Patents Assigned to STC.UNM
  • Patent number: 10089660
    Abstract: Multiple sources of reviews for the same product or service (e.g. hotels, restaurants, clinics, hair saloon, etc.) are utilized to provide a trustworthiness score. Such a score can clearly identify hotels with evidence of review manipulation, omission and fakery and provide the user with a comprehensive understanding of the reviews of a product or establishment. Three types of information are used in computing the score: spatial, temporal and network or graph-based. The information is blended to produce a representative set of features that can reliably produce the trustworthiness score. The invention is self-adapting to new reviews and sites. The invention also includes a validation mechanism by crowd-sourcing and fake review generation to ensure reliability and trustworthiness of the scoring.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: October 2, 2018
    Assignee: STC.UNM
    Inventors: Shuang Luan, Abdullah Mueen, Michalis Faloutsos, Amanda J. Minnich
  • Patent number: 10086132
    Abstract: A mechanical infusion pump device for injecting medication into a patient's IV, includes an IV reservoir and a syringe communicated to the IV reservoir and having a syringe plunger connected to a filling plunger that is moved with the syringe plunger in a first syringe-filling direction to fill the syringe with fluid medication. Biasing weight(s) is/are provided on the filling plunger for exerting bias or force from gravity on the filling plunger and the syringe plunger in a second syringe-discharging direction to dispense medication from the syringe into the patient's IV when the filling plunger is released. Only a calibrated amount of medicine can be discharged to the patent's IV over time as determined by calibration of the biasing weights and the metering element located between the syringe and the patient's IV for a given viscosity of the medication.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: October 2, 2018
    Assignee: STC.UNM
    Inventor: Mark Hauswald
  • Patent number: 10086010
    Abstract: In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the subject a therapeutically effective amount of (a) 5-formyl-2?-deoxyuridine (fdU or foUdR) or a 5-formyl-2?-deoxyuridine derivative, optionally in combination with 5-hydroxy-2?-deoxyuridine (hUdR); and (b) at least one composition selected from the group consisting of either 5-fluorouracil (5-FU), a 5-FU prodrug (e.g. 5-fluoro-2?-deoxyuridine (FdU)) or 5-FU metabolite. In a preferred embodiment, a subject who suffers from colorectal cancer (CRC) or metastatic colorectal cancer (mCRC) is treated with a therapeutically-effective amount of fdU and either 5-FU or the 5-FU prodrug 5-fluoro-2?-deoxyuridine (FdU). Related pharmaceutical compositions are also provided.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: October 2, 2018
    Assignee: STC.UNM
    Inventors: Yoshihiro Matsumoto, Alan Edward Tomkinson, Hiroshi Ide
  • Patent number: 10087429
    Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and/or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: October 2, 2018
    Assignee: STC.UNM
    Inventor: Surojit Paul
  • Publication number: 20180264220
    Abstract: A medical device sealing system for use with a positive pressure ventilation mask and a nasal cannula. The system includes a plurality of sealing elements. The sealing elements include an opening sized to receive a nasal cannula. The sealing elements are spaced apart a distance sufficient to cause the sealing elements to engage the edges of a mask and to form a seal between the edges of a mask and a patient.
    Type: Application
    Filed: August 22, 2016
    Publication date: September 20, 2018
    Applicant: STC.UNM
    Inventor: Hans Fredrick Hurt
  • Publication number: 20180249926
    Abstract: The present invention concerns a method for determining whether brain regions of interest having reversible or irreversible pathology. The method includes acquiring over a predetermined period of time a plurality of magnetic resonance imaging (MRI) images for each brain region of interest; analyzing the MRI images to obtain quantitative measurements of the fractional anisotropy (FA) for each brain region of interest and determining that brain regions of interest have reversible pathology when the measured FA increases and then decreases over the predetermined period of time.
    Type: Application
    Filed: August 31, 2016
    Publication date: September 6, 2018
    Applicant: STC.UNM
    Inventors: Shihoko Kimura-Ohba, Laurel Sillerud
  • Patent number: 10061194
    Abstract: In accordance with some aspects of the present disclosure, a maskless interferomeric lithography system for fabricating a three-dimensional (3D) photonic crystal using a multiple two-beam-exposures is disclosed. The system can comprise an illumination system comprising an optical arrangement operable to receive radiation from a radiation source and provide three or more tilted two-beam interference pattern exposures to be combined into a three-dimensional pattern; and a substrate operable to be supported by a substrate table, wherein the substrate comprises a photoresist formed on a top surface of the substrate and operable to receive the three-dimensional pattern and wherein means are provided to adjust the position of the substrate in all six mechanical degrees of freedom.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: August 28, 2018
    Assignee: STC.UNM
    Inventors: Steven R. J. Brueck, Alexander K. Raub
  • Patent number: 10058099
    Abstract: The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: August 28, 2018
    Assignees: STC.UNM, University of Florida Research Foundation, Inc.
