Abstract: A hybrid laser printing (HLP) technology that utilizes ultrafast laser in sequential additive-subtractive modes to create 3D hydrogel constructs. The approach involves the synergistic use of additive crosslinking and subtractive ablation processes that are conventionally mutually exclusive. HLP can be operated at virtually any penetration depth and allow fabrication of multi-layer hydrogel constructs at micrometer resolution. HLP was used to print ready-to-use functional chips using commonly used hydrogels for potential cellular communication and migration applications. HLP was also found to be compatible with in situ printing of cell-laden hydrogel constructs. HLP makes shaping of soft hydrogels into 3D multiscale functional devices possible.

Abstract: Non-naturally occurring perinatal mesenchymal stem cells differentiated from human induced pluripotent stem cells. The differentiation medium includes an amount of SB431542, an amount of BMP-4, and an amount of PD173074 and is repeated over the course of six days period until perinatal mesenchymal stem-like cells are formed. The resulting non-naturally occurring perinatal mesenchymal stem cells exhibit the relevant characteristics of naturally occurring perinatal mesenchymal stem cells, such as the positive expression of the mesenchymal stem cell markers CD73, CD90, and CD105. The non-naturally occurring perinatal mesenchymal stem cells may be used to produce paracrine factors and similar compounds for therapeutic purposes.

Abstract: A programmable assembly of proteins into well-defined nanoworms with broadened stability regimes is disclosed. Posttranslational modifications (PTMs) were used to generate lipidated proteins with precise topological and compositional asymmetry. Using an integrated experimental and computational approach, the material properties (thermoresponse and nanoscale assembly) of these hybrid amphiphiles are modulated by their amphiphilic architecture. The judicious choice of amphiphilic architecture can be used to program the assembly of proteins into adaptive nanoworms that undergo a morphological transition (sphere-to-nanoworms) in response to temperature stimuli.

Abstract: A system for using radio frequency (RF) communication signals to extract situational awareness information thorough deep learning. Pre-processing is performed to maximally preserve discriminating features in spatial, temporal and frequency domains. A specially designed neural network architecture is used for handling complex RF signals and extracting spatial, temporal and frequency domain information. Data collection and training is used so that the learning system desensitizes from features orthogonal to the underlying classification problem.

Abstract: A conductive nanoporous membrane system has a first ion exchange membrane formed from a nanoporous substrate that is coated with a metal or carbon or conductive polymers to form a conductive membrane, a second ion exchange membrane that is also formed from a nanoporous substrate coated with a metal to form a conductive membrane is positioned in spaced relation to the first conductive membrane and coupled to a voltage source; the negatively potential membrane acts as a cation exchange membrane in the presence of an electrolyte, and the positively connected electrode behave as anodic exchange membrane in the presence of an electrolyte due to the formation of electrical double layers at the interface between metal and liquid electrolyte.

Abstract: A system and method for minimizing indoor infection risk and improving indoor air quality (IAQ) while maximizing energy savings. The system integrates occupancy detection and forecasting, outdoor weather conditions and forecasting, indoor infection risks and air quality modeling, any tunable air filtration, the clean air delivery rate, and any portable air cleaners. The system outputs the total amount of outdoor air intake, the air temperature of the supply air into the space, the supply air flow rate into the space, the operation mode of tunable air filtration/purification/disinfection, the operation mode of the in-room air cleaner, and space/room temperature set-points, and thus can serve as the central controller for an HVAC system.

Abstract: An anti-fouling surface having micron scale pillars embedded with Fe3O4 nanoparticles is designed. The pillars may be repeatedly induced to move according to a predetermined frequency, such as one that mimic that of the beating movement of natural cilia, through the application of a magnetic field. When square-shaped pillars with a height of 10 ?m, width of 2 ?m, and inter-pattern distance of 5 ?m actuated for three minutes, more than 99.9 percent of biofilm cells were detached and via gentle rinsing from the surface having the pillars. The anti-fouling surface enables effective prevention of biofilm formation and removal of established biofilms, and can be applied to a broad spectrum of polymers.

