Abstract: Provided are compositions and methods relating to hydrophobic agent loaded-micelle. The micelles comprise surfactant (such as poloxamer) and have hydrophobic agents incorporated therein. The compositions substantially lack surfactant that is not associated with the micelles. The compositions are able to achieve high hydrophobic agent: surfactant molar ratio. The compositions can be used for drug delivery and imaging applications.
Type:
Grant
Filed:
July 2, 2015
Date of Patent:
September 12, 2017
Assignee:
The Research Foundation for The State University of New York
Inventors:
Jonathan Lovell, Yumiao Zhang, Wentao Song, Jumin Geng, Chulhong Kim, Mansik Jeon
Abstract: A reaction method comprising combining a carbonyl-substituted arylboronic acid or ester and an ?-effect amine in aqueous solution at a temperature between about ?5 C to 55 C, and a pH between 2 and 8 to produce an adduct. A process is also provided comprising: contacting a composition having a boron atom bonded to a sp2 hybridized carbon, the boron having at least one labile substituent, conjugated with a cis-carbonyl, with an ?-effect amine, in an aqueous medium for a time sufficient to form an adduct, which may proceed to further products.
Type:
Grant
Filed:
April 23, 2015
Date of Patent:
September 12, 2017
Assignee:
The Research Foundation for The State University of New York
Inventors:
Susan Bane Tuttle, Ozlem Dilek, Kamalika Mukherjee
Abstract: A compound that is useful for forming a metal by reaction with a reducing agent is described by formula (I): wherein M is a metal selected from Groups 2 through 12 of the Periodic Table; and R1, R2, R3, and R4 are each independently H or C1-C8 alkyl.
Type:
Grant
Filed:
February 13, 2013
Date of Patent:
September 12, 2017
Assignee:
Wayne State University
Inventors:
Charles H. Winter, Lakmal C. Kalutarage
Abstract: A self-balancing optical position sensitive detector includes a pair of spaced apart, parallel, longitudinally extending doped regions on a first surface on a front side of a substrate 16 of opposite doping type with contact pads on the front side at respective ends of a first doped region of the pair. A voltage source applies a potential difference between the contact pads of the first doped region. On the front side, a contact pad of the second doped region of the pair provides an analog output signal representative of a longitudinal position of a center of gravity of an incident light pattern along the doped regions without external circuitry processing the output signal to obtain a readout of the longitudinal position. A resistive line may directly overly, abut and be in contact with at least a portion of the first doped region. A conductive line may directly overly, abut and be in contact with at least a portion of the second doped region.
Type:
Application
Filed:
June 10, 2016
Publication date:
September 7, 2017
Applicant:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventors:
James CASTRACANE, Natalya TOKRANOVA, Leigh LYDECKER
Abstract: A near field communication (NFC) system and method for controlling transmission power of the NFC system includes a NFC reader configured to transmit a radio frequency (RF) signal having an initial amount of RF power, a NFC target device in selective communication with the NFC reader, and a NFC transmission power control platform disposed between the NFC reader and the NFC target device. The platform includes a microcontroller and at least one circuit in communication with the microcontroller and configured to determine an actual amount of RF power needed to sustain near field communications between the NFC reader and the NFC target device and configured to regulate the RF signal, where the regulated RF signal contains the actual amount of RF power needed to sustain near field communications between the NFC reader and the NFC target device.
Type:
Grant
Filed:
October 17, 2014
Date of Patent:
September 5, 2017
Assignee:
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
Abstract: Mutations located within the gene encoding the homeobox transcription factor, ENGRAILED 2 (EN2), have now been identified as molecular markers associated with susceptibility for autism and related disorders. Thus, the present invention relates to compositions in the form of diagnostic kits, primers and target sequences, for use in methods for determining the predisposition, the onset or the presence of autism spectrum disorder in a mammal. Moreover, therapeutic methods for treating a person inflicted with, or predisposed to, an autism spectrum disorder based upon modulating the level or activity of EN2 are also provided.
Type:
Grant
Filed:
March 8, 2013
Date of Patent:
September 5, 2017
Assignee:
Rutgers, The State University of New Jersey
Inventors:
James H. Millonig, Linda Brzustowicz, Neda Gharani
Abstract: Systems and methods for synthesizing high-quality nanocrystals via segmented, continuous flow microwave-assisted reactor were developed.
