Patents Assigned to Sunnybrook Health Sciences Centre
  • Patent number: 10390791
    Abstract: Methods and apparatus are provided for electrically addressing multiple ultrasonic transducers that are connected to a common electrical channel and housed within an imaging probe. An imaging probe may comprise an imaging ultrasonic transducer and a moveable element for controlling the direction of an emitted imaging beam, and an angle sensing ultrasonic transducer, where the angle sensing ultrasonic transducer is configured for determining the direction of an ultrasonic imaging beam. The angle-sensing transducer may be configured to direct an angle sensing ultrasonic beam towards an acoustically reflective substrate and provide a signal by detecting a reflected ultrasonic beam reflected from the acoustically reflective substrate, where the acoustically reflective substrate is positioned relative to the movable element such that motion of the movable element produces a change in the signal.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: August 27, 2019
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Brian Courtney, Amandeep Thind
  • Patent number: 10328463
    Abstract: Methods and devices are provided for suppressing reverberations within an ultrasound transducer with a backing whereby the backing may not sufficiently attenuate the acoustic energy by means of acoustic absorption and scattering alone. At least a portion of a surface of the backing is segmented into a plurality of levels defined by surface segments. The levels may be are spatially offset so that acoustic reflections from the segmented surface are spread out in time, thereby decreasing the net amplitude of the internally reflected waves as they interact with the piezoelectric layer. Adjacent (neighboring) levels may be spatially offset by a longitudinal distance equaling approximately an odd number multiple of a quarter of an operational wavelength of the transducer, so that destructive interference occurs from acoustic waves reflected from adjacent levels. Various example configurations of segmented surfaces are described, and methods for selecting a profile of a segmented surface are provided.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: June 25, 2019
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Marc Lukacs, Brian Courtney, Chelsea Munding
  • Patent number: 10271889
    Abstract: An apparatus for cooling certain tissues in the vicinity of diseased or other tissue undergoing thermal treatment is disclosed. The present apparatus is configured and designed to have certain physical characteristics, e.g., certain acoustic and imaging responses. In some embodiments the present apparatus is compatible with magnetic resonance imaging (MRI) environments used in conjunction with the thermal treatment, or other imaging environments. In some embodiments the present apparatus is detectable by said MRI and is within the imaging field of view (FOV) but causes few or no imaging artifacts. Additionally, the present apparatus does not substantially interfere with the thermal treatment, e.g., ultrasonic therapy, which can proceed to heat the targeted volume of tissue while protective cooling of tissues near the diseased tissue by the present apparatus takes place.
    Type: Grant
    Filed: June 27, 2010
    Date of Patent: April 30, 2019
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Michael J. Bronskill, Rajiv Chopra
  • Patent number: 10266805
    Abstract: Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described. The human progenitor T cells have the phenotype CD34+CD7+CD 1a?CD5? or CD34+CD7+CD1a?CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells by coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4). Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: April 23, 2019
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Juan Carlos Zuniga-Pflucker, Geneve Awong, Ross La Motte-Mohs
  • Patent number: 10045801
    Abstract: The present disclosure discloses a bone stabilization device (also referred to as a bone tape), which includes a composite flexible construct including a rigidifiable biocompatible sheet structure having first and second opposed surfaces. A biocompatible cement is located on the first surface. In use the composite flexible construct is applied to a bone with the cement contacted directly to the bone. The cement is made of a material that, once adhered to the bone, is curable to mechanically and/or ionically bond to the sheet structure and to chemically bond to the bone to achieve a permanent bond. The bone tape allows simultaneous alignment and stabilization of multiple articulated fragments for successful 3D reconstruction of shattered bones. Initial flexibility and translucency provided by the bone tape can facilitate the temporary stabilization and alignment adjustment of multiple fragments, prior to permanent rigid bonding.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: August 14, 2018
    Assignees: The Governing Council of the University of Toronto, Sunnybrook Health Sciences Centre
    Inventors: Cari Marisa Whyne, Robert M. Pilliar, Jeffrey Allan Fialkov, Paul Santerre, Eran Regev
  • Patent number: 9764510
    Abstract: Methods and apparatus are provided for forming a patient-specific surgical implant based on mold system. The apparatus comprises a forming tool and a mold that may be generated using imaging and processing techniques and rapid prototyping methods. The mold apparatus includes at least two non-adjacent surface features for securing an implant forming material (such as a titanium mesh) during the forming process, enabling the implant forming material to be stretched beyond its elastic and thus permanently deformed with the correct patient-specific curvature. The implant may include one or more anatomic surface features for guidance and registration when transferring the implant to a patient.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: September 19, 2017
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Oleh Antonyshyn, Glenn Edwards, James Mainprize
  • Patent number: 9700280
    Abstract: Methods and apparatus are provided for electrically addressing multiple ultrasonic transducers that are connected to a common electrical channel and housed within an imaging probe. An imaging probe may comprise an imaging ultrasonic transducer and a moveable element for controlling the direction of an emitted imaging beam, and an angle sensing ultrasonic transducer, where the angle sensing ultrasonic transducer is configured for determining the direction of an ultrasonic imaging beam. The angle-sensing transducer may be configured to direct an angle sensing ultrasonic beam towards an acoustically reflective substrate and provide a signal by detecting a reflected ultrasonic beam reflected from the acoustically reflective substrate, where the acoustically reflective substrate is positioned relative to the movable element such that motion of the movable element produces a change in the signal.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: July 11, 2017
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Brian Courtney, Amandeep Thind
  • Patent number: 9533009
    Abstract: Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described. The human progenitor T cells have the phenotype CD34+CD7+CD 1a?CD5? or CD34+CD7+CD1a?CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells by coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4). Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: January 3, 2017
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Juan Carlos Zuniga-Pflucker, Geneve Awong, Ross La Motte-Mohs
  • Patent number: 9375147
    Abstract: The present invention provides scanning mechanisms for imaging probes using for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism having including a movable member configured to deliver the energy beam along a path out of an elongate hollow shaft at a variable angle with respect to the longitudinal axis to give forward and side viewing capability of the imaging assembly. The movable member is mounted in such a way that the variable angle is a function of the angular velocity of the imaging assembly.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: June 28, 2016
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Brian Courtney, Nigel Robert Munce, Amandeep Singh Thind, Victor Xiao Dong Yang, Francis Stuart Foster, Alan Soong, Brian Heng Li
  • Patent number: 9357923
    Abstract: The present invention provides minimally invasive imaging probe having an optical encoder integrated therewith for accurately measuring or estimating the rotational velocity near the distal end of the medical device, such as an imaging probe which undergoes rotational movement during scanning of surrounding tissue in bodily lumens and cavities.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: June 7, 2016
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Brian Courtney, Nigel Robert Munce, Amandeep Singh Thind, Victor Xiao Dong Yang, Francis Stuart Foster
  • Patent number: 9310451
    Abstract: A method and system for determination of oxygen saturation in blood flowing in a vessel using magnetic resonance (MR). An MR image sequence is acquired with different echo time (TE) encoding, and different Fourier velocity encoding (FVE). A Fourier transformation is applied along the velocity dimension to determine a velocity distribution of tissue signals in each voxel of the image sequence. Tissue signals indicative of moving tissues are separated from tissue signals indicative of static tissue, based on the velocity distribution. Oxygen saturation in blood may then be determined using only the tissue signals indicative of flowing blood.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: April 12, 2016
    Assignees: The Hospital for Sick Children, Sunnybrook Health Sciences Centre
    Inventors: Christopher Wernik, Venkat Swaminathan, Graham Wright, Christopher MacGowan
  • Patent number: 9268003
    Abstract: A method for automatically measuring currents induced on conducting structures positioned in the bore of a magnetic resonance imaging (“MRI”) scanner using a single magnetic resonance image is provided. A conductive structure is positioned within the bore of the MRI scanner during imaging. When the MRI system is transmitting an RF field, a current is induced in the conductive structure. The current creates a magnetic field at the Larmor frequency, which couples to the RF magnetic field in the vicinity of the conductive structure. The modified magnetic field results in an artifact being generated in phase images. The artifact in the phase image is then analyzed to determine the current induced in the conductive structure.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: February 23, 2016
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Gregory Huntindgon Griffin, Kevan Anderson, Graham Wright
  • Patent number: 9229077
    Abstract: A device for spatially encoding nuclear magnetic resonance signals is provided. The device includes a plurality of spatial-encoding elements configured to produce a spatial-encoding magnetic field in the presence of an external magnetic field, such as the main magnetic field of a magnetic resonance imaging (“MRI”) system. The spatial-encoding elements include paramagnetic and diamagnetic spatial-encoding elements. The device further includes a support configured to hold the plurality of spatial-encoding elements in a fixed arrangement. By adjusting the orientation of the device, the spatial-encoding elements are moved relative to each other and thereby produce a plurality of different spatial-encoding magnetic fields. These spatial-encoding magnetic fields are used to spatially encode nuclear magnetic resonance signals emanating from spins in a volume-of-interest adjacent the device. An image reconstruction method for reconstructing images from signals spatially-encoded with the device is also provided.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: January 5, 2016
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Charles H Cunningham, Hirad Karimi
  • Patent number: 9142018