Abstract: An electrochemical biosensor based on magnetically coupled LC sensors for the rapid detection of microbial growth and sensitivity to microbials. The engineered LC sensors can be placed in 96 well plates and communicate the reading remotely with a receiver coil for signal analysis. The sensors were validated by testing the growth of Escherichia. coli, Staphylococcus. aureus, and Pseudomonas aeruginosa in the presence and absence of different antibiotics. Drug-resistant strains were used as controls. Bacterial growth was detected within 30 mins of culture inoculation, allowing rapid determination of antibiotic susceptibility at the phenotypic level. The pattern shown in the LC sensor AST is consistent with results collected with traditional optical density (OD) 600 nm measurement, additional validation was also performed with lysogeny broth (LB) dosed with fetal bovine serum (FBS). With the compatibility with 96-well plates, this rapid AST may be used for low-cost, point-of-care applications.

Abstract: A system that provides intent-oriented browsing powered by machine learning and crowdsourcing. The system allows users to enter their intents, which are then assigned to target pages via supervised learning models based on hyperlinks and contributions made by other users. The system has a prediction server that is programmed to receive hyperlinks from a website and return target hyperlinks based on known intent, a user interface for inputting user intent, and a browser programmed to connect to the intent repository and to the prediction server via a user script. The list of supported intents can grow over time based on correct page marks for intent-page mappings as well as via continuous training of machine learning models.

Abstract: A torchiere style sanitizing device for disinfecting airborne pathogens while providing aesthetic area lighting. A reversible fan exchanges air between the upper room air plume and the lower air plume by passing the air through a center disinfecting section. The disinfection section may include a linear UV-C light, reflective tube, and light trap positioned at one or both ends of the disinfection section to maximize the exposure of the air to the UV-C light and contain the UV-C light within the device. The device includes a conventional illumination source in an upper shade and can selectively provide one of more of room air flow, room air disinfection, and room illumination.

Abstract: A low-cost, low-power, stand-alone sensor platform having a visible-range camera sensor, a thermopile array, a microphone, a motion sensor, and a microprocessor that is configured to perform occupancy detection and counting while preserving the privacy of occupants. The platform is programmed to extract shape/texture from images in spatial domain; motion from video in time domain; and audio features in frequency domain. Embedded binarized neural networks are used for efficient object of interest detection. The platform is also programmed with advanced fusion algorithms for multiple sensor modalities addressing dependent sensor observations. The platform may be deployed for (i) residential use in detecting occupants for autonomously controlling building systems, such as HVAC and lighting systems, to provide energy savings, (ii) security and surveillance, such as to detect loitering and surveil places of interest, (iii) analyzing customer behavior and flows, (iv) identifying high performing stores by retailers.

Abstract: A multiple-input multiple-output (MIMO) communication system that addresses three major challenges in airborne MIMO communications, namely, antenna blockage due largely to the movement and orientation of the airborne platforms, the presence of unknown interference inherent to the intended application, and the lack of channel state information (CSI) at the transmitter. The system is implemented on a Diagonal Bell-Labs Layered Space-Time (D-BLAST) MIMO architecture and includes spatial spreading to counter antenna blockage, temporal spreading to mitigate signal to interference and noise ratio degradation due to intended or unintended interference, and a simple low rate feedback scheme to enable real time adaptation in the absence of full transmitter CSI.

Abstract: A system and method for determining the pH of tissue in vivo. A Raman spectrometer is used to collect Raman spectra from the target tissue. The Raman spectra are baseline subtracted and assessed to determine the concentration of HPO4?2 and H2PO4?1 for the purposes of calculating the pH. The approach was validate in vitro using PBS solutions of known pH. The approach was confirmed in vivo using rat and swine models by probing the immediate vicinity of a contusive spinal cord injury (SCI) in the first minutes and hours after injury. Using a dynamic analysis and the Henderson-Hasselbalch equation, the average of (N=12) noninvasive Raman-based pH measurements of CSF was 7.073±0.156 and at >95% confidence there is no statistically significant difference between the Raman-based and the physically sampled results.

