Patents Assigned to Symyx Technologies
  • Portable fluid sensing device and method
    Publication number: 20060031030
    Abstract: Fluid monitoring methods, systems and apparatus are disclosed. Preferred embodiments comprise one or more flexural resonator sensing elements. In preferred embodiments a sensor or a sensor subassembly is ported to multiple fluidic systems.
    Type: Application
    Filed: April 20, 2005
    Publication date: February 9, 2006
    Applicant: Symyx Technologies, Inc.
    Inventors: James Bennett, G. Dales, John Feland, Oleg Kolosov, Eric Low, Leonid Matsiev, William Rust, Mikhail Spitkovsky, Mark Uhrich
  • Parallel semicontinuous or continuous reactors
    Patent number: 6994827
    Abstract: Parallel semi-continuous or continuous reactors are disclosed. The parallel reactors preferably comprise four or more reaction vessels. The reaction vessels are preferably small volume reaction vessels, preferably pressure reaction vessels, and/or preferably integral with a common reactor block. The reaction vessels can comprise shaft-driven stirrers. At least two, preferably at least three or at least four liquid feed lines can provide selective fluid communication between each of the reaction vessels and one or more liquid reagent sources. Additional features, suitable in connection with parallel reactors or with single reaction vessels are also disclosed.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: February 7, 2006
    Assignee: Symyx Technologies, Inc.
    Inventors: Adam Safir, Ralph Nielsen, Thomas H. McWaid, Richard Tiede, Lynn Van Erden
  • Methods and apparatus for preparing high-dimensional combinatorial experiments
    Patent number: 6996550
    Abstract: Computer-implemented methods, systems and apparatus, including computer program apparatus, provide techniques for designing a set of experiments to be performed with a set of resources. A plurality of experimental configurations are generated based on a set of parameters describing factors to be varied in the experiments and a set of constraints representing limitations on operations that can be performed with the set of resources. A set of experiments is defined based on a selected configuration. The constraints can be represented as patterns defining an application of a parameter to a set of one or more points of an experimental lattice.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: February 7, 2006
    Assignee: Symyx Technologies, Inc.
    Inventors: Youqi Wang, Marco Falcioni, Stephen J. Turner, C. Eric Ramberg
  • Platinum-ruthenium-palladium fuel cell electrocatalyst
    Patent number: 6995114
    Abstract: A catalyst suitable for use in a fuel cell, especially as an anode catalyst, that contains platinum at a concentration that is between about 20 and about 60 atomic percent, ruthenium at a concentration that is between about 20 and about 60 atomic percent, palladium at a concentration that is between about 5 and about 45 atomic percent, and having an atomic ratio of platinum to ruthenium that is between about 0.7 and about 1.2. Alternatively, the catalyst may contain platinum at a concentration that is between about 25 and about 50 atomic percent, ruthenium at a concentration that is between about 25 and about 55 atomic percent, palladium at a concentration that is between about 5 and about 45 atomic percent, and having a difference between the concentrations of ruthenium and platinum that is no greater than about 20 atomic percent.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: February 7, 2006
    Assignee: Symyx Technologies, Inc.
    Inventor: Alexander Gorer
  • Styrene polymers and phenol-triazole type complexes, catalysts, and processes for polymerizing
    Publication number: 20060025547
    Abstract: Metal-ligand complexes that are useful as precursors to catalysts for the polymerization of olefins are provided. Certain of the catalysts are particularly effective at polymerizing ethylene and styrene into copolymers having novel properties, including a low molecular weight and close comparison between vinyl and methyl end groups.
    Type: Application
    Filed: September 23, 2005
    Publication date: February 2, 2006
    Applicant: Symyx Technologies, Inc.
    Inventors: Oliver Brummer, Gary Diamond, Christopher Goh, Anne LaPointe, Margarete Leclerc, James Longmire, James Shoemaker
  • BRIDGED BI-AROMATIC CATALYSTS, COMPLEXES, AND METHODS OF USING THE SAME
    Publication number: 20060025548
    Abstract: Ligands, compositions, metal-ligand complexes and arrays with substituted bridged bis-biaromatic ligands, and methods of making and using the same, are disclosed that are useful in the catalysis of transformations such as the polymerization of monomers into polymers. The catalysts have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, propylene or styrene. The catalysts also polymerize propylene into isotactic polypropylene.
    Type: Application
    Filed: April 28, 2005
    Publication date: February 2, 2006
    Applicant: Symyx Technologies, Inc.
    Inventors: Thomas Boussie, Oliver Bruemmer, Gary Diamond, Anne LaPointe, Margarete Leclerc, Cynthia Micklatcher, Pu Sun, Xiaohong Bei
  • PLATINUM-INDIUM-IRON/TUNGSTEN/MANGANESE FUEL CELL ELECTROCATALYST
    Publication number: 20060019825
    Abstract: Abstract of the Disclosure A fuel cell electrocatalyst that contains platinum, indium, and at least one of tungsten, iron, and manganese.
    Type: Application
    Filed: May 19, 2004
    Publication date: January 26, 2006
    Applicants: Symyx Technologies, Inc., Honda Giken Kogyo Kabushiki Kaisha
    Inventors: MARTIN DEVENNEY, Alexander Gorer, Peter Strasser, Ting He, Hiroyuki Oyanagi, Daniel Giaquinta, Qun Fan, Konstantinos Chondroudis
  • Combinatorial parameter space experiment design
    Patent number: 6983233
    Abstract: Methods and apparatus, including computer program apparatus, implementing techniques for designing sets of combinatorial experiments. A set of experimental parameters, sampling patterns, and constraints defines a set of experiments that is limited to a volume of a hyperspace defined by the set of experimental parameters. Parameters can be grouped by type such that grouped parameters are constrained to perform a common role in the set of experiments. The practicability of the experiment design can be estimated based on the number of experiments in the set of experiments. The experiment design can be used to prepare one or more combinatorial libraries.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: January 3, 2006
    Assignee: Symyx Technologies, Inc.
    Inventors: Marco Falcioni, C. Eric Ramberg, Youqi Wang
  • Apparatus for high temperature withdrawal or dispensing of fluids
    Patent number: 6976383
    Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: December 20, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: Miroslav Petro, Adam Safir, Ralph B. Nielsen, G. Cameron Dales, Eric D. Carlson, Thomas S. Lee
  • Catalyst ligands, catalytic metal complexes and processes using same
    Patent number: 6974878
    Abstract: A new ligands that include a benzene ring in the backbone can be combined with a metal or metal precursor compound or formed into a metal-ligand complex catalyze a number of different chemical transformations, including olefin polymerization reactions. The ligands, complexes formed with the ligands and compositions including the ligands are useful catalysts, depending on the reaction.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: December 13, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: Anil Guram, Cheryl Lund, Howard W. Turner, Tetsuo Uno
  • Methods for mechanical treatment of materials such as catalysts
    Patent number: 6971593
    Abstract: Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: December 6, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: Claus Lugmair, Alfred Hagemeyer, Lynn Van Erden, Anthony F. Volpe, Jr., David M. Lowe, Yumin Liu
  • Flexural resonator sensing device and method
    Publication number: 20050262944
    Abstract: Fluid monitoring methods, systems and apparatus are disclosed. Preferred embodiments comprise one or more mechanical resonator sensing elements such as flexural resonator sensing elements. In preferred embodiments the sensing elements comprises one or more embedded electrodes.
    Type: Application
    Filed: April 20, 2005
    Publication date: December 1, 2005
    Applicant: Symyx Technologies, Inc.
