Patents Assigned to Stedim
  • Device for conveying a bag comprising a biopharmaceutical fluid and systems and a method using same
    Patent number: 10532870
    Abstract: Disclosed is a device for transporting a biopharmaceutical fluid, including an inner bag forming an inner chamber adapted and intended for receiving a biopharmaceutical fluid, an outer container including an outer receptacle, the outer receptacle including a wall forming an outer chamber, an expandable protective element arranged at least partially between the outer receptacle and the inner bag and adapted to receive the inner bag, the expandable protective element being adapted to expand in volume to an expanded state so as to be interposed between the outer receptacle and the inner bag, the expandable protective element in the expanded state surrounding the inner bag and filling the space between the wall of the outer receptacle and the inner bag.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: January 14, 2020
    Assignee: SARTORIUS STEDIM FMT SAS
    Inventors: Stephane Baud, Isabelle Gay, Danilo Ponassi
  • Method for loading a 3D flexible pouch to be filled, system for loading and storing this flexible pouch and associated support device
    Patent number: 10532837
    Abstract: A support device (20), mounted on an upper edge of a container (3), includes lifting elements that define a support surface (22) which extends transversely outwards from an inner edge (55). The upper end (2b) of a flexible pouch for biopharmaceutical product can rest on this support surface, the rest of the 3D-type pouch extending into the container. The slot (23) which separates the support surface into two portions defines a guide path for a flexible supply line (9a, 9b) for the pouch (2) that is connected at its bottom to the end (2b). A convex surface is formed at the rear end of the slot and above the edge of the container, so as to guide and facilitate the passage of the line (9a) into the housing, when the filling state is sufficiently advanced. The causes of poor deployment of the pouch are thus minimized, without human intervention.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: January 14, 2020
    Assignee: SARTORIUS STEDIM FMT SAS
    Inventors: Stephane Baud, Frederic Bernard
  • Connecting system for filter cassettes
    Patent number: 10525413
    Abstract: A connecting system (1) has at least one connector (2) for a filter cassette (4) that can be inserted into a filter holder and has filter layers (5) between two end plates (6), and seals (7) between the filter layers (5) and/or between the end plates (6) and an adjacent filter layer (5). The connector has tensioning parts that engage in one another in a longitudinally displaceable manner and that can be fixed to the end plates (6) via their ends facing away from one another. The connector exerts a pretensioning force onto the end plates (6) when it is deflected to its maximum extent. The pretensioning force pulls the end plates (6) towards the filter layers (5), and when a contact-pressure force superimposed on the pretensioning force is applied to the end plates (6), the tensioning parts can be pushed towards one another correspondingly with the end plates (6).
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: January 7, 2020
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Thomas Krumbein, Stefan Weisshaar, Michael Bates
  • Method for the sterilization of chromatographic material and chromatographic material sterilized according to said method
    Patent number: 10517973
    Abstract: The present invention relates to a method for sterilizing a chromatography material, more particularly microporous polymer membranes, to a chromatography material which has been sterilized by the method according to the invention, to the use of the chromatography material sterilized according to the invention for the chromatographic removal of contaminants from a fluid, and to a closed chromatographic filtration system comprising a chromatography material sterilized according to the invention.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: December 31, 2019
    Assignee: Sartorius Stedim Biotech GMBH
    Inventors: Martin Leuthold, Louis Villain, Florian Taft
  • System and method for receiving a single-use vessel
    Patent number: 10500554
    Abstract: A system for receiving a single-use vessel containing a mixing device has a support structure adapted to receive the single-use vessel and a drive-unit adapted to power, to control, or to power and control a mixing of contents of the single-use vessel when the single-use vessel is arranged in the support structure. The support structure and the drive-unit are provided as separate components that may be arranged both in an operating position, where the drive-unit is connectable to the mixing device of the single-use bag in the support structure, and in a separated position, where the drive-unit is separated from the support structure. The drive-unit comprises a tag reader that, in the operating position, is arranged to read a vessel tag of the single-use vessel arranged in the support structure.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: December 10, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Lars Boettcher, Jonathan Cutting, Sharon D. West, Martin Oschwald
  • Filtration device
    Patent number: 10493407
    Abstract: A filtration device (1) has a housing (4) and a filter module (2) with hollow fibers (32) surrounded by an outer shell (5). The hollow fiber bundle (6) is sealed to the outer shell (5) at each end by an adhesive (11) transverse to the longitudinal direction (10). Each end of the hollow fibers (32) is unclosed. An unfiltered product chamber (20) is between the outer shell (5) and a wall (19) of the filter housing (4) and a filtered product chamber (13) is inside the filter module (2). The bottom end of the filter module (2) connects with an intermediate section (3) that connects with a receptacle (17) of a bottom portion (15) of the filter housing (4). The intermediate section (3) forms a connection chamber (26) facing the hollow fiber ends (29) and radial feed channels (28) connect the connection chamber (26) with the unfiltered product chamber (20).
