Patents Assigned to State University
  • Endoscope for analyte consumption rate determination with single cell resolution for in vivo applications
    Patent number: 9597026
    Abstract: Novel methods and devices including modified endoscopes that employ fiber optic technology and multiple extrinsic optical sensors for enablement of simultaneous determination of change rates of biological analytes in vivo with single-cell resolution. The devices employ dynamic oscillatory actuation to determine the gradient of analytes of interest along one or multiple directions with respect to the cell. The change rate or flux of the analyte of interest can be easily determined by applying the first Fick's law that relates the flux with the concentration gradient. The dual operation mode of the device markedly increases measurement sensitivity and accuracy.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: March 21, 2017
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Deirdre Meldrum, Laimonas Kelbauskas, Jeff Houkal, Roger Johnson, Yanqing Tian, Cody Youngbull
  • Tobacco inbred and hybrid plants and tobacco products made thereof
    Patent number: 9596823
    Abstract: The present disclosure provides tobacco inbred plants Banket A1 SRC, CMS Banket A1 SRC, NC 2000 SRC, CMS NC 2000 SRC, NC 2002 SRC, CMS NC 2002 SRC, Burley 21 SRC, and CMS Burley 21 SRC. The present disclosure also provides parts of such plants and cured tobacco and tobacco products made from those parts. The present disclosure also includes progenies of the provided plants including hybrids.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 21, 2017
    Assignee: North Carolina State University
    Inventors: Ramsey S. Lewis, Ralph E. Dewey
  • Systems and methods for improving processor efficiency through caching
    Patent number: 9600418
    Abstract: Certain embodiments herein relate to using tagless access buffers (TABs) to optimize energy efficiency in various computing systems. Candidate memory references in an L1 data cache may be identified and stored in the TAB. Various techniques may be implemented for identifying the candidate references and allocating the references into the TAB. Groups of memory references may also be allocate to a single TAB entry or may be allocated to an extra TAB entry (such that two lines in the TAB may be used to store L1 data cache lines), for example, when a strided access pattern spans two consecutive L1 data cache lines. Certain other embodiments are related to data filter cache and multi-issue tagless hit instruction cache (TH-IC) techniques.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: March 21, 2017
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: David Whalley, Hans Magnus Sjalander, Alen Bardizbanyan, Per Larsson-Edefors, Peter Gavin
  • Recombinant bacterium to decrease tumor growth
    Patent number: 9598697
    Abstract: A recombinant bacterium capable of reducing tumor growth is provided, wherein said recombinant bacterium is capable of: a. increased expression of a nucleic acid encoding a chemoreceptor that directs chemotaxis towards tumors, b. accumulation in a quiescent tumor, c. hyper-invasion of a tumor, d. reduced fitness in normal tissue, e. enhanced stimulation of the host innate immune responses, f. delivering a tumor specific DNA vaccine vector to a tumor cell, and g. increased bacterium-induced host programmed cell death.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: March 21, 2017
    Assignee: The Arizona Board of Regents for and on Behalf of Arizona State University
    Inventors: Roy Curtiss, III, Wei Kong
  • Use of genes and proteins for peptide production
    Patent number: 9598686
    Abstract: The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: March 21, 2017
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Heather E. Hallen-Adams, John S. Scott-Craig, Jonathan D. Walton, Hong Luo
  • Production of extracellular matrix, conditioned media and uses thereof
    Patent number: 9598672
    Abstract: Provided is a matrix for promoting survival and differentiation of cells transplanted thereon, comprising a base matrix and a cell-made matrix thereon. Methods and means for making and using same are also provided. Also provided are conditioned media, related compositions, related methods, and related packaging products.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: March 21, 2017
