Patents Assigned to State University
  • Publication number: 20100048380
    Abstract: A method for making a carbon-metal-nitrogen oxygen reducing cathode catalyst, the method comprising mixing a carbon source with a transitional metal precursor to form a metal precursor loaded carbon substrate; adding a nitrogen precursor compound to the metal precursor loaded carbon substrate to form a carbon-metal-nitrogen precursor; and pyrolyzing the carbon-metal-nitrogen precursor in a closed vessel, thereby forming an oxygen reducing cathode catalyst. The carbon-metal-nitrogen catalyst requires no precious metal such as Pt, and also provides benefits such as controlled deposition of catalytically active nitrogenous compounds that can increase the catalytic activity of the catalyst when compared to gaseous deposition of nitrogen to the surface of the carbon support.
    Type: Application
    Filed: August 21, 2009
    Publication date: February 25, 2010
    Applicant: Board of Trustees of Michigan State University
    Inventors: Scott A. Calabrese Barton, Kothandaraman Ramanujam, Vijayadurga Nallathambi
  • Patent number: 7666499
    Abstract: A process for preparing high initial modulus and high tensile strength polyamide fibers is described. The process comprises complexing the polyamide with a Lewis acid, dry-jet wet spinning the complexed fibers, drying the spun fibers for a period of time, drawing the fibers, and soaking the fibers in solvent to remove the Lewis acid. High molecular weight nylon 6,6 fibers prepared according to the described process show initial moduli of up to 30.1 GPa and tenacities of up to 2.5 GPa.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: February 23, 2010
    Assignee: North Carolina State University
    Inventors: Dongwook Jung, Richard Kotek, Alan E. Tonelli, Nadarajah Vasanthan
  • Patent number: 7666144
    Abstract: Method and apparatus are introduced for determining proportional cardiac output (CO), absolute left atrial pressure (LAP), and/or other important hemodynamic variables from a contour of a circulatory pressure waveform or related signal. Certain embodiments of the invention provided herein include the mathematical analysis of a pulmonary artery pressure (PAP) waveform or a right ventricular pressure (RVP) waveform in order to determine beat-to-beat or time-averaged proportional CO, proportional pulmonary vascular resistance (PVR), and/or LAP. The invention permits continuous and automatic monitoring of critical hemodynamic variables with a level of invasiveness suitable for routine clinical application. The invention may be utilized, for example, to continuously monitor critically ill patients with pulmonary artery catheters installed and chronically monitor heart failure patients instrumented with implanted devices for measuring RVP.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: February 23, 2010
    Assignees: Board of Trustees Operating Michigan State University, Massachusetts Institute of Technology
    Inventors: Richard J. Cohen, Ramakrishna Mukkamala
  • Patent number: 7667068
    Abstract: A process for producing organic acid di- or tri-esters, particularly citric acid tri-esters, with the available acid groups esterified using countercurrent reactive distillation using acid catalysts in a structured packing is described. In the reactive distillation an organic acid di- or tri-ester is formed by chemical reaction and purified to its final state within the single column. Organic acid di- or tri-esters are produced at relatively low cost, with less waste production in by-products of the reaction, and in a less complicated manner than prior processes. Organic acid di- and tri-esters have uses as solvents, as plasticizers and in conversion products.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: February 23, 2010
    Assignee: Board of Trustees of Michigan State University
    Inventors: Dennis J. Miller, Navinchandra Asthana, Aspi Kolah, Dung T. Vu, Carl T. Lira
  • Patent number: 7666430
    Abstract: Compositions for stimulating the immune system and for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include immunogenic epitopes of the HER-2 proteins and chimeric and multivalent peptides which comprise such epitopes. The present invention also relates to polynucleotides which encode the chimeric peptides. Also provided are pharmaceutical compositions comprising such immunogenic compositions. Methods for stimulating an immune response to HER-2 protein are provided. Methods for treating breast cancer, ovarian cancer, prostate cancer, colon cancer and lung cancer are provided.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: February 23, 2010
    Assignee: The Ohio State University
    Inventor: Pravin T. P. Kaumaya
  • Patent number: 7667055
    Abstract: The present invention provides processes for the production of polycyclic fused ring compounds. The polycyclic fused ring compounds are produced by protecting a polycyclic fused ring polyol with a bridging silicon-based protecting group and attaching a suitable side chain. Polycyclic fused ring compounds and intermediate compounds are also described.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: February 23, 2010
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Phong Vu, Robert A. Holton
  • Patent number: 7667093
    Abstract: A site specific recombination system and methods of use thereof are disclosed for manipulating the genome of higher plants.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: February 23, 2010
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Pal Maliga, Sylvie Corneille, Kerry Lutz
  • Patent number: 7666599
    Abstract: Aspects of the present invention provide novel compositions and methods based on novel calpastatin (CAST) genetic markers, such as missense mutations in exon 3 that result in G48D or P52L substitutions (NM_174003.2:c.271G>A and 283C>T), a G/T substitution in intron 3 (AAFC02060381.1:g.2110G>T) and a GAAA repeat in intron 8 (AAFC02060381.1:g.6700[(GAAA)4]+[(GAAA)5]. Particular aspects provide novel markers for fertility (e.g., daughter pregnancy rate, DPR) and longevity (e.g., productive life, PL) in, for example, dairy cattle. Additional aspects provide for novel methods comprising marker-assisted selection to improve fertility and/or longevity in dairy cattle. Therefore, in particular embodiments, a combination of genetic selection based on one or more of the novel CAST markers, and high PTA potentials of milk production traits, provides for improved reproductive traits in association with continued high milk production traits.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: February 23, 2010
    Assignee: Washington State University Research Foundation
    Inventors: Zhihua Jiang, Jennifer J. Michal, Matthew D. Garcia
  • Patent number: 7667099
    Abstract: The present invention relates to genes encoding proteins involved in prokaryotic type or plastid division and/or morphology and the encoded proteins, and in particular to isolated Ftn2 (ARC6), ARC5, and Fzo-like genes and polypeptides. The present invention also provides methods for using Ftn2 (ARC6), ARC5, and Fzo-like genes, and polypeptides.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: February 23, 2010
    Assignee: Board of Trustees of Michigan State University
    Inventors: Katherine W. Osteryoung, Stanislav Vitha, Olga A. Koksharova, Hongbo Gao
  • Patent number: 7667090
    Abstract: A transgenic non-human animal, such as a mouse, has a genome that include a nucleic acid construct having at least one transcriptional regulatory sequence capable of directing expression in B cells of the animal, wherein the transcriptional regulatory sequence is operably linked to a nucleic acid encoding a miR155 gene product. A method of testing the therapeutic efficacy of an agent in treating or preventing a lymphoproliferative condition includes assessing the effect(s) of the agent on a transgenic non-human animal.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: February 23, 2010
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • Patent number: 7666380
    Abstract: A porous carbon composition comprises carbon particles having substantially uniform mesopores, wherein the mesopores have a diameter greater than 5 nanometers. A carbon composition may also comprise carbon particles having a predetermined surface configuration, wherein the surface configuration inversely corresponds to the configuration of at least a portion of an imprinting material. A method of synthesizing mesoporous carbon particles comprises the steps of providing particles of at least one carbon precursor, mixing the particles of at least one carbon precursor with a medium containing an imprinting material to form pretreated solid carbon precursor particles, heating the pretreated solid carbon precursor particles to a temperature at least as high as 20° C.
    Type: Grant
    Filed: January 4, 2006
    Date of Patent: February 23, 2010
    Assignee: Kent State University
    Inventors: Mietek Jaroniec, Zuojiang Li
  • Patent number: 7666398
    Abstract: Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are provided. Also provided are methods of producing polymeric drug delivery systems via these polyanhydride linkers as well as methods of administering low molecular weight drugs to a host via the polymeric drug delivery systems.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: February 23, 2010
    Assignee: Rutgers, the State University of New Jersey
    Inventor: Kathryn E. Uhrich
  • Publication number: 20100038550
    Abstract: A neutron source illuminates suspect material leading to emission of gamma rays characteristic of the isotopes present. The system measures Compton scattering of emitted gamma rays using detectors with three dimension event localization capability. Detection does not require full energy deposition. A spatial correlation of projection vectors is computed by a reconstruction that searches for solutions that generate spatial correlation. Identification and location for contraband material is determined from solutions that generate spatial correlation.
