Patents Assigned to Sucampo AG
  • DOSAGE UNIT COMPRISING A PROSTAGLANDIN ANALOG FOR TREATING CONSTIPATION
    Publication number: 20130143958
    Abstract: A dosage unit for treating constipation in a human patient is described. The dosage unit of the invention includes a halogenated prostaglandin analog and a pharmaceutically suitable excipient. The dosage unit relieves constipation without substantial side effects.
    Type: Application
    Filed: January 30, 2013
    Publication date: June 6, 2013
    Applicant: SUCAMPO AG
    Inventor: SUCAMPO AG
  • SOFT-GELATIN CAPSULE FORMULATION
    Publication number: 20130078303
    Abstract: The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
    Type: Application
    Filed: November 16, 2012
    Publication date: March 28, 2013
    Applicants: R-TECH UENO, LTD., SUCAMPO AG
    Inventors: SUCAMPO AG, R-TECH UENO, LTD.
  • Dosage unit comprising a prostaglandin analog for treating constipation
    Patent number: 8389542
    Abstract: A dosage unit for treating constipation in a human patient is described. The dosage unit of the invention includes a halogenated prostaglandin analog and a pharmaceutically suitable excipient. The dosage unit relieves constipation without substantial side effects.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: March 5, 2013
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, Myra L. Patchen
  • Method for preparing prostaglandin derivative
    Patent number: 8389748
    Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: March 5, 2013
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Ryu Hirata, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
  • METHOD FOR TREATING SCHIZOPHRENIA
    Publication number: 20130035393
    Abstract: The present invention provides a novel fatty acid derivative. The present invention also provides a method for treating schizophrenia in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a fatty acid derivative.
    Type: Application
    Filed: August 3, 2012
    Publication date: February 7, 2013
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • METHOD FOR PREPARING A FATTY ACID DERIVATIVE
    Publication number: 20130005995
    Abstract: A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z1 is wherein R3 is a protecting group for a hydroxy group; which includes the step of reacting a compound of formula (II): wherein Z2 is the same as Z1 except for when Z1 is Z2 is with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 3, 2013
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Tatsuya MATSUKAWA, Noriyuki YAMAMOTO, Ryuji UENO, Hiroyuki KOTAJIMA, Shunsuke FUKUYA, Michiharu HANDA, Katsuya SAKATA
  • Enteric coated composition comprising prostaglandin analogs as chloride channel opener
    Patent number: 8337891
    Abstract: The present invention provides an enteric coated composition for oral administration of a chloride channel opener which can provide improved pharmaceutical activity with reduced adverse side effect such as nausea.
    Type: Grant
    Filed: July 5, 2004
    Date of Patent: December 25, 2012
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • Soft-gelatin capsule formulation
    Patent number: 8338639
    Abstract: The present invention provides a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which includes: a soft gelatin capsule shell including gelatin and sugar alcohol as a plasticizer, and a mixture including a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: December 25, 2012
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Yukiko Hashitera, Ryu Hirata, Yasuhiro Harada, Ryuji Ueno
  • Method for preparing prostaglandin derivative
    Patent number: 8304562
    Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: November 6, 2012
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Ryu Hirata, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
  • METHOD FOR MODULATING ION TRANSPORTER
    Publication number: 20120277299
    Abstract: The present invention relates to a method for modulating ion transporter or treating disturbances of electrolyte transport during disease state, comprising an administration at a fatty acid derivative to a mammalian subject. The present invention also relates to a composition for modulating ion transporter or treating disturbances of electrolyte transport during disease state, comprising a fatty acid derivative.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 1, 2012
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • METHOD FOR MODULATING CYTOKINE ACTIVITY
    Publication number: 20120270945
    Abstract: The present invention relates to a method for modulating cytokine activity, immunomodulation or treating esophagitis comprising an administration of a fatty acid derivative to a mammalian subject. The present invention also relates to a composition for modulating cytokine activity, immunomodulation or treating esophagitis comprising a fatty acid derivative.
    Type: Application
    Filed: April 18, 2012
    Publication date: October 25, 2012
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • METHOD FOR TREATING ASTHENOPIA
    Publication number: 20120259008
    Abstract: The present invention relates to a method for treating asthenopia, accommodative dysfunction or ocular pain comprising an administration of a specific prostaglandin compound to a mammalian subject. The present invention also relates to a composition for treating asthenopia, accommodative dysfunction or ocular pain comprising a specific prostaglandin compound.
    Type: Application
    Filed: April 6, 2012
    Publication date: October 11, 2012
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • ANTI-CONSTIPATION COMPOSITION
    Publication number: 20120237598
    Abstract: An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in ratio of bi-cyclic/mono-cyclic structure of at least 1:1. The halogenated-bi-cyclic compound is represented by Formula (I): where X1 and X2 are preferably both fluorine atoms. The composition can be used to treat constipation with out substantive side-effects, such as stomachache.
    Type: Application
    Filed: December 27, 2011
    Publication date: September 20, 2012
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • METHOD FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS
    Publication number: 20120225938
    Abstract: The present invention provides a method for treating a central nervous system disorder in a mammalian subject, which comprises administering an effective amount of a 11-deoxy-prostaglandin compound to a subject in need thereof. The invention also provide novel 11-deoxy-prostaglandin compound.
    Type: Application
    Filed: May 14, 2012
    Publication date: September 6, 2012
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • Method for preparing prostaglandin derivative
    Patent number: 8236969
    Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: August 7, 2012
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Ryu Hirata, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
  • Method for treating central nervous system disorders
    Patent number: 8202909
    Abstract: The present invention provides a method for treating a central nervous system disorder in a mammalian subject, which comprises administering an effective amount of a 11-deoxy-prostaglandin compound to a subject in need thereof. The invention also provide novel 11-deoxy-prostaglandin compound.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: June 19, 2012
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • NOVEL COMPOSITION AND METHOD FOR STABILIZING THE SAME
    Publication number: 20120095090
    Abstract: Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved significantly by dissolving the same in a glyceride.
    Type: Application
    Filed: December 27, 2011
    Publication date: April 19, 2012
    Applicant: SUCAMPO AG
    Inventors: Ryuji UENO, Tsuyoshi HABE
  • DOSAGE UNIT COMPRISING A PROSTAGLANDIN ANALOG FOR TREATING CONSTIPATION
    Publication number: 20120088824
    Abstract: A dosage unit for treating constipation in a human patient is described. The dosage unit of the invention includes a halogenated prostaglandin analog and a pharmaceutically suitable excipient. The dosage unit relieves constipation without substantial side effects.
    Type: Application
    Filed: December 20, 2011
    Publication date: April 12, 2012
    Applicant: SUCAMPO AG
    Inventors: Ryuji UENO, Myra L. PATCHEN
  • Method for treating peripheral vascular diseases
    Patent number: 8143316
    Abstract: The present invention provides a method for treating peripheral vascular diseases in a mammalian subject, which comprises administering to the patient in need thereof an effective amount of 11-deoxy-prostaglandin compound.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: March 27, 2012
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • Prostaglandin compounds for the treatment of obesity
    Patent number: 8114911
    Abstract: Provided is a composition for treating obesity which comprises an effective amount of a prostaglandin compound, especially, a compound of formula (I).
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: February 14, 2012
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno