Patents Assigned to Sunnybrook Health Sciences Centre
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Patent number: 9142018Abstract: A method for determining the three-dimensional location of an object in real-time from a two-dimensional medical image obtained with a medical imaging system is provided. For example, the three-dimensional location of an interventional medical device or a marker positioned on such a device may be determined from a two-dimensional x-ray image obtained with an interventional x-ray imaging system. Template images corresponding to the object under different imaging geometries and orientations are produced and are compared to images acquired with the medical imaging system. Similarity measures, such as normalized cross correlation and normalized similarity integral, are used to determine the similarity between a selected template image and the medical images in different stages of refining the position information for the object.Type: GrantFiled: January 16, 2013Date of Patent: September 22, 2015Assignee: SUNNYBROOK HEALTH SCIENCES CENTREInventors: Normand Robert, Eugene Crystal
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Patent number: 9101752Abstract: A focused ultrasound system includes an ultrasound transducer configured to emit focused ultrasound energy toward a subject and a positioning system configured to position the ultrasound transducer to localize the focused ultrasound energy within a target location. The positioning system includes a drive apparatus to translate the ultrasound transducer along at least one axis of motion and a motor controller to control the drive apparatus. The focused ultrasound system also includes a control system connected to the motor controller that is programmed to receive imaging/location data from an imaging system, determine positional coordinates of the target location based on the imaging/location data, and register the positional coordinates of the target location with the positioning system. The positional coordinates are sent to the motor controller via an input signal to cause the motor controller to control the drive apparatus so as to translate the ultrasound transducer.Type: GrantFiled: November 16, 2009Date of Patent: August 11, 2015Assignee: SUNNYBROOK HEALTH SCIENCES CENTREInventors: Rajiv Chopra, Kullervo Hynynen, Anthony Chau, Adam Christian Waspe
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Publication number: 20150217500Abstract: Methods and apparatus are provided for forming a patient-specific surgical implant based on mold system. The apparatus comprises a forming tool and a mold that may be generated using imaging and processing techniques and rapid prototyping methods. The mold apparatus includes at least two non-adjacent surface features for securing an implant forming material (such as a titanium mesh) during the forming process, enabling the implant forming material to be stretched beyond its elastic and thus permanently deformed with the correct patient-specific curvature. The implant may include one or more anatomic surface features for guidance and registration when transferring the implant to a patient.Type: ApplicationFiled: March 4, 2015Publication date: August 6, 2015Applicant: SUNNYBROOK HEALTH SCIENCES CENTREInventors: Oleh ANTONYSHYN, Glenn EDWARDS, James MAINPRIZE
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Patent number: 9050450Abstract: An ultrasound therapy transducer head comprises an ultrasound source emitting ultrasonic radiation, the ultrasound source comprising a plurality of transducer elements, integrated driving electronics coupled to the transducer elements, the electronics generating at least one output ultrasound waveform and driving at least some of the transducer elements independently based on the at least one output ultrasound waveform and temperature control structure providing cooling for the electronics.Type: GrantFiled: May 20, 2013Date of Patent: June 9, 2015Assignee: Sunnybrook Health Sciences CentreInventors: Kullervo H. Hynynen, Junho Song
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Patent number: 9039626Abstract: The present invention provides minimally invasive imaging probe/medical device having a frictional element integrated therewith for reducing non-uniform rotational distortion near the distal end of a medical device, such as an imaging probe which undergoes rotational movement during scanning of surrounding tissue in bodily lumens and cavities.Type: GrantFiled: March 31, 2010Date of Patent: May 26, 2015Assignee: SUNNYBROOK HEALTH SCIENCES CENTREInventor: Brian Kent Courtney
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Patent number: 8989838Abstract: The present invention provides a method and apparatus for delivering and controlling thermal therapy to a volume of diseased tissue. Specifically, the invention includes using thermal imaging and other inputs to determine an acoustic (ultrasonic) treatment regime employing interstitial ultrasound applicators to deliver a required therapeutic temperature or thermal dose to the affected region in a body or organ. Various aspects of the treatment that can be controlled include individual transducer element operating power and frequency, as well as the rate of cooling and rotation of the entire applicator.Type: GrantFiled: July 6, 2010Date of Patent: March 24, 2015Assignee: Sunnybrook Health Sciences CentreInventors: Rajiv Chopra, Michael Bronskill, Mathieu Burtnyk