Type:
Grant
Filed:
December 24, 2014
Date of Patent:
September 5, 2017
Assignee:
STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY
Inventors:
Ki-Joong Kim, Eric Bradley Hostetler, Gregory Scott Herman, Daniel Alan Peterson, Chih-hung Chang, Brendan Thomas Flynn, Brian Kevin Paul, Richard Paul Oleksak
Abstract: This application relates to techniques for obtaining wide area intermittent video (WAIV). Some embodiments disclosed herein include a method of obtaining WAIV. The method can include, for example, capturing images at a series of sensor stations having pre-determined locations along a flightline. The flightline can be repeated one or more times, where images are captured at the same sensor stations with each pass of the flightline. The captured images from the same sensor station may have replicated view geometry and may be co-registered and precisely aligned with pixel-level precision. The captured images from multiple sensor stations through time may also be displayed together based upon absolute or relative sensor station locations to create a temporal sequence of wide area intermittent video. The approach provides efficient methods for creating wide area video with reduced temporal imaging frame rates. Systems and devices for forming wide area intermittent video are also disclosed.
Type:
Grant
Filed:
June 12, 2013
Date of Patent:
September 5, 2017
Assignee:
San Diego State University Research Foundation
Inventors:
Lloyd Lawrence Arthur Coulter, Christopher Lippitt
Abstract: A point spread function (PSF) of a focused scanning particle beam of an observation instrument is ascertained by obtaining a first image (reference image) based on a reference instrument, the reference image being an image of an area of a reference standard, obtaining a second image (observed image) of the area of the reference standard, and the observed image obtained using the observation instrument configured with a set of operational parameters that define a probe size for the observation instrument, the probe size being larger than a pixel size of the reference image, and then determining, based on the reference image and the observed image, the PSF of the observation instrument as a component of a convolution of the reference image that provides the observed image.
Type:
Grant
Filed:
December 22, 2015
Date of Patent:
September 5, 2017
Assignee:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Abstract: A method of separating a lignin-rich solid phase from a solution suspension, by pretreating a lignocellulosic biomass with a pretreatment fluid having remove soluble components, colloidal material and primarily lignin containing particles; separating the pretreated lignocellulosic biomass from the pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles; flocculating the separated pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles using polyethylene oxide (i.e., PEO) or cationic Poly acrylamide (i.e., CPAM) as a flocculating agent; and filtering the flocculated separated pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles to remove agglomerates.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
September 5, 2017
Assignee:
The Research Foundation for The State University of New York
Inventors:
Lakshmi Rakesh Kumar Yasarla, Bandaru V. Ramarao, Thomas Amidon
Abstract: A method for using plasma to activate biochar is disclosed where reactive gas(es) are excited by external power; biochar set on a sample holder is electrically biased or set at a floating potential so that charged particles of a certain type are attracted to the biochar, leading to intensive chemical reactions.
Abstract: A water treatment system including: a flow regulation control system configured to combine oxo-anion-contaminated water with a reduction-promoting agent, a hole scavenger, or both; a reactor fluidically coupled to the flow regulation control system; a first set of system control probes configured to monitor the concentration of oxygen and oxo-anion in the contaminated water; a second set of system control probes configured to monitor concentration of the oxo-anion and reduction products of the oxo-anion in treated effluent from the reactor; and a controller configured to control the flow regulation control system, thereby controlling the flow rate of the contaminated water and the at least one of the reduction-promoting agent and the hole scavenger to the reactor based at least in part on the concentration of oxo-anion and the reduction products of the oxo-anion in the treated effluent.
