Abstract: A method for virtually configuring a piece of equipment comprises providing an augmented reality system having a computer unit and at least one sensor unit, detecting a sensor dataset associated with a physical environment by means of the at least one sensor unit, determining a virtual environment based on the sensor dataset by means of the computer unit, and determining a virtual arrangement of at least one virtual and/or physical equipment element relative to the virtual environment.

Abstract: An anti-kink device for a hose has a strip-shaped base body, at least one fastening protrusion protruding from the base body and at least one fastening depression provided in the base body. The fastening protrusion is configured such that it can engage into the at least one fastening depression.

Abstract: A mixing vessel for accommodating components to be mixed has a container with at least one mounting depression in a side wall of the container. The mounting depression is adapted so that a mixing impeller housing of a mixing impeller is at least partly insertable, in which at least one magnet is housed for being magnetically connectable to a drive device to be driven. A locking assembly is attachable to the mounting depression from outside for locking the mixing impeller in a storage position, in which the mixing impeller is not rotatable. The locking assembly has a magnetically active element that is adapted to interact with the magnet of the mixing impeller.

Abstract: A method is provided for measuring status parameters of a fluid contained in a container (10). The container (10) is configured for single use and has a wall on which a sensor-carrier plate is fixed in a fluid-tight manner. The plate carries sensors (S1-S5) that are in operative contact with the internal chamber of the container (10) and connected for data exchange (14) with an external control unit (16) that receives and processes the measurement data from the sensors (S1-S5). The sensor plate also carries a temporarily inactive duplicate (D1-D5) of at least one of the sensors (S1-S5) that is activated if measurement data of the sensor (S1-S5) is classified as atypical in the context of an integrity or plausibility test carried out by the external control unit (16).

Abstract: A fluid transport apparatus defining an aseptic pathway configured to direct fluids therethrough is provided. The fluid transport apparatus may include a conduit extending between a first terminus and a second terminus. The conduit may include platinum catalyzed silicone rubber having methyl and phenyl side groups. The conduit may have a storage modulus of 108 or less Pascals at ?75 degrees Celsius. At least one fitting may be connected to the first terminus. A fluid storage accessory may be engaged with the second terminus. A related flexible conduit, method of manufacturing a flexible conduit, and storage method are also provided.

Abstract: The invention relates to a connection device comprising —a line portion (10) having, at its end, a radially outwardly projecting abutment flange (14) for butting against a corresponding abutment flange of a further line portion which is to be coupled to the line portion (10), and —a ring-segment chain (42, 22, 38) comprising a plurality of ring segments (22, 38) connected to one another in a pivotable manner in a common ring plane, wherein the ring-segment ends which formed the chain ends can be latched to one another to give a ring-form connection clamp (42). The invention is distinguished in that the line portion is designed in the form of a tubular connection stub (10) with first thread means (16) spaced apart axially from the abutment surface (141) of its abutment flange (14), and in that each ring segment (22, 38) has a radially inwardly projecting clamping flange (24) and second thread means (26), which are spaced apart axially from said clamping flange and correspond with the first thread means (16).

Abstract: A method for the sterile filling of at least one final basic container, includes: providing at least one sterile chamber having at least one sterile entrance port and providing a source container containing the content, located outside the chamber; providing a communication element, a dispensing element and at least one filling member, to form when all are assembled, a sterile fluid filling and transfer line; inserting at least one final container into the chamber; structurally combining at least one final container with at least one filling member; providing inner members and elements in sterile condition for a single-use; inserting the inner element and members which were previously outside the chamber in the chamber in a sterile manner, such that after filling, a new filling process can be performed without sterilizing the inside of the chamber; transferring in a filling step content from the source container into the final container.

Abstract: A platform has a filter system with a first set of filter modules and a second set of filter modules that is different from the first set of filter modules. Each set of filter modules includes an inflow channel and an outflow channel. A fluid inlet is connected to the first set of filter modules, a fluid outlet is connected to the second set of filter modules, and a separation interface separates the first and second sets of filter modules. The separation interface has a first interface channel to connect to the module outflow channel of the first set of filter modules, and a second interface channel to connect to the module inflow channel of the second set of filter modules. The filter system receives fluid through the fluid inlet and, after the fluid has passed through each set of filter modules, discharges the fluid through the fluid outlet.

Abstract: A method for the preparing mixtures of pharmaceutical or biopharmaceutical substances (11, 11?) includes arranging a preparation container (3, 3?, 3?) already made up with ingredients in a receptacle (2) of a device (1, 1?, 1?) feeding a fluid (10) from a storage container (4, 4?) into the preparation container (3, 3?) via a feed line (6), preparing the ingredients with the fluid (10, 10?) into a substance mixture (11, 11?), and removing the substance mixture (11, 11?) from the preparation container (3, 3?, 3?) into a receiving container via a discharge line (12, 12?, 12?). A device also is provided for carrying out the method.

