Abstract: The invention at hand concerns a device for supporting the patient in panoramic X-ray radiography. The device has a certain head supporting equipment to support the patient's head in order to keep it in a fixed position during the X-ray radiography. The device also has equipment for placing the patient's head in the right position for radiography. These make it possible to move the X-ray machine in relation to the head supporting equipment, so that the patient's head can be placed in the appropriate position in relation to the X-ray machine.
Abstract: Stable compositions of PGE-type compounds are achieved by dissolving those compounds in carbonate diester solvents which may contain water up to the solubility limit of the carbonate diester.
Abstract: A solution for cleaning, storing or wetting contact lenses which comprises a poly(oxyethylene)-poly(oxypropylene) substituted ethylenediamine surfactant having a molecular weight between 1,600 and 27,000; a germicidal agent; a viscosity builder; a tonicity agent; a sequestering agent and water.
Abstract: The 17-butyrate, 17-benzoate, 17,21-methyl orthobutyrate, 17,21-methyl orthobenzoate, and 17,21-dibutyrate esters of cloprednol (6-chloro-11.beta., 17.alpha., 21-trihydroxy-pregna-1,4,6-triene-3,20-dione) are useful as topical, anti-inflammatory steroids.
Type:
Grant
Filed:
March 9, 1978
Date of Patent:
April 6, 1982
Assignee:
Syntex (U.S.A.) Inc.
Inventors:
John H. Fried, Denis J. Kertesz, Michael Marx
Abstract: Certain 1,4,5,6-tetrahydropyrimidine compounds which are substituted with an amino, amido or carbamate at the 2-position, with an optionally substituted phenyl at the 5-position or at the 4-position when there is no alkyl at the 1-position and optionally a lower alkyl at the 1-position when the phenyl is at the 5-position are useful as CNS agents and as antihypertensives.
Abstract: Compounds useful as anticonvulsant agents, antifungals and antibacterials are represented by the formula ##STR1## wherein R.sup.1 is phenyl optionally substituted by one or more substituents selected from the group consisting of halo, lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms and trifluoromethyl; Z is ethylene or propylene optionally substituted by one or more lower alkyl groups of one to four carbon atoms; m is 1, 2, 3 or 4 and n is 0, 1, 2 or 3 with the proviso that the sum of m and n is 2, 3 or 4; and the pharmaceutically acceptable acid addition salts thereof.The ketone intermediates useful in preparing compounds of formula (I) also have anticonvulsant activity.
Abstract: Novel peptides of the formula: ##STR1## wherein: A, A' and A" are each independently Gly, D-Ala, D-Leu, or D-Trp, wherein A may optionally be N-alkylated or N-acylated;B is Pro, .DELTA..sup.3 -Pro, Thz, or diMeThz;C and C' are each independently Thr, Ser, Val, or alloThr;D is Glu, Gln, Asp, or Asn;R is hydrogen, or is lower alkyl or lower acyl, substituted for one of the hydrogens on the .epsilon.-amino group of the lysyl residue;X is Cys, Ala, ABU, or Cys(Me); andY is selected from the group consisting of hydroxy, Pro, Pro-Leu, and Pro-Leu-Met, -NH.sub.2, ProNH.sub.2, Pro-LeuNH.sub.2 and Pro-leu-MetNH.sub.2 ;and the pharmaceutically acceptable salts thereof, are useful for increasing immunologic competence. Methods for preparation of the peptides are also described.
Type:
Grant
Filed:
December 22, 1980
Date of Patent:
March 16, 1982
Assignee:
Syntex (U.S.A.) Inc.
Inventors:
Abraham White, deceased, John J. Nestor, Gordon H. Jones, Pamela M. Burton
Abstract: Nonapeptide and decapeptide analogs of LH-RH of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein: V is tryptophyl, phenylalanyl or 3-(1-naphthyl)-L-alanyl;W is tyrosyl, phenylalanyl or 3-(1-pentafluorophenyl)-L-alanyl;X is a D-amino acid residue of the formula: ##STR2## wherein R is a heterocyclic aryl containing radical selected from the group consisting of radicals represented by the following structural formulas: ##STR3## wherein A and A' are independently selected from the group consisting of hydrogen, lower alkyl, chlorine, and bromine, and G is selected from the group consisting of oxygen, nitrogen, and sulfur;Y is leucyl, isoleucyl, nor-leucyl or N-methyl-leucyl;Z is glycinamide or --NH--R.sup.1, wherein:R.sup.1 is lower alkyl, cycloalkyl, fluoro lower alkyl or ##STR4## wherein R.sup.2 is hydrogen or lower alkyl,are disclosed. These compounds exhibit potent LH-RH agonist properties.
Type:
Grant
Filed:
June 23, 1980
Date of Patent:
March 9, 1982
Assignee:
Syntex (U.S.A.) Inc.
Inventors:
John J. Nestor, Gordon H. Jones, Brian H. Vickery
Abstract: An air-driven dental scaler is disclosed having water transport means associated with the tool assembly for delivering water to a scaling type work tool. The water transport means comprises a tube disposed within a hollow connector body and extending between a water plenum at one end of the connector body to the other end of the connector body, whereat the scaling type work tool is attached. The water transport tube has an internal diameter of greater than 0.010 inch and a surface roughness smoother than 25 micro-inches to minimize clogging of the tube by mineral deposits or sediment. The independent fluid path permits the use of hard, martensitic stainless steels for the work tool and softer, corrosion-resisting austenitic stainless steels for the water transport tube. The water transport means delivers a controlled quantity of water to the work tool and the water is atomized by the vibratory movement of the tool.
