Patents Assigned to Sysmex Corporation
  • Publication number: 20240118272
    Abstract: Disclosed is a method for measuring an activity of alkaline phosphatase contained in an extracellular vesicle in a sample, including acquiring an activity value of alkaline phosphatase contained in an extracellular vesicle in a sample using a calibrator, in which the calibrator contains a conjugate in which a polypeptide having alkaline phosphatase activity and a polypeptide including an amino acid sequence of a membrane protein present on a surface of the extracellular vesicle are covalently bound.
    Type: Application
    Filed: September 18, 2023
    Publication date: April 11, 2024
    Applicant: SYSMEX CORPORATION
    Inventors: Eiya TAMADA, Masatoshi Yanagida, Kazuto Yamashita, Elnaz Nakhael, Mami Onishi, Maria Kiriyama
  • Patent number: 11953511
    Abstract: A sample measurement system and method of transporting of racks are provided that collectively supply the consumables to the sample measurement units. The sample measurement system includes: sample measurement units that perform measurement on samples by using consumables; a setting part in which a user sets consumable racks housing the consumables; a first transport path that supplies the consumable racks set in the setting part to one of the sample measurement units; a collector that is arranged adjacent to the setting part and that collects empty racks that are emptied after being transported to at least one of the sample measurement units; and a second transport path that transports the empty racks to the collector.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: April 9, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Kouichi Masutani, Yuji Wakamiya
  • Patent number: 11946946
    Abstract: A transport system includes a sample rack configured to hold a sample and comprising a notch; a rack storage unit in which the sample rack is stored; a transport path arranged to transport the sample rack moved from the rack storage unit; and a regulating member configured to regulate movement of the sample rack from the rack storage unit toward the transport path, wherein the regulating member is provided at a position corresponding to the notch provided in the sample rack, and enters an interior of the sample rack from the notch and abuts an interior wall of the sample rack as the sample rack moves from the rack storage unit toward the transport path.
    Type: Grant
    Filed: September 16, 2022
    Date of Patent: April 2, 2024
    Assignee: SYSMEX CORPORATION
    Inventor: Kohei Oda
  • Patent number: 11946866
    Abstract: Disclosed is a fluorescence image analyzing apparatus including a light source that emits light to a sample including a plurality of cells labeled with a fluorescent dye at a target site, an imaging unit that captures a fluorescence image of each of the cells that emit fluorescence by being irradiated with the light, a fluorescence image of the cell, and a processing unit that processes the fluorescence image captured by the imaging unit to acquire a bright spot pattern of fluorescence in the fluorescence image. The processing unit selects a reference pattern corresponding to a measurement item of the sample from a plurality of reference patterns corresponding to a plurality of measurement items and generates information used for determination of the sample based on the bright spot pattern of fluorescence in the fluorescence image and the selected reference pattern.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: April 2, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Kazuhiro Yamada, Shohei Matsumoto, Yusuke Konishi
  • Patent number: 11933797
    Abstract: Disclosed is a calibration curve creation method performed by an analyzer, the calibration curve creation method including: preparing a plurality of calibrators at different dilution rates by dispensing a calibrator in a container into one or more different containers; obtaining a plurality of measurement values by measuring each of the prepared plurality of calibrators; creating a calibration curve by use of the plurality of measurement values; selecting a first measurement value to be re-measured, among the plurality of measurement values used for the calibration curve; preparing another calibrator at a dilution rate corresponding to a calibrator from which the selected first measurement value is obtained; obtaining a second measurement value by measuring the prepared another calibrator; and creating a new calibration curve by replacing the first measurement value, among the plurality of measurement values, with the second measurement value.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: March 19, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Kazuma Moriura, Hiroshi Kurono
  • Patent number: 11933796
    Abstract: Provided are a quality control method, a quality control system, a management apparatus, an analyzer, and a quality control abnormality determination method in which measurement results of both a quality control substance and a specimen are sufficiently utilized to improve the quality of quality control. The quality control method used in a management apparatus which is connected via a network to an analyzer installed in each of a plurality of facilities includes obtaining, from an analyzer in each facility via a network, first quality control information obtained by measuring an artificially generated quality control substance, and second quality control information obtained by measuring a plurality of specimens by the analyzer in each facility; and outputting information concerning quality control of an analyzer in at least one facility, based on the obtained first quality control information and second quality control information.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: March 19, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Keiji Fujimoto, Kazuhiko Matsuoka, Yasushi Hasui
  • Patent number: 11927516
    Abstract: A sample scraping method and a sample scraping device capable of efficiently scraping and collecting a biological tissue section without waste while suppressing contamination is provided. In a sample scraping method for scraping and collecting a biological tissue section held on a slide, the FFPE section held on the slide is heated, and the heated FFPE section is scraped by a blade such that the FFPE section that has been scraped off and remains on the blade is collected in a container.
