Patents Assigned to Stedim
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Publication number: 20230405491Abstract: A chromatography system is provided. The chromatography system is configured to process a feed fluid containing a plurality of components, wherein at least one component of the plurality of components of the feed fluid is a target component. The chromatography system comprises: a flow path comprising a plurality of fluid control components configured to control a fluid flow; a stationary phase, wherein the stationary phase is at least one membrane adsorber connected to the flow path and the stationary phase is configured to isolate the target component. The flow path is configured such that harvesting of the target component is optimized.Type: ApplicationFiled: October 28, 2021Publication date: December 21, 2023Applicant: Sartorius Stedim Biotech GmbHInventors: Mario Grünberg, Arne Bluma, Dominik Stein, Martin Leuthold
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Publication number: 20230407229Abstract: A computer-implemented method can configure and/or setup and/or control a downstream process for processing a biomass, including receiving at least one measurement value of at least one feature of an upstream process by which the biomass to be processed in the downstream process has been obtained and/or of at least one feature of a downstream process stage or operation, determining at least one downstream process parameter based on the received at least one measurement value, arid configuring and/or setup and/or controlling at least one downstream process stage or process operation based on the determined at least one downstream process parameter.Type: ApplicationFiled: October 6, 2021Publication date: December 21, 2023Applicant: Sartorius Stedim Biotech GmbHInventors: Marco Leupold, Alexandre Espachs Barroso, Bernward Husemann, Michael Rodenberg, Jens Matuszczyk, Markus Kampmann, Martin Leuthold, Johannes Wortmeyer, Thomas Friese, Jochen Scholz
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Patent number: 11844746Abstract: The invention relates to a protective housing for a biopharmaceutical liquid bag having a lower shell with a bottom and side walls, and an upper shell. The upper shell includes a housing for receiving the bag, and can be inserted into the lower shell, in such a way that the opening of the housing is adjacent to and facing the bottom of the lower shell, and in such a way that the upper shell is laterally held in place between the side walls of the lower shell.Type: GrantFiled: March 28, 2018Date of Patent: December 19, 2023Assignee: Sartorius Stedim FMT SASInventors: Stephane Baud, Frédéric Bazin
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Patent number: 11846566Abstract: Integrity of a flexible bag is verified by a testing system, using helium to detect existence of a possible hole. The flexible bag is preliminary placed in vacuum chamber of a fluid-tightly isolated enclosure. After connecting a port of the bag to a helium feeding pipe, vacuum suction is performed to obtain vacuum outside the bag in the enclosure. Then, a first amount of helium is diffused in the internal volume of the enclosure through a gas permeable wall, to increase helium partial pressure outside the flexible bag. After, in a test phase while said vacuum suction is still performed, the bag is filled with a second amount of helium. A detector detects information representative of helium partial pressure in the internal volume, to allow detection of helium escaping from the bag, by analysis of a helium partial pressure drop.Type: GrantFiled: January 28, 2020Date of Patent: December 19, 2023Assignee: SARTORIUS STEDIM FMT SASInventors: Laurent Thenard, Marc Hogreve, Tomasz Urbaniak, Mandip Nachhattar, Delphine Philippeau, Bastien Cattaux
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Publication number: 20230399705Abstract: The present invention relates to isolated nucleic acid molecules, comprising a functional mammalian EGR-1 (early growth response protein 1) promoter region that is operatively linked to a gene encoding a fluorescent protein and controls expression of said gene. The present invention further relates to nucleic acid vectors, comprising said nucleic, cells comprising said nucleic acids or vectors, being capable of sensing and indicating fluid shear stress acting on themselves, and methods of generating the same. Furthermore, the present invention relates to methods of evaluating fluid shear stress acting on cells in real-time during the operation of a biotechnological device or system, methods of evaluating a biotechnological device or system with respect to fluid shear stress acting on cells caused by operation of said device or system, and methods of designing a biotechnological device or system, said methods using said cells.Type: ApplicationFiled: May 18, 2022Publication date: December 14, 2023Applicant: Sartorius Stedim Biotech GmbHInventors: Samin Akbari, Ann-Cathrin Leroux, Taehong Kwon, Christoph Zehe, David Pollard