    Inventors: David G. Whitten, Kirk S. Schanze, Eunkyung Ji, Dimitri Dascier, Anand Parthasarathy, Thomas S. Corbitt, Kirsten Cicotte, Elizabeth LeBleu Dirk, Xuzhi Zhu
  • Patent number: 10060904
    Abstract: In accordance with the disclosure, a method of forming a nanochannel is provided. The method includes depositing a photosensitive film stack over a substrate; forming a pattern on the film stack using interferometric lithography; depositing a plurality of silica nanoparticles to form a structure over the pattern; removing the pattern while retaining the structure formed by the plurality of silica nanoparticles, wherein the structure comprises one or more enclosed nanochannels, wherein each of the one or more nanochannels comprise one or more sidewalls and a roof; and partially sealing the roof of one or more nanochannels, wherein the roof comprises no more than one unsealed nanochannel per squared micron.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: August 28, 2018
    Assignee: STC.UNM
    Inventors: Steven R. J. Brueck, Yuliya Kuznetsova, Alexander Neumann
  • Patent number: 10048939
    Abstract: This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: August 14, 2018
    Assignee: STC.UNM
    Inventor: James Plusquellic
  • Patent number: 10049469
    Abstract: A fast and a scalable approach for computing the forward and inverse DPRT that uses: (i) a parallel array of fixed-point adder trees to compute the additions, (ii) circular shift registers to remove the need for accessing external memory components, (iii) an image block-based approach to DPRT computation that can fit the proposed architecture to available resources, and (iv) fast transpositions that are computed in one or a few clock cycles that do not depend on the size of the input image.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: August 14, 2018
    Assignee: STC.UNM
    Inventors: Cesar Carranza, Marios Stephanou Pattichis, Daniel Llamocca Obregon
  • Patent number: 10047135
    Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: August 14, 2018
    Assignee: STC.UNM
    Inventor: Yubin Miao
  • Patent number: 10048272
    Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution. The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: August 14, 2018
    Assignees: STC.UNM, Torrey Pines Institute for Molecular Studies
    Inventors: Bruce S. Edwards, Larry A. Sklar, Clemencia Pinilla, Richard A. Houghten, Jon R. Appel, Marc A. Giulianotti, Jose Medina-Franco
  • Patent number: 10050296
    Abstract: A biofuel cell comprising an anode and cathode wherein biocatalytic enzymes are purposefully oriented at each side of the fuel cell so as to increase and/or optimize the enzymes' performance in catalysis and/or electron transfer.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: August 14, 2018
    Assignee: STC.UNM
    Inventors: Sofiya Malinova Babanova, Plamen B Atanassov
  • Patent number: 10039771
    Abstract: In one embodiment, the invention provides a method of inhibiting cAMP efflux and increasing intracellular cAMP in a subject who suffers from, or who is at risk of developing, a cancer by administering to the subject a therapeutically-effective amount of a cAMP efflux inhibitor. Novel compounds, pharmaceutical compositions, diagnostics and screening methods are also provided.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: August 7, 2018
    Assignee: STC.UNM
    Inventors: Alexandre Chigaev, Larry A. Sklar, Dominique Perez
  • Patent number: 10038196
    Abstract: Novel active supports, novel catalysts, and methods of preparing active supports using a sacrificial template particles and methods of preparing the same are all described.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: July 31, 2018
    Assignee: STC.UNM
    Inventors: Alexey Serov, Plamen B Atanassov
  • Publication number: 20180209910
    Abstract: The present invention provides a sensor having, one or more optical slab waveguides having one or more target regions. The target regions may interact with gas molecules or trap, entrain or capture one or more targets of interest. The optical slab waveguides are adapted to receive one or more input optical beams from one or more light sources to create a plurality of propagating optical waves in optical slab waveguide. The propagating optical waves interact with said one or more target regions to create an optical output wavefront that may be in the form of a diffraction pattern. The target regions may be functionalized with an antibody, polymer, cell, tissue, or biological material.
    Type: Application
    Filed: July 11, 2016
    Publication date: July 26, 2018
    Applicant: STC.UNM
    Inventor: Mani Hossein-Zadeh
  • Patent number: 10031135
    Abstract: Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: July 24, 2018
    Assignees: STC.UNM, SANDIA CORPORATION
    Inventors: Richard S. Larson, Brian Hjelle, Pam R. Hall, David C. Brown, Marco Bisoffi, Susan M. Brozik, Darren W. Branch, Thayne L. Edwards, David Wheeler
  • Patent number: 10022327
    Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: July 17, 2018
    Assignees: STC.UNM, Sandia Corporation
    Inventors: C. Jeffrey Brinker, Eric C. Carnes, Carlee Erin Ashley, Cheryl L. Willman
  • Patent number: RE46953
    Abstract: Provided herein are methods and systems for designing a radiation treatment for a subject using single arc dose painting. The methods and systems comprise an algorithm or a computer-readable product having the same, to plan the radiation treatment. The algorithm converts pairs of multiple leaf collimation (MLC) leaves to sets of leaf aperture sequences that form a shortest path single arc thereof where the pairs of MLC leaves each aligned to an intensity profile of densely-spaced radiation beams, and connects each single arc of leaf apertures to form a final treatment single arc. Also provided is a method for irradiating a tumor in a subject using single arc dose painting.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: July 17, 2018
    Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, UNIVERSITY OF NOTRE DAME DU LAC, STC.UNM
    Inventors: Cedric X. Yu, Shuang Luan, Danny Z. Chen, Matthew A. Earl, Chao Wang