Patents Assigned to Stedim
  • Patent number: 11746929
    Abstract: An organizer assembly including a belt and a ribbon. The ribbon has a first clamp member, a second clamp member, and a first carrier portion. The first clamp member is configured to receive a conduit or a support to fix the conduit or the support relative to the ribbon. The belt includes an elongated body that is slidably received in the first carrier portion. The organizer assembly may include one or more adapters that are received in a respective clamp member of the ribbon and configured to receive a conduit or a support to fix the conduit or support relative to the ribbon.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: September 5, 2023
    Assignee: Sartorius Stedim North America Inc.
    Inventors: Michael Zumbrum, William Kimmick, Kevin Perdue
  • Publication number: 20230249184
    Abstract: Fluidic modules configured for flowing fluid through membranes and associated methods are generally provided. In some embodiments, a fluidic module comprises two channels between which a membrane is positioned. The two channels may have geometries such that the pressure drop experienced by a fluid flowing from the first channel, through the membrane, and into the second channel is substantially independent of the location along the channel at which it flows through the membrane. In other words, the pressure drop may be substantially constant over the membrane area.
    Type: Application
    Filed: April 13, 2023
    Publication date: August 10, 2023
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Samin Akbari, Thomas Kruse, David Pollard, Markus Kampmann
  • Patent number: 11712659
    Abstract: A method of filtering a large volume of a medium using a pre-sterilizable, at least partially automated single-use filtration device which includes an unfiltrate inlet, a filtrate outlet, a main line running between the unfiltrate inlet and the filtrate outlet, filter elements arranged in the main line, a venting line and sensors for detecting specific process parameters and regulating means for adjusting specific process parameters, wherein the sensors and regulating means are connected to an external monitoring and control system which is adapted for evaluating and processing sensor data and for piloting the regulating means based on one or more control algorithms, comprises the following process steps: a) filling the single-use filtration device with medium with low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements; e) filtering the medium by means of the filter elements; f)
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: August 1, 2023
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Thomas Loewe, Bernhard Diel, Maik Sommer
  • Patent number: 11707413
    Abstract: A flexible pouch is placed in a stack provided with two plates forming a protecting body to sandwich and constrain the flexible pouch. At opposite margin portions, the protecting body has slots cooperating with positioning members of an outer shell device belonging to the stack. Between the shell parts, the plates can move during filling of the pouch and the margin portions shrink inwardly in a protecting body plane. Some of the positioning members act as stoppers, in order to have lower clearance range for shrink strokes of the protecting body in a middle part thereof, as compared to a higher clearance range at respective longitudinal end parts of the two opposite margin portions. A higher constraining effect can be obtained in a center of the pouch, to limit maximum thickness of its content, which is of interest for managing freeze/thaw operations of biopharmaceutical materials contained in the pouch.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: July 25, 2023
    Assignee: SARTORIUS STEDIM NORTH AMERICA INC
    Inventor: Marc Sanchez
  • Patent number: 11697790
    Abstract: A probe holder (1), for positioning at least one probe (50) such that the probe (50) at least partially engages in a system (100) for biotechnological uses, comprises a holder base (10) for positioning the probe holder (1) on the system (100) for biotechnological uses and at least one probe positioning means (20), which is designed to position the at least one probe (50) such that the probe (50) extends in a probe extension direction (S; S1, S2, S3, S4). The probe positioning means (20) is positioned on the holder base (10) such that the position of the probe (50) is variably adjustable in a probe extension direction (S; S1, S2, S3, S4).
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: July 11, 2023
    Assignee: Sartorius Stedim Blotech GmbH
    Inventors: Simon Topp-Manske, Christian Zahnow, Ute Husemann, Bernward Husemann
  • Publication number: 20230215195
    Abstract: A computer-implemented method is provided for analyzing videos of a living system captured with microscopic imaging. The method can include obtaining a base dataset including one or more videos captured with microscopic imaging with at least one of the one or more videos including a cellular event, and cropping out, from the base dataset, sub-videos including one or more objects of interest that may be involved in the cellular event. An artificial neural network (ANN) model can be trained using the plurality of selected sub-videos as training data, to perform unsupervised video alignment, a query sub-video can be aligned using the trained ANN model, and a determination can be made whether or not the query sub-video includes the cellular event.
    Type: Application
    Filed: May 19, 2021
    Publication date: July 6, 2023
    Applicant: Sartorius Stedim Data Analytics AB
    Inventors: Rickard Sjögren, Christoffer Edlund, Mattias Sehlstedt
  • Patent number: 11691866
    Abstract: A method of aseptically distributing fluid including fluidly connecting a primary vessel to a fluid distribution system via a feedline of the supply vessel to form a closed system, priming the feedline to purge trapped gases and fluid from the feedline via a purge valve, simultaneously distributing fluid from the primary vessel to a plurality of secondary vessels, sensing a complete fill of the plurality of secondary vessels with the control system, and stopping the distribution of fluid when the complete fill is sensed by the control system.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: July 4, 2023
    Assignee: Sartorius Stedim North America Inc.
