Patents Assigned to STC.UNM
  • Patent number: 10317212
    Abstract: Apparatus, systems, and methods associated with enhancement of phase response of intracavity phase interferometers are applicable in a variety of applications.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: June 11, 2019
    Assignee: STC.UNM
    Inventors: Jean-Claude Diels, Ladan Arissian, Matthias Lenzner, James Hendrie
  • Publication number: 20190169583
    Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and/or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.
    Type: Application
    Filed: August 29, 2018
    Publication date: June 6, 2019
    Applicant: STC.UNM
    Inventor: Surojit Paul
  • Patent number: 10299707
    Abstract: The invention provides a quantum dot (QD) modified optical fiber-based biosensor which characterizes matrix metalloproteinase (MMP) enzyme activity at pain signaling sites in the central nervous system (CNS) in vivo. Related systems and peptide biomarker screening methods are also provided.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: May 28, 2019
    Assignee: STC.UNM
    Inventors: John B. Plumley, Erin D. Milligan, Marek Osinski
  • Publication number: 20190138685
    Abstract: A system and method for designing an antenna wherein a plurality of antenna designs are visually compared using performance metric plots that distinguish between geometries that meet all requirements and designs that do not.
    Type: Application
    Filed: May 1, 2017
    Publication date: May 9, 2019
    Applicant: STC.UNM
    Inventors: Joseph Costantine, Sergio A Pellegrino, Maria Sakovsky
  • Patent number: 10283667
    Abstract: The present disclosure relates to an electromagnetic energy detector. The detector can include a substrate having a first refractive index; a metal layer; an absorber layer having a second refractive index and disposed between the substrate and the metal layer; a coupling structure to convert incident radiation to a surface plasma wave; additional conducting layers to provide for electrical contact to the electromagnetic energy detector, each conducting layer characterized by a conductivity and a refractive index; and a surface plasma wave (“SPW”) mode-confining layer having a third refractive index that is higher than the second refractive index disposed between the substrate and the metal layer.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: May 7, 2019
    Assignee: STC.UNM
    Inventors: Steven R. J. Brueck, Sanjay Krishna, Seung-Chang Lee
  • Patent number: 10278649
    Abstract: A technique for classifying lesions as malignant or benign is disclosed. The technique can include: cooling an area of skin including a lesion of a patient to initiate a warm-up process; receiving a temporal sequence of thermal images of the area of skin representing a thermal recovery of the area of skin, the temporal sequence of thermal images generated by an infrared camera; generating a temporal profile of the thermal recovery based on the temporal sequence of thermal images; analyzing temporal statistical properties of the temporal profile; determining a malignancy probability that the lesion is malignant based on an analysis of the temporal profile, wherein the determining includes extracting one or more statistical features based on continuous-time stochastic signals in the sequence of thermal images; and classifying the lesion based on the malignancy probability.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: May 7, 2019
    Assignee: STC.UNM
    Inventors: Majeed M. Hayat, Sanjay Krishna, Sebastian Eugenio Godoy, David A. Ramirez
  • Patent number: 10279019
    Abstract: A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat dyslipidemias and related disease states in a mammal without the frequency of administration required by passive immunity strategies.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: May 7, 2019
    Assignee: STC.UNM
    Inventors: Alan Remaley, John T. Schiller, Marcelo Amar, Bryce Chackerian
  • Patent number: 10265425
    Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: April 23, 2019
    Assignee: STC.UNM
    Inventors: Yubin Miao, Haixun Guo
  • Patent number: 10266904
    Abstract: The disclosure describes a method for sequencing long portions of DNA sequence by assembling a plurality of shorter polynucleotide reads. Generally, The method includes annealing a plurality of primers to a denatured DNA molecule, appending a barcode polynucleotide to the 5? end of the primer, subjecting the DNA molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5? end of the primer, sequencing the barcode polynucleotides and the genomic DNA, and assembling the short read polynucleotide sequences having identical barcode polynucleotides.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: April 23, 2019
    Assignee: STC.UNM
    Inventor: Jeremy Scott Edwards
  • Patent number: 10254295
    Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: April 9, 2019
    Assignee: STC.UNM
    Inventors: Ke Jian Liu, Wenlan Liu, Graham Timmins, Rong Pan
  • Patent number: 10251870
    Abstract: The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: April 9, 2019
    Assignee: STC.UNM
    Inventors: Eric R. Prossnitz, Matthias Barton, Matthias R. Meyer
  • Patent number: 10256546
    Abstract: An antenna having a body that includes a plurality of rigid sections separated by a plurality of flexible sections and at least one conductor attached to the rigid and flexible sections. The flexible sections forming hinges that connect rigid sections together to permit the body to be configured into a conical configuration from a substantially flat trapezoid configuration.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: April 9, 2019
    Assignee: STC.UNM
    Inventors: Joseph Costantine, Christos G. Christodoulou, Youssef Antoine Tawk, Christoph Benedikt Lukas Karl, Nicolas Nik Lee, Ignacio Maqueda Jimenez, Sergio Pellegrino, Maria Sakovsky
  • Patent number: 10248764
    Abstract: A method of calculating radiation fluence and energy deposition distributions on a networked virtual computational cluster is presented. With this method, complex Monte Carlo simulations that require expansive equipment, personnel, and financial resources can be done efficiently and inexpensively by hospitals and clinics requiring radiation therapy dose calculations.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: April 2, 2019
    Assignee: STC.UNM
    Inventors: Roy William Keyes, Christian Romano, Shuang Luan, Dorian C. Arnold
  • Patent number: 10249780
    Abstract: Provided is a method of making a radiation detector, including: growing a thin film on a substrate. The substrate is a silicon substrate. The thin film includes aluminum antimony alloy (AlSb). The growing is epitaxial growth via ultra-high vacuum molecular beam epitaxy (UHV-MBE).