Abstract: A method for quality assurance of filtration processes includes inserting a filter element (24) into a filtration device (14b) in which filter elements (24) can be subjected to integrity tests. The method further includes associating the integrity information with each filter element (24) in a filter element database (16; 34) connected to a shared data network (12) and saving the number of failed integrity tests performed on each filter element (24) as integrity information associated with that filter element. The saved tolerance setting has an auxiliary limit value, which when exceeded in a defined manner by the queried number of failed integrity tests performed on the identified filter element (24), causes a warning message to be sent to a predetermined monitoring unit (20) and the resulting blocking of the selected integrity testing device (14b) is maintained until a release message is received from the predetermined monitoring unit (20).

Abstract: A fluid transfer hub has a first vessel closure, a second vessel closure, a gasket arranged between the first vessel closure and the second vessel closure, and a clamp at least partially surrounding the first vessel closure, the second vessel closure, and the gasket. The first vessel closure has a first body, one or more apertures extending axially through the first body, one or more first inserts extending axially through the one or more apertures, and a cast seal disposed within the first body and surrounding each first insert. The second vessel closure has a second body, one or more apertures extending axially through the second body, one or more second inserts extending axially through the one or more apertures, and a cast seal disposed within the second body and surrounding each second insert.

Abstract: A presterilizable filtration system is provided and is to be disposed of after a single use. The system has a recirculation tank and a filtration module that are connected to each other in a circuit via a hose system that can be regulated by at least one valve. The valve has a disposable separate valve part that can be integrated in the hose system and a reusable actuator.

Abstract: A system and method for transferring chemical, pharmaceutical, and/or biological material into or out of a container are provided. Further, a use of a transfer interface for accessing the interior of a disposable container is provided. The system comprises a disposable container having at least one port for accessing the interior of the container. The system further comprises a transfer interface connectable to the at least one port. The transfer interface comprises a plurality of extendable transfer elements for collecting samples from the disposable container in a sterile manner. The transfer elements may also be referred to as sampling elements, extractors, or probes. Each of the transfer elements has a corresponding biasing element for retracting the transfer element. The biasing element may be implemented as a spring or as another device capable of applying a biasing force.

Abstract: A device (1) is provided for ventilation and integrity testing of a filter unit (2) that can be supplied with pressure. The filter unit (2) has a filter element (9) arranged in a housing (6) between an inlet (7) and an outlet (8). The housing (6) can be ventilated by an air filter (3) connected to the housing interior (12). A filter valve (4) is arranged upstream of the air filter (3) facing the housing interior (12) and connects the air filter (3) to the housing interior (12). The air filter (3) can be connected on its side facing away from the housing interior (12) to a test line (14) for supplying pressure. An inlet valve (5) is arranged upstream of the inlet (7) and connects an inlet line (10) to the housing interior (12).

Abstract: The invention relates to a filtration device and to a method for characterizing a filter medium or a medium to be filtered. The filtration device comprises a plurality of filtration units. Each filtration unit comprises a first container, which is designed to receive a medium to be filtered, a second container, which is designed to receive a filtrate, at least one connecting line, which connects the first container to the second container, and a filter medium between the first container and the second container in order to filter the medium to be filtered. The first container is designed for the application of positive pressure thereto, and the second container is designed to receive a measurement instrument at ambient pressure.

Abstract: Vessel closure assemblies are provided. The vessel closure assemblies may be engaged with vessels. The vessel closure assemblies may each include a vessel closure, inserts such as anchors and fluid conduits extending through the vessel closure, and a respiratory assembly. The respiratory assembly may include a housing and one or more gas permeable membranes. The gas permeable membranes may be oriented substantially perpendicular to a top wall of the vessel closure through which the inserts extend.

Abstract: A method for characterization of a calibrated defect of a film of a bag for biopharmaceutical fluid comprises a bag film sample (3) with a calibrated defect is installed in a test device (1), a leak test is applied to the bag film sample (3) provided with a calibrated defect, in the test device (1), by applying controlled fluid stresses to the bag film sample (3) provided with a calibrated defect, a result of the leak test is measured, and characteristics of the bag film sample (3) provided with a calibrated defect, characteristics of the controlled fluid stresses, and the result of the leak test are recorded in a database (16).

Abstract: A tight connection device for the aseptic transfer of a biopharmaceutical product includes: a stationary temporary clamping means keeping the container hermetically clamped against the chamber; a stationary unlocking means capable of switching the container from an initial locked position to an intermediate unlocked position; a stationary locking means; and an annular functional crown capable of being rotated to actuate the stationary unlocking means and the stationary locking means of the container. The stationary unlocking means and the stationary locking means are mechanically linked to the annular functional crown and arranged such that the rotation of the annular functional crown and the end locked position. The device further includes stationary immobilising/release means capable of allowing and preventing the annular functional crown to rotate.

Abstract: A protective container for a biopharmaceutical liquid bag comprises: a lower shell comprising a bottom and side walls; and an upper shell, said upper shell comprising a reinforcement capable of covering the bag and being insertable in the lower shell, so that the upper shell is retained in the upper part of the side walls of the lower shell by resting on support elements located in the lower shell.