    Type: Grant
    Filed: July 18, 2015
    Date of Patent: December 3, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Wilhelm Requate, Gerid Hellwig
  • Filter module
    Patent number: 10493406
    Abstract: A filter module (1) has a housing (2) formed from a plastic and a filter (3) made from a plastic is arranged in the housing (2). The housing (2) is bonded adhesively to the filter (3) by an adhesive (15) via a first bonding surface (7, 18) made from a first plastic and via a second bonding surface (14, 19, 21) made from a second plastic. The adhesive bonding of the first bonding surface (7, 18) and the second bonding surface (14, 19, 21) is accomplished via an intermediate piece (10, 20) with the bonding surfaces (14, 18, 21) made from a plastic that is identical to or different from the first plastic. At least one of the bonding surfaces (7, 18, 19, 14, 21) has been activated by plasma or corona pre-treatment prior to the adhesive bonding.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: December 3, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Ralf Lausch, Paschalis Nikoloudis, Wilhelm Requate, Johannes Wortmeyer
  • CHROMATOGRAPHY MEDIUM WITH BOUND MICROGLOBULES AND METHOD FOR THE PREPARATION THEREOF
    Publication number: 20190358609
    Abstract: The present invention relates to a chromatography medium which can be used in affinity chromatography and to a method for the preparation thereof.
    Type: Application
    Filed: January 16, 2018
    Publication date: November 28, 2019
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Adrian Ley, Florian Taft, Jan Schwellenbach, Louis Villain
  • Fluid connector with locking ring
    Patent number: 10487967
    Abstract: Female connector for accepting a male connector having a retaining external annular rim, a slot including two parallel lateral grooves and the slot opening at least at one of its ends forming a mouth of the housing, the female connector including a locking slide distinct from the body, movable between a locking position and an unlocking position, the locking slide including a locking plate and an actuating knob formed integrally with the plate, with a retaining portion belonging to the locking plate to come into abutment against the retaining outer annular rim, the locking slide including at least one flexible tab formed integrally, returning the slide toward the first position, the flexible tab pressing on each side of the mouth in the axial direction X so that the return force is balanced about X and creates no torque that could have a tendency to cause the locking plate to jam.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: November 26, 2019
    Assignee: SARTORIUS STEDIM FMT SAS
    Inventors: Jeremy Gibelin, Florian Blake
  • Locking fluid connector
    Patent number: 10487968
    Abstract: Disclosed is a fluid-connection device for connecting a first wall defining a first fluid space, for example a flexible pipe, to a second wall defining a second fluid space, in the form of a flexible pipe or enclosure, including a first male connector, the first connector including a seal and a snap-fitting collar, the seal extending radially prior to coupling from the axis until a first radial distance R1, a second female connector capable of receiving the first connector, the second connector including at least one flexible tab with one end against which the locking collar abuts in coupling position, in order to prevent retraction from the coupling position, the flexible tab being defined relative to the axis between a second radial distance R2 and a third radial distance R3, which is greater than the second radial distance R2, wherein R2>R1.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: November 26, 2019
    Assignee: SARTORIUS STEDIM FMT SAS
    Inventors: Florian Blake, Jeremy Gibelin
  • Fluid transfer interface
    Patent number: 10486959
    Abstract: Fluid transfer interfaces for transferring fluid into or out of vessels, namely flexible polymeric bags. The fluid transfer interfaces have a body for use in connection with a vessel, or combined therewith, one or more apertures extending through the body, and one or more fluid transfer conduits secured to the body by way of a cast seal and extending continuously and axially through the one or more apertures. Also disclosed is a vessel closure having one or more fluid transfer conduits extending through the closure, the fluid transfer conduits affixed to the closure by a cast seal.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: November 26, 2019
    Assignee: Sartorius Stedim North America Inc.
    Inventor: Michael A. Zumbrum
  • Reliability of an integrity or leak test of a sample
    Patent number: 10473677
    Abstract: A method for improving reliability of an integrity or leak test includes determining at least one first parameter indicative of: a first volume of a sample, a first temperature of the sample, a first pressure of the sample and/or a first assessment of integrity of the sample. The method further determines at least one second parameter indicative of a deviation from the first parameter and at least one third parameter indicative of a second assessment of the integrity of the sample. The second assessment provides an indication of a passed or failed test. The method further determines whether the deviation has an impact on the indication of the second assessment. When the deviation is determined to have an impact on the indication of the second assessment, the method comprises identifying a possibility that the indication of the second assessment is incorrect.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: November 12, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventor: Magnus Stering
  • Electron beam induced modification of membranes by polymers
    Patent number: 10471394
    Abstract: A method for producing a microporous membrane includes providing a microporous starting membrane having outer surfaces and pores with inner surfaces extending between the outer surfaces of the membrane and having a microporous starting membrane permeability. The method impregnates the membrane with an impregnating solution consisting essentially of a solvent and a polymer. The polymer is an organic substance with an average molecular weight of at least 500 g/mol and may be selected from the group consisting of poly(2-ethyloxazoline), polyvinylpyrrolidone-vinyl acetate (PVP-VA) and mixtures thereof. The method then includes irradiating the impregnated membrane with electron beam radiation to provide a crosslinked reaction product constituting a three-dimensional network formed of the microporous starting membrane and the polymer without any decomposition of the microporous starting membrane.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: November 12, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Volkmar Thom, Bjoern Hansmann, Tobias Foster
  • SHEET MATERIAL AND FILTER ELEMENT WITH HYDROPHOBIC SEPARATING LAYER, USE THEREOF AND PROCESS FOR PRODUCTION OF SAME
    Publication number: 20190329172
    Abstract: The present invention relates to a sheet material and filter element, where the sheet material and the filter element have a hydrophobic separating layer, and also to use thereof and to a process for production of same.
