Patents Assigned to Symyx Technologies
  • Patent number: 7213034
    Abstract: Methods and apparatus, including computer program products implement techniques for processing experimental data according. An input specifies a set of variable definitions according to a variable definition template for defining a set of variables of a plurality of variable types usable in experiments of a pre-defined experiment class. Data from an experiment of an experiment type is received. A first representation of the data is stored in a format defined according to the plurality of variable types. A second representation of the data, derived from the first representation, is presented in a format defined according to the set of variable definitions. The variable definition template is referenced in the pre-defined experiment class. The data includes a plurality of values corresponding to variables defined in the set of variable definitions.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: May 1, 2007
    Assignee: Symyx Technologies, Inc.
    Inventor: David R. Dorsett, Jr.
  • Patent number: 7210332
    Abstract: A sensor and methods for making and using the same in which a mechanical resonator is employed, comprising a resonator portion for resonating in a fluid without the substantial generation of acoustic waves; and an electrical connection between the resonator portion for oscillating and a source of an input signal; wherein the portion for resonating, the electrical connection or both includes a base material and a performance-tuning material that is different from the base material.
    Type: Grant
    Filed: March 19, 2004
    Date of Patent: May 1, 2007
    Assignee: Symyx Technologies, Inc.
    Inventors: Oleg Kolosov, Leonid Matsiev, David Padowitz
  • Patent number: 7207211
    Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate monitoring the response of a resonator holding a sample and correlating the response with mass change in the samples.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: April 24, 2007
    Assignee: Symyx Technologies, Inc.
    Inventors: Eric D. Carlson, Oleg Kolosov, Leonid Matsiev
  • Patent number: 7205161
    Abstract: Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: April 17, 2007
    Assignee: Symyx Technologies, Inc.
    Inventors: Gerrit Klaerner, Didier Benoit, Dominique Charmot, Srinivas Nomula, Marcelo Eduardo Piotti, Laura T. Mazzola
  • Publication number: 20070077663
    Abstract: An apparatus and method for injection of one or more chemical components into a reaction chamber are disclosed. The apparatus includes a reaction chamber for receiving one or more libraries in a fixed position relative to the chamber and configured to form a sealed enclosure. An injection manifold is located within the reaction chamber and selectively movable relative to the libraries. The injection manifold is configured for receiving at least one fluid transfer line coupled to an external source for injection of one or more chemical components into the reaction chamber.
    Type: Application
    Filed: November 27, 2006
    Publication date: April 5, 2007
    Applicant: Symyx Technologies, Inc.
    Inventors: Christopher Goh, Keith Hall, Thomas Boussie, Vince Murphy, Trevor Frank, William Chandler, Lynn Van Erden
  • Publication number: 20070077657
    Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing.
    Type: Application
    Filed: March 24, 2006
    Publication date: April 5, 2007
    Applicant: Symyx Technologies, Inc.
    Inventors: Eric Carlson, Peijun Cong, William Chandler, Henry Chau, Earl Danielson, Peter Desrosiers, Robert Doolen, Luping Wu, C. Ramberg, Thomas Crevier, Ralph Nielsen, Colin Masui, John Varni
  • Patent number: 7199809
    Abstract: Computer-implemented methods, programs and apparatus for generating a library design for a combinatorial library of materials. A library design includes a set of sources representing components to be used in preparing the combinatorial library, destinations replying arrangements of cells and mappings, defining one or more distribution patterns for assigning components to cells in the destination arrangement or arrangements. Mappings include gradients and sets of user-defined equations, and are used to calculate the amount of on components to be assigned to a cell or cells in an arrangement. A library design can also include one or more process parameters defined to vary over time or across a plurality of destination cells. The invention outputs a data file defining the library design, including electronic data representing the sources, the destinations and the mapping, in a format suitable for implementing manually or using automated material handling apparatus.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: April 3, 2007
    Assignee: Symyx Technologies, Inc.
    Inventors: Steven D. Lacy, Eric W. McFarland, Adam L. Safir, Stephen J. Turner, Lynn Van Erden, Pei Wang
  • Publication number: 20070052970
    Abstract: An improved method and assembly, wherein the method generally includes the steps of providing a coated or uncoated sensor element having an exposed sensing surface; attaching the sensor element to a platform so that the exposed sensing surface is spaced from the platform; and optionally applying a protective layer over the platform while maintaining the sensing surface as exposed. The assembly includes a resonator having a free portion with a sensing surface is incorporated onto a platform, components of the sensor are physically shielded from harsh operating conditions, the requisite space is maintained between the free portion of the resonator and the platform, and the sensing surface of the resonator remains exposed for sensing.
    Type: Application
    Filed: March 19, 2004
    Publication date: March 8, 2007
    Applicant: Symyx Technologies, Inc.
