Patents Assigned to Syracuse University
  • Shape Memory Assisted Self-Healing Polymers Having Load Bearing Structure
    Publication number: 20150343749
    Abstract: A structural shape memory assisted self-healing polymer formed by laminating thin layers of an ionomer, such as a member of the poly(styrene sulfonate) (PSS) family of ionomers, with a WEGP-type SMP, such as atactic poly(styrene) (PS) with molecular weight in the 200 kDa range (or alternatively poly(methyl methacrylate) (PMMA)) in combination with polycyclooctene (PCO). The self-healing polymer may also comprise an interpenetrating, immiscible polymer network (IPN) based on a blend of polystyrene and polystyrene sulfonate (PSS).
    Type: Application
    Filed: January 15, 2014
    Publication date: December 3, 2015
    Applicant: Syracuse University
    Inventors: Patrick MATHER, Wenyang PAN
  • Non-propulsive miniature power device based on solid oxide fuel cell and combustion-driven thermal transpiration pump
    Patent number: 9196916
    Abstract: The present invention relates to a power device and, more particularly, to a non-propulsive thermal transpiration based micro single-chamber solid oxide fuel cell (SCSOFC) power device.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: November 24, 2015
    Assignee: Syracuse University
    Inventors: Jeongmin Ahn, Paul D. Ronney
  • Production of maleic or fumaric acid from levulinic acid
    Patent number: 9187399
    Abstract: The production of maleic acid and fumaric acid (or the anhydride form of either, maleic anhydride) via gas-phase, oxidative cleavage of levulinic acid in a single packed bed reactor over a reducible oxide catalyst. The production may be carried out in an initial mixing vessel into which levulinic acid is continuously charged and mixed with both inert (He, N2, Ar, etc.) and oxidizing (O2, air, etc.) gases. The feed stream can then be safely heated to reaction temperature, which generally ranges from 200-500° C., without initiating polymerization, in a second stage preheater that thermally equilibrates the gaseous mixture of LA, O2, and inert diluent and fed to a third stage catalytic reactor for final processing.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: November 17, 2015
    Assignee: Syracuse University
    Inventors: Jesse Quentin Bond, Anargyros Chatzidimitriou
  • Corrugated and nanoporous microstructures and nanostructures, and methods for synthesizing the same
    Patent number: 9176140
    Abstract: A method of synthesizing corrugated and nanoporous microspheres including the steps of synthesizing substantially smooth spherical microspheres, and controlled wet-etching of the substantially smooth spherical microspheres with a basic solution having a pH above 10.00 is provided. The microspheres can include, for example, silica microspheres or titania microspheres of various sized diameters of between 50 nm and 600 nm. The basic solution can include an aqueous potassium cyanide solution or an aqueous potassium hydroxide solution. Methods of using the corrugated and nanoporous microspheres described herein are also provided.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: November 3, 2015
    Assignee: Syracuse University
    Inventors: Tewodros Asefa, Yan-Li Shi
  • Non-amphiphile-based water-in-water emulsion and uses thereof
    Patent number: 9150788
    Abstract: The present invention relates to a non-amphiphile-based water-in-water emulsion composition. The non-amphiphile-based water-in-water emulsion composition includes a water-soluble polymer, a non-amphiphilic lyotropic mesogen encapsulated by the water-soluble polymer; and water. In one embodiment, the non-amphiphilic lyotropic mesogen includes, without limitation, a lyotropic chromonic liquid crystal, and more specifically disodium cromoglycate (DSCG). In another embodiment, the water-soluble polymer can include, without limitation, a polyacrylamide, a polyol, a polyvinylpyrrolidone, a polysaccharide, or a water-soluble fluoride-bearing polymer. The present invention also relates to a porous hydrogel made with the use of the non-amphiphile-based water-in-water emulsion. The present invention further relates to using the emulsion and hydrogel for various applications.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: October 6, 2015
    Assignee: Syracuse University
    Inventors: Yan-Yeung Luk, Karen A. Simon, Dacheng Ren
  • WATER-TRIGGERED ORIGAMI WITH A POLYMERIC WEB
    Publication number: 20150267328
    Abstract: A hydrophobic polymer fiber mat that folds in response to the application of water along a predetermined fold line, thereby allowing for the formation of three-dimensional objects strictly through the targeted application of water. The fiber mat is preferably formed by electrospinning a polymer, such as poly(vinyl acetate), to form mats with average fiber diameters ranging from 0.5 to 1 ?m.