Type:
Grant
Filed:
October 8, 2014
Date of Patent:
September 5, 2017
Assignee:
Arizona Board of Regents for and on behalf of Arizona State University
Inventors:
Kyle Doudrick, Kiril D. Hristovski, Paul K. Westerhoff
Abstract: Provided are compositions and methods of use thereof that modulate C/EBP homologous stress-related protein (Chop) activity in Myeloid-derived Suppressor Cells (MDSCs). Chop is a key point in the response of MDSCs to tumor-generated stress factors. In turn, the MDSCs release cytokines and other factors that function as immune suppressors, thereby allowing the tumors to thrive and expand. By inhibiting the level of Chop activity, the immunosuppressive function of MDSCs is disrupted. It has also been unexpectedly found that there is a concomitant increase in the ability of MDSCs to act as antigen-presenting and cytokine producing cells so as to act in increasing the efficacy of anti-tumor immune-based therapies.
Type:
Grant
Filed:
March 16, 2015
Date of Patent:
September 5, 2017
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Paulo Cesar Rodriguez, Augusto C. Ochoa
Abstract: Processes are described for making methacrylic acid via methacrolein from a biobased isobutene, wherein the biobased isobutene is prepared from ethanol or from acetic acid in the presence of a ZnxZryOz mixed oxide catalyst, the biobased isobutene is oxidized to methacrolein and the methacrolein is further oxidized to methacrylic acid.
Type:
Grant
Filed:
June 16, 2016
Date of Patent:
September 5, 2017
Assignees:
Archer Daniels midland Co., Washington state University
Abstract: A method for controlling a data center, comprising a plurality of server systems, each associated with a cooling system and a thermal constraint, comprising: a concurrent physical condition of a first server system; predicting a future physical condition based on a set of future states of the first server system; dynamically controlling the cooling system in response to at least the input and the predicted future physical condition, to selectively cool the first server system sufficient to meet the predetermined thermal constraint; and controlling an allocation of tasks between the plurality of server systems to selectively load the first server system within the predetermined thermal constraint and selectively idle a second server system, wherein the idle second server system can be recruited to accept tasks when allocated to it, and wherein the cooling system associated with the idle second server system is selectively operated in a low power consumption state.
Type:
Grant
Filed:
January 13, 2014
Date of Patent:
September 5, 2017
Assignee:
The Research Foundation for The State University of New York
Abstract: A method and system for enabling the determination of kinetic rates within a fluid of interest including directing fluid flow exiting a test bed to a multi-port switching valve. The multi-port switching valve to switches the fluid to a number of channels connected to in in-flow extraction cartridge. Analytes of interest from the fluid flow our concentrated and captured on an extraction medium. Rates are determined by (i) sequentially channeling the fluid through the each of the plurality of channels for a preselected time duration, (ii) analyzing the extraction cartridges, and computing the kinetic rate of interest.
Type:
Application
Filed:
May 11, 2017
Publication date:
August 31, 2017
Applicant:
Arizona Board of Regents on behalf of Arizona State University
Abstract: This disclosure relates generally to digital synchronous circuits that introduce clock skew without requiring clock buffers in a clock network. In one embodiment, the digital synchronous circuit includes a first flip flop and a second flip flop. The first flip flop is synchronized to be transparent and to be opaque in accordance with a first clock signal while the second flip flop is configured such that the second flip flop is synchronized to be transparent and to be opaque in accordance with a second clock signal. However, the second flip flop is configured to generate the first clock signal such that the second flip flop provides the first clock signal in a first clock state in response the second flip flop becoming transparent and provides the first clock signal in a second clock state in response the second flip flop becoming opaque thereby providing a clock skew without clock buffers.
Type:
Application
Filed:
February 27, 2017
Publication date:
August 31, 2017
Applicant:
Arizona Board of Regents on behalf of Arizona State University
Abstract: The disclosed technology concerns methods, apparatus, and systems for designing and generating networks-on-chip (“NoCs”), as well as to hardware architectures for implementing such NoCs. The disclosed NoCs can be used, for instance, to interconnect cores of a chip multiprocessor (aka a “multi-core processor”). In one example implementation, a wire-based routerless NoC design is disclosed that uses deterministically specified wire loops to connect the cores of the chip multiprocessor. The disclosed technology also comprises network interface architectures for use in an NoC. For example, a core can be equipped with a low-area-cost interface that is deadlock-free, uses buffering sharing, and provides low latency.
Type:
Application
Filed:
February 28, 2017
Publication date:
August 31, 2017
Applicant:
Oregon State University
Inventors:
Lizhong Chen, Fawaz M. Alazemi, Bella Bose