Patents Assigned to STC.UNM
  • Inteferometric Sensor Basid on Slab Waveguide
    Publication number: 20180209910
    Abstract: The present invention provides a sensor having, one or more optical slab waveguides having one or more target regions. The target regions may interact with gas molecules or trap, entrain or capture one or more targets of interest. The optical slab waveguides are adapted to receive one or more input optical beams from one or more light sources to create a plurality of propagating optical waves in optical slab waveguide. The propagating optical waves interact with said one or more target regions to create an optical output wavefront that may be in the form of a diffraction pattern. The target regions may be functionalized with an antibody, polymer, cell, tissue, or biological material.
    Type: Application
    Filed: July 11, 2016
    Publication date: July 26, 2018
    Applicant: STC.UNM
    Inventor: Mani Hossein-Zadeh
  • Detection of bioagents using a shear horizontal surface acoustic wave biosensor
    Patent number: 10031135
    Abstract: Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: July 24, 2018
    Assignees: STC.UNM, SANDIA CORPORATION
    Inventors: Richard S. Larson, Brian Hjelle, Pam R. Hall, David C. Brown, Marco Bisoffi, Susan M. Brozik, Darren W. Branch, Thayne L. Edwards, David Wheeler
  • Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same
    Patent number: 10022327
    Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: July 17, 2018
    Assignees: STC.UNM, Sandia Corporation
    Inventors: C. Jeffrey Brinker, Eric C. Carnes, Carlee Erin Ashley, Cheryl L. Willman
  • Light-Emitting Device Having III-V Semiconductor Gain Section Coupled to Whistle-Geometry Tunable Filter
    Publication number: 20180191134
    Abstract: The invention concerns a wavelength tunable semiconductor laser comprising a laser gain section (510) optically coupled to an underlying optical waveguide (520). According to an embodiment of the invention, a first and a second passive microring resonators (530, 560) having a whistle geometry, are arranged on both sides of the laser gain section and evanescently coupled with the optical waveguide (520). Highly reflective broadband mirrors (541, 571) are provided at the free ends of optical waveguide branches (240, 270) tangentially connected to the microring resonators. The first and second passive microrings resonators provide an optical feedback to the laser gain section and allow to select the desired wavelength. The laser structure can be implemented according to a III-V/Si technology.
    Type: Application
    Filed: June 29, 2016
    Publication date: July 5, 2018
    Applicants: INSTITUT MINES-TELECOM, STC.UNM
    Inventors: Merek Osinski, Frédéric Grillot
  • METHODS TO INTRODUCE SUB-MICROMETER, SYMMETRY-BREAKING SURFACE CORRUGATION TO SILICON SUBSTRATES TO INCREASE LIGHT TRAPPING
    Publication number: 20180190841
    Abstract: Provided is a method for fabricating a nano-patterned surface. The method includes forming a mask on a substrate, patterning the substrate to include a plurality of symmetry-breaking surface corrugations, and removing the mask. The mask includes a pattern defined by mask material portions that cover first surface portions of the substrate and a plurality of mask space portions that expose second surface portions of the substrate, wherein the plurality of mask space portions are arranged in a lattice arrangement having a row and column, and the row is not oriented parallel to a [110] direction of the substrate. The patterning the substrate includes anisotropically removing portions of the substrate exposed by the plurality of spaces.
    Type: Application
    Filed: February 23, 2018
    Publication date: July 5, 2018
    Applicant: STC.UNM
    Inventors: Sang Eon Han, Brittany R. Hoard, Sang M. Han, Swapnadip Ghosh
  • Coenzyme Q10 Aerosol
    Publication number: 20180177722
    Abstract: The present invention provides a formulation of Coenzyme Q10 that can be re-dispersed from a stable dry powder to formulation to yield a nano dispersion that can be readily aerosolized for inhalation.
    Type: Application
    Filed: June 24, 2016
    Publication date: June 28, 2018
    Applicants: STC.UNM, RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jason Thomas McConville, Thiago Carvalho, Kristina Schonhoff
  • Inflatable, free-standing solar updraft tower with optimal geometry and active control
    Patent number: 10006443
    Abstract: The present invention provides a self-supporting chimney apparatus. The chimney apparatus having at least one inflatable compartment. In some embodiments, the chimney apparatus may have a plurality of toroidal compartments, with the dimensions of the toroidal compartments calculated to maximize the structural integrity of the chimney apparatus, and with the pressure in the compartments dynamically adjusted to minimize deflection under wind loading. The self-supporting chimney apparatus may be used to construct an improved solar updraft tower, with the shape of the tower, the greenhouse surrounding its base, and the ground under the greenhouse optimized together to minimize energy losses. The efficiency of the power plant based on the design is further enhanced by combining solar thermal energy generation with photovoltaic energy generation and utilizing the waste heat of the latter.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: June 26, 2018
    Assignee: STC.UNM
    Inventors: Peter V. Vorobieff, Nima Fathi, Andrea A. Mammoli, Vakhtang Putkaradze, Michael Chi, Seyed Sobhan Aleyasin, Francois Gay-Balmaz
  • Methods for diagnosing bacterial infections
    Patent number: 10000787
    Abstract: The present invention is directed to methods of determining the presence or absence of a bacterial infection in a patient using isotopically-labeled tyrosine and/or isotopically-labeled p-hydroxyphenylacetic acid.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: June 19, 2018
    Assignees: STC.UNM, LOS ALAMOS NATIONAL SECURITY, LLC.
    Inventors: Graham Timmins, Louis Pete Silks
  • Biological and Stand-Alone Super-Capacitors for Water Treatment
    Publication number: 20180166760
    Abstract: Supercapacitive bioelectrical systems (SC-BESs) wherein the anode and cathode act as electrodes for a self-powered internal supercapacitor. The BES may further be enhanced by the use of optimized catalysts and enzymes to increase cell voltage and the use of a third capacitive electrode (AdE) short-circuited to the BES cathode and coupled to the BES anode to improve the power output of the self-powered internal supercapacitor.
    Type: Application
    Filed: May 2, 2016
    Publication date: June 14, 2018
    Applicants: STC.UNM, Alma Mater Studiorum - Università di Bologna
    Inventors: Carlo Santoro, Alexey Serov, Plamen B Atanassov, Francesca Soavi, Catia Arbizzani
  • CXCR antagonistic peptides and uses thereof
    Patent number: 9981003
    Abstract: The present invention provides a novel class of medicament based on CXCR antagonistic peptides. Among other things, the present invention provides peptides, compositions and methods for treating diseases, disorders and conditions in which a CXCR mediated pathway is implicated. Compositions and methods for effective treatment of inflammation, stroke, traumatic brain injury, pancreatic cancer, and others are provided.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: May 29, 2018
    Assignee: STC.UNM
    Inventor: Jeff Wade Hill
  • Polony sequencing methods
    Patent number: 9982296
    Abstract: We describe ultra-high throughput polony genome sequencing that can permit, for example, generating raw data to re-sequencing the human genome in about one week (including library prep and sequencing) at a reasonable cost. The methods described herein include one or more of the following: (1) increasing polony sequencing read length, (2) improving library construction and emulsions protocols, (3) increasing bead density and/or moving to alternative clonal amplication strategies (other than emulsion PCR or ePCR), (4) extending software capabilities to allow SNP calls from our new sequencing raw data, (5) Dual Primer Emulsion PCR, and (6) diagnostic method exploiting one or more of the foregoing.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: May 29, 2018
    Assignee: STC.UNM
    Inventor: Jeremy Edwards
  • Method for Simultaneous Spectrally Resolved Detection or Imaging of Items in Multiple Flowing Streams
    Publication number: 20180143138
    Abstract: A method to simultaneously detect emission intensity or images at multiple distinct emission wavelengths in the analysis of parallel sample streams in a flow-based analysis system and apparatus for performing the described method.
    Type: Application
    Filed: April 20, 2016
    Publication date: May 24, 2018
    Applicant: STC.UNM
    Inventors: Andrew P Shreve, Steven Wayde Graves, Bruce S Edwards, Jaime Javier Juarez
  • Quantitative [Fe]-MRI (Femri) of anti-PSMA-Conjugated SPIONs Based on PSMA Expression Levels
    Publication number: 20180143278
    Abstract: A method of measuring the concentration of a magnetic material in an object using magnetic resonance imaging comprising administering magnetic material to the object; obtaining a set of T1-weighted and T2-weighted images of the object in order to determine a background magnetic resonance imaging signal intensity and measurements of the background nuclear magnetic relaxation times (T1, T2) of the object without magnetic material; and obtaining a set of T1-weighted and T2-weighted magnetic resonance images of the object with magnetic materials added; measuring effect of magnetic material on the relaxation times; and converting the T1-weighted and T2-weighted images into a set of contrast images which are subtracted from each other to yield a contrast difference image proportional to the concentration of the magnetic material.