Abstract: 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles having the general formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted phenyl, and optionally substituted phenyl lower alkyl;R.sup.3 is hydrogen, alkyl, or optionally substituted phenyl lower alkyl;n is an integer equal to 0, 1 or 2;with the proviso that R.sup.1, R.sup.2 and R.sup.3 cannot all be hydrogen and/or alkyl; and the pharmaceutically acceptable acid addition salts thereof, are useful as antidepressants.
Type:
Grant
Filed:
December 3, 1980
Date of Patent:
February 9, 1982
Assignee:
Syntex (U.S.A.) Inc.
Inventors:
Arthur F. Kluge, Arthur M. Strosberg, Roger Whiting, George A. Christie
Abstract: The method of making plastic lenses ready for fitting to the contour of the wearer's eye comprising supporting a blank of plastic at one end for rotation about a predetermined axis, turning the blank down to a predetermined diameter, making an annular face cut at the distal end of the blank of predetermined radial width, making a spherically concave base cut at said distal end of predetermined depth relative to said annular face cut, reversing the blank end-for-end, making a first spherically convex cut at said end of the blank of a predetermined radius such that the distance between the inner and outer surfaces is of a predetermined thickness and making a flange cut at the marginal edge of the outer convex surface of lesser radius of curvature; and apparatus for carrying out the method.
Abstract: Benzene ring substituted benzimidazole-2-carbamate derivatives represented by the formula: ##STR1## where R is a lower alkyl group having 1 to 4 carbon atoms; ##STR2## is a 5, 6, 7 or 8 membered heterocyclic ring containing 1 or 2 hetero atoms; the ##STR3## substitution being at the 5(6)-position; and the pharmaceutically acceptable salts thereof.The compounds are useful as pesticides, particularly as anthelmintic and antifungal agents.
Abstract: An articulating headrest for a dental chair having a unidirectional locking means is described. The locking means comprises a locking plate engageable with a pivotable shaft connected to a headrest support means. The locking means is adapted to one-handed operation by an operator and permits unhindered forward rotational movement of the headrest about the support means in order to prevent accidental jamming of the headrest against an object during downward movement of the dental chair.
Abstract: Certain 16.beta.-methyl-3-oxoandrost-4-ene and 16.beta.-methyl-3-oxoandrosta-1,4-diene 17.beta.-thiocarboxylic acid esters are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 6.alpha.-position with fluoro or chloro; optionally substituted at the 9.alpha. position with fluoro, chloro or bromo; substituted at the 11 position with a keto, a .beta.-hydroxy or a .beta.-chloro (the latter only when there is a 9.alpha.-chloro); and substituted with 17.alpha.-hydroxy (or an ester thereof).
Abstract: A dental wrench is described having a structure which permits application of differing torques to the bur securing collet of a dental handpiece and the end cap of the turbine housing in a single wrench assembly. The wrench combines a shaft, for engaging the bur securing collet, supported rotatively in a frame member and secured to a support member which has means for engaging the end cap of the turbine housing. Interlocking means are provided between the support member and the frame member so that the wrench can be rotated as a unitary assembly to secure or remove the end cap of a turbine housing. The interlocking means are releaseable so that the shaft can be rotated independently within the frame member to secure or remove a dental bur in or from the collet of the handpiece housing.
Abstract: 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles having the general formula: ##STR1## wherein R.sup.1, and R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, and alkyl, and wherein n is an integer equal to 0, 1 or 2, and the pharmaceutically acceptable acid addition salts thereof, are useful as antidepressants.
Type:
Grant
Filed:
September 10, 1980
Date of Patent:
November 24, 1981
Assignee:
Syntex (U.S.A.) Inc.
Inventors:
Arthur F. Kluge, Arthur M. Strosberg, Roger Whiting, George Christie
Abstract: Compounds of the formula ##STR1## and the pharmaceutically acceptable, non-toxic salts thereof, wherein: R is hydrogen, lower alkyl, or benzyl;X is a substitution for hydrogen at any position in the benzene ring and is selected from the group consisting of lower alkyl, lower alkoxyl, benzyl and halo;m is an integer from 0 to 4; andn is an integer from 0 to 2;are novel. These compounds have been shown to be .alpha..sub.2 blockers, and are, therefore, anti-depressants.
Type:
Grant
Filed:
December 3, 1980
Date of Patent:
November 17, 1981
Assignee:
Syntex (U.S.A.) Inc.
Inventors:
Arthur F. Kluge, Arthur M. Strosberg, Roger Whiting, George A. Christie
Abstract: This process relates to the synthesis of unsaturated aliphatic esters useful as insect sex attractants, including gossyplure, the insect sex pheromone of the pink bollworm moth, Pectinophora gossypiella, and intermediates therefor. The process utilizes a cyclic phosphonium (Wittig) reagent.
Abstract: 4,5-Dihydro-2-lower alkoxycarbonylamino-4-phenyl imidazoles and substituted phenyl derivatives thereof lower the blood pressure in a human being when administered at low doses.