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Ilene Sugino, Marco Zarbin, Qian Sun, Raymond B. Birge
  • Pyridine-oxyphenyl coordinated iridium (III) complexes and methods of making and using
    Patent number: 9598449
    Abstract: Iridium (III) complexes are described together with methods to prepare and use such complexes. Also described are devices that utilize the iridium (III) complexes.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: March 21, 2017
    Assignee: ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Jian Li, Eric Turner, Nathan J. Bakken
  • Therapeutic and diagnostic method for ataxia-telangiectasia
    Patent number: 9599626
    Abstract: ATM kinase is shown to regulate proteasome-mediated protein turnover through suppression of the expression of the ubiquitin-like protein ISG15 (Interferon Stimulated Gene 15). Silencing of the ISG15 pathway restored both the ubiquitin and autophagy pathways, and the UV-mediated degradation of their substrates in A-T cells. The ATM kinase negatively regulates the ISG15 pathway, and the constitutively elevated ISG15 pathway induces proteinopathy in A-T cells, and in A-T patients. These findings indicate that proteasome-mediated protein degradation is impaired in A-T cells due to elevated expression of the ISG15 conjugation pathway, which contributes to progressive neurodegeneration in A-T patients. The ISG15 pathway is a new target for both detection and treatment of A-T Inhibitors if ISG15 expression can be used to inhibit or attenuate neurodegeneration in A-T patients.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: March 21, 2017
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventor: Shyamal D. Desai
  • METHOD OF DIAGNOSING DEPRESSION BY PET IMAGING
    Publication number: 20170071522
    Abstract: The present invention provides a method of determining whether a subject is afflicted with a depressive disorder comprising: (i) introducing into the subject a positron emission tomography (PET) radioligand capable of binding with a serotonin 5-HT1A receptor; (ii) performing one or more PET scans of the subject; (iii) determining, by analysis of the one or more PET images, a receptor binding potential of the PET radioligand for the serotonin 5-HT1A receptor in a region of interest in the subject; (iv) comparing the receptor binding potential value of the PET radioligand in the region of interest in the subject to a predetermined receptor binding potential threshold value; and (v) classifying the subject as having the depressive disorder or as not having the depressive disorder based on the comparison of step (iv), thereby determining whether the subject is afflicted with the depressive disorder.
    Type: Application
    Filed: March 5, 2015
    Publication date: March 16, 2017
    Applicants: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Ramin PARSEY, Christine DELORENZO, Gregory SULLIVAN
  • METHODS OF DIFFERENTIATING PREADIPOCYTES AND USES THEREOF
    Publication number: 20170073639
    Abstract: Described herein are methods of transdifferentiating preadipocytes, populations of transdifferentiated preadipocytes, and methods of using the transdifferentiated preadipocytes.
    Type: Application
    Filed: September 15, 2016
    Publication date: March 16, 2017
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Kenneth James Eilertsen, Jong Rim
  • APPARATUS AND METHOD FOR NANOCOMPOSITE SENSORS
    Publication number: 20170074635
    Abstract: A sensing material for use in a sensor is disclosed. Such a sensing material includes a polymer base and a piezoresistive nanocomposite embedded into the polymer base in a continuous pattern. The nanocomposite comprises a polymer matrix and a plurality of conductive nanofillers suspended in the matrix. The conductive nanofillers may be one or a combination of nanotubes, nanowires, particles and flakes. The density of the plurality of nanofillers is such that the nanocomposite exhibits conductivity suitable for electronic and sensor applications.
