Abstract: The invention relates to a container device (1), comprising: a container receiving portion (4) for receiving a container; at least one valve (6) for controlling a flow of fluid in a fluid line connected to said container; a pump device (8) for generating a conveyor pressure of the fluid in the fluid line; a control device (10) which can be connected to the valve (6) and/or the pump device (8) in order to control the valve (6) and/or pump device (8); and a frame (2) which supports said container receiving portion (4), valve (6), pump device (8) and control device (10).
Type:
Grant
Filed:
May 12, 2016
Date of Patent:
July 28, 2020
Assignee:
Sartorius Stedim Biotech GmbH
Inventors:
Jan Schaefer, Christian Manzke, Etienne Evrard
Abstract: A bag for containing a biopharmaceutical product includes at least one fluid input/output port and a measurement opening remote from the fluid port. A probe holder port has a body with an axial through-bore and a peripheral collar with a second fastening zone and defining a fastening plane. A contact probe, extending in the axial through-bore, is assembled on the probe holder port, has an active measurement end portion in contact with the product, and has an end portion opposite the end portion. The probe holder port includes a transition portion between the body and the collar, which extends between a radially central end portion of the collar and a first axial end portion of the body. The first axial end portion is the axial end portion closest to the radially central end portion of the collar. The first axial end portion is disposed on the outer side relative to the fastening plane, and the active measurement end portion is axially disposed on the outer side relative to the fastening plane.
Type:
Application
Filed:
September 26, 2018
Publication date:
July 23, 2020
Applicant:
SARTORIUS STEDIM FMT SAS
Inventors:
Alain PALLARES, Shuai YI, Mathilde SALAUN, Andreas PREDIGER, Julia LUEDERS, Thomas REGEN
Abstract: The protecting body for a flexible pouch is specially designed to contain a biopharmaceutical fluid. It includes two substantially planar plates which respectively form a lower surface and an upper surface and which are fixed to each other. The two plates are able to sandwich the flexible pouch for constraining the flexible pouch such that the protecting body is substantially planar, and includes, on a peripheral side, at least one opening able to receive at least one port of the flexible pouch.
Abstract: A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.
Type:
Grant
Filed:
July 8, 2019
Date of Patent:
July 7, 2020
Assignee:
SARTORIUS STEDIM FTM SAS
Inventors:
Sebastien Chaussin, Jeremy Gibelin, Stefan Zeuch, Michael Bates
Abstract: Systems and a method for transferring chemical, pharmaceutical, and/or biological material into or out of a container are provided. One system comprises a disposable container having at least one port for accessing the interior of the container, the port comprising at least one connecting protrusion extending parallel to the container. The system further comprises a transfer interface connectable to the port. The transfer interface comprises a plate, and at least one connecting flange extending from the plate, the connecting flange to be arranged under the respective connecting protrusion to connect the transfer interface to the port, such that when the transfer interface is connected to the port the plate is parallel to a surface of the container.
Abstract: One aspect relates to a bioreactor and/or mixing container that includes an outer wall and a spectroscopy cell arranged in and/or on the outer wall. The spectroscopy cell includes a first optical area and a second optical area arranged opposite the first optical area. The first optical area and the second optical area can be set at at least two different distances from one another. A specimen-receiving area is located between the first optical area and the second optical area.
Abstract: A method of aseptically distributing fluid to a plurality of vessels includes securing the plurality of vessels relative to a hub and flowing fluid through an input tube into a plenum of the hub such that a substantially equal amount of fluid flows from the plenum into each of the vessels simultaneously. The vessels are positioned in the same plane relative to one another with each vessel having an inflow conduit extending from the hub to the vessel such that an arc segment is formed between the hub and the vessel.
Type:
Application
Filed:
November 13, 2019
Publication date:
June 11, 2020
Applicant:
Sartorius Stedim North America Inc.
Inventors:
Michael A. Zumbrum, Kevin M. Perdue, William Kimmick, Jan Neuhaus
Abstract: The present invention relates to a device for separating and/or isolating substances in or from a mixture with improved utilization of the capacity of chromatographic media, the device comprising a first chromatography system, a second chromatography matrix downstream of the first chromatography system, and a sensor for detecting the substances present in the fluid. Furthermore, the present invention relates to both the use of said device and a method for separating and/or isolating substances in or from a mixture in a fluid.