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Patent number: 11835501Abstract: Determining optimum operating binding capacity for a MCC process using one column, the process including N number of columns, comprises loading target product on a first column at a first residence time and/or flow rate; loading the product on the column at a second residence time and/or flow rate, the first residence time and/or flow rate being different than the second residence time and/or flow rate; generating a first breakthrough curve for the first residence time and/or flow rate and a second breakthrough curve for the second residence time and/or flow rate, wherein the first curve represents product breakthrough for the first column and the second curve represents product breakthrough for an Nth column; and using the curves to determine product loading capacity of the first column before product breakthrough at the Nth column; the product loading capacity of the first column equaling optimum operating binding capacity for the process.Type: GrantFiled: July 13, 2015Date of Patent: December 5, 2023Assignee: Sartorius Stedim Chromatography Systems Ltd.Inventors: Xhorxhi Gjoka, Karl K. Rogler, Mark J. Schofield
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Patent number: 11826720Abstract: The present invention relates to an improved diatomaceous earth composition containing salt water. The diatomaceous earth composition according to the present invention comprises an agglomerated mixture of calcined diatomaceous earth particles, water and at least one inorganic salt, wherein the mass ratio of the calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the content of the at least one inorganic salt is equal to or more than 0.25 parts by mass based on 100 parts by mass of water. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition according to the present invention. In another aspect, the present invention relates to the use of the diatomaceous earth composition according to the present invention as an agent for precoat filtration or dynamic body feed filtration in biopharmaceutical applications.Type: GrantFiled: November 6, 2020Date of Patent: November 28, 2023Assignee: Sartorius Stedim Biotech GmbHInventors: Karl Pflanz, Andreas Pickl, Florian Hebenstreit
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Patent number: 11827874Abstract: A bioreactor (1; 2; 3) includes a receiving container (10) for receiving a disposable bag (44). A bottom surface (11) of the receiving container (10) is designed to support the disposable bag (44) in the receiving container (10). An outlet opening (5) is formed in the bottom surface (11) and tapers down with respect to the ground for receiving a drain port (45) of the disposable bag (44). The drain port is complementary to the outlet opening (5).Type: GrantFiled: January 25, 2021Date of Patent: November 28, 2023Assignee: Sartorius Stedim Biotech GmbHInventors: Bernward Husemann, Simon Topp-Manske, Bjoern Nickel, Marco Leupold
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Publication number: 20230375101Abstract: An assembly is provided that comprises: a valve cassette block (20) comprising a plurality of valves (25) which are controllable via a control surface (24) of the valve cassette block (20); a valve control block (10) having an operation surface (11), the valve control block (10) being configured to control each of the plurality of valves when the operation surface (11) is in close contact with the control surface (24) of the valve cassette block (20) in an operation position; at least one swiveling door (30) hinged to the valve control block (20) such that an open state of the swiveling door (30) allows arranging the valve cassette block (20) into the operation position with its control surface (24) arranged at the operation surface (11) of the valve control block, while a closed position of the swiveling door (30) is configured to hold the valve cassette block (20) in the operation position with an inner surface of the swiveling door (30) abutting a rear surface (26) of the valve cassette block (20) opposType: ApplicationFiled: May 20, 2022Publication date: November 23, 2023Applicant: Sartorius Stedim Chromatography Systems Ltd.Inventor: Dinesh Shukla
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Publication number: 20230375488Abstract: An analysis container includes an outer tube and a plurality of inner tubes. The outer tube defines a buffer volume that is configured to receive a buffer material. The plurality of inner tubes is disposed within the buffer volume. Each inner tube has an inner diameter equal to or less than 6 mm and is configured to receive a biopharmaceutical composition therein. The outer tube is configured such that the buffer material and the biopharmaceutical composition are axially frozen.Type: ApplicationFiled: May 16, 2023Publication date: November 23, 2023Applicant: Sartorius Stedim North America Inc.Inventors: Jonathan Cutting, Thomas Mickleburgh, Nicholas Phillips, Alexander Kaiser