Abstract: A Smart Products Lifecycle Management (sPLM) system that is built upon the smart component data model and the NPD3 process model, is enabling engineers, data scientists, and other stakeholders to collaborate on a common platform to develop smart products. The sPLM system is validated by applying it to unmanned aircraft systems (UAS) development and operations, referred to as UsPLM. The UsPLM has shared lifecycle management functions that are provided as web services and can be applied to all digital models of UAS devices, software, autonomy functions, and missions. The individual models can be versioned, tracked, and be composed with other compatible models, if needed. The rule and scoring engines embedded in the UsPLM allow building and executing configuration rules, regulation rules, and various machine-learning models. This facilitates modular UAS architecture design so that the UAS has the flexibility to be reconfigured for various mission applications.

Abstract: A patterned surface structure formed from a ferrofluidic polymer resin having a plurality of magnetic nanoparticles. The polymer resin is patterned with a magnetic field that is applied to the ferrofluidic polymer resin during curing. The ferrofluidic polymer resin may be cast over a non-magnetic planar substrate. A magnetic field is applied to the ferrofluidic polymer resin to induce a pattern in a surface of the ferrofluidic polymer resin. The patterned ferrofluidic polymer resin is then cured to form the permanently patterned surface.

Abstract: A developmental toxicity screening assay using spatially organized cardiac organoids with contracting cardiomyocytes in the center surrounded by stromal cells distributed along the pattern perimeter engineered from human induced pluripotent stem cells (hiPSCs). Cardiac organoids generated from 600 ?m-diameter circles were used as a developmental toxicity screening assay for the quantification of the embryotoxic potential of nine pharmaceutical compounds. The cardiac organoids were demonstrated as having a potential use as an in vitro platform for studying organoid structure-function relationships, developmental processes, and drug-induced cardiac developmental toxicity.

Abstract: An enzyme responsive shape memory polymer formed from a glassy, cross-linked shape memory polymer that incorporates ester bonds that are responsive to the present of an enzyme. PCL-based polyurethanes (featuring simple alternation of PCL diol and lysine-based diisocyanate) are degradable by Amano lipase PS. A non-degradable thermoplastic elastomer may be dual electrospun with a polycaprolactone based TPU with the fixing phase compressed so that the composite is ready for enzymatically triggered contraction. Alternatively, the elastomer may be a PCL copolymer-based polyurethane amorphous elastomer that is both degradable and elastomeric and put into compression so that upon enzymatic degradation of the elastomeric phase the scaffold expands.

Abstract: In an example, a computer-implemented method to structure an analytical workflow that improves reasoning based on a problem context and demonstrated abilities of each individual user may include displaying a reasoning problem to an analyst. The method may include receiving input from the analyst to identify a reasoning problem type of the reasoning problem. providing a recommended analytic approach for the reasoning problem type to the analyst. The method may include assisting the analyst in analyzing and evaluating one or more information sources relevant to the reasoning problem. The method may include guiding the analyst through a structured technique (ST) to support reasoning of the analyst in formulation of a solution to the reasoning problem. The method may include generating a report that includes the analyst's solution to the reasoning problem based on input from the analyst.

Abstract: A two-stage treatment process for destroying per- and polyfluoroalkyl substances (PFAS) in an aqueous stream. The two-stage treatment process uses a combination of multifunctional crystalline molecular sieves, such as zeolites and zeotypes, to separate PFAS from the aqueous stream, catalytically decompose and defluorinate any PFAS molecules, and generate non-toxic waste products that are safe for disposal. The first stage includes adsorption of the PFAS within one of a pair of vessels containing porous, hydrophobic, hydrothermally stable molecular sieves, dehydration of the captured PFAS on the sieves, and catalytic ozonation of the captured PFAS molecules on the dried sieves. The second stage involves catalytic decomposition and neutralization of the ozonation results with one of a pair of vessels including a zeolite-supported CaO catalyst, catalytic oxidation of any toxic CO generated by the decomposition, and an acid wash for regeneration of the spent catalyst.

Abstract: A dampening device that can be coupled to a medical implant to eliminate harmful electrical oscillations. The device includes circuity that detects harmful electrical oscillations in the implant. The device also includes circuity that generates cancelling electrical signals that counter the detected electrical oscillations. Alternatively, in a medical implant having a taper junction such as a standard hip implant, resistance welding of the taper junction just prior to surgical implanting may be performed after the appropriately dimensioned components are selected to eliminate a metal on metal interface where corrosion is most likely to occur.