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: April 2, 2019
    Assignee: STC.UNM
    Inventors: Ganesh Balakrishnan, Adam Alexander Hecht, Erin Ivey Vaughan
  • Patent number: 10238758
    Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue, suggesting favorable selective activity of compounds according to the present invention, which can be used as effective therapeutic agents against melanoma, including metastatic melanoma. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are useful to initiate therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic and therapeutic tools for a number of conditions and diseases states, especially melanoma.
    Type: Grant
    Filed: September 10, 2016
    Date of Patent: March 26, 2019
    Assignee: STC.UNM
    Inventor: Yubin Miao
  • Patent number: 10230369
    Abstract: A Hardware-Embedded Delay PUF (HELP) leverages entropy by monitoring path stability and measuring path delays from core logic macros. HELP incorporates techniques to deal with bias. A unique feature of HELP is that it may compare data measured from different test structures. HELP may be implemented in existing FPGA platforms. HELP may leverage both path stability and within-die variations as sources of entropy.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: March 12, 2019
    Assignee: STC.UNM
    Inventors: James Plusquellic, James Aarestad
  • Patent number: 10220008
    Abstract: Using high-throughput screening, in an oxygen-glucose deprivation (OGD) model, isoxsuprine hydrochloride was identified as a potent neuroprotective compound. In an animal middle artery occlusion (MCAO) model of transient focal ischemia, isoxsuprine significantly reduced infarct volume compared to vehicle. The invention, therefore, provides methods of treatment and pharmaceutical compositions that are useful in the treatment and prevention of a wide-variety of ischemia-related injuries, including stroke.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: March 5, 2019
    Assignee: STC.UNM
    Inventor: Jeff Wade Hill
  • Patent number: 10221446
    Abstract: This disclosure describes a structured polynucleotide, devices that include the structured polynucleotide, and methods involving the structured polynucleotide and/or devices. Generally, the structured polynucleotide includes five domains. A first domain acts as a toehold for an input DNA logic gate to initiate binding to an SCS biomolecule. A second domain acts as a substrate recognition sequence for an upstream DNA logic gate. A third domain acts as a toehold for a output DNA logic gate to initiate binding of the SCS biomolecule to the gate. A fourth domain acts as an effector sequence to alter the state of the output logic gate. A fifth domain acts as a cage sequence to lock the effector sequence in an inactive state until an input gate binds to the structured polynucleotide.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: March 5, 2019
    Assignee: STC.UNM
    Inventors: Carl Brown, III, Steven Wayde Graves, Darko Stefanovic, Matthew Richard Lakin
  • Patent number: 10216965
    Abstract: This disclosure describes techniques for generating physically unclonable functions (PUF) from non-volatile memory cells. The PUFs leverage resistance variations in non-volatile memory cells. Resistance variations in array of non-volatile memory cells may be produce a bitstring during an enrollment process. The bitstring may be stored in the non-volatile memory array. Regeneration may include retrieving the bitstring from the non-volatile memory array.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: February 26, 2019
    Assignee: STC.UNM
    Inventors: James Plusquellic, Swarup Bhunia
  • Publication number: 20190056184
    Abstract: The present prevention provides a surface coating for cooling a surface by light scattering comprising a plurality of successive layers, each of the layers may be comprised of a plurality of spheres arranged to form a structure comprised of packed spheres. Each layer may have a different arrangement of packed spheres to create to a different light scattering property in each of the layers. The coating of the structures may also be formed by randomly packed spheres and the spheres may have a uniform diameter.
    Type: Application
    Filed: October 17, 2016
    Publication date: February 21, 2019
    Applicant: STC.UNM
    Inventors: Sang Eon Han, Sang M. Han