    Inventors: James Bennett, Oleg Kolosov, Leonid Matsiev
  • System and methods for integration of custom classes into pre-existing objects models
    Patent number: 6968538
    Abstract: Computer-implemented methods, systems and apparatus implement techniques for generating custom coclasses. A runtime environment includes a client application implementing an object model, which includes a hierarchy of object classes that can be instantiated in the client application. The object model includes class templates, each having an associated class type, and includes class functionality information—including required class functionality and elective class functionality—for custom classes that can be implemented in the client application. When a user requests the creation of a custom class of a specified type, a design-time environment is launched and class functionality information is retrieved for a class template associated with the type. A custom class is created, based on a class definition defining a class having the required class functionality and the specified elective class functionality.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: November 22, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: William C. Rust, Dennis W. Worthem
  • Ethylene-styrene copolymers and phenol-triazole type complexes, catalysts, and processes for polymerizing
    Patent number: 6965004
    Abstract: Metal-ligand complexes that are useful as precursors to catalysts for the polymerization of olefins are provided. Certain of the catalysts are particularly effective at polymerizing ethylene and styrene into copolymers having novel properties, including a low molecular weight and close comparison between vinyl and methyl end groups.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: November 15, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: Oliver Brümmer, Gary M. Diamond, Christopher Goh, Anne M. LaPointe, Margarete K. Leclerc, James Longmire, James A. W. Shoemaker
  • Method and apparatus for characterizing materials by using a mechanical resonator
    Patent number: 6957565
    Abstract: A method for measuring properties of a fluid that includes oscillating a tuning fork resonator in a fluid. The invention is particularly suitable for in-line monitoring of various physical and electrical properties of fluids flowing in a conduit.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: October 25, 2005
    Assignee: SYMYX Technologies, Inc.
    Inventors: Leonid Matsiev, James Bennett, Eric McFarland
  • Pressurized reactor apparatus with magnetic stirring
    Publication number: 20050232074
    Abstract: An apparatus for parallel processing of reaction mixtures comprises a plurality of vessels for holding a plurality of reaction mixtures for processing. A plurality of vessel supports are adapted for supporting the plurality of vessels. Caps sealingly engage the vessel supports for sealing the vessels within the vessel supports. The vessels, vessel supports, and caps define reaction chambers having bearings and stirrers rotatable therein. The stirrers each comprise a spindle rotatable in a respective bearing and at least one stirring implement extending from the spindle for contacting a respective reaction mixture. The stirrers further comprise at least one magnet adapted to be subjected to a rotating magnetic field in the vessel for causing the stirrer to rotate thereby to mix the respective reaction mixture.
    Type: Application
    Filed: April 20, 2005
    Publication date: October 20, 2005
    Applicant: Symyx Technologies, Inc.
    Inventors: Kenneth Higashihara, Robert Saxton, Jason Wells
  • High throughput mechanical rapid serial property testing of materials libraries
    Patent number: 6951144
    Abstract: A library of materials is screened for mechanical properties such as strength, tack or other properties. A library of materials is provided. A stimulus such as a stress or force is provided to each member of the library. A response (e.g., a strain) of each of the materials due to the stimulus is measured and the response, the stimulus or both are recorded and related to provide data. Thereafter, the data is analyzed to reach conclusions regarding properties of the material samples.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: October 4, 2005
    Assignee: Symyx Technologies, Inc.
    Inventor: Paul Mansky
  • Apparatuses and methods for creating and testing pre-formulations and systems for same
    Publication number: 20050211622
    Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing.
    Type: Application
    Filed: May 16, 2005
    Publication date: September 29, 2005
    Applicant: Symyx Technologies, Inc.
    Inventors: Eric Carlson, Peijun Cong, William Chandler, Peter Desrosiers, J. Freitag, John Varni
  • Integrated circuitry for controlling analysis of a fluid
    Publication number: 20050209796
    Abstract: A circuit for determining characteristics of a fluid under-test is provided. The circuit includes analog-to-digital processing circuitry for interfacing with a sensor and host electronics.
    Type: Application
    Filed: May 4, 2005
    Publication date: September 22, 2005
    Applicant: Symyx Technologies, Inc.
    Inventors: Oleg Kolosov, Leonid Matsiev, Mikhail Spitkovsky, Vladimir Gammer
  • Apparatuses and methods for creating and testing pre-formulations and systems for same
    Patent number: 6939515
    Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: September 6, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: Eric D. Carlson, Peijun Cong, William H. Chandler, Jr., Peter J. Desrosiers, J. Christopher Freitag, John F. Varni