Type:
Grant
Filed:
May 12, 2015
Date of Patent:
June 2, 2020
Assignee:
Sartorius Stedim Biotech GmbH
Inventors:
Louis Villain, Jörg Mittelstät, Ana Raquel Santos De Matos Fortuna, Katrin Töppner
Abstract: A mixing method, a controller and a mixing device for mixing components in a mixing vessel are provided. The mixing method includes providing a mixing impeller in the mixing vessel; accelerating the mixing impeller from an inactive state to a rotating state in which the mixing impeller rotates at a first desired speed in a first rotation direction; rotating the mixing impeller at the first desired speed for a first time tsteady,1 in the first rotation direction; changing the rotation direction of the mixing impeller, so that the mixing impeller rotates in a second rotation direction at a second desired speed; and rotating the mixing impeller at the second desired speed for a second time tsteady,2.
Type:
Grant
Filed:
March 19, 2019
Date of Patent:
May 5, 2020
Assignee:
Sartorius Stedim Biotech GmbH
Inventors:
Lars Boettcher, Jonathan E. Cutting, Sharon D. West, Martin Oschwald
Abstract: A bioreactor for culturing of microorganisms or cells comprising: a casing defining an interior space of the bioreactor, wherein said interior space is configured to receive and hold a culture medium with microbial or cellular liquid cultures; and at least one coupling element provided on the casing for coupling with a foam mitigation device for mitigation of foam built-up in the interior space of the bioreactor during use of the bioreactor for culturing of microorganisms or cells; wherein the coupling element is configured to allow ultrasonic waves generated by the foam mitigation device act upon foam built-up in the interior space of the bioreactor.
Abstract: The container includes a lower wall and an erect side wall limiting an upper opening of a housing for accommodating a flexible pouch containing a fluid; containment elements including a containment wall, the gap between its peripheral edge and the side wall being limited; the containment wall adapted to be applied against the pouch and held fixed in this position by holding elements arranged in the container and borne by the containment elements by a structural and functional combination, and being movable between an inactive retracted state and an active expanded state, in which a distal end part is either moved away from the side wall or applied there against without any chance of sliding; and adapted to be applied at any desired location of a zone of the side wall such that the containment wall can be applied and held against the pouch regardless of how full the latter is.
Abstract: A fluid connection set includes a connector (1), a flexible hose (2), and a crimping collar (5) for fixing the front end of the flexible hose to the connector, the connector including a connector body (10), a tubular nozzle (3), the tubular nozzle including retaining radial projections (31) of the hose as well as a clamping area (30) of the hose, and a temporary accommodation space (4), arranged between the tubular nozzle (3) and the connector body (10), for housing the collar during the operation of inserting the flexible tube, after which the collar is moved with respect to the clamping area and then crimped.
Abstract: A clamping device (1) is provided for cartridge filtration modules (2) that have a distribution plate (3) with a feed channel (18), a retentate channel (21), a filtrate channel, and a first contact surface (8). At least one filter cartridge can be clamped between a contact surface (8) of the distribution plate (3) and a clamping surface (29) of a clamping plate (4) that can be moved orthogonally to the contact surface (8). The cartridge filtration modules (2) can be stacked on one another in an area of their distribution plates (3). A common distribution plate (3) for adjacent filter cartridge arrangements can clamped against the contact surface (8). Adjacent filter cartridge arrangements can be connected in a parallel circuit via the distribution plate (3), and the cartridge filtration modules (2) that can be stacked on top of one another can be connected in series via the distribution plates (3).
Abstract: A container (1) has a flexible wall (2) and at least one emptying tube (4, 4?, 4?) that projects through a wall aperture (7) into the container interior (3) surrounded by the flexible wall (2). The free end (12) of the emptying tube has an emptying opening (13) that can be set in position vertically to different emptying heights (14). The container (1) is distinguished in that an adapter piece (8), in which the emptying tube (4, 4?, 4?) is held in a longitudinally displaceable manner, is arranged in the wall aperture and in that a portion of the emptying tube (4, 4?, 4?) is surrounded by a flexible sheath (5) that is connected at a first end (11) to the emptying tube (4, 4?, 4?) and at its second end (10), which is remote from the first end (11), to the wall (2) or the adapter piece (8).
