Abstract: An aqueous cleaning, coating and polishing composition consisting essentially of 1 to 20% by weight of a water insoluble alkali soluble addition polymer comprising at least one hydrophilic monomer selected from acrylic acid and methacrylic acid and at least one hydrophobic monomer selected from alkyl acrylate and alkyl methacrylate, where alkyl has from 1 to 6 carbon atoms, and at least one hydrophobic monomer selected from styrene and monoalkylstyrene where monoalkyl has from 1 to 6 carbon atoms, 1 to 13% by weight of an alkyli soluble 2:1 to 3:1 styrene:acrylic acid resin, 5 to 15% by weight of a fugitive plasticizer, 1 to 3% by weight of a permanent plasticizer, 0.01 to 0.05% by weight of an anionic or nonionic fluorocarbon surfactant leveling agent, 0.0003 to 0.003% by weight of a dimethylpolysiloxane antifoaming agent; 0.0003 to 0.003% by weight of a 1,2-benzoisothiazol-3(2H)-one or 3(2H)-isothiazolone preservative, ammonia to provide a pH of 8.0 to 9.6 and water q.s.
Abstract: The method of regulating fertility in swine which comprises administering to a pregnant sow near term an amount of epostane sufficient to induce parturition of live piglets on the following day is disclosed.
Abstract: An improvement in the preparation and purification of lower-alkyl 7-choro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate which involves preferential separation of its pottasium salt from a dimethylformamide solution of the potassium salt of a mixture of said compound and its 5-chloro isomer.
Abstract: Compounds of the formula ##STR1## wherein the substituents are as defined herein are useful as antiviral agents, in particular against picornaviruses.
Abstract: Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms;Z is N or HC;R is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when Z is N, R is lower-alkyl;R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; andHet is selected from specified heterocyclic groups,are useful and antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.
Abstract: A container convertible to a child's pail includes a generally hollow container body having an annular handle-accommodating groove extending therearound, a closure detachably secured to the container body and a handle. When the container is in use as a storage receptacle, the handle is supportable on the container body at a stored position within the handle-accommodating groove. The container can be converted to a child's pail by removing the closure, removing the handle from the handle-accommodating groove and securing the handle to attachment members of the container body so that the handle extends in a pail-facilitating position.
Abstract: A method for enhancing the body of hair comprising applying to the hair a composition comprising as essential ingredients in certain critical amounts an alkali metal or ammonium bisulfite, an alkanolamine, a guar hydroxypropyltrimonium chloride, a certain quaternary ammonium conditioner, an alkali metal or ammonium carbonate or an alkali metal phosphate when the bisulfite is alkali metal bisulfite and water; working the composition into the hair, lifting the hair with, e.g., the finger tips, a hair pick or the tail of a comb, allowing the composition to remain in contact with the hair for about 20 to 30 minutes, rinsing the hair and drying the hair.
Type:
Grant
Filed:
August 28, 1987
Date of Patent:
July 11, 1989
Assignee:
Sterling Drug Inc.
Inventors:
Vikas M. Deshpande, John M. Walts, Susan A. Decker
Abstract: Compounds of the formulas: ##STR1## wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.
Abstract: 4-Arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles, useful as analgesic agents, are prepared by reaction of a 3-arylcarbonyl-2-methylnitrobenzene with DMF dimethyl acetal; reductive cyclization of the product with hydrogen over a catalyst; and N-alkylation of the resulting 4-arylcarbonylindole with an appropriate 4-(halo-lower-alkyl)morpholine in the presence of a strong base.
Abstract: N-[1-alkyl or arylmethyl)-4(1H)-pyridinylidine]-alkanamine and pharmaceutically acceptable acid addition salts thereof, for example, N-(1-octyl-4(1H)-pyridinylidine)-octanamine monohydrochloride salt, which are useful as antimicrobial agents, especially on living tissues and nonliving surfaces and most especially against pathogenic dental microbes, and a process for perparation, methods of use and compositions thereof are disclosed.