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Patent number: 8974535Abstract: Methods and apparatus are provided for forming a patient-specific surgical implant based on mold system. The apparatus comprises a forming tool and a mold that may be generated using imaging and processing techniques and rapid prototyping methods. The mold apparatus includes at least two non-adjacent surface features for securing an implant forming material (such as a titanium mesh) during the forming process, enabling the implant forming material to be stretched beyond its elastic and thus permanently deformed with the correct patient-specific curvature. The implant may include one or more anatomic surface features for guidance and registration when transferring the implant to a patient.Type: GrantFiled: June 10, 2011Date of Patent: March 10, 2015Assignee: Sunnybrook Health Sciences CentreInventors: Oleh Antonyshyn, Glenn Edwards, James Mainprize
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Patent number: 8957022Abstract: The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing. The present invention also features pharmaceutical compositions comprising the multimeric Tie 2 agonists, including those suitable for topical or systemic administration. Methods of using the multimeric Tie 2 agonists of the invention for stimulating angiogenesis and for promoting healing of wounds, such as diabetic ulcers or skin grafts, are also provided.Type: GrantFiled: October 26, 2007Date of Patent: February 17, 2015Assignee: Sunnybrook Health Sciences CentreInventors: Paul Van Slyke, Daniel Dumont
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Patent number: 8909322Abstract: A catheter for magnetic resonance (MR) guided procedures comprising: a catheter body having a lumen for accommodating an intravascular device; a magnetic coupling component in the catheter body, the magnetic coupling component being designed to magnetically couple with a conductive length on the intravascular device, the magnetic coupling resulting in a signal; the catheter having a connection to deliver the signal to a processor.Type: GrantFiled: September 11, 2009Date of Patent: December 9, 2014Assignee: Sunnybrook Health Sciences CentreInventors: Kevan Anderson, Graham Wright
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Publication number: 20140323860Abstract: The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image signals during scanning a region of interest.Type: ApplicationFiled: May 20, 2014Publication date: October 30, 2014Applicant: SUNNYBROOK HEALTH SCIENCES CENTREInventors: Brian COURTNEY, Nigel Robert MUNCE, Amandeep Singh THIND, Victor Xiao Dong YANG, Francis Stuart FOSTER
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Publication number: 20140323877Abstract: The present invention provides minimally invasive imaging probe having an optical encoder integrated therewith for accurately measuring or estimating the rotational velocity near the distal end of the medical device, such as an imaging probe which undergoes rotational movement during scanning of surrounding tissue in bodily lumens and cavities.Type: ApplicationFiled: April 28, 2014Publication date: October 30, 2014Applicant: SUNNYBROOK HEALTH SCIENCES CENTREInventors: Brian COURTNEY, Nigel Robert MUNCE, Amandeep Singh THIND, Victor Xiao Dong YANG, Francis Stuart FOSTER
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Publication number: 20140248248Abstract: Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described. The human progenitor T cells have the phenotype CD34+CD7+CD1a?CD5? or CD34+CD7+CD1a?CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells by coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4). Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.Type: ApplicationFiled: May 22, 2014Publication date: September 4, 2014Applicant: Sunnybrook Health Sciences CentreInventors: JUAN CARLOS ZUNIGA-PFLUCKER, GENEVE AWONG, ROSS LA MOTTE-MOHS
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Patent number: 8801701Abstract: The invention provides a method and apparatus for monitoring a thermal effect of a conformal thermal treatment to diseased tissue in a target volume. The method includes acquiring a reference image of the volume containing the diseased tissue at a first position of the device, determining a baseline temperature distribution of the reference image, acquiring an image of the volume containing the diseased tissue while delivering a treatment to the volume, performing a phase subtraction between the image and the reference image to determine a change in phase between the image and the reference image and determining a current spatial temperature distribution in the volume containing the diseased tissue.Type: GrantFiled: March 27, 2007Date of Patent: August 12, 2014Assignee: Sunnybrook Health Sciences CentreInventors: Rajiv Chopra, Michael Bronskill, Kee Tang