    Abstract: A method for determining the three-dimensional location of an object in real-time from a two-dimensional medical image obtained with a medical imaging system is provided. For example, the three-dimensional location of an interventional medical device or a marker positioned on such a device may be determined from a two-dimensional x-ray image obtained with an interventional x-ray imaging system. Template images corresponding to the object under different imaging geometries and orientations are produced and are compared to images acquired with the medical imaging system. Similarity measures, such as normalized cross correlation and normalized similarity integral, are used to determine the similarity between a selected template image and the medical images in different stages of refining the position information for the object.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: September 22, 2015
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Normand Robert, Eugene Crystal
  • Patent number: 9101752
    Abstract: A focused ultrasound system includes an ultrasound transducer configured to emit focused ultrasound energy toward a subject and a positioning system configured to position the ultrasound transducer to localize the focused ultrasound energy within a target location. The positioning system includes a drive apparatus to translate the ultrasound transducer along at least one axis of motion and a motor controller to control the drive apparatus. The focused ultrasound system also includes a control system connected to the motor controller that is programmed to receive imaging/location data from an imaging system, determine positional coordinates of the target location based on the imaging/location data, and register the positional coordinates of the target location with the positioning system. The positional coordinates are sent to the motor controller via an input signal to cause the motor controller to control the drive apparatus so as to translate the ultrasound transducer.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: August 11, 2015
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Rajiv Chopra, Kullervo Hynynen, Anthony Chau, Adam Christian Waspe
  • Publication number: 20150217500
    Abstract: Methods and apparatus are provided for forming a patient-specific surgical implant based on mold system. The apparatus comprises a forming tool and a mold that may be generated using imaging and processing techniques and rapid prototyping methods. The mold apparatus includes at least two non-adjacent surface features for securing an implant forming material (such as a titanium mesh) during the forming process, enabling the implant forming material to be stretched beyond its elastic and thus permanently deformed with the correct patient-specific curvature. The implant may include one or more anatomic surface features for guidance and registration when transferring the implant to a patient.
    Type: Application
    Filed: March 4, 2015
    Publication date: August 6, 2015
    Applicant: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Oleh ANTONYSHYN, Glenn EDWARDS, James MAINPRIZE
  • Patent number: 9050450
    Abstract: An ultrasound therapy transducer head comprises an ultrasound source emitting ultrasonic radiation, the ultrasound source comprising a plurality of transducer elements, integrated driving electronics coupled to the transducer elements, the electronics generating at least one output ultrasound waveform and driving at least some of the transducer elements independently based on the at least one output ultrasound waveform and temperature control structure providing cooling for the electronics.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: June 9, 2015
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Kullervo H. Hynynen, Junho Song
  • Patent number: 9039626
    Abstract: The present invention provides minimally invasive imaging probe/medical device having a frictional element integrated therewith for reducing non-uniform rotational distortion near the distal end of a medical device, such as an imaging probe which undergoes rotational movement during scanning of surrounding tissue in bodily lumens and cavities.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: May 26, 2015
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventor: Brian Kent Courtney
  • Patent number: 8989838
    Abstract: The present invention provides a method and apparatus for delivering and controlling thermal therapy to a volume of diseased tissue. Specifically, the invention includes using thermal imaging and other inputs to determine an acoustic (ultrasonic) treatment regime employing interstitial ultrasound applicators to deliver a required therapeutic temperature or thermal dose to the affected region in a body or organ. Various aspects of the treatment that can be controlled include individual transducer element operating power and frequency, as well as the rate of cooling and rotation of the entire applicator.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: March 24, 2015
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Rajiv Chopra, Michael Bronskill, Mathieu Burtnyk
  • Patent number: 8974535
    Abstract: Methods and apparatus are provided for forming a patient-specific surgical implant based on mold system. The apparatus comprises a forming tool and a mold that may be generated using imaging and processing techniques and rapid prototyping methods. The mold apparatus includes at least two non-adjacent surface features for securing an implant forming material (such as a titanium mesh) during the forming process, enabling the implant forming material to be stretched beyond its elastic and thus permanently deformed with the correct patient-specific curvature. The implant may include one or more anatomic surface features for guidance and registration when transferring the implant to a patient.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: March 10, 2015
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Oleh Antonyshyn, Glenn Edwards, James Mainprize