    Type: Application
    Filed: October 21, 2009
    Publication date: February 18, 2010
    Applicant: Utah State University
    Inventor: Raymond DeVito
  • Publication number: 20100040668
    Abstract: The present invention is related to methods for preparing composite materials, which include nanoscale hydroxyapatite, and the composite materials and articles prepared therewith.
    Type: Application
    Filed: January 11, 2008
    Publication date: February 18, 2010
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Richard E. Riman, Christina Sever
  • Publication number: 20100041078
    Abstract: Gamma-hydroxybutyrate (GHB) can be used as a recreational party drug, aphrodisiac, and attenuator of other drugs and make a person a vulnerable target of robbery or rape. The present invention provides methods and kits for detection of GHB in a sample using an antibody-based assay. Antibodies that specifically bind to GHB or the conjugates of GHB and its derivatives to larger molecules and methods for detecting GHB or its derivatives in bodily fluids and non-alcoholic and alcoholic drinks by employing such antibodies in ELISA or RIA assays are provided by the present invention.
    Type: Application
    Filed: January 10, 2008
    Publication date: February 18, 2010
    Applicant: The Research Foundation of State University of New York
    Inventors: Kestutis G. Bendinskas, Tia Hendershott, James A. MacKenzie
  • Publication number: 20100041902
    Abstract: Cyclic alkyl, particularly cyclohexyl, substituted glycolides and polylactides are described. The polylactides have a high glass transition temperature and improved clarity.
    Type: Application
    Filed: August 24, 2009
    Publication date: February 18, 2010
    Applicant: Board of Trustees of Michigan State University
    Inventors: Gregory L. Baker, Feng Jing, Milton R. Smith, III
  • Patent number: 7662864
    Abstract: Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: February 16, 2010
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Suseela Kanamathareddy, Stephen Goodrich, Yun Choe
  • Patent number: 7662405
    Abstract: This invention provides methods and compositions for localized delivery of IL-12 to a desired site. The composition comprises liposomes carrying IL-12. The liposomes comprise phosphatidyl choline, phosphatidyl glycerol and cholesterol. The size and composition of the liposomes is such that there is minimal leakage into the systemic circulation. These compositions can be used for delivery of IL-12 to selected sites such as tumors.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: February 16, 2010
    Assignee: The Research Foundation of State University of New York
    Inventors: Sathy V. Balu-Iyer, Richard B. Bankert, Vivek S. Purohit
  • Patent number: 7662567
    Abstract: Aspects of the present invention also provide methods based on novel UCN3 nucleotide polymorphisms selected from the group consisting of AAFC03043460.1:g.8272-8281AATAATAAAT(SEQ ID NO: 9)>GGAGC, g.8208C>T, g.8265C>T, g.8287T>C, g.8412A>G, g.8426T>A, c.8786C>T, g.9074T>C, c.12609C>T, c.12621T>C, c.12667T>G and c.12669C>A , which may provide novel markers for marbling and/or subcutaneous fat. Additional aspects provide for novel methods which may comprise marker-assisted selection or marker-assisted management to improve marbling and/or subcutaneous fat depth in cattle.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: February 16, 2010
    Assignee: Washington State University Research Foundation
    Inventors: Zhihua Jiang, Jennifer J. Michal, Galen A. Williams
  • Patent number: PP20765
    Abstract: ‘NCHA1’ is a new Hydrangea plant particularly distinguished by having a medium-sized, rounded, multi-stemmed shrub, a unique combination of compound, corymb inflorescences with prevalent sterile flowers and rose to pink colored sepals, is disclosed.
    Type: Grant
    Filed: November 17, 2008
    Date of Patent: February 16, 2010
    Assignee: North Carolina State University
    Inventor: Thomas G. Ranney