinases are also provided.
Type:
Grant
Filed:
March 2, 2016
Date of Patent:
August 14, 2018
Assignee:
Arizona Board of Regents on Behalf of Arizona State University
Inventors:
Fernanda Festa, Joshua Labaer, Jin Park, Femina Rauf
Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.
Type:
Grant
Filed:
January 12, 2017
Date of Patent:
August 14, 2018
Assignees:
THE OHIO STATE UNIVERSITY, NATIONWIDE CHILDREN'S HOSPITAL, INC.
Abstract: Gait rehabilitation systems, methods, and apparatuses thereof are disclosed. In accordance with one aspect of the invention, a gait rehabilitation system may include a harness configured for attachment to an individual and at least one sensor configured to sense at least one parameter associated with gait of an individual, the individual having an affected leg and an unaffected leg. The system includes a braking system configured for attachment to the harness and in communication with the at least one sensor. The braking system is further configured for monitoring the at least one sensor to sense the at least one parameter associated with an individual's gait, determining when the affected leg is in a modification portion of the individual's gait from the sensed at least one parameter, and applying a braking force resisting movement of the harness during the determined modification portion.
Type:
Application
Filed:
August 5, 2016
Publication date:
August 9, 2018
Applicants:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE STATE UNIVERSITY OF NEW YORK
Abstract: A heterojunction device is provided. The heterojunction device includes a silicon (Si) substrate; and a film of silicon carbide (SiC) deposited on a surface of the Si substrate. The SiC has a Si:C ratio that increases or decreases from a SiC surface in contact with the Si substrate to an opposing SiC surface that is not in contact with the Si substrate.
Type:
Application
Filed:
April 2, 2018
Publication date:
August 9, 2018
Applicant:
Board of Trustees of Michigan State University
Inventors:
Premjeet CHAHAL, Tim HOGAN, Amanpreet KAUR
Abstract: An ionization detector that reduces the filtering effects of the ignition coil inductances by shorting an inductance of a primary winding of the ignition coil. The ionization detector includes a bias voltage source and an inductance control switch. The bias voltage source supplies electric voltage across an electric gap of a spark plug for detecting ionization within the combustion chamber. The inductance control switch is electrically parallel with a primary winding of an ignition coil and is operable to short an inductance of the primary winding.
Type:
Application
Filed:
August 11, 2016
Publication date:
August 9, 2018
Applicant:
Board of Trustees of Michigan State University
Abstract: The disclosure relates to in vitro cultures of human hepatocytes, and in particular co-cultures systems including human hepatocytes, non-parenchymal cells, and human endothelial cells, and the use of the co-cultures in developing and screening drugs.
Type:
Application
Filed:
August 5, 2016
Publication date:
August 9, 2018
Applicant:
Colorado State University Research Foundation
Inventors:
Salman R. Khetani, Mitchell J. Durham, Brenton R. Ware
Abstract: A novel silver-lithium-iodine solid-state energy device and system are disclosed. The rechargeable, self-assembled, dual-function, metal-iodide battery exhibits small size and high deliverable power. Inert until activation, the device may be stored for long periods of time. Upon activation, the device assembles the required electrochemical moieties for operation without external intervention. The device limits short-circuiting and self-discharge of the system by spontaneous reactions at the electrode/electrolyte interfaces, and thus is self-healing. By incorporating both silver and lithium in the same system, a dual function is achieved, whereby the characteristics of a lithium-based battery dominate at a low load and those of a silver-based battery dominate under a high load.
Type:
Application
Filed:
August 1, 2016
Publication date:
August 9, 2018
Applicant:
The Research Foundation for the State University of New York
Inventors:
Esther S. TAKEUCHI, Kenneth J. TAKEUCHI, Amy C. MARSCHILOK
Abstract: Mechanisms for simultaneously monitoring colonoscopic video quality and detecting polyps in colonoscopy are provided. In some embodiments, the mechanisms can include a quality monitoring system that uses a first trained classifier to monitor image frames from a colonoscopic video to determine which image frames are informative frames and which image frames are non-informative frames. The informative image frames can be passed to an automatic polyp detection system that uses a second trained classifier to localize and identify whether a polyp or any other suitable object is present in one or more of the informative image frames.
Type:
Application
Filed:
August 8, 2016
Publication date:
August 9, 2018
Applicant:
Arizona Board of Regents on behalf of Arizona State University
Abstract: The cis- and trans-isomers of the plant-derived compound suffruticosol D are shown to have anticancer properties. Therapeutic and prophylactic compositions that contain cis- or trans-suffruticosol D, as well as methods of making and using said compositions, are provided. The cis- or /ra«s-suffruticosol D can be used in purified form or as a plant extract.
Abstract: Aspects of the present disclosure involve systems, methods, and the like, for an electrochemical sensing platform for point-of-care diagnostic applications. The ES platform may include functionality for many types of ES applications, including but not limited to, voltammetry, galvanometry, amperometry, and electrochemical impedance spectroscopy (EIS). In some embodiments, the platform includes sensor analog front end, stimulus generation, analog sensor data acquisition and conditioning, digital-to-analog conversion, back-end digital signal processing, wired or wireless interface, and a user application for interacting with the platform. In some embodiments, the platform includes a number of functional modules to provide a low cost and high mobility to the device, while maintaining the performance specifications. Signal generation, digital data acquisition/processing may be managed by an on-board microcontroller or off-board computing device.
Type:
Application
Filed:
February 7, 2018
Publication date:
August 9, 2018
Applicant:
Colorado State University Research Foundation
Abstract: Disclosed is a method and system that receives sensor information from each of a plurality of sensors. Each sensor in the plurality is associated with a vehicle. The sensor information includes location coordinates of each vehicle in the plurality. The sensor information associated with each vehicle in the plurality then is translated to parking statistics information. In one embodiment, the translation is based on an aggregate of sensor information corresponding to the plurality of vehicles. The system then communicates parking statistics information to the vehicle.
Type:
Grant
Filed:
February 3, 2017
Date of Patent:
August 7, 2018
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Abstract: A method for determining a pathology of a tissue sample. The method includes steps of coupling the tissue sample between two oppositely-facing ultrasonic transducers; acquiring a pulse-echo ultrasonic measurement and a through-transmission ultrasonic measurement of the tissue sample using the ultrasonic transducers; analyzing at least one of the pulse-echo ultrasonic measurement and the through-transmission ultrasonic measurement using time domain analysis; analyzing at least one of the through-transmission ultrasonic measurements and the pulse-echo ultrasonic measurements using frequency domain analysis; and determining the pathology of the tissue sample based on at least one of the time domain analysis and the frequency domain analysis.
Type:
Grant
Filed:
November 14, 2011
Date of Patent:
August 7, 2018
Assignees:
UNIVERSITY OF UTAH RESEARCH FOUNDATION, UTAH STATE UNIVERSITY