    Type: Application
    Filed: March 24, 2015
    Publication date: September 24, 2015
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Patrick T. Mather, Jaimee Marie Robertson, Amir Torbati
  • Fluorescence assay for ghrelin O-acyltransferase activity
    Patent number: 9115383
    Abstract: An assay to detect ghrelin O-acyltransferase activity using an acrylodan-labeled peptide mimic of ghrelin that provides for high-throughput screening for ghrelin O-acyltransferase inhibitors and detection via high performance liquid chromatography. Alternatively, the assay for ghrelin acylation may be based on a synthetic peptide substrate that mimics the N-terminal sequence of ghrelin and has an environmentally-sensitive fluorophore attached to its C-terminal amino acid through chemoselective ligation.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: August 25, 2015
    Assignee: Syracuse University
    Inventors: James Hougland, Joseph Darling
  • Method and apparatus for separation of pharmaceutical materials on the basis of their density
    Patent number: 9089850
    Abstract: Systems and methods for separating particles of pharmaceutically active materials, based on differences in density.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: July 28, 2015
    Assignee: Syracuse University
    Inventors: Bruce S. Hudson, Jack Melton
  • PRODUCTION OF MALEIC OR FUMARIC ACID FROM LEVULINIC ACID
    Publication number: 20150191411
    Abstract: The production of maleic acid and fumaric acid (or the anhydride form of either, maleic anhydride) via gas-phase, oxidative cleavage of levulinic acid in a single packed bed reactor over a reducible oxide catalyst. The production may be carried out in an initial mixing vessel into which levulinic acid is continuously charged and mixed with both inert (He, N2, Ar, etc.) and oxidizing (O2, air, etc.) gases. The feed stream can then be safely heated to reaction temperature, which generally ranges from 200-500° C., without initiating polymerization, in a second stage preheater that thermally equilibrates the gaseous mixture of LA, O2, and inert diluent and fed to a third stage catalytic reactor for final processing.
    Type: Application
    Filed: January 8, 2015
    Publication date: July 9, 2015
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Jesse Quentin Bond, Anargyros Chatzidimitriou
  • Multi-solution bone cements and methods of making the same
    Patent number: 9072808
    Abstract: The present invention relates to bone cements and, more particularly, to acrylic-based orthopedic bone cements, their use in spinal applications, and methods for making the same. An embodiment of the present invention provides multi-solution bone cements which include cross-linked PMMA beads, a linear polymer, and a monomer with various polymer to monomer ratios, and polymer bead to linear polymer ratios. The bone cement can include a polymer to monomer (P:M) ratio of between about 1:1 and 1.4:1, and can also include a polymer bead to linear polymer ratio of between about 1:1 and 2:1. Another embodiment of the present invention provides the use of a radiopacifier in the bone cement composition, such as ZrO2, in increasing concentrations.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: July 7, 2015
    Assignee: Syracuse University
    Inventors: Danieli C. Rodrigues, Jeremy L. Gilbert, Julie M. Hasenwinkel
  • COBALT PYROPHOSPHATE COMPLEXES AND METHODS OF TREATMENT USING THE COMPLEXES
    Publication number: 20150158897
    Abstract: The present invention involves pyrophosphate bridged coordination complexes and the treatment of medical conditions, such as cancer, using the pyrophosphate bridged coordination complexes. The pyrophosphate bridged coordination complexes include four new compounds, [Co(phen)2(H2P2O7)].4H2O(1.4H2O), [Ni(phen)2(H2P2O7)].8H2O(2.8H2O), [Cu(phen)(H2O)(H2P2O7)], and {[Cu(phen)(H2O)(P2O7)][Na2(H2O)8]}.6H2O(4.14H2O) found effective for treating cancer cells. The pyrophosphate bridged coordination complexes also include three compounds, {[Ni(phen)2]2(?-P2O7)}.27H2O (compound 11), {[Cu(phen)(H2O)]2(?-P2O7)}.8H2O (compound 12), and {[Co(phen)2]2(?-25P2O7)}.6MeOH (compound 13), (where phen is 1,10-phenanthroline), whose effectiveness in treating cancer cells was previously unknown.
