Patents Assigned to Synthesis (U.S.A.)
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Patent number: 9809546Abstract: The present invention provides a low-toxic and high-recovery industrial process for synthesizing an optically active diamine derivative represented by formula (D), the process comprising the steps of: (a) mixing a compound represented by formula (A) and a compound represented by formula (C) in organic solvents and secondary amine; (b) reaction under heating; (c) cooling and adding water to the mixed solution, allowing it to crystallize to obtain the compound represented by formula (D).Type: GrantFiled: May 12, 2016Date of Patent: November 7, 2017Assignee: Chungwha Chemical Synthesis & Biotech Co., Ltd.Inventors: Tzu-Chiang Lu, Chien-Yi Chen, Ching-Shuen Cheng, Chin-Cheng Mai
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Patent number: 9651496Abstract: A rare earth (RE) downconverting phosphor composition may contain two or more lanthanide materials each having a host and at least one downconverting emitter. Each lanthanide material emits a detectable electromagnetic radiation emission peak at an intensity, which is proportional to the amount of emitter present, upon excitation with an absorbable electromagnetic radiation, the emitted radiation having a lower energy, i.e., a longer wavelength than the absorbable radiation. One or more ratios of the intensities of the emitted detectable electromagnetic radiation may be used to uniquely identify the composition. Alternatively, the RE downconverting phosphor composition may contain a lanthanide material having a host and at least two emitters. The lanthanide material emits at least two different detectable electromagnetic radiation emission peaks each at an intensity upon excitation with an absorbable electromagnetic radiation, the emitted radiation having a lower energy, i.e.Type: GrantFiled: October 31, 2014Date of Patent: May 16, 2017Assignee: Parallel Synthesis TechnologiesInventors: Robert W. Haushalter, Robert C. Haushalter
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Patent number: 9610572Abstract: The invention concerns the ruthenium complexes of the formula 1: acting as pre(catalysts) in the reaction of metathesis of olefins, as well as a method for their production, and their usage.Type: GrantFiled: November 14, 2013Date of Patent: April 4, 2017Assignee: Apeiron Synthesis Spolka AkcyjnaInventors: Karol Grela, Stefan Czarnocki
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Patent number: 9579625Abstract: A fluid processing assembly includes a lumen for receiving at least one inlet stream and dispensing a primary product stream, and an energizing device for supplying energy to an energizable portion of the lumen. A primary product collection assembly is in fluid communication with the lumen for receiving the primary product stream. The energizable portion is positioned exterior to the primary product collection assembly. A pressurized gas source is downstream of the lumen. The pressurized gas source supplies pressurized gas to the primary product collection assembly for pressurizing at least a portion of the primary product collection assembly and the lumen.Type: GrantFiled: September 20, 2013Date of Patent: February 28, 2017Assignee: Total Synthesis Ltd.Inventors: Michael Organ, Debasis Mallik
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Patent number: 9533937Abstract: The invention concerns use of metal scavengers of the formula (1), wherein the variables are as defined in the description of the invention, for removal of ruthenium residues, compounds, or complexes thereof, from the post-reaction mixtures, from the products of reactions catalyzed with ruthenium complexes, as well as from organic compounds contaminated with ruthenium.Type: GrantFiled: June 24, 2014Date of Patent: January 3, 2017Assignee: Apeiron Synthesis S.A.Inventors: Grzegorz Szczepaniak, Stefan J. Czarnocki, Krzysztof Skowerski
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Patent number: 9532935Abstract: A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility as a tooth whitening composition and is applied to the teeth in need of whitening, and then removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.Type: GrantFiled: September 23, 2014Date of Patent: January 3, 2017Assignees: A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Corium International, Inc.Inventors: Parminder Singh, Gary W. Cleary, Sri Mudumba, Mikhail M. Feldstein, Danir F. Bayramov
