Patents Assigned to Sysmex Corporation
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Publication number: 20240241029Abstract: Disclosed is a flow cytometer comprising: a flow cell; a sample supply part configured to supply, to the flow cell, a predetermined amount of a measurement sample prepared by mixing a specimen containing measurement-target substances and a labeled antibody which binds to the measurement-target substances; a light source configured to apply light to the measurement sample passing through the flow cell; a detector configured to detect lights derived from the measurement-target substances contained in the measurement sample to which the light has been applied, and output signals; and an analysis unit configured to count the measurement-target substances contained in the measurement sample on the basis of the signals and obtain a concentration of the measurement-target substances on the basis of the number of the counted measurement-target substances and the predetermined amount.Type: ApplicationFiled: January 11, 2024Publication date: July 18, 2024Applicant: SYSMEX CORPORATIONInventors: Masatsugu OZASA, Motoi KINISHI, Clare WEIR
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Publication number: 20240241360Abstract: An imaging method is disclosed that images specimen using a microscope system. An imaging method according to one or more embodiments may include determining candidate relative positions based on captured images of the specimen, the images being obtained by capturing images while changing a relative position between the specimen and a focal point of a light receiving optical system of the microscope system, determining a relative position for capturing among the candidate relative positions, and capturing an image of the specimen at the determined relative position.Type: ApplicationFiled: March 29, 2024Publication date: July 18, 2024Applicant: SYSMEX CORPORATIONInventor: Kohei MURAKAMI
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Publication number: 20240230580Abstract: An ion sensor is disclosed that includes an ion selective electrode including a first internal solid layer including a first insertion material, and a first ion conductive ceramic, an ion selective membrane provided on the first internal solid layer, a reference electrode including a second internal solid layer including a second insertion material, and a second ion conductive ceramic, an ionic liquid containing membrane provided on the second internal solid layer, and an insulator on which the ion selective electrode and the reference electrode are arranged.Type: ApplicationFiled: December 27, 2023Publication date: July 11, 2024Applicant: SYSMEX CORPORATIONInventors: Junko KOJIMA, Kenichi UCHIYAMA, Sayaka HONGO
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Patent number: 12026880Abstract: A fluorescence image display method and a fluorescence image analyzer capable of suppressing the influence of the operator's skill level and improving the classification accuracy when an operator visually classifies cells is provided. A fluorescence image analyzer, which is an example of an embodiment, includes a light source that irradiates light on a cell having a target site labeled with a fluorescent dye, an imaging unit that acquires a fluorescence image of a cell which emits fluorescence via irradiation by light, and a processing unit that analyzes the fluorescence image by software based on the fluorescence bright spot of the fluorescence image. The processing unit is configured to display a fluorescence image of the cell, the result of the image analysis, and auxiliary information that assists the visual analysis of the fluorescence bright spot included in the fluorescence image.Type: GrantFiled: December 23, 2021Date of Patent: July 2, 2024Assignee: SYSMEX CORPORATIONInventors: Keisuke Kuwano, Chikako Murata
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Publication number: 20240210425Abstract: Disclosed is a poor blood collection determination method that includes: mixing a blood specimen and a blood coagulation measurement reagent to prepare a measurement sample; obtaining measurement values representing a degree of coagulation of the blood specimen from the measurement sample; obtaining coagulation waveform data of the blood specimen based on a plurality of the measurement values; and performing determination as to poor blood collection of the blood specimen based on the coagulation waveform data.Type: ApplicationFiled: December 21, 2023Publication date: June 27, 2024Applicant: SYSMEX CORPORATIONInventors: Keisuke NISHI, Yuka TABUCHI, Takeshi SUZUKI
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Publication number: 20240207009Abstract: A method of managing a surgical instrument according to one or more embodiments is disclosed that is removably attached to a surgical robot and is reusable up to a usage limit. The method may include obtaining information on a usage status of the surgical instrument used in a surgery by the surgical robot, obtaining a judgment result indicating that the surgical instrument whose usage status is within the usage limit is unavailable for use, and associating information on the surgical instrument with the judgment result.Type: ApplicationFiled: December 26, 2023Publication date: June 27, 2024Applicant: SYSMEX CORPORATIONInventors: Masanao OHASHI, Yutaka KITAYAMA
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Patent number: 12019009Abstract: A measurement method, a measurement device, and a measurement program for acquiring information related to lipid particles contained in a measurement sample prepared without using a fluorescent dye are provided. The problem is resolved by the measurement method for measuring the number of particles in a measurement sample prepared without using a fluorescent dye, the method including obtaining information related to lipid particles contained in the measurement sample based on a plurality of characteristic values regarding light scattering in each particle obtained by a flow cytometer from the individual particles contained in the measurement sample.Type: GrantFiled: August 27, 2021Date of Patent: June 25, 2024Assignee: SYSMEX CORPORATIONInventors: Yuji Masuda, Konobu Kimura