    Type: Application
    Filed: April 25, 2019
    Publication date: October 31, 2019
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Eberhard Wünn, Thomas Friese, Benjamin Schneider, Mario Strauss
  • Mixer-container and method for assembling a mixer-container including a telescopic shaft
    Patent number: 10456761
    Abstract: A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: October 29, 2019
    Assignee: SARTORIUS STEDIM FMT SAS
    Inventors: Sebastien Chaussin, Jeremy Gibelin, Stefan Zeuch, Michael Bates
  • POUCH COMPRISING A SHAPE MEMORY MATERIAL TO CONTAIN A BIOPHARMACEUTICAL FLUID
    Publication number: 20190307642
    Abstract: A pouch for transporting and/or processing a biopharmaceutical fluid, the pouch comprising a flexible wall, the flexible wall comprising a shape memory material being adapted to change shape when induced by an external stimulus, so that the pouch can be alternately in a collapsed state and in an unfolded state, the wall of the pouch in the unfolded state delimiting a closed internal cavity adapted to contain the biopharmaceutical fluid.
    Type: Application
    Filed: June 30, 2017
    Publication date: October 10, 2019
    Applicant: SARTORIUS STEDIM FMT SAS
    Inventors: Stefan SCHLACK, Jean-Marc CAPPIA
  • Mixing vessel with locking assembly for locking a mixing assembly in storage position and mixing impeller with central disc-like member
    Patent number: 10434481
    Abstract: A mixing vessel for accommodating components to be mixed has a container with at least one mounting depression in a side wall of the container. The mounting depression is adapted so that a mixing impeller housing of a mixing impeller is at least partly insertable, in which at least one magnet is housed for being magnetically connectable to a drive device to be driven. A locking assembly is attachable to the mounting depression from outside for locking the mixing impeller in a storage position, in which the mixing impeller is not rotatable. The locking assembly has a magnetically active element that is adapted to interact with the magnet of the mixing impeller.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: October 8, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Lars Boettcher, Jonathan E. Cutting, Sharon D. West, Martin Oschwald, Mike Bates
  • CONTAINER FOR TRANSPORTING A BIOPHARMACEUTICAL FLUID COMPRISING A SHAPE MEMORY MATERIAL
    Publication number: 20190300238
    Abstract: A container for transporting and/or processing a biopharmaceutical fluid, the container comprising a wall, the wall comprising a shape memory material being adapted to change shape when induced by an external stimulus, so that the container can be alternately in a collapsed state and in an unfolded state, the wall of the container in the unfolded state delimiting an internal cavity adapted to contain the biopharmaceutical fluid.
    Type: Application
    Filed: June 30, 2017
    Publication date: October 3, 2019
    Applicant: SARTORIUS STEDIM FMT SAS
    Inventors: Stefan SCHLACK, Jean-Marc CAPPIA
  • SERVICE UNIT AND METHOD FOR MONITORING AND DOCUMENTING MAINTENANCE WORK
    Publication number: 20190303884
    Abstract: The invention relates to a service unit that can be carried on the body of a user by means of a carrying system, having at least one power source for supplying power to electrically operated tools connectable to the power source, the power source being formed from at least one rechargeable battery. The invention also relates to a method for monitoring and documenting maintenance work. The invention is distinguished in that the carrying system has an integrated computation and documentation unit for monitoring and documenting maintenance work, wherein the computation and documentation unit is powered from the power source, wherein the computation and documentation unit is connected to at least one motion sensor and/or locating sensor and wherein the motion sensor is arranged on the tool or the hand of the user.
    Type: Application
    Filed: June 2, 2017
    Publication date: October 3, 2019
    Applicant: Sartorius Stedim Biotech GmbH
    Inventor: Lars BÖTTCHER
  • Aeration device for bioreactors
    Patent number: 10427112
    Abstract: Aeration device for bioreactors with an aeration element with gas outlet openings arranged in a housing, the aeration element taking the form of a microsparger, the gas outlet openings of which are in each case spaced apart from one another and have a size of between 100 ?m and 200 ?m. At least one second aeration element with gas outlet openings of a second size is preferably provided, the aeration elements being formed by a common housing with separate aeration channels.
    Type: Grant
    Filed: August 6, 2011
    Date of Patent: October 1, 2019
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventor: Stefan Weisshaar