Abstract: The present invention provides method of identifying molecules that cooperatively and positively interact with either a ligand or a target molecule of a ligand/target molecule pair, or molecules that interact with a ligand/target molecule complex.

Abstract: A capsule configured for in vivo refilling of a thereapeutic agent. In certain embodiments, the capsule may contain methotrexate.

Abstract: According to the invention a novel vegetable protein fractionation procedure is disclosed which includes a straightforward process to obtain ?-conglycinin-rich and glycinin-rich isolated protein fractions with unique functional and nutritional properties desired by the food industry. The process is much simplified compared to the art and avoids multiple steps in the usual fractionation of soy protein and uses very small amounts of salts avoiding the necessity of excessive washing and desalting steps. The process yields high amounts of protein fractions with high isoflavone contents and improved functional properties.

Abstract: This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier.

Abstract: A diagnostic biomarker including a mechanism for determining a patient's propensity to develop cancer. A diagnostic kit for determining a patient's propensity to develop cancer. A method of predicting both a patient's and a population's propensity to develop cancer, by detecting the presence of an H64 and/or P98 allele of galectin-3 from a patient's serum sample, and predicting that the patient or population has the propensity to develop cancer based on the presence of the allele. A method of providing prophylactic cancer treatment, by detecting the presence of an H64 and/or P98 allele of galectin-3 from a patient's serum sample, predicting that the patient has the propensity to develop cancer based on the presence of the allele, and recommending and providing prophylactic treatment to the patient to reduce their risk of cancer. A prophylactic anticancer treatment and method of preventing onset or further proliferation of cancer.

Abstract: A method for controlling the hydrophobicity of a surface of an article by alternately depositing solutions comprising net positively charged polymers and net negatively charged polymers onto the surface to form a polyelectrolyte film of an interpenetrating network of net positively charged polymers and net negatively charged polymers on the surface of the article.

Abstract: Provided are chalcogenoxanthylium compounds which can effectively be used as sensitizers in photodynamic therapy, virucides in photodynamic antimicrobial chemotherapy and reversal agents of Pgp function in cancer cells. Further provided is a general method for the preparation of chalcogenoxanthylium compounds.

Abstract: Systems and methods for extracting lipids of varying polarities from oleaginous material.

Abstract: Apparatus and method to verify the integrity of a digital image (i.e., deciding whether or not the entire image or just a portion has been tampered with, and/or finding the doctored area in the image). One first determines the imaging sensor's reference pattern noise, which serves as a unique fingerprint that identifies the imaging sensor that captured the image. To verify the integrity of the content in a region of the image, a correlation detector determines the presence or absence of the imaging sensor's reference pattern noise in that region, thereby verifying whether or not the image has integrity. The correlation detector can also find automatically one or more regions in the image that were tampered with. In another embodiment, one determines the pattern noise of only the image in question and tests that noise to determine whether or not the image has integrity.

Abstract: Particular aspects provide a method for recovering phosphate, comprising: obtaining an effluent or wastewater, etc. having calcium-sequestered phosphate; adding to the effluent or wastewater a calcium chelating or sequestration agent suitable to chelate or sequester Ca++ ions from the calcium-sequestered phosphate to facilitate release of phosphate from the calcium-sequestered phosphate; transferring, facilitated by said Ca++ ion capture and in the presence of sufficient concentrations of NH4+ and Mg2 ions, of the phosphate into struvite (magnesium ammonium phosphate hexahydrate or MgNH4PO4.6H2O), or hydrated magnesium ammonium complex of phosphate; and recovering the struvite, or the formed hydrated magnesium ammonium complex. Preferably, the method further comprises acidification of the effluent or wastewater to facilitate release of Ca++ ions from the calcium-sequestered phosphate and chelation of sequestration of the Ca++ ions by the calcium chelating or sequestration agent.

Abstract: A method of determining change in a state of an object using images of the object, the method including providing a first image and a second image of the object, the first image and the second image being spaced apart in time, performing a plurality of pixel-based change detection algorithms to obtain a plurality of output difference products/images containing change information and pseudo change information, combining the plurality of output difference products to form a hybrid output difference product and thresholding the output difference product to detect changes in the object.

