Patents Assigned to Sterling Drug Inc.
  • Anticoagulant/surfactant rodenticidal compositions and method
    Patent number: 4950482
    Abstract: Rodenticidal compositions comprising an anticoagulant type rodenticide in combination with a fluorosurfactant of the amphoteric, anionic or cationic type, optionally admixed with a cereal grain bait, and a method of killing rodents by oral administration of such compositions.
    Type: Grant
    Filed: July 11, 1988
    Date of Patent: August 21, 1990
    Assignee: Sterling Drug Inc.
    Inventor: Garland G. Corey
  • 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
    Patent number: 4945164
    Abstract: Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms;R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms;R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; andHet is selected from 1,3,4-oxadiazol-2-yl and 5-alkylated derivatives thereof,are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.
    Type: Grant
    Filed: August 18, 1989
    Date of Patent: July 31, 1990
    Assignee: Sterling Drug Inc.
    Inventor: Guy D. Diana
  • 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
    Patent number: 4942241
    Abstract: Compounds of the formulas ##STR1## wherein: Y is an alkylene bridge of 1-9 carbon atoms;R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms;R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; andR.sub.8 is hydrogen or lower-alkyl of 1-5 carbon atoms,are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.
    Type: Grant
    Filed: August 21, 1989
    Date of Patent: July 17, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Guy D. Diana, Thomas R. Bailey
  • 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazin es
    Patent number: 4939138
    Abstract: 2- and 3-Aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazines , useful as analgesic agents, are prepared either by reaction of a 2- or 3-aminomethyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine with an arylcarboxylic acid halide in the presence of a Lewis acid or by reaction of a 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine with a 1-lower-alkyl-3-aryl-1,3-diketone or with a .beta.-aryl-.beta.-ketopropionaldehyde under dehydrating conditions and heating the resulting hydrazone in an acid medium.
    Type: Grant
    Filed: December 7, 1989
    Date of Patent: July 3, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Thomas E. D'Ambra, Malcolm R. Bell
  • Haloalkoxy phenyl 4,5 dihydro oxazoles
    Patent number: 4939267
    Abstract: Compounds of the formulas: ##STR1## wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: July 3, 1990
    Assignee: Sterling Drug Inc.
    Inventor: Guy D. Diana
  • Ratchet connector for hypodermic syringe pistons
    Patent number: 4931043
    Abstract: A connector for attachment of a plunger to a rubber piston in hypodermic syringe cartridge ampoules comprises a pin having a shank portion with a contiguous screw-threaded post portion and a ratchet head portion sized to rotatably fit within a cavity in said piston which thus prevents overtightening the plunger to the piston thereby obviating jamming of the piston in the bore of the cartridge.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: June 5, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Jefferson L. Ray, Michael E. Cooper
  • Pyridinyl-1H-pyrazole-1-alkanamides as antiarrhythmic agents
    Patent number: 4925857
    Abstract: N-[(alkylamino)alkyl]-4,5-diaryl-1H-pyrazole-1-acetamides, wherein at least one of the aryl substituents is a pyridine, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine.
    Type: Grant
    Filed: March 22, 1989
    Date of Patent: May 15, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Denis M. Bailey, Thomas E. D'Ambra, Alan M. Ezrin
  • Pyrazolo[3,4-b]quinolines and their use as antiviral agents
    Patent number: 4920128
    Abstract: Pyrazolo[3,4-b]quinolines having the formula ##STR1## where R is hydrogen, hydroxy or alkoxy; R.sub.2 is halogen, cyano, carbamyl, carboxy, lower-alkylcarbonyl, amino or aminomethyl; and R.sub.1 is hydrogen or selected substituents as defined herein, are useful as antiviral agents and/or as vasodilators.
    Type: Grant
    Filed: May 20, 1988
    Date of Patent: April 24, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Malcolm R. Bell, James H. Ackerman
  • Stable aqueous aromatic percarboxylic acid solution
    Patent number: 4917815
    Abstract: Aqueous solutions of aromatic percarboxylic acids, such as perbenzoic acids, stabilized with at least an equal amount in parts by weight as the amount of aromatic percarboxylic acid of the corresponding aromatic carboxylic acid and an aqueous solution of perglutaric acid stabilized with hydrogen peroxide and/or a 10% to 60% aqueous solution of hydrogen peroxide.
    Type: Grant
    Filed: June 10, 1988
    Date of Patent: April 17, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Wolfgang Beilfuss, Karl-Heinz Diehl
  • 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use
    Patent number: 4916150
    Abstract: N-[alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.