    Type: Application
    Filed: February 17, 2015
    Publication date: June 11, 2015
    Applicant: SYRACUSE UNIVERSITY
    Inventor: Robert Doyle
  • Electrochemical coupling of metallic biomaterial implants for biological effect
    Patent number: 9039764
    Abstract: The invention discloses a novel method of controlling the open circuit potential (OCP) of a medical implant by coupling it with small amounts of metals having a lower OCP than the implant. Coupling of Mg to less than 1% of the surface area of a titanium implant is shown to induce cathodic polarization of the titanium that inhibits cell proliferation at the surface of the implant. Mg—Ti coupling in medical devices promises to attenuate or eliminate potential complications of surgery such as peri-implantitis and bacterial infections at the site of implantation.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: May 26, 2015
    Assignee: Syracuse University
    Inventor: Jeremy L. Gilbert
  • Butanal production using engineered
    Patent number: 9034616
    Abstract: A method of producing butanal by optimizing the growth of Streptomyces using cellulose as food source, overexpressing a key ‘gate’ enzyme in butyric acid/butyraldehyde production, and knocking out the isobutyryl-CoA synthase gene to shunt the pathway. Optionally, the produced butanal can be isolated and converted into butanol.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: May 19, 2015
    Assignee: Syracuse University
    Inventors: Robert Doyle, Joshua Lensbouer, Anthony Vortherms
  • Methods of improving detectors and classifiers using optimized stochastic resonance noise
    Patent number: 9026404
    Abstract: Apparatus and method for improving the performance of a threshold-based detector or classifier, or a generic detector or classifier and increasing the probability of detecting at least one object in an image using novel algorithms and stochastic resonance noise is provided, where a suitable dose of noise is introduced to the image data such that the performance of the above-referenced detectors or classifiers is improved without altering the detector's or classifier's parameters. Several stochastic resonance (SR) noise-based detection and classification enhancement schemes are presented. The SR noise-enhanced detection and classification schemes can improve any algorithms and systems. To implement these schemes, the only knowledge that is needed is the original input data (no matter 1D, 2D, 3D or others) and the output (detection results) of the existing algorithms and systems.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: May 5, 2015
    Assignee: Syracuse University
    Inventors: Renbin Peng, Pramod K. Varshney
  • Metal-citrate transporter antigen from and uses thereof
    Patent number: 8992921
    Abstract: The present invention relates to an isolated antigen from Streptomyces coelicolor that is useful for developing, inter alia, vaccines against pathogenic bacteria of humans and animals. The present invention also relates to vaccines and antibodies developed using the isolated antigen. The present invention also relates to methods of using the antigen, vaccines, and antibodies of the present invention to detect, treat, and prevent infection and diseases associated with pathogenic bacteria.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: March 31, 2015
    Assignee: Syracuse University
    Inventors: Robert P. Doyle, Joshua J. Lensbouer
  • Squarylated lactones inhibitors for bacterial biofilm formation
    Patent number: 8940911
    Abstract: A library of unnatural squarylated homoserine lactones (SHLs) and squarylated lactones that bear potential to modulate biofilm formation in Gram negative bacteria. At low concentrations (˜200 ?M), these small molecules inhibit biofilm formation of E. coli. Moreover, these compounds are not toxic up to 300 ?M and do not significantly attenuate E. coli growth. The SHLs have potential to disperse established biofilm and demonstrate an enhanced reduction (˜50%) of the maximum biofilm thickness by use of SHLs during biofilm growth.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: January 27, 2015
    Assignee: Syracuse University
    Inventors: Yan-Yeung Luk, Sri Kamesh Narasimhan, Eric Falcone
  • INHIBITORS TARGETING HUMAN GHRELIN O-ACYLTRANSFERASE
    Publication number: 20150018520
    Abstract: Grhelin O-acyltransferase inhibitors using a triazole linkage to incorporate aromatic and alkyl substituents to mimic the natural octanoyl group attached to ghrelin. Inhibitors include a triazole portion, an alkyl linker, and a hydrophobic aromatic group on a side chain. The hydrophobic aromatic group may include various length alkyl linkers.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 15, 2015
    Applicant: SYRACUSE UNIVERSITY
    Inventor: James Hougland
  • Method for the discovery of high-affinity, high specificity oligonucleotide and derivatized oligonucleotide sequences for target recognition
    Patent number: 8921278
    Abstract: A method is disclosed to obtain oligonucleotide sequences with high affinity to target molecules. By design, the oligonucleotides have a defined primary and secondary structure. The affinity for binding to target species is classified or quantified by assay measurements using physical measurements rather than being based primarily on separations. Targets include but are not limited to proteins, polymers, biological membranes including cells and organelles and small molecules.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: December 30, 2014
    Assignee: Syracuse University
    Inventors: Bruce S. Hudson, Philip N. Borer
  • Bioengineered protein pores
    Patent number: 8916684
    Abstract: A mutant Escherichia coli ?-barrel monomeric protein pore bioengineered to remove a lumen-occluding domain and modify some of its extracellular domains. The modified protein, FhuA ?/C?4L, forms a highly conductive pore as compared to other known pores and is capable of sensing large polypeptides and discriminating between modified protein analytes.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: December 23, 2014
    Assignee: Syracuse University
    Inventors: Liviu Movileanu, Mohammad M. Mohammad
  • Furnace with an Integrated Flame Assisted Fuel Cell for Combined Heating and Power
    Publication number: 20140363776
    Abstract: The present invention relates to a flame-assisted fuel cell (FFC) and, more particularly, to the integration of a FFC in a fuel fired furnace or boiler to enable the generation of both electricity and heat from the fuel's chemical energy, transforming the furnace/boiler into a Combined Heating and Power (CHP) system.
    Type: Application
    Filed: June 10, 2014
    Publication date: December 11, 2014
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Jeongmin Ahn, H. Ezzat Khalifa