Patents Assigned to Syntex (U.S.A.)
  • 1-(Naphthyl-n-propyl)imidazole derivatives
    Patent number: 4293561
    Abstract: Compounds of the formula ##STR1## wherein Z is C.sub.1 and C.sub.4 alkoxymethylene, hydroxymethylene, esterified hydroxymethylene, carbonyl, or ketal-protected carbonyl, and the pharmaceutically acceptable acid addition salts thereof, are useful as anticonvulsant and anti-secretory agents.
    Type: Grant
    Filed: March 9, 1979
    Date of Patent: October 6, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Dental scaler having scaling tip with rounded edge work surfaces particularly suitable for circular or ellipsoidal patterns of vibration
    Patent number: 4283175
    Abstract: A powered dental scaler is disclosed of a type which drives a vibrating scaling tip in a circular or ellipsoidal pattern of motion. A scaling tip having working surfaces provided by the edges of an elongated, curved element which has a cross-sectional configuration in the shape of a multi-sided figure, e.g., a triangle or a diamond, is particularly useful with a scaler having this type of vibrational pattern. Each of the longitudinal edges has a radius of curvature in the range of about 0.001 inch to about 0.005 inch. The free end of the scaler work tool preferably terminates in rounded or ball-shaped configurations, and the working surfaces can be joined along inactive edges by a convex surface to provide "safe" surfaces. The absence of sharp edges or points on the scaler tool work surfaces substantially reduces the likelihood of damage to tooth dentin, cementum or gums.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: August 11, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: John E. Nash
  • 3-Oxo-4-halo-16.beta.-methylandrost-4-ene 17.beta.-carboxylic acids and esters
    Patent number: 4278669
    Abstract: Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17.beta.-carboxylic acids (and esters thereof) substituted at the 4-position with a fluoro or chloro, optionally substituted at the 6- position with fluoro or chloro and at 16.beta. with methyl are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9.alpha. position with fluoro, chloro or bromo; substituted at the 11 with a keto, a beta-hydroxy or a beta-chloro (the latter only when there is a 9.alpha.-chloro); when there is a 17.alpha.-hydroxy (or an ester).
    Type: Grant
    Filed: August 29, 1979
    Date of Patent: July 14, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Francisco S. Alvarez
  • 1-[(Substituted-naphthyl)ethyl]-imidazole derivatives
    Patent number: 4277486
    Abstract: Compounds of the formula ##STR1## wherein m is the integer 1, 2 or 3; R is independently selected from the group C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, halo, trifluoromethyl and hydroxy when m is the integer 1, 2 or 3 and methylenedioxy when m is the integer 2; Z is hydroxymethylene, esterified hydroxymethylene, alkoxymethylene, alkylthiomethylene, carbonyl, or ketal-, thioketal- or hemithioketal- protected carbonyl, and the pharmaceutically acceptable acid addition salts thereof, are useful as anticonvulsants, anti-secretory agents and spermatocides.
    Type: Grant
    Filed: March 9, 1979
    Date of Patent: July 7, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Contraceptive methods employing 1-substituted imidazole derivatives
    Patent number: 4277475
    Abstract: 1-Substituted imidazole derivatives exhibit spermatostatic and spermatocidal activity and are useful for contraceptive purposes both in male and female mammals.
    Type: Grant
    Filed: January 11, 1979
    Date of Patent: July 7, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Brian H. Vickery
  • 4-Halo steroids
    Patent number: 4273770
    Abstract: Certain pregn-4-ene-3,20-diones or pregn-1,4-diene-3,20-diones 4-substituted with a fluoro or chloro are useful as topical anti-inflammatory steroids. These compounds are substituted at 9.alpha. with hydrogen, fluoro, chloro or bromo; at 6.alpha. with hydrogen, fluoro or chloro; at the 11 position with a keto, a .beta.-hydroxy or a .beta.-chloro (the latter only when there is a 9.alpha.-chloro); at 16.alpha., 17.alpha.-positions with isopropylidenedioxy or at 16.alpha.- (or 16.beta.) with methyl when 17.alpha. is hydroxy (or an ester); and at the 21-position with mono-fluoro, chloro, bromo, hydroxy or alkanoyloxy of 2-6 carbons or difluoro, dichloro, dihydroxy or dimethoxy.
