Patents Assigned to Symyx Technologies
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Patent number: 7281408Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.Type: GrantFiled: November 20, 2003Date of Patent: October 16, 2007Assignee: Symyx Technologies, Inc.Inventors: Ravi Srinivasan, Daniel M. Pinkas, Shenheng Guan, Michael Myslovaty, Mikhail Spitkovsy, James R. Engstrom, H. Sam Bergh
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Patent number: 7270798Abstract: The invention relates to methods of using noble metal-free nickel catalysts to generate a hydrogen-rich gas from gas mixtures containing carbon monoxide and water, such as water-containing syngas mixtures, where the nickel may exist in either a supported or a bulk state. The noble metal-free water gas shift catalyst of the invention comprises Ni in either a supported or a bulk state and at least one of Ge, Cd, In, Sn, Sb, Te, Pb, their oxides and mixtures thereof. The invention is also directed toward noble metal-free nickel catalysts that exhibit both high activity and selectivity to hydrogen generation and carbon monoxide oxidation.Type: GrantFiled: December 18, 2003Date of Patent: September 18, 2007Assignees: Honda Giken Kogyo Kabushiki Kaisha, Symyx Technologies, Inc.Inventors: Alfred Hagemeyer, Christopher James Brooks, Raymond E. Carhart, Karin Yaccato, Michael Herrmann
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Publication number: 20070214101Abstract: Computer-implemented methods, systems and apparatus, including computer program apparatus, provide techniques for designing a set of experiments to be performed with a set of resources. A plurality of experimental configurations are generated based on a set of parameters describing factors to be varied in the experiments and a set of constraints representing limitations on operations that can be performed with the set of resources. A set of experiments is defined based on a selected configuration. The constraints can be represented as patterns defining an application of a parameter to a set of one or more points of an experimental lattice.Type: ApplicationFiled: February 6, 2006Publication date: September 13, 2007Applicant: Symyx Technologies, Inc.Inventors: Youqi Wang, Marco Falcioni, Stephen Turner, C. Ramberg
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Publication number: 20070203951Abstract: Methods and apparatus, including computer program products, implement techniques for processing experimental data in a laboratory data management system. An input specifies a set of variable definitions that define a set of variables for an experiment type to be represented by a pre-defined experiment class. The variables in the set of variables have types selected from a predefined set of data types. Data from an experiment of the experiment type is received. A first representation of the data is stored in a format defined according to the set of variable types. A second representation of the data, derived from the first representation, is presented in a format defined according to the set of variable definitions.Type: ApplicationFiled: April 30, 2007Publication date: August 30, 2007Applicant: Symyx Technologies, Inc.Inventor: David Dorsett
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Patent number: 7259217Abstract: Controlled architecture polymers made preferably with acrylamide type monomers are prepared in living-type or semi-living-type free radical polymerizations, with the architecture preferably being other than linear, such as star, branched, grafted or hyper-branched. The controlled architecture polymers have high weight average molecular weights and low viscosities, which make they particularly useful in replaceable capillary electrophoresis separation media for biological molecules, such as DNA fragments.Type: GrantFiled: February 10, 2004Date of Patent: August 21, 2007Assignee: Symyx Technologies, Inc.Inventors: Gerrit Klaerner, Miroslav Petro, Dominique Charmot, Didier Benoit
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Patent number: 7256296Abstract: Ligands, compositions, and metal-ligand complexes that incorporate heterocycle-amine compounds are disclosed that are useful in the catalysis of transformations such as the polymerization of monomers into polymers. The catalysts have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, propylene or styrene. The catalysts also polymerize propylene to form isotactic polypropylene.Type: GrantFiled: September 21, 2005Date of Patent: August 14, 2007Assignee: Symyx Technologies, Inc.Inventors: Gary M. Diamond, Anne M. LaPointe, Margarete K. Leclerc, James Longmire, Victor Nava-Salgado, James A. W. Shoemaker, Pu Sun
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Patent number: 7255474Abstract: A library of material samples is provided in a condition suitable for imaging using infrared (IR) spectroscopy. The samples are provided to one or more detection cells, each of the cells including or containing a reflective surface. Preferably, for imaging, an energy source (e.g. a source of infrared radiation) provides energy to the detection cells to interact with the samples. Thereafter, images (e.g., spectra) related to the samples are created based upon the interaction.Type: GrantFiled: July 28, 2004Date of Patent: August 14, 2007Assignee: Symyx Technologies, Inc.Inventors: Peijun Cong, Shenheng Guan, Stephen Cypes, Jason Wells, H. Sam Bergh