    Inventors: Michael A. Zumbrum, Kevin M. Perdue, William Kimmick, Jan Neuhaus
  • Patent number: 11690784
    Abstract: The invention relates to a biopharmaceutical container comprising: a connector to be secured to a chamber connector; a bag serving as a receptacle, one part of which is secured to the connector; and a flexible tube tucked inside the bag, which tube can extend out from the bag through the connector. The biopharmaceutical container, wherein: the tube forms part of the bag, the tube is a neck of reduced size extending from the body of the bag, and the aforementioned part of the bag that is secured to the connector is a fold in the wall of the bag, said wall of the bag forming the body of the bag on one side of the fold and the tube on the other side of the fold.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: July 4, 2023
    Assignee: SARTORIUS STEDIM FMT SAS
    Inventor: Nicolas Mendyk
  • Publication number: 20230202827
    Abstract: A fluid distribution system includes an input tube, a plurality of vessels, and a distribution hub. The input tube is configured to extend from a supply vessel. Each vessel of the plurality of vessels includes an inflow conduit. The distribution hub includes a single inlet and a plurality of outlets. The single inlet is defined in a bottom of the distribution hub and is in fluid communication with the input tube such that the distribution hub is configured to receive fluid from the input tube through the single inlet. Each outlet of the plurality of outlets is in fluid communication with the single inlet and in fluid communication with a respective inflow conduit such that the distribution hub is configured to provide an equal portion of the fluid received through the single inlet to each of the inflow conduits.
    Type: Application
    Filed: February 8, 2023
    Publication date: June 29, 2023
    Applicant: Sartorius Stedim North America Inc.
    Inventors: Michael A. Zumbrum, Kevin M. Perdue, William Kimmick, Jan Neuhaus
  • Patent number: 11684913
    Abstract: A tight connection device for the aseptic transfer of a biopharmaceutical product includes: a stationary temporary clamping means keeping the container hermetically clamped against the chamber; a stationary unlocking means capable of switching the container from an initial locked position to an intermediate unlocked position; a stationary locking means; and an annular functional crown capable of being rotated to actuate the stationary unlocking means and the stationary locking means of the container. The stationary unlocking means and the stationary locking means are mechanically linked to the annular functional crown and arranged such that the rotation of the annular functional crown and the end locked position. The device further includes stationary immobilising/release means capable of allowing and preventing the annular functional crown to rotate.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: June 27, 2023
    Assignee: SARTORIUS STEDIM FMT SAS
    Inventor: Shuai Yi
  • Publication number: 20230196720
    Abstract: A computer-implemented method for data analysis comprises obtaining a plurality of first observations, each one of the plurality of first observations including one or more values of one or more first parameters, the plurality of first observations grouped into a plurality of groups; constructing a first histogram using the values of at least one of the one or more first parameters, included in the plurality of first observations; constructing, for each one of the plurality of groups, a second histogram having bins corresponding to bins of the first histogram, wherein each one of the bins of the second histogram includes a count of the first observations, among the first observations that belong to the one of the plurality of groups, having one or more values corresponding to the one of the bins for the at least one of the one or more first parameters; and outputting the second histograms.
    Type: Application
    Filed: June 9, 2021
    Publication date: June 22, 2023
    Applicant: SARTORIUS STEDIM DATA ANALYTICS AB
    Inventor: Olivier Cloarec
  • Publication number: 20230183635
    Abstract: Devices and methods are provided for determining viability and/or a cell counts of biological cells in a cell suspension culture using collimated transmission. Devices can include an illumination source for generating an electromagnetic illumination beam; beam manipulation means for collimating the illumination beam; and a detection unit for detecting an electromagnetic transmission beam being a portion of the collimated illumination beam which has been transmitted through a sample of the cell suspension culture.
