Abstract: Provided is a computer-implemented method for testing blood of a subject, comprising: obtaining a plurality of haematological parameters for the blood; performing a plausibility check of haematological parameters; and outputting an indication of a determined probability of an infectious response of the subject based on parameters according to a result of the plausibility check.

Abstract: Disclosed is an image analysis method including inputting analysis data, including information regarding an analysis target cell to a deep learning algorithm having a neural network structure, and analyzing an image by calculating, by use of the deep learning algorithm, a probability that the analysis target cell belongs to each of morphology classifications of a plurality of cells belonging to a predetermined cell group.

Abstract: Disclosed is a method for improving affinity of an antibody for an antigen, the method comprising: in the antibody, changing at least 3 amino acid residues of framework region 3 (FR3) as defined by Kabat method to arginine residues or lysine residues, thereby improving affinity of an antibody for an antigen as compared with that of an antibody before said at least 3 amino acid residues are changed to arginine residues or lysine residues, wherein said at least 3 amino acid residues comprise at least 3 selected from the group consisting of amino acid residues at positions 68, 70, 72, 74, 75, 77, 79, 81, 82A, 82B, 83, 84, 85 and 87 of a heavy chain as defined by the Kabat method.

Abstract: Disclosed is a sample analyzer including: an imaging part configured to image a test strip; a controller programmed to analyze a test strip image obtained through imaging; a display part configured to display an image analysis result of the test strip image; and an input part configured to receive an input of a predetermined instruction, wherein the controller is programmed to cause the display part to display a plurality of the test strip images selected by the input part.

Abstract: Disclosed is a sample analyzer configured to image a test strip and analyze an image of the test strip, to analyze a sample, the sample analyzer including: a transport part having a placement part on which the test strip is placed, the transport part being configured to move the placement part to an imaging position for the test strip; a controller programmed to analyze the image of the test strip obtained through imaging; and an imaging part configured to be able to image the placement part, wherein the controller is programmed to analyze an image of the placement part obtained through imaging, to detect dirt on the placement part.

Abstract: A smear system includes smear preparing apparatus that prepares a smear slide and a smear transporting apparatus that transports the smear slide to a smear-image capture apparatus. The smear preparing apparatus includes: a smear preparation part that smears a sample on a slide; and a smear arrangement part that places smear slides in a smear container. The smear transporting apparatus includes: a smear-container transport part that transports the smear container with the smear slides; an identification-information acquisition part that acquires identification information on whether image capturing by the smear-image capture apparatus is necessary, from each of the smear slides accommodated in the smear container positioned on a transport path of the smear-container transport part; and a smear transfer part that transfers the smear slide whose image is to be captured to the smear-image capture apparatus on the basis of the identification information acquired by the identification-information acquisition part.

Abstract: Disclosed is: a fluorescent dye comprising a compound, a tautomer of the compound, or a salt of the compound or the tautomer; a labeled composite substance comprising the fluorescent dye and a composite substance which are bonded to each other; a composition containing the fluorescent dye or the labeled composite substance; and a method for acquiring information about a substance of interest by a super-resolution microscopy.

Abstract: Disclosed is a sample analyzer including a storage section configured to store a plurality of containers for containing a sample, and including a discharge port through which the container is discharged; a production lot information acquisition unit that acquires production lot information on a production lot of the container; an analysis processing unit that performs analysis processing of the sample contained in the container discharged through the discharge port; a recorder that records the production lot information, an analysis result of the sample contained in the container, and time information related to time of analyzing the sample; and a display information generation unit that generates, based on information recorded in the recorder, display information for displaying at least one analysis result of at least one sample analyzed during a period of time on a display unit in a manner that associates the at least one analysis result with the production lot information.

Abstract: A specimen analyzer including: a measurement part configured to apply light to a measurement sample and a fluorescent dye that stains white blood cells contained in the blood specimen, detect fluorescence from the white blood cells contained in the measurement sample to which the light has been applied, and measure fluorescence signals on the basis of the detected fluorescence; an information processing part configured to generate, on the basis of the fluorescence signals, information about a distribution width of fluorescence intensities regarding a population of neutrophils contained in the measurement sample, and determine information about a degree of severity of an organ dysfunction due to an infection on the basis of the information about the distribution width of the fluorescence intensities regarding the population of neutrophils; and an output part configured to output the information about the degree of severity of the organ dysfunction due to the infection.

Abstract: A general-purpose flow cytometer capable for using a plurality of combinations of fluorescent-labeled antibodies is provided.

Abstract: Disclosed is an analysis method for analyzing a nucleic acid sequence of a sample by using a computer, the analysis method including detecting a predetermined mutation on the basis of sequence information having been read from the nucleic acid sequence; and creating, in accordance with a disease that corresponds to the sample, a report that includes information related to efficacy of a predetermined drug that corresponds to the predetermined mutation.