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Patent number: 12020492Abstract: The present invention is to facilitate analysis of a plurality of analysis items. A cell analysis method for analyzing cells is provided in which data for analysis of cells contained in a sample are generated, and an artificial intelligence algorithm to be the input destination of the generated analysis data is selected from among a plurality of artificial intelligence algorithms, data indicating the properties of the cells are generated based on the analysis data via the artificial intelligence algorithm.Type: GrantFiled: November 25, 2020Date of Patent: June 25, 2024Assignee: SYSMEX CORPORATIONInventors: Momoko Imakubo, Jianyin Lu, Kentaro Shirai, Eri Katsumata, Yuji Okamoto
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Patent number: 12013409Abstract: Disclosed is a testing apparatus comprising a disposal container body comprising: a first opening portion that faces upward to receive a used test piece dropped by a test piece transfer part of the testing apparatus, wherein the test piece transfer part is configured to transfer the used test piece to the first opening portion; and a second opening portion that faces laterally to receive a liquid waste and to which an end of a discharge pipe of the testing apparatus is inserted, wherein the discharge pipe is configured to transfer the liquid waste to the second opening portion.Type: GrantFiled: November 10, 2020Date of Patent: June 18, 2024Assignee: SYSMEX CORPORATIONInventors: Nobuya Tamura, Hiroki Koike, Toru Nishikawa
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Patent number: 11994527Abstract: A sample measuring apparatus and a method of circulating air in a reagent storage are provided. The sample measuring apparatus includes: a measuring unit that measures a sample by using a reagent stored in a reagent container; a reagent storage that stores the reagent container; a reagent container holder arranged in the reagent storage and that holds the reagent container; a fin that circulates air in the reagent storage; and a driving unit that drives the reagent container holder and the fin to rotate.Type: GrantFiled: July 24, 2020Date of Patent: May 28, 2024Assignee: SYSMEX CORPORATIONInventors: Yutaka Kawamoto, Tomohiro Kuroiwa, Shingo Kaida
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Patent number: 11981728Abstract: Disclosed is an isolated monoclonal antibody comprising a heavy chain and a light chain, wherein the heavy chain comprises CDR1, CDR2 and CDR3 consisting of amino acid sequences set forth in SEQ ID NOs: 1, 2 and 3, respectively, and the light chain comprises CDR1, CDR2 and CDR3 consisting of amino acid sequences set forth in SEQ ID NOs: 4, 5 and 6, respectively.Type: GrantFiled: February 18, 2022Date of Patent: May 14, 2024Assignee: SYSMEX CORPORATIONInventors: Kouji Sakaguchi, Naoya Okitsu, Minori Yamada, Naoko Kitamura, Tetsuji Yamaguchi
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Publication number: 20240151612Abstract: An oil removal method is disclosed that removes an oil for an oil immersion object lens adhering to a smear surface of a smear of a sample. The method may include removing the oil by moving at least one of a first holder holding the smear to be subjected to oil removal or a second holder holding an oil absorption member that absorbs the oil from a separated state where a contact surface of the oil absorption member and the smear surface are positioned away from each other to a contacting state where the smear surface and the contact surface are in contact with each other, and moving at least one of the first holder or the second holder from the contacting state to the separated state after removing the oil.Type: ApplicationFiled: November 2, 2023Publication date: May 9, 2024Applicant: SYSMEX CORPORATIONInventors: Naoshi TAKARA, Mitsuo YAMASAKI
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Patent number: 11977089Abstract: A transport system includes a sample rack configured to hold a sample and comprising a notch; a rack storage unit in which the sample rack is stored; a transport path arranged to transport the sample rack moved from the rack storage unit; and a regulating member configured to regulate movement of the sample rack from the rack storage unit toward the transport path, wherein the regulating member is provided at a position corresponding to the notch provided in the sample rack, and enters an interior of the sample rack from the notch and abuts an interior wall of the sample rack as the sample rack moves from the rack storage unit toward the transport path.Type: GrantFiled: September 16, 2022Date of Patent: May 7, 2024Assignee: SYSMEX CORPORATIONInventor: Kohei Oda
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Patent number: 11977080Abstract: Disclosed is a method for acquiring information of a target polypeptide, comprising: acquiring a diffusion time of a fluorescently labeled target polypeptide and a diffusion time of each of a plurality of fluorescently labeled reference polypeptides by fluorescence correlation spectroscopy or fluorescence cross-correlation spectroscopy, and acquiring information on size of the fluorescently labeled target polypeptide from the diffusion time of the fluorescently labeled target polypeptide with reference to the diffusion times of the plurality of fluorescently labeled reference polypeptides, wherein information on size of each of the plurality of fluorescently labeled reference polypeptides is known, and the sizes of the plurality of reference polypeptides are different from each other.Type: GrantFiled: April 27, 2021Date of Patent: May 7, 2024Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, SYSMEX CORPORATIONInventors: Masataka Kinjo, Akshay Ganguly, Lausonia Ramaswamy