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Publication number: 20230358343Abstract: An organizer assembly including a belt and a ribbon. The ribbon has a first clamp member, a second clamp member, and a first carrier portion. The first clamp member is configured to receive a conduit or a support to fix the conduit or the support relative to the ribbon. The belt includes an elongated body that is slidably received in the first carrier portion. The organizer assembly may include one or more adapters that are received in a respective clamp member of the ribbon and configured to receive a conduit or a support to fix the conduit or support relative to the ribbon.Type: ApplicationFiled: July 18, 2023Publication date: November 9, 2023Applicant: Sartorius Stedim North America Inc.Inventors: Michael Zumbrum, William Kimmick, Kevin Perdue
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Publication number: 20230356108Abstract: An assembly is provided that comprises: at least one valve cassette block (20) comprising a plurality of valves (25) which are controllable via a control surface (24) of the valve cassette block (20); a valve control block (10) having an operation surface (11), the valve control block (10) being configured to control each of the plurality of valves (25) when the operation surface (11) is in contact with the control surface (24) of the at least one valve cassette block (20), the valve control block (10) comprising at least one sliding trench (14) formed in the operation surface (11); at least one sliding component (30) configured to slidably interlock with the at least one sliding trench (14) such that the at least one sliding component (30) is movable relative to the valve control block (10) in a sliding direction parallel to the operation surface (11), at least one pulling bracket (40, 50) configured to embrace the at least one valve cassette block (20) and to interact with the at least one sliding componType: ApplicationFiled: May 6, 2022Publication date: November 9, 2023Applicant: SARTORIUS STEDIM CHROMATOGRAPHY SYSTEMS LTD.Inventor: Dinesh Shukla
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Publication number: 20230349472Abstract: A clamp for closing a flexible tube includes an anvil and a hammer. The anvil includes a passage and a slot defined therein. The passage is configured to receive a flexible tube therethrough. The hammer is slidably received within the slot of the anvil. The hammer is securable in a first position in which the passage of the anvil is substantially unoccluded and a second position in which the passage of the anvil is occluded. The hammer and the anvil are configured to prevent fluid from flowing through the flexible tube received in the passage when the hammer is in the closed position. The hammer is substantially within the anvil in the closed position.Type: ApplicationFiled: December 8, 2021Publication date: November 2, 2023Applicant: Sartorius Stedim North America, lnc.Inventors: Michael Zumbrum, William Kimmick
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Patent number: 11794135Abstract: A single-use filtration device including a plurality of single-use filter capsules connected with each other by rigid lines, of which at least a part is firmly mounted in a raster universally specified by a holder. The filter capsules, in particular as regards the type of filter, type of construction and/or size, and/or the connections of the filter capsules, are preconfigured for a desired filtration process.Type: GrantFiled: May 15, 2018Date of Patent: October 24, 2023Assignee: SARTORIUS STEDIM BIOTECH GMBHInventors: Thomas Loewe, Andre Dell, Sebastian Handt, Maik Sommer, Thomas Friese, Mandar Dixit, Bernhard Diel
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Patent number: 11795425Abstract: The invention relates to an installation for biotechnological applications (1, 101), comprising an improved holder system (4) with at least one carrier (10) for the mounting of components (5) of the installation (1, 101) on the installation (1, 101). The carrier (10), which comprises a frame (12) with two arms (14) and with a recess (16) and includes a deformable element (30) with at least two fastening sections (32), which may be understood to have a flat base (20) by which the carrier (10) can be fastened to the installation (1, 101). The deformable element (30) is designed to assume the following states: a receiving state AUZ, in which the deformable element (30) is available for receiving a component (5) of the installation (1, 101); and a locking state ARZ.Type: GrantFiled: March 16, 2017Date of Patent: October 24, 2023Assignee: Sartorius Stedim Biotech GmbHInventors: Robin Heese, Andreas Klemm, André Grebe, Michael Rodenberg
