Abstract: Disclosed is an analysis method for analyzing a nucleic acid sequence of a sample by using a computer, the analysis method including detecting a predetermined mutation on the basis of sequence information having been read from the nucleic acid sequence; and creating, in accordance with a disease that corresponds to the sample, a report that includes information related to efficacy of a predetermined drug that corresponds to the predetermined mutation.

Abstract: A specimen analyzer including: a measurement part configured to apply light to a measurement sample and a fluorescent dye that stains white blood cells contained in the blood specimen, detect fluorescence from the white blood cells contained in the measurement sample to which the light has been applied, and measure fluorescence signals on the basis of the detected fluorescence; an information processing part configured to generate, on the basis of the fluorescence signals, information about a distribution width of fluorescence intensities regarding a population of neutrophils contained in the measurement sample, and determine information about a degree of severity of an organ dysfunction due to an infection on the basis of the information about the distribution width of the fluorescence intensities regarding the population of neutrophils; and an output part configured to output the information about the degree of severity of the organ dysfunction due to the infection.

Abstract: A general-purpose flow cytometer capable for using a plurality of combinations of fluorescent-labeled antibodies is provided.

Abstract: A nucleic acid molecule having a nucleotide sequence encoding a chimeric antigen receptor, where the nucleic acid molecule includes a segment encoding an extracellular domain, a segment encoding a transmembrane domain, and a segment encoding an intracellular domain. The segment encoding the extracellular domain includes a nucleotide sequence encoding an antigen binding region including a light chain variable region and a heavy chain variable region, and at least three codons in a nucleotide sequence encoding framework region 3 of the light chain variable region as defined by the Chothia method are codons encoding acidic amino acid residues.

Abstract: Disclosed is a detection apparatus that transfers magnetic particles through a plurality of chambers in a cartridge which includes the plurality of chambers and a channel connecting between the plurality of chambers, and that causes the magnetic particles to carry a complex of a test substance and a labelling substance, to detect the test substance on the basis of the labelling substance in the complex. The detection apparatus includes: a rotation mechanism configured to rotate the cartridge about a rotation shaft; a magnet configured to collect the magnetic particles in the chambers; a movement mechanism configured to move the magnet in a direction different from a circumferential direction of a circle in which the rotation shaft is centered; a detector configured to detect the test substance; and a controller programmed to control the rotation mechanism and the movement mechanism so as to transfer the magnetic particles from one of the chambers to another one of the chambers.

Abstract: Disclosed is an analyzer including an analysis unit configured to analyze a specimen; a first storage part capable of storing a container capable of containing the specimen, the first storage part including an outlet that allows the container to be discharged therethrough; a second storage part capable of storing the container having been discharged through the outlet of the first storage part; a transporter configured to send out, from the second storage part, the container stored in the second storage part; and a discharge controller capable of controlling discharge of the container through the outlet of the first storage part.

Abstract: Disclosed is a specimen measurement method for measuring platelet aggregation of a specimen, and the specimen measurement method includes: automatically preparing a diluted reagent solution that contains a platelet-aggregating reagent diluted with a diluent; preparing a measurement sample that contains a predetermined concentration of the platelet-aggregating reagent, from the diluted reagent solution and the specimen; and performing optical measurement of the measurement sample.

Abstract: In a method of managing surgical instruments that are used in surgical robotic systems installed in each of facilities, that are collected, for each of which a maintenance comprising at least cleaning and sterilization is performed, and that are shipped to any one of the facilities, the method according to one or more embodiments may include storing, for each of the surgical instruments, status information regarding status of the surgical instruments in association with identification information for each of the surgical instruments, and updating the status information corresponding to a surgical instrument that has been made available for shipping by the maintenance to the status information indicating that the surgical instrument is available to be selected for shipping to any one of the facilities.

Abstract: Disclosed is a measurement apparatus that includes: a measurement unit configured to measure a control sample for quality control; a display unit; and a processing unit configured to cause the display unit to display an input screen for setting an evaluation criterion used in the quality control, and, in the measurement apparatus, the processing unit causes the display unit to display a quality control result of a test item, based on the evaluation criterion and a measurement result of the control sample.

Abstract: Disclosed is a Bst DNA polymerase comprising: (1) an amino acid sequence set forth in SEQ ID NO: 1, or (2) an amino acid sequence comprising a consensus sequence Asn-X-(Ser/Thr) (X is any amino acid residue other than a proline residue), and comprising an amino acid sequence having 80% or more identity to the amino acid sequence set forth in SEQ ID NO: 1, and having 5? to 3? DNA polymerase activity and strand displacement activity, wherein the consensus sequence comprises an N-linked sugar chain, and the N-linked sugar chain comprises three or more mannose residues.