    Inventors: Oleg Kolosov, Leonid Matsiev, John Varni, G. Dales, Olaf Ludtke, Dirk Wullner, Andreas Buhrdorf, Heiko Dobrinski
  • Publication number: 20070050092
    Abstract: Systems, methods and apparatus for designing a process to be performed at regions of an experiment library, the process involving the application of components at the library regions. Components are associated with regions of the experiment library. Each of the components represents a material or process parameter to be applied at the regions. A plurality of experiment stages are defined, each having one or more associated event types that are selected from predetermined event types and define a start condition for the corresponding stage. For each of the library regions, the components are associated with one or more of the experiment stages. A plurality of component profiles are generated, which represent processes to be performed at the various regions, and which describe the application over time of one or more of the components associated with a corresponding region or regions according to the associated experiment stages.
    Type: Application
    Filed: August 14, 2006
    Publication date: March 1, 2007
    Applicant: Symyx Technologies, Inc.
    Inventors: Kirk Kenyon, Eric Low, Adam Safir
  • Publication number: 20070042259
    Abstract: A fuel cell catalyst comprising platinum, titanium and tungsten. In one or more embodiments, the concentration of platinum is less than 60 atomic percent, and/or the concentration of titanium is at least 20 atomic percent, and/or the concentration of tungsten is at least 25 atomic percent.
    Type: Application
    Filed: June 7, 2004
    Publication date: February 22, 2007
    Applicants: Symyx Technologies, Inc., Honda Giken Kogyo Kabushiki Kaisha
    Inventors: Qun Fan, Peter Strasser, Alexander Gorer, Martin Devenney, Ting He, Hiroyuki Oyanagi, Daniel Giaquinta, Kenta Urata, Hiroichi Fukuda, Konstantinos Chondroudis, Keith Cendak
  • Patent number: 7179442
    Abstract: A method and catalysts and fuel processing apparatus for producing a hydrogen-rich gas, such as a hydrogen-rich syngas are disclosed. According to the method a CO-containing gas, such as a syngas, contacts a water gas shift (“WGS”) catalyst, in the presence of water, preferably at a temperature of less than about 450° C. to produce a hydrogen-rich gas, such as a hydrogen-rich syngas. Also disclosed is a water gas shift catalyst formulated from: a) at least one of Rh, Ni, Pt, their oxides and mixtures thereof, b) at least one of Cu, Ag, Au, their oxides and mixtures thereof; and c) at least one of K, Cs, Sc, Y, Ti, Zr, V, Mo, Re, Fe, Ru, Co, Ir, Pd, Cd, In, Ge, Sn, Pb, Sb, Te, La, Ce, Pr, Nd, Sm, Eu, their oxides and mixtures thereof. Another disclosed catalyst formulation comprises Rh, its oxides or mixtures thereof, Pt, its oxides or mixtures thereof and Ag, its oxides or mixtures thereof.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: February 20, 2007
    Assignees: Honda Giken Kogyo Kabushiki Kaisha, Symyx Technologies, Inc.
    Inventors: Alfred Hagemeyer, Raymond E. Carhart, Karin Yaccato, Peter Strasser, Michael Herrmann, Robert K. Grasselli, Christopher James Brooks, Cory Bernard Phillips
  • Publication number: 20070037696
    Abstract: A composition for use as a catalyst in, for example, a fuel cell, the composition comprising platinum, palladium and titanium, or an oxide, carbide and/or salt of one or more of platinum, palladium and titanium, wherein the sum of the concentrations of platinum, palladium and titanium, including an oxide, carbide and/or salt thereof, is greater than about 90 atomic percent.
    Type: Application
    Filed: January 23, 2006
    Publication date: February 15, 2007
    Applicants: Symyx Technologies, Inc., Honda Giken Kogyo Kabushiki Kaisha
    Inventors: Alexander Gorer, Peter Strasser, Qun Fan, Konstantinos Chondroudis, Daniel Giaquinta, Keith Cendak, Hiroyuki Oyanagi, Kenta Urata
  • Publication number: 20070037039
    Abstract: A composition for use as a catalyst in, for example, a fuel cell, the composition comprising platinum, copper and tungsten, or an oxide, carbide and/or salt of one or more of platinum, copper and tungsten, wherein the sum of the concentrations of platinum, copper and tungsten, or an oxide, carbide and/or salt thereof, is greater than 90 atomic percent.
    Type: Application
    Filed: December 21, 2005
    Publication date: February 15, 2007
    Applicants: Symyx Technologies, Inc., Honda Giken Kogyo Kabushiki Kaisha
    Inventors: Konstantinos Chondroudis, Alexander Gorer, Peter Strasser, Martin Devenney, Qun Fan, Daniel Giaquinta, Keith Cendak, Hiroyuki Oyanagi, Kenta Urata
  • Patent number: 7172732
    Abstract: An apparatus and method for synthesis and screening of materials are disclosed. According to one aspect of the present invention, a parallel batch reactor for effecting chemical reactions includes a pressure chamber, and a plurality of reaction wells. Each of the reaction wells is in isolatable fluid communication with the pressure chamber such that during a first pressurizing stage of operation, each of the reaction wells can be simultaneously pressurized through common fluid communication with the pressure chamber, and such that during a second reaction stage of operation, each of the reaction wells can be fluidically isolated from at least one other of said plurality of reaction wells.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: February 6, 2007
    Assignee: Symyx Technologies, Inc.