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Patent number: 9527026Abstract: A fluidized bed reactor including a reaction vessel, which contains a conical gas distribution grid, a first venturi connected to the bottom of the gas distribution grid, and a classifier connected to the bottom of the first venturi; a fine ash particle collection system; and a fine ash particle conveyor system. Also disclosed is a method for recycling fine ash particles, the method including separating the fine ash particles from an exit gas stream, and using a transport gas to deliver the fine ash particles into the classifier.Type: GrantFiled: March 14, 2014Date of Patent: December 27, 2016Assignee: Synthesis Energy Systems, Inc.Inventor: John Winter
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Patent number: 9443181Abstract: The present invention relates generally to encoding samples. More specifically, it relates to barcodes and compositions involving upconverters and methods including them. In a composition aspect of the invention, a composition comprising two or more lanthanide materials is provided. Each lanthanide material comprises a host, an absorber, and an emitter, and the materials emit detectable electromagnetic radiation upon excitation with absorbable electromagnetic energy. One or more relative ratios of emission intensities uniquely identify the composition.Type: GrantFiled: July 29, 2014Date of Patent: September 13, 2016Assignee: Parallel Synthesis TechnologiesInventor: Robert C. Haushalter
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Publication number: 20160250185Abstract: The invention relates to medicine, in particular S-Phenotropil ((S)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide) containing pharmaceutical compositions and their use in control of body mass gain.Type: ApplicationFiled: October 20, 2014Publication date: September 1, 2016Applicant: Latvian Institute of Organic SynthesisInventors: Ivars KALVINS, Liga ZVEJNIECE, Larisa VARACEVA, Aleksandrs CERNOBROVIJS, Antons LEBEDEVS, Maija DAMBROVA, Baiba SVALBE, Edgars LIEPINS
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Patent number: 9403860Abstract: Disclosed herein is a general method for the preparation of complexes containing a quaternary onium group in an inert ligand. Some of these complexes may be represented by formula 1: Methods for the preparation of complexes of formula 1, the preparation of intermediates and the use of complexes of formula 1 in metathesis reactions and a method for conducting an olefin metathesis reaction are also described.Type: GrantFiled: February 27, 2013Date of Patent: August 2, 2016Assignee: Apeiron Synthesis S.A.Inventors: Krzysztof Skowerski, Lukasz Gulajski, Michal Bieniek, Stefan Czarnocki, Grzegorz Szczpaniak, Celina Wierzbicka
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Patent number: 9371345Abstract: Disclosed herein is a general method for the preparation of complexes containing a quaternary onium group in an inert ligand. Some of these complexes may be represented by formula 1: Methods for the preparation of complexes of formula 1, the preparation of intermediates and the use of complexes of formula 1 in metathesis reactions and a method for conducting an olefin metathesis reaction are also described.Type: GrantFiled: June 4, 2015Date of Patent: June 21, 2016Assignee: Apeiron Synthesis S.A.Inventors: Krzysztof Skowerski, Lukasz Gulajski, Michal Bieniek, Stefan Czarnocki, Grzegorz Szczpaniak, Celina Wierzbicka
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Patent number: 9353411Abstract: The invention relates to a composition, method and apparatus for determining the sequence of a nucleic acid strand utilizing a pH-sensing agent.Type: GrantFiled: March 30, 2012Date of Patent: May 31, 2016Assignee: Parallel Synthesis TechnologiesInventor: Robert C. Haushlater
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Patent number: 9273087Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.Type: GrantFiled: January 19, 2015Date of Patent: March 1, 2016Assignee: Prime Synthesis, Inc.Inventors: Marc L. Rothstein, Dianne M. Rothstein, Dan P. Lee
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Patent number: 9259504Abstract: Hydrogel compositions are provided (a) that have a continuous hydrophobic phase and a discontinuous hydrophilic phase, (b) that have a discontinuous hydrophilic phase and a continuous hydrophilic phase, or (c) that are entirely composed of a continuous hydrophilic phase. The hydrophobic phase, if present, is composed of a hydrophobic polymer, particularly a hydrophobic pressure-sensitive adhesive (PSA), a plasticizing elastomer, a tackifying resin, and an optional antioxidant. The discontinuous hydrophilic phase, if present, is composed of a crosslinked hydrophilic polymer, particularly a crosslinked cellulosic polymer such as crosslinked sodium carboxymethylcellulose. For those hydrogel compositions containing a continuous hydrophilic phase, the components of the phase include a cellulose ester composition or an acrylate polymer or copolymer, and a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding thereto.Type: GrantFiled: May 10, 2013Date of Patent: February 16, 2016Assignees: A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Corium International, Inc.Inventors: Gary W. Cleary, Shoreh Parandoosh, Mikhail M. Feldstein, Anatoly E. Chalykh, Nicolai A. Platè, Valery G. Kulichikhin
