Abstract: Provided is a method for treating ocular hypertension and glaucoma, which comprises administrating an effective amount of 15-keto-prostaglandin compound having a ring structure at the end of the &ohgr; chain to the eyes of a mammalian subject in need of such treatment once a day. According to the method, single administration of the compound effectively lower the IOP of the subject throughout the day.

Abstract: The present invention provides a composition for topical administration comprising an interleukin 2 inhibitor and an antimicrobial agent as active ingredients thereof, wherein said interleukin 2 inhibitor contains a tricyclo compound as shown by the general formula (I) or pharmaceutically acceptable salt thereof. The present invention further provides a method for treating inflammations and/or infections comprising topical administration of an effective amount of an interleukin 2 inhibitor and an antimicrobial agent to a subject in need of the treatment of inflammations and/or infections.

Abstract: An agent for topical ophthalmic treatment of ocular inflammatory disease of a human contains a tricyclo compound or a pharmaceutically acceptable salt thereof as an active ingredient in a concentration of 0.01%-0.1%. The agent shows superior ocular anti-inflammatory effects by topical administration in a low dose to the eye of a human having an ocular inflammatory disease. The agent is effective for symptoms caused by ocular inflammatory diseases. The agent is also effective for subjects in whom conventional anti-inflammatory agents show no improving effect and is effective for subjects for whom other anti-inflammatory agents cannot be used. The agent is effective by topical administration to the eye one to four times daily.

Abstract: An ocular infusion solution containing a prostaglandin-like compound or prostaglandin-analog is used during ocular surgery for maintaining desired intraocular pressure of the patient.