    Type: Grant
    Filed: August 20, 1979
    Date of Patent: June 16, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Francisco S. Alvarez
  • Process for preparing flunisolide
    Patent number: 4273710
    Abstract: A unique crystalline form of flunisolide is prepared by crystallizing flunisolide from a solution of an alkanol of three or four carbon atoms, e.g. n-butanol, containing 0.2 to 5%, preferably 1.0 to 4.0% by volume water.
    Type: Grant
    Filed: May 16, 1980
    Date of Patent: June 16, 1981
    Assignee: Syntex Corporation
    Inventors: Richard E. Jones, Jacquelyn A. Smithers
  • Derivatives of thienyl- and furyl-substituted N-butyl and N-phenyl imidazoles
    Patent number: 4272545
    Abstract: The compounds of the present invention are represented by the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are optionally substituted furyl or thienyl the substituents independently selected from the group halo, C.sub.1 to C.sub.6 alkyl and C.sub.1 to C.sub.6 alkoxy or optionally substituted phenyl the substituents independently selected from the group halo, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy and trifluoromethyl; X is oxygen or sulfur; m is the integer 0; and n is the integer 2 or 3; and the antimicrobial acid addition salts thereof, with the proviso that when either R.sup.1 or R.sup.2 is said optionally substituted phenyl the other R.sup.1 or R.sup.2 is said optionally substituted furyl or thienyl.The compounds are useful for combatting fungi, bacteria and protozoa. They also have spermatocidal and spermatostatic activity.
    Type: Grant
    Filed: February 2, 1979
    Date of Patent: June 9, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Abrasive dental tool
    Patent number: 4270903
    Abstract: A dental tool for generating a relatively smooth surface on tooth enamel comprises an elongated shank with an operative end and an end adapted to engage a chuck of a dental handpiece. Any cross-section of the operative end perpendicular to the shank's longitudinal axis is circular with a diameter of less than 0.140 inch. Adjacent, continuous annular grooves extend around the operative end, each groove being defined by a pair of inwardly sloping side surfaces intersecting with each other at least about 0.010 inch from the shank's longitudinal axis and forming an included angle of 60.degree. to 150.degree. between the side surfaces. An abrasive material, such as diamond grit, having a particle size of less than 0.006 inch covers at least a portion of each surface.
    Type: Grant
    Filed: September 17, 1979
    Date of Patent: June 2, 1981
    Assignee: Syntex Inc.
    Inventor: John E. Nash
  • Polymeric compositions and hydrogels formed therefrom
    Patent number: 4267295
    Abstract: The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.
    Type: Grant
    Filed: February 9, 1979
    Date of Patent: May 12, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Paul M. Gallop, Donald R. Korb
  • Thio etianic acid derivatives
    Patent number: 4263289
    Abstract: Certain 16.beta.-methyl-3-oxoandrost-4-ene and 16.beta.-methyl-3-oxoandrosta-1,4-diene 17.beta.-thiocarboxylic acid esters are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 6.alpha.-position with fluoro or chloro; optionally substituted at the 9.alpha. position with fluoro, chloro or bromo; substituted at the 11 position with a keto, a .beta.-hydroxy or a .beta.-chloro (the latter only when there is a 9.alpha.-chloro); and substituted with 17.alpha.-hydroxy (or an ester thereof).