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Patent number: 9242021Abstract: An adhesive composition is described which has improved initial tack, long-term adhesion, water uptake and translucency characteristics and may be prepared by melt extrusion. Uses of these compositions are also described, for example, their use as blister pads and wound dressings.Type: GrantFiled: August 4, 2005Date of Patent: January 26, 2016Assignees: Corium International, Inc., A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of SciencesInventors: Parminder Singh, Gary W. Cleary, Valery G. Kulichikhin, Sergey Antonov
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Publication number: 20150313862Abstract: The invention discloses the use of pharmaceutical compositions containing 3-(2,2,2-trimethylhydrazinium)propionate dihydrate and pharmaceutically acceptable salts thereof for trimethylamine N-oxide level decrease in a body.Type: ApplicationFiled: October 24, 2013Publication date: November 5, 2015Applicant: Latvian Institute of Organic SynthesisInventors: Ivars KALVINS, Maija DAMBROVA, Edgars LIEPINS, Elina MAKAROVA, Osvalds PUGOVICS, Solveiga GRINBERGA, Eduards SEVOSTJANOVS
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Patent number: 9149461Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.Type: GrantFiled: December 13, 2012Date of Patent: October 6, 2015Assignee: FOB Synthesis, Inc.Inventors: Woo-Baeg Choi, Ewa Gruszecka-Kowalik, Hyung-Yeul Joo, Shuangpei Liu, Shuli Mao, Yongfeng Li, Deog-Il Kim
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Patent number: 9144552Abstract: A rapidly dissolving film is provided for delivery of an active agent to a moist body surface, e.g., mucosal tissue. The film comprises a film-forming binder, a rapidly dissolving polymeric material, and an active agent.Type: GrantFiled: February 3, 2014Date of Patent: September 29, 2015Assignees: A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Corium International, Inc.Inventors: Parminder Singh, Sri Mudumba, Danir F. Bayramov, Valery G. Kulichikhin, Mikhail M. Feldstein, Gary W. Cleary
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Patent number: 9127140Abstract: An adhesive composition is provided that is water-insoluble yet water-absorbent, i.e., capable of absorbing up to 15 wt. % water or more. The composition in composed of a film-forming hydrophilic polymer with at least one linear segment having a plurality of recurring polar groups along the polymer backbone, a complementary multifunctional polymer with a plurality of recurring functional groups that non-covalently bind to the polar groups on the film-forming polymer, and plasticizer. A method for manufacturing the adhesive composition is provided as well.Type: GrantFiled: December 23, 2013Date of Patent: September 8, 2015Assignees: A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Corium International, Inc.Inventors: Mikhail M. Feldstein, Danir F. Bayramov, Mikhail Borisovich Novikov, Valery G. Kulichikhin, Nicolai A. Platè, Gary W. Cleary, Parminder Singh
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Patent number: RE45666Abstract: A method for preparing hydrophilic pressure sensitive adhesive (PSA) compositions is provided, wherein the method enables preparation of adhesives having a particular, optimized degree of adhesion. That is, the hydrophilic PSA is comprised of a hydrophilic polymer and a complementary short-chain plasticizing agent, wherein the hydrophilic polymer and plasticizing agent are capable of hydrogen bonding or electrostatic bonding to each other and are present in a ratio that optimizes key characteristics of the adhesive composition, such as adhesive strength, cohesive strength and hydrophilicity. The adhesive is useful in a wide variety of contexts, e.g., as a biomedical adhesive for application to the skin or other body surface, and as such finds utility in the areas of drug delivery systems (e.g., topical, transdermal, transmucosal, iontophoretic), medical skin coverings and wound healing products and biomedical electrodes.Type: GrantFiled: February 6, 2013Date of Patent: September 8, 2015Assignees: A.V. Topchiev Institute of Petrochemical Synthesis, Corium International, Inc.Inventors: Mikhail M. Feldstein, Nicolai A. Platè, Anatoly E. Chalykh, Gary W. Cleary