    Type: Grant
    Filed: February 15, 2022
    Date of Patent: March 12, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Soichi Oue, Yutaka Maeda, Junyi Ding, Takayuki Koshihara, Hironori Kobayashi, Yasuhiro Kouchi
  • Patent number: 11927599
    Abstract: Included are: a main body including an installation part in which a cartridge housing a liquid for treating a test substance contained in a specimen is installed and a detector configured to detect the test substance treated with the liquid within the cartridge installed in the installation part; a lid part arranged rotatably on the main body about a shaft so as to open and close the installation part; a biasing part biasing the lid part in an opening direction; and a plurality of regulators each generating resistance against a biasing force in the opening direction at different timing during an opening motion of the lid part.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: March 12, 2024
    Assignees: JVCKENWOOD Corporation, SYSMEX CORPORATION
    Inventors: Masahiro Yamamoto, Shigeru Yokota, Hideki Samata, Tomoyuki Nose, Sayuri Tomoda
  • Patent number: 11921106
    Abstract: A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.
    Type: Grant
    Filed: February 18, 2022
    Date of Patent: March 5, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Takaaki Nagai, Noriyuki Narisada, Daigo Fukuma, Masanori Imazu
  • Publication number: 20240060870
    Abstract: Disclosed is an information processing method to be executed by a computer, for analysis performed by a flow cytometer capable of acquiring a test result through a test using an antibody reagent, the information processing method including: acquiring a first test result obtained through a first test performed by the flow cytometer with respect to a first specimen of a subject; acquiring a second test result obtained through a second test different from the first test with respect to a second specimen of the subject; and displaying the first test result and the second test result in association with each other.
    Type: Application
    Filed: August 11, 2023
    Publication date: February 22, 2024
    Applicant: Sysmex Corporation
    Inventors: Takashi Karino, Hideki Hirayama
  • Patent number: 11908589
    Abstract: A method of supporting an expert meeting of medical specialists to interpret genetic information, may include: accepting a test request for genetic information on a patient; extracting test progress information that is stored in association with the accepted test request and indicates progress of a test for the test request, and schedule information on a schedule of the expert meeting to interpret the genetic information obtained in the test for the test request; and displaying the extracted test progress information and the extracted schedule information on terminal devices of the medical specialists.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: February 20, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Takayuki Takahata, Tatsuru Wakimoto, Yusaku Matsuo
  • Patent number: 11901043
    Abstract: Disclosed is a sequence analysis method for analyzing nucleic acid sequence, the sequence analysis method including: obtaining a plurality of read sequences read from the nucleic acid sequence; and determining each nucleic acid sequence by aligning each read sequence with reference to a single reference sequence, wherein the reference sequence includes at least a first rearrangement sequence and a second rearrangement sequence that is different from the first rearrangement sequence.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: February 13, 2024
    Assignees: National Cancer Center, Mitsui Knowledge Industry Co., Ltd., Sysmex Corporation
    Inventors: Mamoru Kato, Hideya Kuwabara, Tomohiro Sakuma, Fumio Inoue, Kenichiro Suzuki
  • Patent number: 11894110
    Abstract: To facilitate management of the entirety of one or a plurality of clinical laboratories. This information processing apparatus is used in management of a clinical laboratory in which an analyzer configured to analyze specimens is installed. The information processing apparatus includes: a communication section configured to communicate with a terminal operable by a user; and a controller configured to control display of the terminal via the communication section. On the basis of information collected from a plurality of analyzers installed in one or a plurality of clinical laboratories and from apparatuses relevant to the analyzers, the controller causes the terminal to display a screen including an index that indicates a status of the entirety of the one or the plurality of clinical laboratories. In response to the user selecting the index displayed in the screen, the controller causes the terminal to display the selected index so as to be divided in a plurality of categories.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: February 6, 2024
    Assignee: Sysmex Corporation
    Inventors: Akio Miyauchi, Naoki Tsuro, Norio Kowata, Naoki Kai, Shirou Kuwaoka, Yukihisa Minematsu, Mark Dahlberg, Steve Postma, Chris Carrier, Jackie Guenther, Anselm Mueller
  • Patent number: 11884741
    Abstract: Disclosed is a method for producing a modified antibody, comprising: in a heavy chain of the antibody, changing at least one amino acid residue selected from the group consisting of 8th to 11th amino acid residues based on Kabat method to a cysteine residue, and changing at least one amino acid residue selected from the group consisting of 109th and 110th amino acid residues based on IMGT method to a cysteine residue; and recovering the modified antibody.
