Patents Assigned to Sucampo AG
  • Anti-constipation composition
    Patent number: 8114890
    Abstract: An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in ratio of bi-cyclic/mono-cyclic structure of at least 1:1. The halogenated-bi-cyclic compound is represented by Formula (I): where X1 and X2 are preferably both fluorine atoms. The composition can be used to treat constipation with out substantive side-effects, such as stomachache.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: February 14, 2012
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • ANTI-CONSTIPATION COMPOSITION
    Publication number: 20120022152
    Abstract: An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in ratio of bi-cyclic/mono-cyclic structure of at least 1:1. The halogenated-bi-cyclic compound is represented by Formula (I): where X1 and X2 are preferably both fluorine atoms. The composition can be used to treat constipation with out substantive side-effects, such as stomachache.
    Type: Application
    Filed: October 17, 2011
    Publication date: January 26, 2012
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • Dosage unit comprising a prostaglandin analog for treating constipation
    Patent number: 8097653
    Abstract: A dosage unit for treating constipation in a human patient is described. The dosage unit of the invention comprises a halogenated prostaglandin analog and a pharmaceutically suitable excipient. The dosage unit relieves constipation without substantial side effects.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: January 17, 2012
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, Myra L. Patchen
  • Composition and method for stabilizing the same
    Patent number: 8097649
    Abstract: Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved significantly by dissolving the same in a glyceride.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: January 17, 2012
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, Tsuyoshi Habe
  • Composition and method for stabilizing the same
    Patent number: 8088934
    Abstract: Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved significantly by dissolving the same in a glyceride.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: January 3, 2012
    Assignee: SUCAMPO AG
    Inventors: Ryuji Ueno, Tsuyoshi Habe
  • SOFT-GELATIN CAPSULE FORMULATION
    Publication number: 20110300211
    Abstract: The present invention provides a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which includes: a soft gelatin capsule shell including gelatin and sugar alcohol as a plasticizer, and a mixture including a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
    Type: Application
    Filed: August 16, 2011
    Publication date: December 8, 2011
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Yukiko HASHITERA, Ryu HIRATA, Yasuhiro HARADA, Ryuji UENO
  • Anti-constipation composition
    Patent number: 8071613
    Abstract: An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in a ratio of bi-cyclic/mono-cyclic structure of at least 1:1. The halogenated-bi-cyclic compound is represented by Formula (I): where X1 and X2 are preferably both fluorine atoms. The composition can be used to treat constipation without substantive side-effects, such as stomachache.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: December 6, 2011
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • PHARMACEUTICAL COMPOSITION COMPRISING A BI-CYCLIC COMPOUND AND METHOD FOR STABILIZING THE BI-CYCLIC COMPOUND
    Publication number: 20110244036
    Abstract: Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.
    Type: Application
    Filed: June 15, 2011
    Publication date: October 6, 2011
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Ryu HIRATA, Yasuhiro HARADA, Ryuji UENO
  • PHARMACEUTICAL COMPOSITION COMPRISING A BI-CYCLIC COMPOUND AND METHOD FOR STABILIZING THE BI-CYCLIC COMPOUND
    Publication number: 20110244037
    Abstract: Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.
    Type: Application
    Filed: June 15, 2011
    Publication date: October 6, 2011
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Ryu HIRATA, Yasuhiro HARADA, Ryuji UENO
  • Soft-gelatin capsule formulation
    Patent number: 8026393
    Abstract: The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: September 27, 2011
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Yukiko Hashitera, Ryu Hirata, Yasuhiro Harada, Ryuji Ueno
  • Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
    Patent number: 7985770
    Abstract: Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (i): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: July 26, 2011
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Ryu Hirata, Yasuhiro Harada, Ryuji Ueno
  • PHARMACEUTICAL COMBINATION AND METHOD FOR TREATING TUMOR
    Publication number: 20110064748
    Abstract: Disclosed is a method for treating tumor in a mammalian subject, which comprises administering a combination of (a) an anti-tumor agent and (b) a fatty acid derivative represented by the formula (I): to the subject in need thereof. The application also discloses a method for treating damages, especially gastrointestinal damages including mucositis such as stomatitis induced by an anti-tumor agent, wherein the method comprises administering a fatty acid derivative of formula (I) to the subject who is receiving the anti-tumor agent.