    Type: Grant
    Filed: March 22, 1989
    Date of Patent: April 10, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Denis M. Bailey, Ronald G. Powles
  • N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmic agents, compositions and use
    Patent number: 4898880
    Abstract: N-[(heterocycle)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl) amine or by reacting a pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl)amine.
    Type: Grant
    Filed: March 22, 1989
    Date of Patent: February 6, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Denis M. Bailey, George Y. Lesher, Thomas E. D'Ambra
  • 3,4, or 5-aryl-1H-pyrazole-1-alkanamides as antiarrhythmic agents, compositions and use
    Patent number: 4888352
    Abstract: N-[(disubstituted amino)alkyl]-3,4 or 5-aryl-1H-pyrazole-1-acetamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine.
    Type: Grant
    Filed: March 22, 1989
    Date of Patent: December 19, 1989
    Assignee: Sterling Drug Inc.
    Inventors: Denis M. Bailey, Virendra Kumar
  • Method of use of 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles
    Patent number: 4885295
    Abstract: 3-Arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, useful as analgesic, anti-rheumatic and anti-inflammatory agents, are prepared by reacting a 3-arylcarbonyl- or 3-cycloalkylcarbonylindole with an aminoalkyl halide in the presence of an acid-acceptor; by reacting a 1-aminoalkyl-1H-indole with an arylcarboxylic acid halide or a cycloalkanecarboxylic acid halide in the presence of a Lewis acid; or by reacting a 3-arylcarbonyl- or 3-cycloalkanecarbonyl-1-tosyloxyalkyl- or haloalkyl-1H-indole with an amine.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: December 5, 1989
    Assignee: Sterling Drug Inc.
    Inventor: Malcolm R. Bell
  • Valved dispensing applicator
    Patent number: 4878774
    Abstract: A dispenser including a container body, a mounting member fitted on the container body and a dispensing head such as an applicator head movably mounted on the mounting member. The mounting member includes an axially extending closure member with a pin member thereon. The dispensing head includes an aperture and an axially extending wall forming a skirted chamber beneath the aperture, the skirted chamber including slits at least one opening through the wall for controlling flow of material from outside the wall, through the opening and into the skirted chamber from the container body. The dispensing head is movable from an open position to a closed position wherein the closure member fits within the skirted chamber and the pin member fits within the aperture.
    Type: Grant
    Filed: August 12, 1987
    Date of Patent: November 7, 1989
    Assignee: Sterling Drug Inc.
    Inventors: Craig E. Karasin, Joseph Thompson
  • 4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles
    Patent number: 4874761
    Abstract: 4-Arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles, useful as analgesic agents, are prepared by reaction of a 3-arylcarbonyl-2-methylnitrobenzene with DMF dimethyl acetal; reductive cyclization of the product with hydrogen over a catalyst; and N-alkylation of the resulting 4-arylcarbonylindole with an appropriate 4-(halo-lower-alkyl)morpholine in the presence of a strong base.
    Type: Grant
    Filed: April 12, 1989
    Date of Patent: October 17, 1989
    Assignee: Sterling Drug Inc.
    Inventors: Thomas E. D'Ambra, Malcolm R. Bell
  • Carpet freshening and deodorizing composition
    Patent number: 4873000
    Abstract: A powdered composition for freshening and deodorizing carpets comprising an inorganic sulfate, bicarbonate or chloride, an aluminum silicate clay, a liquid agglomerating agent, and a fragrance, and a method of use thereof comprising applying the composition uniformly to the carpet and thereafter removing it from the rug.
    Type: Grant
    Filed: June 3, 1988
    Date of Patent: October 10, 1989
    Assignee: Sterling Drug Inc.
    Inventor: Jeanne M. Weller
  • 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use
    Patent number: 4870095
    Abstract: N-[(disubstituted amino)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate diamine or by reacting a lower-alkyl ester of a pyrazole-1-acetic or propanoic acid with an .omega.-aminoalkanol, followed by activation of the alcohol and displacement by an appropriate amine.
    Type: Grant
    Filed: March 22, 1989
    Date of Patent: September 26, 1989
    Assignee: Sterling Drug, Inc.
    Inventor: Denis M. Bailey
  • Bottle
    Patent number: D307113
    Type: Grant
    Filed: May 7, 1987
    Date of Patent: April 10, 1990
    Assignee: Sterling Drug Inc.
    Inventor: Joseph Thompson
  • Bottle
    Patent number: D307241
    Type: Grant
    Filed: April 25, 1988
    Date of Patent: April 17, 1990
    Assignee: Sterling Drug Inc.
    Inventor: Joseph Thompson
  • Bottle
    Patent number: D308481
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: June 12, 1990
    Assignee: Sterling Drug Inc.
    Inventor: Joseph Thompson