Abstract: The present invention provides a practical design of a megavoltage x-ray detector with both high quantum efficiency (QE) and high resolution. The x-ray detector includes an optical-fiber taper (OFT) made from a large number of optical fibers, each of which is aligned with the incident x-rays from an x-ray source hitting a top surface of the optical fiber taper. The optical-fiber taper is a matrix of optical fibers with the core material made of, e.g., silica and coated with a cladding glass or polymer such that light created within the core of each optical fiber will be guided to the bottom ends of the fiber with the ends of the fibers at the bottom being optically coupled to and optical image read-out device. Each optical fiber in the optical fiber taper is fully aligned with the incident x-ray source so that x-rays entering the top of the fiber travel directly towards the bottom of the same fiber.

Abstract: The present invention provides a practical design of a megavoltage x-ray detector with both high quantum efficiency (QE) and high resolution. The x-ray detector disclosed herein has a QE that can be an order of magnitude higher than that of current flat panel systems and yet has a spatial resolution equivalent to that of current flat panel systems used for portal imaging. The x-ray detector includes a large number of micro-structured electrically conducting plates, packed together with thin spacers placed between neighboring plates with the micro-structured plates oriented to be parallel to the incident x-rays in operation. Each plate includes an electrically conductive substrate with a first planar surface, elongate electrically conductive strip electrodes separated from each other with strip spacers placed in between and sitting on an insulating layer interposed between the first planar surface of the electrically conductive substrate and the strip electrodes.

Abstract: Methods for isolating ILK genes are provided. The ILK nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

Abstract: Methods for isolating ILK genes are provided. The ILK nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

Abstract: Methods for isolating ILK genes are provided, The ILK nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

Abstract: Methods for isolating ILK genes are provided. The ILK nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

Abstract: An MRI system is employed to produce an image of an ultrasonic wave propagating through tissue or the like. An imaging pulse sequence used to acquire the image data is performed in synchronism with the operation of an ultrasonic transducer, and reconstructed phase images measure the motion of excited spins. Physical parameters of the acoustic field such as acoustic pressure, acoustic intensity and wave number may be calculated and imaged. Non-linear propagation characteristics of the acoustic field are also measured and imaged.

Abstract: An ultrasonic diagnostic imaging method and apparatus are presented which separates broadband linear and nonlinear echo signal components while simultaneously distinguishing the effects of motion. The inventive method maps ultrasonic echo signals in the r.f. (time) domain to Doppler shift frequencies in the Doppler domain in a way that depends upon the linearity of the echoes. The inventive method does this by analyzing the phase shifts between successive echoes. Apparatus is described in which a Doppler echo ensemble is acquired by a transmit sequence of cyclically phase-varying waveforms. When the echoes of the ensemble are combined during Doppler processing, the resulting Doppler spectrum is divided into separate regions, with odd harmonics (e.g., linear signal components) residing in one region and even harmonics (e.g., second harmonic signal components) residing in another region.

Abstract: An MR oximetry measurement of % O.sub.2 employs a pulse sequence comprised of a T.sub.2 preparatory segment and an image data acquisition segment. The pulse sequence is used in methods for measuring coronary flow reserve and for measuring myocardial oxygen consumption.

Abstract: Methods for isolating ILK genes are provided. The ILK nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

Abstract: A high frequency focused transducer may be formed by fabricating a piezoelectric or ferroelectric wafer of a thickness less than about 100 microns and bonding a malleable sheet to the wafer with a thin layer of adhesive. Thereafter, the composite may be pressed into a spherical mold to form a curved transducer without fracturing the wafer. In another embodiment, a conductive adhesive layer may be applied to the wafer to a thickness sufficient to hold the wafer in a curved state, when set. After the adhesive is set, the composite may be pressed into the mold while the adhesive is held at an elevated temperature whereat it is elastic. Thereafter the composite is cooled so that the adhesive layer is stabilized and the curved transducer is removed from the well.