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Publication number: 20070185657Abstract: Computer-implemented methods, programs and apparatus for generating a library design for a combinatorial library of materials. A library design includes a set of sources representing components to be used in preparing the combinatorial library, destinations representing arrangements of cells and mappings, defining one or more distribution patterns for assigning components to cells in the destination arrangement or arrangements. Mappings include gradients and sets of user-defined equations, and are used to calculate the amount of one or more components to be assigned to a cell or cells in an arrangement. A library design can also include one or more process parameters defined to vary over time or across a plurality of destination cells. The invention outputs a data file defining the library design, including electronic data representing the sources, the destinations and the mapping, in a format suitable for implementing manually or using automated material handling apparatus.Type: ApplicationFiled: April 2, 2007Publication date: August 9, 2007Applicant: Symyx Technologies, Inc.Inventors: Steven Lacy, Eric McFarland, Adam Safir, Stephen Turner, Lynn Erden, Pei Wang
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Patent number: 7250475Abstract: The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.Type: GrantFiled: June 25, 2004Date of Patent: July 31, 2007Assignee: Symyx Technologies, Inc.Inventors: Didier Benoit, Adam Safir, Han-Ting Chang, Dominique Charmot, Kenji Okamoto, Isao Nishimura, Yong Wang
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Patent number: 7250950Abstract: The database is populated with target chemicals, corresponding listings of reagent chemicals, corresponding listings of equipment and corresponding listings of procedures. The database is then searched in response to user identification of a target chemical. In response, a listing is displayed of reagent chemicals that are used to synthesize the target chemical, equipment that is used to synthesize the target chemical, and a procedure that is used to synthesize the target chemical by reacting the reagent chemicals in the equipment according to the procedure. An icon-based reaction editor and/or context-sensitive Boolean query option generators may be provided. A reaction template may be used to perform predictive chemistry. A reaction relay may be used to graphically display related chemicals and procedures using a hub and spoke arrangement.Type: GrantFiled: March 24, 2003Date of Patent: July 31, 2007Assignee: Symyx Technologies, Inc.Inventors: Robin Young Smith, William Brian Ballard, David Albert Coleman
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Patent number: 7241715Abstract: New ligands and compositions with bridged bis-aromatic ligands are disclosed that catalyze the polymerization of monomers into polymers. These catalysts with metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, propylene or styrene. The catalysts also polymerize propylene into isotactic polypropylene.Type: GrantFiled: May 16, 2006Date of Patent: July 10, 2007Assignee: Symyx Technologies, Inc.Inventors: Thomas R. Boussie, Oliver Brümmer, Gary M. Diamond, Christopher Goh, Anne M. LaPointe, Margarete K. Leclerc, James A. W. Shoemaker
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Patent number: 7241714Abstract: Ligands, compositions, metal-ligand complexes and arrays with substituted bridged bis-biaromatic ligands, and methods of making and using the same, are disclosed that are useful in the catalysis of transformations such as the polymerization of monomers into polymers. The catalysts have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, propylene or styrene. The catalysts also polymerize propylene into isotactic polypropylene.Type: GrantFiled: May 16, 2006Date of Patent: July 10, 2007Assignee: Symyx Technologies, Inc.Inventors: Thomas R. Boussie, Oliver Brümmer, Gary M. Diamond, Anne M. LaPointe, Margarete K. Leclerc, Cynthia Micklatcher, Pu Sun, Xiaohong Bei
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Patent number: 7241424Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.Type: GrantFiled: February 8, 2002Date of Patent: July 10, 2007Assignee: Symyx Technologies, Inc.Inventors: Shenheng Guan, Lynn Van Erden, Robert C. Haushalter, Xiao Ping Zhou, Xuejun Jason Wang, Ravi Srinivasan