Abstract: The present invention provides a novel way of operating sensing elements or bolometers in the resistive hysteresis region of a phase-transitioning VO2 (or doped VO2) films. The invention is based on a novel principle that minor hysteresis loops inside the major loop become single-valued or non-hysteretic for sufficiently small temperature excursions. This single valued R(T) branches being characterized by essentially the same temperature coefficient of resistivity (TCR) as the semiconducting phase at room temperature. These non-hysteretic branches (NHB) can be located close to the metallic-phase end of the major loop, thus providing for tunable resistivity orders of magnitude lower than that of a pure semiconducting phase. Operating the Focal Plan Array in one of these NHBs allows for having high TCR and low resistivity simultaneously.

Abstract: The present invention includes methods for producing GaAs/Si composites, GaAs/Si composites, apparatus for preparing GaAs/Si composites, and a variety of electronic and photoelectric circuits and devices incorporating GaAs/Si composites of the present invention.

Abstract: An otoscopic model is disclosed herein. In one embodiment, the otoscopic model includes an artificial ear, an artificial head and at least one tympanic membrane portion. The artificial ear includes a base portion and an ear portion extending from the base and having ear-like features including an auditory canal. The artificial head includes an opening adapted to receive the base portion. The at least one tympanic membrane portion includes an artificial tympanic membrane. The tympanic membrane portion is configured to be coupled with the artificial ear such that the artificial tympanic membrane is located relative to the auditory canal in a generally anatomically correct manner.

Abstract: Composite materials are provided that include one or more CNT yarns embedded in a matrix material. The composite materials may be transparent. Methods for making the composite materials are also provided. The composite materials may be made by arranging at least one CNT yarn into a desired pattern and embedding the at least one CNT yarn into a matrix material.

Abstract: Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 Daltons. The analysis can be solvent-based or solvent-free. Solvent-free analysis following LSI allows for improved spatial resolution beneficial in surface and/or tissue imaging.

Abstract: The stability of an animal joint, especially a knee, is assessed with an arrangement having track arranged about perpendicular to the axis of the distal portion; a cart slidably engaged to the track; a fork positioned on the cart; a support adapted to receive the distal linear portion, the support connected to the fork; a lever arm connected to the support, the lever arm positioned to rotate the support about the axis of the distal portion; and at least one instrumented handle, the instrumented handle detachably engages at least one of the cart and the lever arm. In some embodiments, the fork can rotate freely on the cart. Additionally, in various embodiments, the cart may be selectively locked at a position along the length of the track. In various embodiments, the arrangement further comprises: a bracket rigidly attached to the distal portion and positioned between the support and the joint; and the at least one instrumented handle detachably engages the bracket.

Abstract: Systems and methods are provided for detecting and quantitating one or more compounds or molecules in a sample. An aptamer-based point-of-care device (such as a strip) is described for rapid detection of target molecules such as the cancer marker p-glycoprotein (Pgp). Fluorescent molecules or gold nanoparticles may be used to detect the binding between a target molecule and the aptamer. By way of example, fluorescence resonance energy transfer (FRET) or Dynamic Light Scattering (DLS) may be used for detecting the physical and/or chemical changes caused by the binding of the aptamers to the target molecules.

Abstract: An isolated microorganism comprising a Propionibacteria strain is described. When the microorganism is fed to a ruminant, protein and fat levels in milk produced by the ruminant are increased, while body condition and milk production levels are maintained. When fed to the ruminant, the microorganism also has positive effects on various metabolic hormones and metabolites, e.g, an increase in energy balance, plasma non-esterified fatty acids levels, and plasma leptin level. Supplementation with propionibacteria reduced dry matter intake but did not affect milk production in the cows. Therefore, the propionibacteria of the invention made the cows more energy efficient as cows produced the same amount of milk, yet consumed less dry matter.

Abstract: The present invention provides a recombinant bacterium and methods of using the recombinant bacterium to induce an immune response.