Patents Assigned to Stedim
  • Publication number: 20220214318
    Abstract: A chromatography method, a method of determining the concentration of at least one compound in a chromatography method and a method of obtaining at least one chromatography method parameter are provided. The methods can include selecting at least one compound, a stationary phase, a mobile phase, and/or a chromatography device having a chromatography bed comprising the stationary phase and the mobile phase.
    Type: Application
    Filed: May 8, 2020
    Publication date: July 7, 2022
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Jan Schwellenbach, Volkmar Thom, Dominik Stein
  • Publication number: 20220214319
    Abstract: Chromatography methods, methods of determining the concentration of at least one compound in a chromatography method and methods of obtaining at least one chromatography method parameter are provided. The chromatography methods include performance based on results obtained from the methods of determining the concentration of at least one compound or methods of obtaining at least one chromatography method parameter.
    Type: Application
    Filed: May 8, 2020
    Publication date: July 7, 2022
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Jan Schwellenbach, Volkmar Thom, Dominik Stein
  • Publication number: 20220203306
    Abstract: The present invention relates to a method for producing a porous membrane, the method being characterized in that a solvent system comprising 2-pyrrolidone and N-alkyl-2-pyrrolidone is used, wherein the content ratio of 2-pyrrolidone to N-alkyl-2-pyrrolidone in the solvent system is from 90%:10% to 10%:90%, based on mass %, and wherein N-alkyl-2-pyrrolidone is N-propyl-2-pyrrolidone and/or N-butyl-2-pyrrolidone. Furthermore, the present invention relates to a porous membrane obtainable by said method. Moreover, the present invention relates to the use of a specific solvent system for the production of a porous membrane.
    Type: Application
    Filed: June 25, 2020
    Publication date: June 30, 2022
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Jan Schwellenbach, Catharina Warnke, Sandra Otto
  • Patent number: 11364480
    Abstract: A chromatography medium includes a porous matrix and nonporous globules bound on the inner and outer surfaces of the porous matrix. The average radius of the microglobules is not more than 30% of the average pore diameter of the porous matrix. The chromatography medium can be used in affinity chromatography. A method for preparing the chromatography medium may include providing a porous starting matrix, providing a polymerization solution, and initiating polymerization of the polymerization solution in the presence of the porous starting matrix to form insoluble nonporous microglobules that are bound to the inner and outer surfaces of the porous starting matrix.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: June 21, 2022
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Adrian Ley, Florian Taft, Jan Schwellenbach, Louis Villain
  • Publication number: 20220184556
    Abstract: The present invention relates to a crossflow filtration method, a method for obtaining at least one crossflow filtration parameter and a system for obtaining at least one crossflow filtration parameter.
    Type: Application
    Filed: August 12, 2020
    Publication date: June 16, 2022
    Applicant: Sartorius Stedim Biotech GmbH
    Inventor: Martin Leuthold
  • Patent number: 11359172
    Abstract: A single-use chamber comprising a primary subchamber containing at least one primary component configured to perform an operation comprising at least one of generation and handling of a biological material; and a secondary subchamber containing at least one of a connection to equipment external to the single-use chamber and a secondary component, wherein the external equipment and the secondary component are configured to support the operation of the at least one primary component; wherein the primary subchamber and the secondary subchamber are configured to be connected to each other so that the at least one primary component is operatively coupled to at least one of the connection and the secondary component.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: June 14, 2022
    Assignee: Sartorius Stedim Biotech GmbH
    Inventor: Frank Maggiore
  • Publication number: 20220178782
    Abstract: Integrity of a flexible bag already filled with a biopharmaceutical fluid is verified by a receiving and controlling device. The first wall and a second wall, forming two opposite walls on both sides of a longitudinal axis of the bag, are in contact with the fluid and with two parallel restraining plates of the device, while test pressure is controlled. Additionally, an integrity/non-integrity indicator device that comprises a pair of covering walls is provided to be interposed between the bag walls and the restraining plates. A leak through the bag walls can be detected by a color change of at least one continuous colorimetric detection layer, integral with or included in the pair of covering walls. Such continuous colorimetric detection layer is included in a permeable or impregnable layer.