Type:
Grant
Filed:
August 18, 2014
Date of Patent:
April 14, 2020
Assignee:
SARTORIUS STEDIM BIOTECH GMBH
Inventors:
Bernward Husemann, Gerhard Greller, Wolfgang Kahlert, Heinz-Ruediger Keitel, Davy de Wilde
Abstract: Disclosed is a bag including: a first envelope having at least one fill and/or discharge orifice for a biopharmaceutical fluid and a fill and/or discharge tube associated in a fluidtight manner with the fill and/or discharge orifice, a second envelope within which the first envelope is located, and a spacer element. The first envelope, the second envelope, and the spacer element form a coherent whole, in particular during use of the bag, and the fill and/or discharge tube traverses the second envelope by a fluidtight connection, the fill and/or discharge inlet being located outside the second envelope.
Type:
Grant
Filed:
March 17, 2016
Date of Patent:
March 10, 2020
Assignee:
SARTORIUS STEDIM FMT SAS
Inventors:
Laurent Thenard, Marc Hogreve, Marie-Christine Menier
Abstract: Disclosed is a fluid-connection device for connecting a first wall defining a first fluid space, in the form of a flexible pipe, to a second wall defining a second fluid space, in the form of a flexible or rigid disposable pipe or enclosure, in a biopharmaceutical assembly, including a first connector in fluid communication with the first space, the first connector including a tubular nozzle for receiving the pipe by insertion along the axis A, a pipe clamp arranged around the end of the pipe in order to clamp the pipe onto the tubular nozzle of the first connector, a protective cover forming a separate part, capable of being snap-fit in an operative position in which the cover is at least partially surrounding the first connector and the pipe clamp thereof, by way of which the pipe clamp cannot come into direct contact with external elements.
Type:
Grant
Filed:
June 24, 2014
Date of Patent:
March 10, 2020
Assignee:
SARTORIUS STEDIM FMT SAS
Inventors:
Florian Blake, Jeremy Gibelin, Isabelle Gay
Abstract: Fluid transfer assemblies for transferring fluid into or out of a single vessel and distributing the fluid to multiple other vessels are provided. The fluid transfer assemblies are customizable, substantially aseptic, and single-use. The fluid transfer assemblies may be manufactured by solidifying polymeric materials to form a body around a mandrel with protrusions engaged to fluid conduits and leaving recesses in the solidified polymeric material to stretch the resultant body and remove the mandrel with protrusions. The resultant fluid transfer assembly may be surrounded by a rigid housing and valves may be engaged with the conduits and/or body to control the fluid flow within the fluid transfer assembly.
Type:
Application
Filed:
December 20, 2017
Publication date:
February 27, 2020
Applicant:
Sartorius Stedim North America Inc.
Inventors:
Michael A. Zumbrum, Charles Meadows, Kevin Perdue
Abstract: The present invention relates to a porous sheet product, to a filter element comprising the porous sheet product, to a method for producing the porous sheet product, to a method for producing the filter element, and to the use of the sheet product and of the filter element.
Type:
Application
Filed:
October 30, 2017
Publication date:
February 20, 2020
Applicant:
Sartorius Stedim Biotech GmbH
Inventors:
Thomas LOEWE, Thomas FRIESE, Sebastian HANDT, Mario STRAUSS, Paschalis NIKOLOUDIS
Abstract: A fluid connection device (10) for connecting two fluid conduits (11, 12), includes a female plug (1), a male plug (2), intended to be inserted into the female plug into a final coupling position, a movable primary locking device (3), having a locked position (30) in which it prevents the male and female plugs from being released from the final coupling position, and a movable secondary latch (4) having an active position (40) designed to prevent the primary locking device (3) from being moved out of the locked position of same, whereby the fluid connection device can establish a permanent connection of the first and second conduits.
Abstract: The invention relates to a protective housing for a biopharmaceutical liquid bag having a lower shell with a bottom and side walls, and an upper shell. The upper shell includes a housing for receiving the bag, and can be inserted into the lower shell, in such a way that the opening of the housing is adjacent to and facing the bottom of the lower shell, and in such a way that the upper shell is laterally held in place between the side walls of the lower shell.