    Inventors: Lynn Van Erden, William H. Chandler, Jr.
  • Patent number: 7169731
    Abstract: A method for forming a supported metal-containing powder. The method comprises forming a dispersion of a particulate support in a solution, which comprises a solvent and a dissolved metal. Heat is removed from the dispersion to precipitate the dissolved metal from the solution onto the particulate support. Preferably, enough heat is removed to freeze the solution. Also, the heat is removed is preferably removed from the dispersion by contacting a container containing the dispersion with a cryogenic liquid. After precipitating the dissolved metal onto the particulate support, the particulate support is separated from the solution, preferably by freeze-drying, to yield the supported metal-containing powder, which comprises the particulate support and a precipitated metal thereon.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: January 30, 2007
    Assignees: Symyx Technologies, Inc., Honda Giken Kogyo Kabushiki Kaisha
    Inventors: Konstantinos Chondroudis, Martin Devenney, Alexander Gorer
  • Publication number: 20070017291
    Abstract: Fluid sensor methods and systems adapted for monitoring and/or controlling distillation operations in fluidic systems, such as batch distillation operations or continuous distillation operations, are disclosed. Preferred embodiments are directed to process monitoring and/or process control for unit operations involving endpoint determination of a distillation, for example, as applied to a liquid-component-switching operation (e.g., a solvent switching operation), a liquid-liquid separation operation, a solute concentration operation, a dispersed-phase concentration operation, among others.
    Type: Application
    Filed: March 31, 2006
    Publication date: January 25, 2007
    Applicant: Symyx Technologies, Inc.
    Inventors: Stephen Cypes, Mark Uhrich, Eric Carlson, Oleg Kolosov, David Padowitz, James Bennett, Leonid Matsiev
  • Patent number: 7166470
    Abstract: A combinatorial method for discovering or optimizing materials is disclosed. The method uses solution-based components that are mixed and dispensed into regions on a substrate for drying and/or heat-treating. The drying and/or heat-treating produces materials that can be tested for a desired property.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: January 23, 2007
    Assignee: Symyx Technologies, Inc.
    Inventors: Daniel M. Giaquinta, Martin Devenney, Keith A. Hall, Isy Goldwasser
  • Publication number: 20070007372
    Abstract: Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.
    Type: Application
    Filed: September 11, 2006
    Publication date: January 11, 2007
    Applicant: Symyx Technologies, Inc.
    Inventors: Claus Lugmair, Alfred Hagemeyer, Lynn Van Erden, Anthony Volpe, David Lowe, Yumin Liu
  • Publication number: 20070010396
    Abstract: The present invention is directed to a composition for use as a catalyst in, for example, a fuel cell, the composition comprising platinum and copper, wherein the concentration of platinum is greater than 50 atomic percent and less than about 80 atomic percent, and further wherein the composition has a particle size which is less than 35 angstroms. The present invention is further directed to various methods for preparing such a composition.
    Type: Application
    Filed: August 18, 2004
    Publication date: January 11, 2007
    Applicants: Honda Giken Kogyo Kabushiki Kaisha, Symyx Technologies, Inc.
    Inventors: Daniel Giaquinta, Peter Strasser, Alexander Gorer, Martin Devenney, Hiroyuki Oyanagi, Kenta Urata, Hiroichi Fukuda, Keith Cendak, Konstantinos Chondroudis
  • Patent number: 7160534
    Abstract: A method and catalysts and fuel processing apparatus for producing a hydrogen-rich gas, such as a hydrogen-rich syngas are disclosed. According to the method, a CO-containing gas, such as a syngas, contacts a platinum-free ruthenium-cobalt water gas shift (“WGS”) catalyst, in the presence of water and preferably at a temperature of less than about 450° C., to produce a hydrogen-rich gas, such as a hydrogen-rich syngas. Also disclosed is a platinum-free ruthenium-cobalt water gas shift catalyst formulated from: a) Ru, its oxides or mixtures thereof; b) Co, Mo, their oxides or mixtures thereof; and c) at least one of Li, Na, K, Rb, Cs, Ti, Zr, Cr, Fe, La, Ce, Eu, their oxides and mixtures thereof. The WGS catalyst may be supported on a carrier, such as any one member or a combination of alumina, zirconia, titania, ceria, magnesia, lanthania, niobia, zeolite, perovskite, silica clay, yttria and iron oxide. Fuel processors containing such water gas shift catalysts are also disclosed.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: January 9, 2007
    Assignees: Honda Giken Kogyo Kabushiki Kaisha, Symyx Technologies, Inc.
    Inventors: Alfred Hagemeyer, Raymond E. Carhart, Karin Yaccato, Michael Herrmann, Andreas Lesik, Christopher James Brooks, Cory Bernard Phillips