Abstract: Di(D-tryptophyl and/or tetrahydropyridoindolylcarbonyl)-containing peptide amides useful as Substance P agonists and/or antagonists and as antihypertensives and/or analgesics and a process for preparing them are disclosed.
Abstract: Fluorinated 10-(2,6-dimethyl-4-pyridinyl)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-d e][1,4]benzoxazine-6-carboxylic acids and -benzothiazine-6-carboxylic acids of the formula ##STR1## wherein R is hydrogen, R' is hydrogen or fluoro, R" is alkyl of 1-3 carbon atoms and X is O or S are superior antibacterial agents.
Abstract: N-(.omega.-cyanoalkyl)aminophenols of formula ##STR1## useful as lipoxygenase inhibitors and anti-asthmatic agents, are prepared by acylation of an aminophenol with an .omega.-haloalkanoyl chloride followed by reduction of the resulting amide then displacement of the halide by cyanide.
Abstract: The method of regulating fertility in cattle which comprises administering to a normally cycling cow in the early luteal phase of the cycle an amount of epostane sufficient to induce estrus is disclosed.
Abstract: A method for inhibiting the growth of malignant cells in a mammal, said cells being susceptible to the action of a compound of the formulaH.sub.2 NSO.sub.2 O(CH.sub.2).sub.n OSO.sub.2 NH.sub.2where n is 6-8, which comprises administering to said mammal an antineoplastically effective amount of said compound incorporated in a suitable pharmaceutically acceptable excipient.The compounds are particularly effective against malignant cells derived from or associated with leukemia, mammary tumors, melanoma or colon adenocarcinoma.
Abstract: Bio- and blood compatible materials are prepared by treating the surface of a substrate to provide reactive primary or secondary amine groups sites which are activated by treatment with a dialdehyde or arylchloride for coupling to a biological in an amount sufficient to provide compatibility. The use of specific substrates, such as a compliant, and elastic material, such as a fabric-elastomer membrane matrix, results in a product having advantageous qualities as a thermal burn dressing, breast prostheses and implants. Detailed procedures and various products are described.
Abstract: The invention comprises a syringe for extrusion of a semi-plastic mass, or a mass having a paste-like consistency. In a preferred embodiment, the syringe is so-designed to permit mixing of two components of a plasticizable mixture within the syringe barrel. The bore of the syringe barrel is flared to facilitate extrusion of the plastic mass therefrom. The parts of the syringe ready for use are packaged in a one-piece tray which serves not only for shipping and storing of the syringe, which may be preloaded with one of the components of the plasticizable mixture, together with the associated syringe parts, but which also serves, when opened for use, as a convenient tray for handling the syringe while mixing the two components of the plasticizable mixture prior to extrusion.
Abstract: Bio- and blood compatible materials are prepared by treating the surface of a substrate to provide reactive primary or secondary amine groups sites which are activated by treatment with a dialdehyde or arylchloride for coupling to a biological in an amount sufficient to provide compatibility. The use of specific substrates, such as a compliant, and elastic material, such as a fabric-elastomer membrane matrix, results in a product having advantageous qualities as a thermal burn dressing, breast prostheses and implants. Detailed procedures and various products are described.
Abstract: Stable, isotropic, liquid laundry detergents with good detergency, effective microbicidal and low irritancy properties comprising anionic, nonionic and cationic surfactants and an alkali metal benzoate in an aqueous vehicle.
Abstract: Sustained-release compositions for oral administration comprising medicament-coated nonpareils surrounded by a sustaining coating of at least three admixed polymers afford exceptionally good plasma levels of the medicament.
Type:
Grant
Filed:
May 24, 1985
Date of Patent:
February 21, 1989
Assignee:
Sterling Drug Inc.
Inventors:
Paul J. Harrison, John R. Langridge, Christopher J. Potter