    Type: Grant
    Filed: August 31, 1979
    Date of Patent: April 21, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: John A. Edwards
  • 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives
    Patent number: 4261995
    Abstract: Certain 1,4,5,6-tetrahydropyrimidine compounds which are substituted with an amino, amido or carbamate at the 2-position, with an optionally substituted phenyl at the 5-position or at the 4-position when there is no alkyl at the 1-position and optionally a lower alkyl at the 1-position when the phenyl is at the 5-position are useful as CNS agents and as antihypertensives.
    Type: Grant
    Filed: August 31, 1979
    Date of Patent: April 14, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Klaus Weinhardt, Michael Marx
  • 17.beta.-thiocarboxylic acid esters of 3-oxo-4-halo-16.beta.-methylandrost-4-enes
    Patent number: 4261984
    Abstract: Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17.beta.-thiocarboxylic acid esters substituted at the 4-position with a fluoro or chloro, optionally substituted at the 6- position with fluoro or chloro and at 16.beta. with methyl are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9.alpha. position with fluoro, chloro or bromo; substituted at the 11 with a keto, a beta-hydroxy or a beta-chloro (the latter only when there is a 9.alpha.-chloro); when there is a 17.alpha.-hydroxy (or an ester).
    Type: Grant
    Filed: August 29, 1979
    Date of Patent: April 14, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Francisco S. Alvarez
  • 4-Halo etianic acids and derivatives thereof
    Patent number: 4261986
    Abstract: Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17.beta.-carboxylic acids and esters substituted at the 4-position with a fluoro or chloro and optionally substituted at the six position with fluoro or chloro are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9.alpha.-position with fluoro, chloro or bromo; substituted at the 11 with a keto, a .beta.-hydroxy or a .beta.-chloro (the latter only when there is a 9.alpha.-chloro); substituted at 16.alpha. (or 16.beta.) with methyl or hydrogen, and at 17.alpha. with hydroxy or an ester.
    Type: Grant
    Filed: November 19, 1979
    Date of Patent: April 14, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Francisco Alvarez
  • Vibratory device with fluid transport means
    Patent number: 4260380
    Abstract: An air-driven dental scaler is disclosed having water transport means for delivering water to a scaling type work tool. The water transport means comprises a tube coaxially disposed within a vibratable hollow shaft. The water tube is supported at one end within a resilient support assembly which provides a water seal between the coaxially disposed vibratable shaft and water transport tube. The water seal assembly is positioned forwardly of a vibrational node characteristic of a standing wave created during operation of the dental scaler. An axial force exerted on the water seal assembly during vibration of the vibratable shaft improves the efficacy of the water seal between the shaft and the water transport tube. The single, resilient support for the water transport tube provides for quick replacement of the water tube in the event of clogging of the tube by mineral deposits or sediment.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: April 7, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: John E. Nash
  • Long acting depot injectable formulations for LH-RH analogues
    Patent number: 4256737
    Abstract: The biological activity of super agonist analogues of LH-RH is extended for long periods of time by incorporation of such analogues in a vehicle comprising an oil of vegetable origin and a gelling agent, preferably an aluminum mono-fatty acid ester. Pharmaceutical compositions thus formed are suitable for depot injection.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: March 17, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: John J. Nestor, Brian H. Vickery
  • Naphthoquinone anti-psoriatic agents
    Patent number: 4255405
    Abstract: The 2,3-diesters of 6-substituted-2,3-dihydroxy-1,4-naphthoquinones exhibit useful anti-psoriatic activity in mammals.
    Type: Grant
    Filed: May 29, 1979
    Date of Patent: March 10, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Gordon H. Jones, John Young
  • Dental bur wrench tool
    Patent number: D259362
    Type: Grant
    Filed: September 29, 1978
    Date of Patent: May 26, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Richard P. Lewis
  • Dental chair
    Patent number: D260703
    Type: Grant
    Filed: January 19, 1979
    Date of Patent: September 15, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Harold B. Pearson
  • Dental handpiece
    Patent number: D261032
    Type: Grant
    Filed: February 28, 1979
    Date of Patent: September 29, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: N. Dominic Marucci, Arthur A. Knopp