    Type: Grant
    Filed: February 22, 2021
    Date of Patent: January 30, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Tomofumi Nakada, Nobuyuki Ide
  • Publication number: 20240025047
    Abstract: Disclosed is a medical robot system including medical robots placed at different locations and a data analysis apparatus. Each of the medical robots includes a controller that transmits data on a state of operation of the medical robot to the data analysis apparatus. The data analysis apparatus includes a data analysis unit that generates a reference for determining whether or not the medical robots are normal, based on the data transmitted from the medical robots. The data analysis unit monitors the data transmitted from each of the medical robots in operation based on the reference.
    Type: Application
    Filed: October 2, 2023
    Publication date: January 25, 2024
    Applicants: SYSMEX CORPORATION, Medicaroid Corporation
    Inventors: Kaoru ASANO, Yasuhiro KOUCHI, Mitsuichi HIRATSUKA, Tetsuya NAKANISHI
  • Patent number: 11881290
    Abstract: To facilitate management of the entirety of one or a plurality of clinical laboratories. This information processing apparatus is used in management of a clinical laboratory in which an analyzer configured to analyze specimens is installed. The information processing apparatus includes: a communication section configured to communicate with a terminal operable by a user; and a controller configured to control display of the terminal via the communication section. On the basis of information collected from a plurality of analyzers installed in one or a plurality of clinical laboratories and from apparatuses relevant to the analyzers, the controller causes the terminal to display a screen including an index that indicates a status of the entirety of the one or the plurality of clinical laboratories. In response to the user selecting the index displayed in the screen, the controller causes the terminal to display the selected index so as to be divided in a plurality of categories.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: January 23, 2024
    Assignee: Sysmex Corporation
    Inventors: Akio Miyauchi, Naoki Tsuro, Norio Kowata, Naoki Kai, Shirou Kuwaoka, Yukihisa Minematsu, Mark Dahlberg, Steve Postma, Chris Carrier, Jackie Guenther, Anselm Mueller
  • Patent number: 11881318
    Abstract: A method of supporting an expert meeting of medical specialists to interpret genetic information, may include: accepting a schedule of the expert meeting; extracting the medical specialists to participate in the expert meeting, the medical specialists stored in association with the accepted schedule of the expert meeting; and transmitting the accepted schedule of the expert meeting to terminal devices of the extracted medical specialists.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: January 23, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Takayuki Takahata, Tatsuru Wakimoto, Yusaku Matsuo
  • Publication number: 20230419696
    Abstract: The present invention provides an image analysis method for generating data indicating a region of a cell nucleus in an image of a tissue or a cell. The image analysis method is a method for analyzing an image of a tissue or a cell using a deep learning algorithm of a neural network structure, and generates data indicating a region of a cell nucleus in an analysis target image by the deep learning algorithm by generating analysis data from the analysis target image including an analysis target tissue or cell, and inputting the analysis data in the deep learning algorithm.
    Type: Application
    Filed: September 7, 2023
    Publication date: December 28, 2023
    Applicant: SYSMEX CORPORATION
    Inventors: Yosuke Sekiguchi, Kazumi Hakamada, Yuki Aihara, Kohei Yamada, Kanako Masumoto, Krupali Jain
  • Publication number: 20230408381
    Abstract: Disclosed is a control method for a test system including a smear imaging unit configured to image a smear of a specimen, the control method including: preparing a plurality of the smears; sequentially storing, in a storing container capable of storing therein a plurality of the smears, the smears having been prepared; and transporting, when information about a standby situation for imaging processing by the smear imaging unit satisfies a predetermined condition, the storing container that stores therein the smears to the smear imaging unit regardless of the number of the smears stored in the storing container.
    Type: Application
    Filed: June 12, 2023
    Publication date: December 21, 2023
    Applicant: Sysmex Corporation
    Inventors: Daiki Kawakami, Seiya Shinabe, Tomoyuki Asahara
  • Publication number: 20230404690
    Abstract: Disclosed is a surgical image providing method using a surgical robot for providing an image of a surgery performed by the surgical robot, the surgical robot including an arm device to which a surgical instrument is attached, and an operation device that an operator operates to drive the arm device. The method includes: obtaining a state log indicating a state of an operation target of the operation device, the state being changed according to an operation of the operator to the operation target; generating a reconstructed image visualizing the operation of the operator to the operation target, on the basis of the state log; and providing a surgical image in which a motion image showing a motion of the surgical robot or the surgical instrument is associated with the reconstructed image.
    Type: Application
    Filed: June 12, 2023
    Publication date: December 21, 2023
    Applicant: SYSMEX CORPORATION
    Inventors: MASANAO OHASHI, Yutaka Kitayama, Keiko Ishino, Arisa Ikeda