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Patent number: 11978198Abstract: Disclosed is a method for supporting disease analysis, the method including classifying, on the basis of images obtained from a plurality of analysis target cells contained in a specimen collected from a subject, a morphology of each analysis target cell, and obtaining cell morphology classification information corresponding to the specimen, on the basis of a result of the classification; and analyzing a disease of the subject by means of a computer algorithm, on the basis of the cell morphology classification information.Type: GrantFiled: April 24, 2020Date of Patent: May 7, 2024Assignees: JUNTENDO EDUCATIONAL FOUNDATION, SYSMEX CORPORATIONInventors: Akimichi Ohsaka, Yoko Tabe, Konobu Kimura
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Publication number: 20240142482Abstract: Disclosed is a specimen measurement apparatus comprising: a measurement unit configured to suction a specimen from a specimen container and measure the suctioned specimen; and a specimen transport unit configured to transport the specimen container to the measurement unit, wherein the specimen transport unit includes a rack setting part configured to allow a specimen rack to be set thereon, the specimen rack holding the specimen container that has not been subjected to specimen suction by the measurement unit, a rack collection part configured to collect the specimen rack holding the specimen container that has been subjected to specimen suction by the measurement unit, and an interruption specimen setting part configured to allow the specimen rack to be set thereon, the specimen rack holding the specimen container that is to be subjected to specimen suction by the measurement unit in preference to the specimen container held by the specimen rack having been set on the rack setting part, and the interruptionType: ApplicationFiled: October 23, 2023Publication date: May 2, 2024Applicant: Sysmex CorporationInventors: Masashi Tada, Taku INOUE, Hironori Katsumi, Takaaki Nagai
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Publication number: 20240142789Abstract: Disclosed is an optical system including: a light source configured to emit light; an irradiation optical system including a diffractive optical element on which the light is incident, the irradiation optical system being configured to apply illumination light in which a plurality of diffracted lights generated by the diffractive optical element are distributed; a flow cell in which a sample containing cells is caused to flow to a position at which the illumination light is applied by the irradiation optical system; and a light receiver configured to receive light generated from each cell flowing in the flow cell, upon application of the illumination light by the irradiation optical system. The illumination light includes zero-order diffracted light whose relative intensity relative to another diffracted light is not greater than 10 times. The irradiation optical system applies the illumination light to a position through which the cell in the flow cell passes.Type: ApplicationFiled: October 27, 2023Publication date: May 2, 2024Applicant: SYSMEX CORPORATIONInventors: Takuya KUWANA, Takeshi SUGIYAMA, Kazuhiro YAMADA, Ayato TAGAWA
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Publication number: 20240142483Abstract: Disclosed is a specimen measurement apparatus comprising: a measurement unit configured to suction a specimen from a specimen container and measure the suctioned specimen; and a specimen transport unit configured to transport the specimen container to the measurement unit, wherein the specimen transport unit includes a first transport part including a first placement surface configured to allow a specimen rack to be placed thereon, the first transport part being configured to transport a plurality of the specimen racks, each holding the specimen container, on the first placement surface, and a second transport part disposed above the first transport part and including a second placement surface configured to allow the specimen rack to be placed thereon, the second transport part being configured to transport a plurality of the specimen racks on the second placement surface, and at least one of the first transport part and the second transport part is configured to allow the specimen rack to be taken out thereType: ApplicationFiled: October 23, 2023Publication date: May 2, 2024Applicant: Sysmex CorporationInventors: Masashi Tada, Taku INOUE, Hironori KATSUMI
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Patent number: 11971342Abstract: The sample preparation apparatus includes a measurement unit configured to measure a sample containing particles acquired from a sample container and detect measurement target particles in the sample, a sample preparation unit capable of adjusting the concentration of measurement target particles in a sample acquired from a sample container and configured to prepare a measurement sample by mixing a sample and any of a plurality of types of particle detection reagents including a particle labeling substance, and a control unit for controlling the sample preparation unit so as to generate concentration information of the measurement target particles in the sample in the sample container based on the measurement data of the measurement unit and adjust the concentration of the measurement target particles in the sample acquired from the sample container according to the generated concentration information and the type of particle detection reagent used for preparing the measurement sample.Type: GrantFiled: December 6, 2021Date of Patent: April 30, 2024Assignee: SYSMEX CORPORATIONInventors: Takaaki Nagai, Shinichiro Oguni, Tomohiro Tsuji
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Patent number: D1033673Type: GrantFiled: August 26, 2021Date of Patent: July 2, 2024Assignee: SYSMEX CORPORATIONInventors: Fumie Shibata, Masayuki Seki, Noriyuki Nakanishi