Patents Assigned to Syracuse University
  • WATER-TRIGGERED SHAPE MEMORY OF PCL-PEG MULTIBLOCK TPUS
    Publication number: 20140135454
    Abstract: Water-triggered shape memory polymers based on poly(?-caprolactone) (PCL) and poly(ethylene glycol) (PEG) multiblock hybrid thermoplastic polyurethanes. Urethane linkages were formed through the addition reaction between isocyanate groups of the lysine methyl-ester diisocyanate (LDI) and the hydroxyl groups of either (PEG) or PCL diol.
    Type: Application
    Filed: November 13, 2013
    Publication date: May 15, 2014
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Patrick T. Mather, Gu Xinzhu
  • Rare earth elements separation using phosphorus based adsorbent
    Patent number: 8721893
    Abstract: The present invention relates to methods for the separation of rare earth elements from aqueous solutions and, more particularly, to the separation of lanthanides (e.g., neodymium(III)) from aqueous solutions using an organo phosphorus functionalized adsorbent.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: May 13, 2014
    Assignee: Syracuse University
    Inventors: Lawrence Tavlarides, Hyung-Jun Park
  • Metabolically engineered for enhanced production of sialic acid
    Patent number: 8722365
    Abstract: A metabolically engineered E. coli strain which produces sialic acid and a method of making said strain. In the engineered E. coli cells, the nanT (sialic acid transporter) and nanA (sialic acid adolase) genes are inactivated, and the neuC and neuB genes of sialic acid biosynthesis in Neisseria meningitidis group B are introduced and overexpressed in the nanT? nanA? E. coli cell. In addition, the glucosamine synthase gene, glmS, of E. coli is co-overexpressed with neuB and neuC.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: May 13, 2014
    Assignee: Syracuse University
    Inventors: Christopher N. Boddy, Benjamin R. Lundgren
  • Method for inhibiting the formation of SET1 family core complexes
    Patent number: 8715678
    Abstract: Disclosed in this specification is a method for inhibiting the formation of vertebrate SET1 family core complexes. A guanidinium-containing molecule is used to competitively inhibit the binding of the N-SET region of a SET1 protein to WDR5, thus inhibiting the formation of the SET1 family core complex. The guanidinium-containing molecule may be, for example, an arginine-containing peptide.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: May 6, 2014
    Assignee: Syracuse University
    Inventors: Michael S. Cosgrove, Anamika Patel
  • System and method for the heterologous expression of polyketide synthase gene clusters
    Patent number: 8709781
    Abstract: A system and method for heterologous expression of polyketide biosynthetic pathways from streptomycetes hosts in Escherichia coli for the production and discovery of secondary metabolites. Genomic DNA from Streptomyces rimosus encoding the oxytetracycline biosynthetic pathway is inserted into the genome of the surrogate host Myxococcus xanthus. The M. xanthus transcriptional machinery recognizes and uses the streptomycetes promoter regions to express the biosynthetic enzymes. Co-expression in E. coli of S. rimosus oxytetracycline biosynthesis enzymes and M. xanthus ?54, a key piece of the M. xanthus transcriptional machinery, enables E. coli to recognize and use the promoters from the S. rimosus oxytetracycline biosynthetic pathway, facilitating production of oxytetracycline.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: April 29, 2014
    Assignee: Syracuse University
    Inventors: Christopher N. Boddy, Anthony Garza
  • Waterborne Shape Memory Polymer Coatings
    Publication number: 20140099848
    Abstract: The present invention relates to shape memory polymers and waterborne coating materials and, more particularly, to waterborne shape memory polymer coatings.
    Type: Application
    Filed: October 5, 2012
    Publication date: April 10, 2014
    Applicant: Syracuse University
    Inventors: Patrick Mather, Kazuki Ishida, Pamela Wilson
  • Integrated supercritical technology to produce high quality biofuels and power
    Patent number: 8690967
    Abstract: The present invention relates to a power generation system, which includes a source of a seed oil, a source of alcohol, and a reactor in communication with the source of seed oil and the source of alcohol. The reactor produces a biofuel product. The system has a power source that operates on a biofuel energy source to produce heated exhaust. The power source is in communication with the reactor to utilize a portion of the biofuel product as its biofuel energy source. The system has a heat transfer mechanism that transfers heat from the exhaust manifold to the reactor. The power source also converts mechanical power into electrical power. Also disclosed is a system that involves extraction of oil from an oilseed product. A method of extracting oil from an oilseed product, a method of making a transesterified seed oil, and a method of making a biofuel are also disclosed, as are products obtained thereby.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: April 8, 2014
    Assignee: Syracuse University
    Inventors: Gheorghe Anitescu, Lawrence L. Tavlarides
  • Stimuli-responsive product
    Patent number: 8683798
    Abstract: Embodiments of a product such as a stimuli-responsive product can comprise a shape memory component and a nanofiber component that forms a fibrous microstructure or network. The resulting product can be responsive to stimuli, such as electrical stimuli, in a manner that cause the product to deform, deflect, and rebound. In one embodiment, the product can comprise an epoxy and a continuous non-woven nanofiber, the combination of which provides a product with enhanced actuation speed.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: April 1, 2014
    Assignee: Syracuse University
    Inventors: Patrick Mather, Xiaofan Luo
  • Metal-citrate transporter antigen from and uses thereof
    Patent number: 8673320
    Abstract: The present invention relates to an isolated antigen from Streptomyces coelicolor that is useful for developing, inter alia, vaccines against pathogenic bacteria of humans and animals. The present invention also relates to vaccines and antibodies developed using the isolated antigen. The present invention also relates to methods of using the antigen, vaccines, and antibodies of the present invention to detect, treat, and prevent infection and diseases associated with pathogenic bacteria.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: March 18, 2014
    Assignee: Syracuse University
    Inventors: Robert P. Doyle, Joshua J. Lensbouer
  • Method for secure communication over heterogeneous networks
    Patent number: 8671277
    Abstract: A method for securely communicating a message from a source node to a destination node over a network can comprise the steps of converting the message into an initial bit sequence, pre-processing the initial bit sequence by a modulo adding the initial bit sequence with an auxiliary key message, constructing a reduced network, determining a multitude of paths from the source node to the destination node over the reduced network, constructing an expanded bit sequence comprising the initial bit sequence and the auxiliary key message, splitting the expanded bit sequence into two or more parts, transmitting the two or more parts of the expanded bit sequence over two or more paths of the multitude of paths, re-assembling the two or more parts of the expanded bit sequence at the destination node, and recovering the initial bit sequence by modulo adding the expanded bit sequence with the auxiliary key message.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: March 11, 2014
    Assignee: Syracuse University
    Inventors: Jin Xu, Biao Chen
  • SENSOR FOR SENSING SUBSTANCES IN AN ENVIRONMENT
    Publication number: 20140060191
    Abstract: There is set forth herein a sensor for sensing of substances. The sensor can include a sensing crystal oscillator and a reference crystal oscillator. The sensing crystal oscillator and the reference crystal oscillator can be arranged in a phase locked loop so that the oscillators oscillate at a common frequency. The sensor can be configured so that there is a baseline phase differential between the oscillation frequencies of the sensing crystal oscillator and the reference crystal oscillator. Detectable substances accumulating on the sensing crystal oscillator will induce a phase shift between output frequencies of the reference oscillator and the sensing crystal oscillator to allow for highly sensitive sensing of substances in small concentrations.
    Type: Application
    Filed: September 4, 2013
    Publication date: March 6, 2014
    Applicant: Syracuse University
    Inventor: Fritz H. Schlereth
  • System and method for controlling bacterial cells with weak electric currents
    Patent number: 8663914
    Abstract: A system and method for treating bacterial cells with an electrochemical process, alone or in combination with antibiotics. Weak electric currents are used to effectively eliminate bacterial cells. The method may be adapted for novel therapies of chronic infections and strategies to control persistent biofouling. The system has broad spectrum applications in treating chronic and drug resistant infections, such as those caused by Pseudomonas aeruginosa, Mycobacterium tuberculosis and methicillin resistant Staphylococcus aureus, and may also be used for decontamination of medical devices.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: March 4, 2014
    Assignee: Syracuse University
    Inventors: Dacheng Ren, Mi Zhang, Tagbo Niepa, Jeremy Gilbert
  • Squarylated Lactones Inhibitors for Bacterial Biofilm Formation
    Publication number: 20140039195
    Abstract: A library of unnatural squarylated homoserine lactones (SHLs) and squarylated lactones that bear potential to modulate biofilm formation in Gram negative bacteria. At low concentrations (˜200 ?M), these small molecules inhibit biofilm formation of E. coli. Moreover, these compounds are not toxic up to 300 ?M and do not significantly attenuate E. coli growth. The SHLs have potential to disperse established biofilm and demonstrate an enhanced reduction (˜50%) of the maximum biofilm thickness by use of SHLs during biofilm growth.
    Type: Application
    Filed: August 1, 2013
    Publication date: February 6, 2014
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Yan-Yeung Luk, Sri Kamesh Narasimhan, Eric Falcone
  • System and method for delivery of DNA-binding chemotherapy drugs using nanoparticles
    Patent number: 8632789
    Abstract: System and method for loading the front line anticancer drug, doxorubicin (DOX) onto DNA-capped gold nanoparticles whose duplex DNA has been designed for specific DOX intercalation. Since each AuNP contains about 108 high affinity drug sites, this design allows for a high local DOX concentration on the particle. Drug binding was confirmed by monitoring the increase in DNA melting temperature, the shift in the plasmon resonance maximum, and the increase in the NP hydrodynamic radius as a function of [DOX]/[DNA] ratio. The feasibility of the nanoparticles as a drug delivery system was demonstrated by showing that particle-bound DOX could be transferred to a target DNA.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: January 21, 2014
    Assignee: Syracuse University
    Inventors: Mathew Maye, James Dabrowiak, Colleen Alexander
  • NONINVASIVE, CONTINUOUS IN VITRO SIMULTANEOUS MEASUREMENT OF TURBIDITY AND CONCENTRATION
    Publication number: 20140016117
    Abstract: The invention provides a method of determining turbidity and concentration simultaneously a sample by irradiating the sample with a single incident wavelength and simultaneously measuring wavelength shifted (IE) and unshifted (EE) light emitted. A relative volume of light emitted from two phases may be determined, wherein the two phases comprise a first Rayleigh and Mie scattering and fluorescent phase associated with suspended particles, and a second, non-scattering but fluorescent phase associated with suspending solution. Volumes of the phases and/or concentrations of specific fluorophores or Raman active species are calculated from the volume of light emitted by the first phase relative to the total volume of light emitted from the first and second phases.
    Type: Application
    Filed: September 16, 2013
    Publication date: January 16, 2014
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Joseph Chaiken, Jerry Goodisman
  • Controlling Bacterial Persister Cells with Host Immune Factors
    Publication number: 20140010778
    Abstract: The present invention relates to host immune factors and antibiotics and, more particularly, to a system and method for controlling and reducing the antibiotic tolerance of bacterial persister cells with host immune factors.
    Type: Application
    Filed: May 20, 2013
    Publication date: January 9, 2014
    Applicant: Syracuse University
    Inventors: Dacheng Ren, Geetika S. Choudhary, Xiangyu Yao
  • Power and Refrigeration Cascade System
    Publication number: 20130312435
    Abstract: The present invention relates generally to combined power and cooling generation systems, and, more particularly, to a combined power and refrigeration cascade system (“PARCS”) that includes an electric power system (PS) that produces both electric power and medium-to-high-grade waste heat that can be used for providing the cooling and power supply needs of data centers and the like.
    Type: Application
    Filed: July 11, 2013
    Publication date: November 28, 2013
    Applicant: SYRACUSE UNIVERSITY
    Inventor: H. Ezzat Khalifa
  • Multi-solution bone cements and methods of making the same
    Patent number: 8575274
    Abstract: The present invention relates to bone cements and, more particularly, to multi-solution bone cements and methods for making the same. An embodiment of the present invention provides multi-solution bone cements which include cross-linked PMMA beads, thereby providing for a significant increase in the polymer-to-monomer (P:M) ratio. Another embodiment of the present invention provides cross-linked PMMA beads which are surface modified with unsaturated carbon double bonds. A further embodiment of the present invention provides multi-solution bone cements made with PMMA-PMMA spherical brush polymers.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: November 5, 2013
    Assignee: Syracuse University
    Inventors: Julie M. Hasenwinkel, Imad K. Merkhan, Jeremy L. Gilbert
  • System and method for controlling bacterial persister cells with weak electric currents
    Patent number: 8569027
    Abstract: A system and method for treating persister cells with an electrochemical process, alone or in combination with antibiotics. Weak electric currents are used to effectively eliminate persister cells and the efficacy can be further improved through synergistic effects with antibiotics. The method may be adapted for novel therapies of chronic infections and strategies to control persistent biofouling. The system has a broad spectrum applications in treating chronic and drug resistant infections, such as those caused by Pseudomonas aeruginosa, Mycobacterium tuberculosis and methicillin resistant Staphylococcus aureus, and may also be used for decontamination of medical devices.
    Type: Grant
    Filed: August 10, 2010
    Date of Patent: October 29, 2013
    Assignee: Syracuse University
    Inventors: Dacheng Ren, Mi Zhang, Tagbo Niepa, Jeremy Gilbert
  • Method of covalently modifying proteins with organic molecules to prevent aggregation
    Patent number: 8569463
    Abstract: A system and method for preventing protein aggregation is developed by covalent modification of proteins with organic molecules that can preserve the native protein folding. Proteins are covalently modified with sugar alcohols or cyclodextrins (organic Kosmotropes) or other small molecule drugs by water-driven bioorganic reactions in water. In the water-driven bioorganic reactions, the reagent is stable in water and can modify lysine residues or cysteine residue of a protein at physiological conditions with high yield and fast rate. Proteins and antibodies will be modified by non-natural sugar alcohols. As a result, the efficacy of protein drugs (reduction in aggregation and enzymatic degradation, and increase in blood stream life time) may be improved.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: October 29, 2013
    Assignee: Syracuse University
    Inventors: Yan-Yeung Luk, DaWei Cui, Debjyoti Bandyopadhyay, Deepali Prashar, Preeti Sejwal, Karen Simon