    Type: Application
    Filed: March 20, 2020
    Publication date: June 9, 2022
    Applicant: SARTORIUS STEDIM FMT SAS
    Inventors: Marc HOGREVE, Martin DAHLBERG
  • Patent number: 11351513
    Abstract: A device (1) for producing a solution of at least one liquid first medium and at least one second medium has a first container (2) for the first medium and a second container (3) for the second medium. Each container (2, 3) is connected to a supply line of a static mixer (9) via a pump (4, 5) that can be regulated by a controller (6). A sensor (10) is connected to the controller (6) downstream of the static mixer (9) in the flow direction. A branching valve (17) is downstream of the static mixer (9) in the flow direction and is controlled by the controller (6). A sterile filter (11) is downstream of the static mixer (9) and has an RFID tag (15) that stores process-relevant data to at least be read by the controller (6). A method also is provided for producing a solution using the device.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: June 7, 2022
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Franziska Krumbein, Alexander Tappe
  • Publication number: 20220162538
    Abstract: A container for storing, mixing and/or cultivating a medium, in particular a bioreactor for a medium, comprises a line system as a discharge line, feed line and/or bypass line of the bioreactor. The system can comprise a line body formed as a single piece for a medium to flow therethrough. The has a first and a second connection region for connecting in particular to the container and/or the line system and at least a first and a second coupling apparatus in the region between the connection regions.
    Type: Application
    Filed: March 19, 2020
    Publication date: May 26, 2022
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Christian Grimm, Andreas Prediger, Matthias Bode, Arkadiusz Pajak
  • Publication number: 20220146987
    Abstract: Aspects of the application relate to methods, a computer program and a process control device. According to one aspect, a computer-implemented method for determining a multivariate process chart is provided. The multivariate process chart is to be used to control a process to produce a chemical, pharmaceutical, biopharmaceutical and/or biological product. The multivariate process chart includes a first trajectory, an upper limit for the first trajectory and a lower limit for the first trajectory.
    Type: Application
    Filed: February 24, 2020
    Publication date: May 12, 2022
    Applicant: Sartorius Stedim Data Analytics AB
    Inventors: Marek Hoehse, Christian Grimm
  • Publication number: 20220137579
    Abstract: Aspects of the application relate to computer-implemented methods, process control devices, and a computer program. According to one aspect, a computer-implemented method for controlling a process in a plurality of first scale vessels via a first process control device is provided. Each of the first scale vessels contains fluid and the process is for producing a chemical, pharmaceutical, biopharmaceutical and/or biological product. The method comprises controlling, by the first process control device and at least partially in parallel, the process in each of the first scale vessels. The method can include periodically determining, prior to an assigning decision and at a first frequency, first sets of process parameter values for each of the process parameters from each of the first scale vessels.
    Type: Application
    Filed: February 25, 2020
    Publication date: May 5, 2022
    Applicant: Sartorius Stedim Data Analytics AB
    Inventors: Christian Grimm, Marek Höhse, Johan Hultman, Chloe Lang
  • Patent number: 11319201
    Abstract: A fluid distribution system is configured to distribute fluid from a first vessel to second vessels includes a hub assembly and a frame assembly. The hub assembly has an input cap, a distribution cap, a first clamp, and a second clamp. The input cap defines an inlet and the distribution cap is sealingly secured to the input cap with a plenum being defined between the input and distribution caps. The distribution cap includes conduit connectors that each defines an outlet in fluid communication with the plenum. The first clamp is disposed over the distribution cap and is engaged with the input cap to secure the input cap to the distribution cap and the second clamp is disposed over the input cap and engaged with the distribution cap to secure the distribution cap to the input cap. The frame assembly supports the hub assembly and is configured to secure each of the secondary vessels at a predetermined distance relative to the hub assembly.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: May 3, 2022
    Assignee: Sartorius Stedim North America Inc.
    Inventors: Michael A. Zumbrum, William Kimmick, Kevin Perdue, Jan Neuhaus
  • Publication number: 20220119161
    Abstract: A stopper configured to hermetically close a nozzle intended to contain a biopharmaceutical fluid with a cylindrical bore of diameter (D1) and a flange having a groove. The stopper has a body with a front part with a cylindrical outer wall about an axis A, with a diameter at rest greater than (D1), intended to be received under stress in the cylindrical bore of the nozzle, a stop disc extending a rear part of the body radially towards the outside and extending in a plane transverse to the axis. The body and the stop disc are rotationally symmetric about the axis A. The stop disc includes an annular bulge, interposed radially between a first annular shoulder and a second annular shoulder, the bulge extending forward from the stop disc and being intended to be received in the groove in the flange of the nozzle.