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Patent number: 8784321Abstract: The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image, signals during scanning a region of interest.Type: GrantFiled: January 22, 2008Date of Patent: July 22, 2014Assignee: Sunnybrook Health Sciences CentreInventors: Brian Courtney, Nigel Robert Munce, Amandeep Singh Thind, Victor Xiao Dong Yang, Francis Stuart Foster
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Patent number: 8772028Abstract: Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described The human progenitor T cells have the phenotype CD34+CD7+CD1a?CD5? or CD34+CD7+CD1a?CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells b\ coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4) Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.Type: GrantFiled: November 6, 2009Date of Patent: July 8, 2014Assignee: Sunnybrook Health Sciences CentreInventors: Juan Carlos Zuniga-Pflucker, Geneve Awong, Ross La Motte-Mohs
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Publication number: 20140163433Abstract: An ultrasound therapy transducer head comprises an ultrasound source emitting ultrasonic radiation, the ultrasound source comprising a plurality of transducer elements, integrated driving electronics coupled to the transducer elements, the electronics generating at least one output ultrasound waveform and driving at least some of the transducer elements independently based on the at least one output ultrasound waveform and temperature control structure providing cooling for the electronics.Type: ApplicationFiled: May 20, 2013Publication date: June 12, 2014Applicant: Sunnybrook Health Sciences CentreInventors: Kullervo H. Hynynen, Junho Song
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Patent number: 8712506Abstract: The present invention provides minimally invasive imaging probe having an optical encoder integrated therewith for accurately measuring or estimating the rotational velocity near the distal end of the medical device, such as an imaging probe which undergoes rotational movement during scanning of surrounding tissue in bodily lumens and cavities.Type: GrantFiled: January 22, 2008Date of Patent: April 29, 2014Assignee: Sunnybrook Health Sciences CentreInventors: Brian Courtney, Nigel Robert Munce, Amandeep Singh Thind, Victor Xiao Dong Yang, Francis Stuart Foster
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Patent number: 8460195Abstract: The present invention provides scanning mechanisms for imaging probes using for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism including a movable member configured to deliver the energy beam along a path out of said elongate hollow shaft at a variable angle with respect to said longitudinal axis to give forward and side viewing capability of the imaging assembly. The movable member is mounted in such a way that the variable angle is a function of the angular velocity of the imaging assembly.Type: GrantFiled: March 27, 2009Date of Patent: June 11, 2013Assignee: Sunnybrook Health Sciences CentreInventors: Brian Courtney, Nigel Robert Munce, Amandeep Singh Thind, Victor Xiao Dong Yang, Francis Stuart Foster, Alan Soong, Brian Heng Li
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Publication number: 20130115226Abstract: The present disclosure provides methods and uses of Tie2 binding and/or activating agents. In particular, the present disclosure provides methods and uses for inhibiting the expansion of colony forming unit-granulocytes, reducing eosinophils and/or basophils, for treating allergic disease or response or eosinophil/basophil associated condition and for reducing inflammatory cytokine and/or chemokine levels.Type: ApplicationFiled: April 28, 2011Publication date: May 9, 2013Applicant: Sunnybrook Health Sciences CentreInventors: Paul Van Slyke, Daniel Dumont
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Publication number: 20130088227Abstract: A method and system for determination of oxygen saturation in blood flowing in a vessel using magnetic resonance (MR). An MR image sequence is acquired with different echo time (TE) encoding, and different Fourier velocity encoding (FVE). A Fourier transformation is applied along the velocity dimension to determine a velocity distribution of tissue signals in each voxel of the image sequence. Tissue signals indicative of moving tissues are separated from tissue signals indicative of static tissue, based on the velocity distribution. Oxygen saturation in blood may then be determined using only the tissue signals indicative of flowing blood.Type: ApplicationFiled: April 15, 2011Publication date: April 11, 2013Applicants: SUNNYBROOK HEALTH SCIENCES CENTRE, THE HOSPITAL FOR SICK CHILDRENInventors: Christopher Wernik, Venkat Swaminathan, Graham Wright, Christopher MacGowan