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Patent number: 7242000Abstract: This invention discloses methods, materials, and devices for making and screening combinatorial libraries to identify semi-conducting and thermoelectric materials. The disclosed method includes preparing a combinatorial library of materials, and identifying library members that are semiconductors. The method may include determining a thermoelectric figure of merit, ZT, for each member of a second combinatorial library of materials. The method determines ZT by applying an oscillatory voltage across the library members, measuring power dissipated by library members, and calculating ZT from the power dissipated. The method may also include isolating single-phase materials of the semiconducting library members. The present invention also discloses an apparatus for discovering thermoelectric materials using combinatorial techniques.Type: GrantFiled: March 18, 2003Date of Patent: July 10, 2007Assignee: Symyx Technologies, Inc.Inventors: William B. Archibald, Marc D. Hornbostel
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Publication number: 20070154361Abstract: An apparatus for use in parallel reaction of materials. The apparatus includes a base having a plurality of reaction wells, each of the reaction wells having a closed lower end and open upper end for receiving reactant materials. A cover is configured for sealing engagement with the base to form a housing enclosing the plurality of reaction wells and defining a common pressure chamber in communication with the reaction wells. The apparatus further includes an inlet port in communication with the pressure chamber for supplying pressurized fluid to the chamber to pressurize the reaction wells. The housing is configured to sustain a pressure substantially above atmospheric pressure.Type: ApplicationFiled: February 20, 2007Publication date: July 5, 2007Applicant: Symyx Technologies, Inc.Inventors: Lynn Van Erden, Howard Turner, David Lowe
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Patent number: 7234365Abstract: Methods and systems for determining a dissolution profile of a sample material, and for solubilization screening of a library defined by an array comprising multiple sample materials are disclosed. The methods and systems are particularly advantageous for sampling and evaluation of very small samples, and can be advantageously applied in connection with evaluation of drug candidates.Type: GrantFiled: January 12, 2006Date of Patent: June 26, 2007Assignee: Symyx Technologies, Inc.Inventors: Eric D. Carlson, Miroslav Petro, Son Hoai Nguyen
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Publication number: 20070143240Abstract: Methods, apparatus, and business processes enabling individual chemists to design, order, and obtain data for multiple experiments or measurements in a timely and cost-effective manner. In particular implementations, the invention includes methods and apparatus for designing sets of custom experiments, ordering the execution of the experiments, communicating the order to a remote laboratory, executing the experiments at that laboratory using high-throughput technologies, and communicating the experimental results to the user.Type: ApplicationFiled: February 8, 2007Publication date: June 21, 2007Applicant: Symyx Technologies, Inc.Inventors: Isy Goldwasser, David Dorsett, Jere Fellmann
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Patent number: 7225081Abstract: A circuit chip is disclosed. The circuit chip includes analog-to-digital processing circuitry that is capable of interfacing with a sensor and host electronics. The analog-to-digital processing circuitry includes a frequency generator configured for providing stimulus to the sensor and signal detection circuitry that is configured for identifying amplitude data of a response signal. Further included is analog-to-digital conversion circuitry that is configured for converting the detected amplitude data into digital form. A memory that is capable of holding data characterizing the sensor is also provided. The digital form of the response signal is capable of being processed to generate fluid characteristics of fluids under-test.Type: GrantFiled: February 15, 2005Date of Patent: May 29, 2007Assignee: Symyx Technologies, IncInventors: Oleg V. Kolosov, Leonid Matsiev, Mikhail B. Spitkovsky, Vladimir Gammer
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Patent number: 7216113Abstract: Methods, apparatus, and business processes enabling individual chemists to design, order, and obtain data for multiple experiments or measurements in a timely and cost-effective manner. In particular implementations, the invention includes methods and apparatus for designing sets of custom experiments, ordering the execution of the experiments, communicating the order to a remote laboratory, executing the experiments at that laboratory using high-throughput technologies, and communicating the experimental results to the user.Type: GrantFiled: March 26, 2001Date of Patent: May 8, 2007Assignee: Symyx Technologies, Inc.Inventors: Isy Goldwasser, David R. Dorsett, Jr., Jere D. Fellmann
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Publication number: 20070100145Abstract: New compositions, titanium-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. These catalysts with titanium metal centers have high performance characteristics, including high styrene incorporation into ethylene/styrene copolymers.Type: ApplicationFiled: December 19, 2006Publication date: May 3, 2007Applicant: Symyx Technologies, Inc.Inventors: Thomas Boussie, Gary Diamond, Christopher Goh, Anne LaPointe, Margarete Leclerc, Cheryl Lund