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Patent number: 11794154Abstract: A mixing apparatus (1) for mixing a fluid and/or solid. The mixing apparatus includes a mixing container (100) having an interior in which the fluid and/or solid can be arranged. A feed-through passage (10) extends through a container wall (101) of the mixing container. A drive shaft (50) is fed through the feed-through passage, to drive a stirring element (30) arranged at least partly in the interior of the mixing container. The stirring element is used to mix the fluid and/or solid arranged in the mixing container. A drive-side shaft end (51) of the drive shaft couples the drive shaft to a drive (120) arranged outside of the mixing container. An adjustable seal (70) seals off the feed-through passage. A setting apparatus (80) is provided to switch the adjustable seal into at least two sealing operation states having different sealing effects.Type: GrantFiled: February 10, 2020Date of Patent: October 24, 2023Assignee: SARTORIUS STEDIM BIOTECH GMBHInventors: Stefan Zeuch, Markus Haeusser, Stefan Weisshaar, Jens Ludwig
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Patent number: 11795516Abstract: Techniques for predicting an amount of at least one biomaterial produced or consumed by a biological system in a bioreactor are provided. Process conditions and metabolite concentrations are measured for the biological system as a function of time. Metabolic rates for the biological system, including specific consumption rates of metabolites and specific production rates of metabolites are determined. The process conditions and the metabolic rates are provided to a hybrid system model configured to predict production of the biomaterial. The hybrid system model includes a kinetic growth model configured to estimate cell growth as a function of time and a metabolic condition model based on metabolite specific consumption or secretion rates and select process conditions, wherein the metabolic condition model is configured to classify the biological system into a metabolic state. An amount of the biomaterial based on the hybrid system model is predicted.Type: GrantFiled: November 18, 2022Date of Patent: October 24, 2023Assignee: Sartorius Stedim Data Analytics ABInventors: Christopher McCready, Nicholas Trunfio
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Publication number: 20230332091Abstract: A bioreactor system for receiving a disposable bioreactor bag comprises a receiving container having a container wall which defines a receiving space in which the disposable bioreactor bag is received in an operating state of the bioreactor system. A stirring system projects at least partially into the receiving space and is designed and configured to stir a biomedium present in the disposable bioreactor bag in the operating state of the bioreactor system. At least one baffle, which makes the receiving space smaller and differs from the container wall, serves to reduce a laminar flow of the biomedium. A temperature control medium flows through at least part of the at least one baffle, said temperature control medium controlling the temperature of the baffle.Type: ApplicationFiled: June 17, 2021Publication date: October 19, 2023Applicant: Sartorius Stedim Biotech GmbHInventors: Marco Leupold, Simon Topp-Manske, Ute Husemann, Sebastian Ruhl, Sascha Gärtner, Yannick Stapel, Regina Wollschmidt, Gerhard Greller, Thomas Dreher
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Publication number: 20230310272Abstract: A biocontainer including a rigid frame and a flexible membrane. The frame includes a lattice core. The membrane may flex to adjust to a volume of biomaterial sealed within the interior of the biocontainer as a temperature of the biomaterial changes.Type: ApplicationFiled: March 28, 2023Publication date: October 5, 2023Applicant: Sartorius Stedim North America Inc.Inventors: Michael Zumbrum, William Kimmick, Kevin Perdue
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Publication number: 20230311113Abstract: A fluid processing system includes a fluid processing unit and a tubing arrangement providing fluid flow to and from the fluid processing unit. The tubing arrangement includes one or more flow cells and the fluid processing unit is selected from a unit comprising a single use tangential flow filtration mobile skid and a unit comprising a device for chromatographic separation. Each one of the flow cells includes a body having an inlet and an outlet and a fluid flow channel extending from the inlet to the outlet of the body.Type: ApplicationFiled: April 8, 2021Publication date: October 5, 2023Applicant: Sartorius Stedim Biotech GmbHInventors: Kevin Ashley Lamport, Natasha Jayne Kelly