Abstract: A nucleic acid molecule having a nucleotide sequence encoding a chimeric antigen receptor, where the nucleic acid molecule includes a segment encoding an extracellular domain, a segment encoding a transmembrane domain, and a segment encoding an intracellular domain. The segment encoding the extracellular domain includes a nucleotide sequence encoding an antigen binding region including a light chain variable region and a heavy chain variable region, and at least three codons in a nucleotide sequence encoding framework region 3 of the light chain variable region as defined by the Chothia method are codons encoding acidic amino acid residues.

Abstract: Disclosed is an analyzer including an analysis unit configured to analyze a specimen; a first storage part capable of storing a container capable of containing the specimen, the first storage part including an outlet that allows the container to be discharged therethrough; a second storage part capable of storing the container having been discharged through the outlet of the first storage part; a transporter configured to send out, from the second storage part, the container stored in the second storage part; and a discharge controller capable of controlling discharge of the container through the outlet of the first storage part.

Abstract: Disclosed is a detection apparatus that transfers magnetic particles through a plurality of chambers in a cartridge which includes the plurality of chambers and a channel connecting between the plurality of chambers, and that causes the magnetic particles to carry a complex of a test substance and a labelling substance, to detect the test substance on the basis of the labelling substance in the complex. The detection apparatus includes: a rotation mechanism configured to rotate the cartridge about a rotation shaft; a magnet configured to collect the magnetic particles in the chambers; a movement mechanism configured to move the magnet in a direction different from a circumferential direction of a circle in which the rotation shaft is centered; a detector configured to detect the test substance; and a controller programmed to control the rotation mechanism and the movement mechanism so as to transfer the magnetic particles from one of the chambers to another one of the chambers.

Abstract: Disclosed is a specimen measurement method for measuring platelet aggregation of a specimen, and the specimen measurement method includes: automatically preparing a diluted reagent solution that contains a platelet-aggregating reagent diluted with a diluent; preparing a measurement sample that contains a predetermined concentration of the platelet-aggregating reagent, from the diluted reagent solution and the specimen; and performing optical measurement of the measurement sample.

Abstract: In a method of managing surgical instruments that are used in surgical robotic systems installed in each of facilities, that are collected, for each of which a maintenance comprising at least cleaning and sterilization is performed, and that are shipped to any one of the facilities, the method according to one or more embodiments may include storing, for each of the surgical instruments, status information regarding status of the surgical instruments in association with identification information for each of the surgical instruments, and updating the status information corresponding to a surgical instrument that has been made available for shipping by the maintenance to the status information indicating that the surgical instrument is available to be selected for shipping to any one of the facilities.

Abstract: Disclosed is a measurement apparatus that includes: a measurement unit configured to measure a control sample for quality control; a display unit; and a processing unit configured to cause the display unit to display an input screen for setting an evaluation criterion used in the quality control, and, in the measurement apparatus, the processing unit causes the display unit to display a quality control result of a test item, based on the evaluation criterion and a measurement result of the control sample.

Abstract: Disclosed is a Bst DNA polymerase comprising: (1) an amino acid sequence set forth in SEQ ID NO: 1, or (2) an amino acid sequence comprising a consensus sequence Asn-X-(Ser/Thr) (X is any amino acid residue other than a proline residue), and comprising an amino acid sequence having 80% or more identity to the amino acid sequence set forth in SEQ ID NO: 1, and having 5? to 3? DNA polymerase activity and strand displacement activity, wherein the consensus sequence comprises an N-linked sugar chain, and the N-linked sugar chain comprises three or more mannose residues.

Abstract: Disclosed is a method for evaluating cell differentiation state, including inducing pluripotent stem cells to differentiate into mesodermal cells in a liquid medium by a first differentiation treatment for inducing pluripotent stem cells to differentiate into mesodermal cells and a second differentiation treatment for inducing the mesodermal cells to differentiate into cardiomyocytes; collecting a supernatant of the liquid medium comprising cells induced to differentiate by the second differentiation treatment; and measuring miRNA-3p in miR-1/133a cluster in the supernatant, where the miRNA-3p is at least one selected from a group consisting of miR-1-3p and miR-133a-3p, and the measured value of miRNA-3p is an index of differentiation into cardiomyocytes.

Abstract: A sample measurement system includes sample measurement devices that measures samples using a first reagent and a second reagent, and a reagent supply apparatus, which includes a first piping connected to reagent containers of a first reagent container group, a first reagent reservoir that stores the first reagent transferred through the first piping, a second piping connected to reagent containers of a second reagent container group, and a second reagent reservoir that stores the second reagent transferred through the second piping. The first reagent stored in the first reagent reservoir is supplied to each of the sample measurement devices. The second reagent stored in the second reagent reservoir is supplied to each of the sample measurement devices.