    Type: Application
    Filed: September 15, 2010
    Publication date: March 17, 2011
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • METHOD FOR PROMOTING GASTROINTESTINAL BICARBONATE SECRETION
    Publication number: 20110065784
    Abstract: Provided is a method for promoting gastrointestinal bicarbonate secretion in a mammalian subject, which comprises administering an effective amount of a compound of Formula (I): to a subject in need thereof. The compound is also useful for protecting the gastrointestinal tract of a mammal from mucosal damage.
    Type: Application
    Filed: November 23, 2010
    Publication date: March 17, 2011
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • METHOD FOR THE LONG TERM NSAID USE
    Publication number: 20110034424
    Abstract: Provided is a method for the long term treatment of a condition or disease which is one of the indications for NSAID use in a human patient, which comprises administering to the patient a pharmaceutically effective amount of a NSAID and at least 36 mcg per day of cobiprostone or its pharmaceutically acceptable salt, ester, ether or amide. By administering cobiprostone or its pharmaceutically acceptable salt, ester, ether or amide in combination with a NSAID, the patient can receive the NSAID for longer time period.
    Type: Application
    Filed: June 29, 2010
    Publication date: February 10, 2011
    Applicant: SUCAMPO AG
    Inventor: Ryuji Ueno
  • Method for promoting gastrointestinal bicarbonate secretion
    Patent number: 7868045
    Abstract: Provided is a method for promoting bicarbonate secretion in the stomach or duodenum in a mammalian subject, which comprises administering an effective amount of a compound of Formula (I): to a subject in need thereof, wherein A, Y, W1, W2, X1, X2 R1 and R2 are herein defined. The compound are also useful for protecting the gastrointestinal tract of a mammal from mucosal damage.
    Type: Grant
    Filed: September 5, 2007
    Date of Patent: January 11, 2011
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • METHOD FOR MODULATING CLAUDIN MEDIATED FUNCTIONS
    Publication number: 20100305203
    Abstract: Disclosed is a method for modulating a claudin-mediated function in a mammalian subject which comprises administering to a subject in need thereof an effective amount of a specific fatty acid derivative. The application also discloses a method for treating a dermatological disease and a method for modulating an expression of a claudin in a mammalian subject using the same fatty acid derivative as above.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 2, 2010
    Applicants: SUCAMPO AG, OSAKA UNIVERSITY
    Inventors: Ryuji Ueno, Sachiko Tsukita
  • METHOD FOR TREATING ABDOMINAL DISCOMFORT
    Publication number: 20100298424
    Abstract: Disclosed is a novel use of a chloride channel opener, especially a prostaglandin compound for the treatment of abdominal discomfort. Further disclosed is a novel use of a chloride channel opener, especially a prostaglandin compound for the treatment of functional gastrointestinal disorders.
    Type: Application
    Filed: August 2, 2010
    Publication date: November 25, 2010
    Applicant: SUCAMPO AG
    Inventors: Ryuji UENO, Sachiko KUNO
  • METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE
    Publication number: 20100274032
    Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
    Type: Application
    Filed: April 19, 2010
    Publication date: October 28, 2010
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Ryu HIRATA, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
  • METHOD FOR TREATING MACULAR DEGENERATION
    Publication number: 20100267832
    Abstract: Disclosed is a method for treating macular degeneration in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a 15-keto-prostaglandin compound such as 13,14-dihydro-15-keto-20-ethyl-prostaglandin F2? isopropyl ester.
    Type: Application
    Filed: April 12, 2010
    Publication date: October 21, 2010
    Applicant: Sucampo AG
    Inventors: Ryuji Ueno, John Cuppoletti
  • Method for preparing prostaglandin derivative
    Patent number: 7812182
    Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: October 12, 2010
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Ryu Hirata, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno