Abstract: Compounds, compositions and methods for inhibiting gene expression are disclosed. The compounds comprise oligonucleotide sequences of from about 9 to about 200 bases having a diol at either or both termini. Preferred diols are polyalkyleneglycols, preferably polyethyleneglycols. Pharmaceutical compositions comprising the compounds and a physiologically acceptable carrier and methods of inhibiting gene expression in mammals comprising administering such compounds are also provided. Methods for inhibiting nuclease cleavage of compounds are also provided.

Abstract: A carpet cleaning composition is disclosed. The composition contains, on a weight-to-weight basis,a. about 0.30 to 2.2 percent of hydrogen peroxide;b. from about 0.05 to about 5.0 percent of a nonionic, anionic or amphoteric surfactant or mixture thereof; andc. a pH in the range above 3.5 and below 6.4.

Abstract: A method of inhibiting mammalian topoisomerase II and inhibiting the growth and inducing the regression of malignant cells in mammals by the action of a (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine or -benzothiazine of the formula ##STR1## wherein R.sub.1 is hydrogen or fluoro, R.sub.2 and R.sub.3 each independently is hydrogen or alkyl having 1 to 4 carbon atoms, and X is O, S or S=O; a pharmaceutically acceptable acid-addition salt thereof; or a salt thereof with a pharmaceutically acceptable cation; and certain novel compounds of formula I.

Abstract: Extrudable elastic oral pharmaceutical gel compositions, especially containing aetaminophen as the therapeutically active agent, and manually operable metered dose dispensers containing them and method of making and method of use thereof are disclosed.

Abstract: In accordance with the present invention, certain multiply substituted anilines, phenols and pyridines and pharmaceutically acceptable salts thereof are provided which mimic IL-1 activity by inducing IL-2 synthesis and subsequent IL-2 receptor expression.

Abstract: Compounds, compositions and methods for inhibiting gene expression are disclosed. The compounds comprise oligonucleotide sequences of from about 9 to about 200 bases having a diol at either or both termini. Preferred diols are polyalkyleneglycols, preferably polyethyleneglycols. Pharmaceutical compositions comprising the compounds and a physiologically acceptable carrier and methods of inhibiting gene expression in mammals comprising administering such compounds are also provided. Methods for inhibiting nuclease cleavage of compounds are also provided.

Abstract: Low solubility drug coated bead compositions, capsules filled therewith and method of preparation thereof, especially wherein the low solubility drug is an antiandrogenic steroid and most especially wherein the antiandrogenic steroid is (5.alpha.,17.alpha.)1'-(methylsulfonyl)-1'H-pregn-20-yno[3,2-c]pyrazol-17- ol, are disclosed.

Abstract: Sugar or sugar/starch beads coated with a first coating of a drug, for example 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(4-pyridinyl)-nicotinonitrile (milrinone), hydroxypropyl methylcellulose or hydroxypropyl cellulose and a plasticizer selected from triacetin, diacetylated monoglycerides, glycerin, propylene glycol, polyethylene glycol, diethyl phthalate and triethyl citrate or a mixture of two or more thereof and a second coating of high-viscosity ethylcellulose, low-viscosity ethylcellulose, hydroxypropyl cellulose, polyvinyl acetate phthalate and a plasticizer selected from diacetylated monoglycerides and triacetin or a mixture thereof and optionally coated with additional first coating and capsules filled therewith and method of preparation thereof are disclosed.

Abstract: Selenomerocyanines, for example the compound having the structural formula ##STR1## a process for preparation thereof, methods of use thereof as photosensitizers for generation of singlet oxygen, virus inactivation and cancer cell inactivation, and photosensitized silver halide photographic emulsions containing them are disclosed.

Abstract: Novel 2,5-benzodiazocines of formulas II and IV, pharmaceutical compositions containing them, processes for preparing them and methods of treating cardiac arrhythmias in mammals utilizing them.

Abstract: Compounds of the formulas ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms;R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms;R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; andR.sub.8 is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when R.sub.8 is hydrogen R' is hydroxy-lower-alkyl,are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.

Abstract: Compounds of the formula ##STR1## wherein: Y is alkylene of 3 to 9 carbon atoms;R.sub.1 is lower-alkyl, lower-alkoxy-(C.sub.1-3 -alkyl), lower-alkoxycarbonyl, cyclopropyl or trifluoromethyl;R.sub.2 and R.sub.3 independently are hydrogen, lower-alkyl, halogen, lower-alkoxy, nitro, trifluoromethyl or hydroxy; andR.sub.4 is hydrogen or lower-alkyl; where lower-alkyl and lower-alkoxy, each occurrence, have from 1-5 carbon atoms;with the proviso that when R.sub.1 is lower-alkyl, at least one of R.sub.2 and R.sub.3 is hydroxy; or pharmaceutically acceptable acid-addition salts thereof are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.

Abstract: A trap for catching mice and rats includes a standard mousetrap mounted within a two-part housing. The standard mousetrap includes a tab which projects through a slot an arcuate upper wall of one portion of the housing, allowing one to cock the trap from the exterior of the housing. The first portion of the housing is pivoted to the second portion of the housing so that the housing can be conveniently opened to dispose of a mouse or rat caught in the trap. The housing shields the cocked trap so as to enhance the safety thereof while allowing one to empty the trap without running the risk of touching the mouse or rat caught therein.

Abstract: Fluorinated 1- cyclopropyl-7-(substituted-pyridinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxy lic acids of the formula ##STR1## wherein R is hydrogen, R' and R" are hydrogen or fluoro, and Z is 3- or 4-pyridinyl substituted by alkyl groups or substituted alkyl groups, are superior antibacterial agents. They are prepared via a coupling reaction between the corresponding esters (R=alkyl) having a halo group in the 7-position and a substituted (trialkylstannyl)-pyridine.

Abstract: A single pump assembly is used to dispense liquid from a selected one of a plurality of compartments in a container vessel. The pump assembly is detachably mounted on the container vessel and rotates with respect to the container vessel to select the liquid to be pumped.

Abstract: An antimicrobial composition for preserving products or systems containing an aqueous phase comprising from 10 to 60% by weight or tert.-butyl hydroperoxide, from 3 to 50% by weight of a monophenylglycol ether of formulas I or II herein, and the remainder a diluent which is water, an organic solvent or a mixture of water and organic solvent; and a method of use of the antimicrobial composition. The antimicrobial composition may additionally include up to about 20% by weight of a biocide selected from certain non-halogenated phenols, certain heterocyclic compounds and guanidine, phthalimide and urea derivatives.

Abstract: Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions containing the particles. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.

Abstract: An aqueous composition for impregnating a nonwoven wipe having a pH of from 3.5 to 4.5 and containing a preservative system comprising potassium sorbate, citric acid, disodium EDTA and a cationic biocide selected from polyhexamethylene biguanide hydrochloride and poly[oxyethylene(dimethyliminio)ethylene(dimethyliminio)ethylene dichloride]; and a moistened wipe, impregnated with the aqueous composition, useful for cleaning or delivering active ingredients to animate and inanimate surfaces.

Abstract: 2'-Alkylsulfonylsteroido[2,3-d]oxazoles, for example 2'-methylsulfonyl-5.alpha.-pregn-2-en-20-yno[2,3-d]oxazol-17.beta.-ol, which are useful as antiandrogenic agents, and proceses for preparation, method of use and compositions thereof are disclosed.

Abstract: Rodenticidal compositions comprising an anticoagulant type rodenticide in combination with a fluorosurfactant of the amphoteric, anionic or cationic type, optionally admixed with a cereal grain bait, and a method of killing rodents by oral administration of such compositions.