    Type: Application
    Filed: May 3, 2021
    Publication date: June 15, 2023
    Applicants: Sartorius Stedim Biotech GmbH, Institut für Lasertechnologien in der Medizin und Messtechnik (Stiftung Bürgerliches Recht)
    Inventors: Steffen Nothelfer, Alwin Kienle, Florian Foschum, Marek Hoehse
  • Patent number: 11666840
    Abstract: A filtering system (10) includes a filtering apparatus having a filter unit for receiving liquid to be filtered, a receptacle for receiving filtered liquid, and an adapter (14) for coupling the filter unit to the receptacle, and also includes a base (12) having a cradle (26) for receiving the filtering apparatus and a base vacuum delivery port (28). The adapter includes an adapter vacuum receiving port (22) coupled to the vacuum delivery port for driving the liquid through the filter and—as filtered liquid—into the receptacle. The cradle and the adapter have an interlocking mechanism (52, 54) that locks the filtering apparatus to the cradle in a locking position in which the vacuum receiving port is sealingly coupled to the base vacuum delivery port. The base vacuum delivery port has a vacuum valve (30) constituted as a normally-closed valve automatically forced open when the filtering apparatus locks to the cradle.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: June 6, 2023
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Karl Pflanz, Sebastian Pruehl, Andreas Pickl, Roland Leetsch, Adam Gilbert, Martin Purshouse
  • Patent number: 11668418
    Abstract: A connection device has a line portion having, at its end, a radially outwardly projecting abutment flange for abutting against a corresponding abutment flange of a further line portion which is to be coupled to the line portion, and a ring-segment chain comprising a plurality of ring segments connected to one another in a pivotable manner in a common ring plane, wherein the ring-segment ends which form the chain ends can be latched to one another to give a ring-form connection clamp. The line portion is designed in the form of a tubular connection stub with first thread means spaced apart axially from the abutment surface of its abutment flange and in that each ring segment has a radially inwardly projecting clamping flange and second thread means, which are spaced apart axially from said clamping flange and correspond to the first thread means.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: June 6, 2023
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Norbert Aue, Sebastian Handt, Sebastian Purmann, Volker Limpert
  • Patent number: 11654084
    Abstract: A pouch for transporting and/or processing a biopharmaceutical fluid, the pouch comprising a flexible wall, the flexible wall comprising a shape memory material being adapted to change shape when induced by an external stimulus, so that the pouch can be alternately in a collapsed state and in an unfolded state, the wall of the pouch in the unfolded state delimiting a closed internal cavity adapted to contain the biopharmaceutical fluid.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: May 23, 2023
    Assignee: SARTORIUS STEDIM FMT SAS
    Inventors: Stefan Schlack, Jean-Marc Cappia
  • Patent number: 11655058
    Abstract: A sterile filling unit, of a basic container with contents that can be distributed in a fluid form and that is originally located in a source container in a sterile manner, includes a sterile chamber with at least one sterile entry port and/or outlet; a sterile fluid transfer and filling line with an intake and an outlet, such that for a filling stage the line passes through the wall of the sterile chamber in a sterile manner, with the intake located outside of the sterile chamber in sterile fluid communication with the source container, with the filling element at the outlet located inside the sterile chamber and positioned to be operating; and a unit that can introduce the disposable internal elements that, in a stage prior to the filling stage, were located outside of the sterile chamber, into the interior of the sterile chamber in a sterile manner.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: May 23, 2023
    Assignee: SARTORIUS STEDIM FMT SAS
    Inventors: Isabelle Gay, Nicolas Mendyk
  • Publication number: 20230149934
    Abstract: Methods for forming arrays of droplets, and associated arrays of droplets, are generally provided.
    Type: Application
    Filed: January 17, 2023
    Publication date: May 18, 2023
    Applicant: Sartorius Stedim Cellca GmbH
    Inventors: Samin Akbari, Christoph Zehe, David Pollard
  • Publication number: 20230137412
    Abstract: The present invention relates to a filtration unit with a filtration membrane, nutritive cardboard disc and, if necessary, a support structure, wherein the nutritive cardboard disc and/or the support structure comprises a solid, water-soluble nutrient medium and a water-soluble and/or water-swellable polymer, a method for producing the filtration unit, a method for detecting microorganisms in a fluid, wherein the filtration unit is used, and the use of the filtration unit for detecting microorganisms in a fluid.
    Type: Application
    Filed: April 28, 2021
    Publication date: May 4, 2023
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Karl Pflanz, Stephan Scholz, Jörg Hosch
  • Publication number: 20230125762
    Abstract: System for detecting at least one presence of foam of a medium in a bioreactor plant, wherein the system comprises: —a bioreactor plant having at least one disposable container for receiving the medium that may comprise the foam; and—at least two capacitive sensor units which are attached at at least two different situating positions of the bioreactor plant, wherein the capacitive sensor units each comprise at least one electrode system for capacitive measurement and are able to detect the presence of foam at the at least two situating positions on the basis of the capacitive measurement; and wherein the capacitive sensor units are designed to transmit captured data relating to the presence of foam to at least one monitoring unit for monitoring, open-loop and/or closed-loop control of foam formation in the bioreactor plant on the basis of said data.
    Type: Application
    Filed: October 16, 2020
    Publication date: April 27, 2023
    Applicant: Sartorius Stedim Biotech GMBH
    Inventors: Andreas Prediger, Sina Götemann, Marco Leupold, Jochen Scholz
  • Patent number: 11633328
    Abstract: A bag for containing a biopharmaceutical product includes at least one fluid input/output port and a measurement opening remote from the fluid port. A probe holder port has a body with an axial through-bore and a peripheral collar with a second fastening zone and defining a fastening plane. A contact probe, extending in the axial through-bore, is assembled on the probe holder port, has an active measurement end portion in contact with the product, and has an end portion opposite the end portion. The probe holder port includes a transition portion between the body and the collar, which extends between a radially central end portion of the collar and a first axial end portion of the body. The first axial end portion is the axial end portion closest to the radially central end portion of the collar. The first axial end portion is disposed on the outer side relative to the fastening plane, and the active measurement end portion is axially disposed on the outer side relative to the fastening plane.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: April 25, 2023
    Assignee: SARTORIUS STEDIM FMT SAS
    Inventors: Alain Pallares, Shuai Yi, Mathilde Salaun, Andreas Prediger, Julia Lueders, Thomas Regen