    Type: Application
    Filed: November 4, 2016
    Publication date: March 16, 2017
    Applicant: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventors: Jin-Woo CHOI, Chao-Xuan LIU
  • LIPOSOMAL CIPROFLOXACIN FORMULATIONS WITH ACTIVITY AGAINST NON-TUBERCULOUS MYCOBACTERIA
    Publication number: 20170071934
    Abstract: Methods of treatment of NTM lung infections using formulations of liposomal ciprofloxacin. Specific liposome formulations and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
    Type: Application
    Filed: November 28, 2016
    Publication date: March 16, 2017
    Applicants: ARADIGM CORPORATION, OREGON STATE UNIVERSITY
    Inventors: Igor GONDA, James BLANCHARD, David C. CIPOLLA, Luiz Eduardoo Moreira BERMUDEZ
  • Method and system for minimally-invasive surgery training using tracking data
    Patent number: 9595207
    Abstract: A system and method for training a person in minimally-invasive surgery (“MIS”) utilizing a video of the MIS. The system comprises a processor, a display, and a first interaction device. The processor programmed to receive the video and to obtain tracking data. The tracking data may correspond to the motion of a tool controller. The tracking data may correspond to motion of a first surgical tool in the video. The processor programmed to calculate motion of the first interaction device corresponding to the tracking data, to display the video, and to cause the first interaction device to move according to the calculated motion. The method comprises receiving the video, obtaining the tracking data, calculating a motion of a first interaction device corresponding to the tracking data, displaying the video, and causing the first interaction device to move according to the calculated motion.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: March 14, 2017
    Assignees: Health Research, Inc., The Research Foundation for The State University of New York
    Inventors: Thenkurussi Kesavadas, Khurshid Guru
  • Genetically engineered microbes and uses thereof
    Patent number: 9594869
    Abstract: This invention concerns methods of identifying genetic alterations with which a microbe can be used to produce fatty acids at a large amount for making biofuels. Also disclosed are microbes with such genetic alterations and uses thereof.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: March 14, 2017
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Desmond Siu Men Lun
  • Nanopore based sequencer
    Patent number: 9593372
    Abstract: The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: March 14, 2017
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Stuart Lindsay, Peiming Zhang
  • Antibacterial agents: aryl myxopyronin derivatives
    Patent number: 9592221
    Abstract: The invention provides compounds of formula Ia, Ib and Ic: and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: March 14, 2017
    Assignees: Rutgers, The State University of New Jersey, Provid Pharmaceuticals Inc.
    Inventors: Richard H. Ebright, Yon W. Ebright, Juan Shen, James Bacci, Anne-Cecile Hiebel, William Solvibile, Christopher Self, Gary Olson
  • Methods for quantitative analysis of metabolic mixtures by 2D C-constant-time TOCSY NMR spectroscopy
    Patent number: 9594880
    Abstract: This disclosure provides for new methods for quantification of metabolite concentrations in metabolomics studies, which addresses the difficulties in quantification through 1D peak integrals due to significant peak overlaps in metabolomics samples. For samples from uniformly 13C-labeled organisms the 2D NMR 13C-13C constant-time (CT) TOCSY experiment provides high-resolution information about individual metabolites that allows their identification via database searching or, in the case of novel compounds, through the reconstruction of their backbone-carbon topology. This disclosure further demonstrates using CT-TOCSY spectra for quantification purposes.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: March 14, 2017
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Rafael Brüschweiler, Kerem Bingol
  • Nitrile-containing enzyme inhibitors and ruthenium complexes thereof
    Patent number: 9593138
    Abstract: The invention provides nitrile-containing protease inhibitors caged to ruthenium compounds. The nitrile-caged ruthenium compounds provide inactivated inhibitors that can be delivered to surface or site for activation, for example, but exposure to light. The invention also provides methods for delivering protease inhibitors to subjects for the therapeutic treatment of conditions such as cancer.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: March 14, 2017
    Assignees: Wayne State University, Ohio State Innovation Foundation
    Inventors: Jeremy J. Kodanko, Claudia Turro
  • Estimating the location of a wireless terminal based on radio-frequency pattern matching and cooperative measurements
    Patent number: 9596571
    Abstract: A method for estimating the location of a wireless terminal is disclosed that is based on using: the known location of one or more devices, empirical data that indicates the relative position of the wireless terminal to the devices, and empirical data that indicates the relative position of the wireless terminal (which is at an unknown location) relative to other wireless terminals that are also at unknown locations.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: March 14, 2017
    Assignees: Polaris Wireless, Inc., Virginia Polytechnic Institute & State University
    Inventors: Scot Douglas Gordon, Sayed Reza Monir Vaghefi, R. Michael Buehrer
  • Control of ripening and senescence in pre-harvest and post-harvest plants and plant materials by manipulating alternative oxidase activity
    Patent number: 9591847
    Abstract: Methods of controlling the maturation of plants and/or plant products (e.g. fruit, vegetable, ornamentals, etc.) by manipulating Alternative Oxidize (AOX) activity. An increase in activity hastens the maturation process while a decrease in activity slows or stops maturation.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 14, 2017
    Assignee: Washington State University
    Inventors: Amit Dhingra, Christopher Hendrickson