    Type: Application
    Filed: February 7, 2020
    Publication date: April 21, 2022
    Applicant: SARTORIUS STEDIM FMT SAS
    Inventor: Frédéric BAZIN
  • Patent number: 11304874
    Abstract: The protecting package for a flexible pouch specially designed to contain a biopharmaceutical fluid, includes two frames which respectively form a lower frame and an upper frame and which have a peripheral area, respectively to a main plane of the frames, each frame has an opening on a central area, the two frames are fixed to each other such that they are able to respectively surround two plates which sandwich the flexible pouch.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: April 19, 2022
    Assignee: SARTORIUS STEDIM NORTH AMERICA, INC.
    Inventors: Marc Sanchez, Jonathan Cutting
  • Patent number: 11299704
    Abstract: The present invention relates to a system comprising a mixing device for mixing the content of a bioreactor. The system is comprising at least one movement device for initiating a mixing movement in the bioreactor or in a holder for receiving a bioreactor and at least one sensor that can be arranged in or on the bioreactor for receiving at least one physiological or physical measurement variable. The mixing device or the bioreactor further comprises a sensor or transmitter for generating a synchronization measurement variable.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: April 12, 2022
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Simon Brütsch, Jochen Scholz
  • Patent number: 11285410
    Abstract: A filtration system (1) has a filtration unit (2) with at least one filter element (4) for filtration of a fluid. The at least one filter element (4) has a main flow direction (C) for the fluid. The filtration unit (2) is configured to tilt the at least one filter element (4) around a tilting axis (B) to change an orientation of the main flow direction (C). A main unit (3) is fluidly connectable to the filtration unit (2) and includes a supply unit (18) configured to supply the fluid to the at least one filter element (4). A control unit is configured to control supplying and/or evacuating the fluid to/from the at least one filter element (4) and to control tilting of the at least one filter element (4) around the tilting axis (B).
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: March 29, 2022
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Jan Schaefer, Ganeshkumar Padmanabhan, Michael Huth, Ralf Korzuschek, Rolf Matthiesen
  • Publication number: 20220090980
    Abstract: Integrity of a flexible bag is verified by a testing system, using helium to detect existence of a possible hole. The flexible bag is preliminary placed in vacuum chamber of a fluid-tightly isolated enclosure. After connecting a port of the bag to a helium feeding pipe, vacuum suction is performed to obtain vacuum outside the bag in the enclosure. Then, a first amount of helium is diffused in the internal volume of the enclosure through a gas permeable wall, to increase helium partial pressure outside the flexible bag. After, in a test phase while said vacuum suction is still performed, the bag is filled with a second amount of helium. A detector detects information representative of helium partial pressure in the internal volume, to allow detection of helium escaping from the bag, by analysis of a helium partial pressure drop.
    Type: Application
    Filed: January 28, 2020
    Publication date: March 24, 2022
    Applicant: SARTORIUS STEDIM FMT SAS
    Inventors: Laurent THENARD, Marc HOGREVE, Tomasz URBANIAK, Mandip NACHHATTAR, Delphine PHILIPPEAU, Bastien CATTAUX
  • Patent number: 11280730
    Abstract: The invention relates to a bioprocess container (10) having an optical measuring device (100) for non-invasive spectroscopic measurement comprising: a container housing (12), a port housing (102), which is connected to the container housing (12) and is sealed off with respect to the interior (18) of the container housing (12); at least one radiation-emitting element (124), which is designed to transmit electromagnetic radiation through the at least one fluid contained in the container housing (12); at least one radiation-receiving element (126), which is designed to at least partly receive the radiation which was transmitted by the radiation-emitting element (124); and at least one measuring insert (122), which holds and supports the at least one radiation-emitting element (124) and/or the at least one radiation-receiving element (126).
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: March 22, 2022
    Assignee: Sartorius Stedim Biotech GMBH
    Inventors: Marek Höhse, Christian Grimm, Thomas Regen
  • Publication number: 20220082540
    Abstract: A chromatography method, a method of determining the concentration of at least one compound in a chromatography method and a method of obtaining at least one chromatography method parameter are provided. The methods can include selecting at least one compound, at least one stationary phase, at least one mobile phase, and at least one chromatography device having a chromatography bed comprising the at least one stationary phase and the at least one mobile phase.
    Type: Application
    Filed: May 8, 2020
    Publication date: March 17, 2022
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Jan Schwellenbach, Volkmar Thom, Dominik Stein
  • Patent number: D950357
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: May 3, 2022
    Assignee: Sartorius Stedim North America, Inc.
    Inventors: Michael A. Zumbrum, William Kimmick, Kevin Perdue