Abstract: Disclosed is a method for evaluating cell differentiation state, including inducing pluripotent stem cells to differentiate into mesodermal cells in a liquid medium by a first differentiation treatment for inducing pluripotent stem cells to differentiate into mesodermal cells and a second differentiation treatment for inducing the mesodermal cells to differentiate into cardiomyocytes; collecting a supernatant of the liquid medium comprising cells induced to differentiate by the second differentiation treatment; and measuring miRNA-3p in miR-1/133a cluster in the supernatant, where the miRNA-3p is at least one selected from a group consisting of miR-1-3p and miR-133a-3p, and the measured value of miRNA-3p is an index of differentiation into cardiomyocytes.

Abstract: A sample measurement system includes sample measurement devices that measures samples using a first reagent and a second reagent, and a reagent supply apparatus, which includes a first piping connected to reagent containers of a first reagent container group, a first reagent reservoir that stores the first reagent transferred through the first piping, a second piping connected to reagent containers of a second reagent container group, and a second reagent reservoir that stores the second reagent transferred through the second piping. The first reagent stored in the first reagent reservoir is supplied to each of the sample measurement devices. The second reagent stored in the second reagent reservoir is supplied to each of the sample measurement devices.

Abstract: Disclosed is a method for detecting a target substance, comprising: forming on a carrier a complex comprising Wisteria floribunda lectin (WFA) and a target substance by mixing the WFA immobilized on the carrier with the target substance comprising a sugar chain that binds to the WFA in the presence of an alcohol having 1 to 7 carbon atoms consisting of carbon atoms, hydrogen atoms, and oxygen atoms; and detecting the target substance by detecting the complex.

Abstract: Disclosed is a method for analyzing blood cells. The method includes irradiating a measurement sample that contains particles stained with a fluorescent dye with at least one light, to acquire fluorescence information and scattered light information generated from the particle. The method includes classifying blood cells from the particles in the measurement sample, with reference to the fluorescence information and the scattered light information. The fluorescent dye including a halogen, an alkyl group, sulfo group, and/or a benzyl group.

Abstract: A method for analyzing blood cells includes acquiring first scattered light information, second scattered light information, and fluorescence information generated by irradiating a measurement sample that contains a particle stained with a fluorescent dye with a light of a first wavelength and a light of a second wavelength. The method includes identifying blood cells other than white blood cell from the particles in the measurement sample, with reference to the first scattered light information and the second scattered light information, and/or with reference to the first scattered light information and the fluorescence information. The method includes classifying the blood cells other than white blood cell into reticulocyte and platelet, with reference to the fluorescence information and the second scattered light information The first wavelength can be 315 nm or longer and 600 nm or shorter, and the second wavelength can be 610 nm or longer and 750 nm or shorter.

Abstract: A quality control support method for displaying a control chart of quality control related to an analyzer that measures a subject sample, the method comprising: generating a first control chart showing results of measured quality control substances by the analyzer in a first period; receiving a designation of a second period different from the first period, the second period being shorter than the first period and at least partially overlapping with the first period; generating a second control chart showing results of the measured subject samples by the analyzer in the second period; displaying the generated first control chart; and displaying the generated second control, is provided.

Abstract: Disclosed is a method for detecting platelet aggregation. The method includes acquiring first scattered light information and second scattered light information generated by irradiating a measurement sample that contains particles with a light of a first wavelength and a light of a second wavelength. The method includes acquiring information that indicates presence or absence of platelet aggregation, with reference to the first scattered light information and the second scattered light information. The first wavelength can be 315 nm or longer and 600 nm or shorter, and the second wavelength can be 610 nm or longer and 750 nm or shorter.

Abstract: The present invention is to present a status notification method for the sample analyzer. The method includes a detection step for detecting the status of the sample analyzer for analyzing the sample, and an irradiating step for irradiating light upward in accordance with the detection step.

Abstract: Disclosed is a method for displaying a result of analysis performed on a specimen containing formed components. The method includes: obtaining, from each of the formed components, measurement values of at least three parameters; displaying a screen including a three-dimensional distribution chart in which the three parameters are used as axes and the formed components are represented by dots; and hiding specific dots on the three-dimensional distribution chart or changing a display format of the specific dots, according to an operation performed by a user.

Abstract: Disclosed is a specimen measurement apparatus that includes a measurement unit configured to measure a specimen; a detector configured to detect at least one of a container that can store the specimen or a cap of the container; and a movement mechanism configured to move at least one of the container or the detector. In the specimen measurement apparatus, the detector detects at least one of the container and the cap in a state where the movement mechanism is moving the container relative to the detector.