    Type: Application
    Filed: May 13, 2016
    Publication date: May 24, 2018
    Applicant: STC.UNM
    Inventor: Laurel Sillerud
  • Charged singlet-oxygen sensitizers and oppositely-charged surfactants
    Patent number: 9968698
    Abstract: The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: May 15, 2018
    Assignee: STC. UNM
    Inventors: David G. Whitten, Eric H. Hill, Harry C. Pappas
  • Raman fiber laser
    Patent number: 9966728
    Abstract: Improved Raman Fiber Laser (RFL) generators may include a mid-infrared fiber, e.g., a fiber comprising a tellurite glass, a chalcogenide glass, a fluoride glass, or similar material. A phase-shifted fiber Bragg grating may be inscribed in the fiber. A pump laser generator may be coupled with the fiber in order to supply a pump laser to the fiber. When stimulated by the pump laser, the RFL generator may emit an output laser having a mid-infrared wavelength. A tuner may be used to tune the output laser.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: May 8, 2018
    Assignee: STC.UNM
    Inventor: Ravinder K. Jain
  • Biological detector and method
    Patent number: 9958516
    Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: May 1, 2018
    Assignees: ABQMR, Inc., Sandia Corporation, STC.UNM
    Inventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
  • Intracavity fiber sensors using two orthogonal polarization modes in an optical parametric oscillator cavity coupled to a sensing element
    Patent number: 9958252
    Abstract: Apparatus, systems, and methods of operating a fiber laser having polarization-preserving fibers can be applied as a sensor to detect a physical quantity. In various embodiments, polarization-preserving fibers can provide a laser cavity having an interferometer disposed in the laser cavity. In various embodiments, a fiber optical parametric oscillator can include an interferometer disposed in the cavity of the optical parametric oscillator. Additional apparatus, systems, and methods are disclosed.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: May 1, 2018
    Assignee: STC. UNM
    Inventors: Jean-Claude Diels, Ladan Arissian
  • COMPOSITIONS AND METHODS FOR TREATMENT OF PULMONARY HYPERTENSION
    Publication number: 20180110774
    Abstract: Methods and composition for treating or preventing pulmonary hypertension are provided. In certain aspects, compounds that inhibit TH17 cell maturation or activity, such as retinoic acid receptor-related orphan nuclear receptor (ROR) inhibitors, are used to for the treatment of pulmonary hypertension.
    Type: Application
    Filed: April 28, 2016
    Publication date: April 26, 2018
    Applicant: STC. UNM
    Inventors: Laura V. Gonzalez Bosc, Levi D. Maston, Thomas Resta
  • Malaria vaccine
    Patent number: 9943580
    Abstract: Embodiments are directed to malaria vaccines comprising a bacteriophage VLP displaying a heterologous peptide identified by affinity selection as an anti-malaria mimotope.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: April 17, 2018
    Assignees: STC.UNM, LEIDOS, INC.
    Inventors: David S. Peabody, Bryce Chackerian, James Pannucci, Gabriel M. Gutierrez, Amy Rene Noe, Scott Budd Winram, Steve Chienwen Huang
  • Single-arc dose painting for precision radiation therapy
    Patent number: RE46953
    Abstract: Provided herein are methods and systems for designing a radiation treatment for a subject using single arc dose painting. The methods and systems comprise an algorithm or a computer-readable product having the same, to plan the radiation treatment. The algorithm converts pairs of multiple leaf collimation (MLC) leaves to sets of leaf aperture sequences that form a shortest path single arc thereof where the pairs of MLC leaves each aligned to an intensity profile of densely-spaced radiation beams, and connects each single arc of leaf apertures to form a final treatment single arc. Also provided is a method for irradiating a tumor in a subject using single arc dose painting.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: July 17, 2018
    Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, UNIVERSITY OF NOTRE DAME DU LAC, STC.UNM
    Inventors: Cedric X. Yu, Shuang Luan, Danny Z. Chen, Matthew A. Earl, Chao Wang