Patents Assigned to Sysmex Corporation
  • Patent number: 11181540
    Abstract: A measurement system according to one or more embodiments may include a measurement unit that measures a sample contained in a sample container; a transport unit including a first transporter that transports a rack holding sample containers in a longitudinal direction of the rack to the measurement unit, and a second transporter that transports the rack from the measurement unit; and a rack export-import unit that sets racks thereon, that is capable of transferring each of the set racks in a lateral direction of the rack, that exports the rack to the first transporter from one end side of the rack export-import unit, and that imports the rack transported by the second transporter from another end side of the rack export-import unit. The rack export-import unit includes a transfer prevention section that prevents the rack imported from the other end side from being transferred from the one end side.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: November 23, 2021
    Assignee: SYSMEX CORPORATION
    Inventors: Yuichiro Ohmae, Hiroo Tatsutani
  • Publication number: 20210356454
    Abstract: Disclosed is a method for measuring an immunostimulatory response of an immune cell, including (i) bringing a measurement target immune cell into contact with an immunostimulator, (ii) forming a contact surface with a substance different from the measurement target immune cell on the measurement target immune cell, (iii) bringing the measurement target immune cell into contact with a capturing body that binds to a surface antigen on the contact surface and is capable of generating an optical signal, (iv) detecting the optical signal generated from the capturing body, and (v) determining whether or not the measurement target immune cell from which the contact surface has been eliminated before detecting the optical signal has an immunostimulatory response, based on the detected optical signal.
    Type: Application
    Filed: July 29, 2021
    Publication date: November 18, 2021
    Applicant: SYSMEX CORPORATION
    Inventors: Masatoshi YANAGIDA, Keiko MIWA, Yuma OKA
  • Publication number: 20210347910
    Abstract: Disclosed is a method for producing a modified antibody, comprising: in a heavy chain of the antibody, changing at least one amino acid residue selected from the group consisting of 8th to 11th amino acid residues based on Kabat method to a cysteine residue, and changing at least one amino acid residue selected from the group consisting of 109th and 110th amino acid residues based on IMGT method to a cysteine residue; and recovering the modified antibody.
    Type: Application
    Filed: February 22, 2021
    Publication date: November 11, 2021
    Applicant: SYSMEX CORPORATION
    Inventors: Tomofumi NAKADA, Nobuyuki IDE
  • Patent number: 11169148
    Abstract: Provided is a method for detecting a test substance, the method including the steps of: forming an immune complex on a first solid phase by bringing a test substance, a labeled antibody, a capture antibody and the first solid phase into contact with one another; transferring the immune complex onto a second solid phase by breaking the binding between the capture antibody and the first solid phase to liberate the immune complex, and bringing the second solid phase and the immune complex into contact with each other, where the second solid phase is bound to the capture antibody; and detecting the test substance by measuring a label contained in the complex on the second solid phase. The test substance detected by the method is a multimeric antigen, particularly amyloid ? or tau protein.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: November 9, 2021
    Assignee: SYSMEX CORPORATION
    Inventor: Toshihiro Watanabe
  • Patent number: 11169057
    Abstract: A particle dispersion method for dispersing particles (500) fixed on the inner surface of a container (12) into a liquid. The particle dispersion method includes a discharge step of discharging a liquid into the container (12). The container (12) has a cylindrical main body part (310), and an inclined part (311) having an inner diameter that decreases from the main body part (310) side to the bottom part side and having a constant angle relative to the central axis of the container. In the discharge step, the liquid is discharged from above the inclined part (311) toward the inclined part (311) on the side opposite the particles (500) fixed to the inner surface of the container (12) across the central axis (300) of the container (12).
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: November 9, 2021
    Assignee: Sysmex Corporation
    Inventors: Hiroaki Tobimatsu, Toshimi Sato
  • Patent number: 11162957
    Abstract: A blood analyzing method includes optically measuring a first calibration sample prepared from a fibrin/fibrinogen degradation product (FDP) measurement reagent and a first calibrator containing D-dimer (DD) and having a first value relating to the ratio of the content of FDP to the content of DD, acquiring first calculation data based on temporal change of optical information of the first calibration measurement sample, performing optical measurement of a second calibration measurement sample prepared from FDP measurement reagent and a second calibrator containing DD and having a second value that is different from the first value, acquiring second calculated data based on a temporal change in optical information of the second calibration measurement sample, and acquiring calibration curve information indicating the relationship between the calculation data and the value relating to the amount of DD.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: November 2, 2021
    Assignee: Sysmex Corporation
    Inventor: Junki Hayasaki
  • Publication number: 20210333261
    Abstract: Provided is a computer-implemented method for testing blood of a subject, comprising: obtaining a plurality of haematological parameters for the blood; performing a plausibility check of haematological parameters; and outputting an indication of a determined probability of an infectious response of the subject based on parameters according to a result of the plausibility check.
    Type: Application
    Filed: April 22, 2021
    Publication date: October 28, 2021
    Applicant: SYSMEX CORPORATION
    Inventors: Gabi BAUER, Stefanie Klatte, Joachim Linssen, Katharina Fuerst
  • Publication number: 20210325408
    Abstract: Disclosed is a method for assisting prediction of exacerbation of respiratory infection, comprising measuring a biomarker in a specimen collected from a subject suffering from a respiratory infection or a subject suspected of having a respiratory infection, wherein the biomarker is at least one selected from the group consisting of IFN?3, CCL17, CXCL11, IP-10, IL-6 and CXCL9, and a measured value of the biomarker is used as an index to predict exacerbation of the respiratory infection.
    Type: Application
    Filed: April 15, 2021
    Publication date: October 21, 2021
    Applicants: NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE, SYSMEX CORPORATION
    Inventors: Masashi MIZOKAMI, Masaya SUGIYAMA, Norio OHMAGARI, Noriko KINOSHITA, Youichi TAKAHAMA, Kazuki NAKABAYASHI
  • Patent number: 11150252
    Abstract: Disclosed is a method for measuring phosphorylated tau protein in a biological sample collected from a subject, comprising the steps of: preparing a measurement sample containing a non-capture bead and a capture bead to which an immune complex is bound, by forming the immune complex of the phosphorylated tau protein in the biological sample, a capture antibody and a detection antibody on the capture bead, in the presence of the non-capture bead; and detecting a signal derived from the immune complex in the measurement sample.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: October 19, 2021
    Assignees: SYSMEX CORPORATION, National Institutes for Quantum and Radiological Science and Technology
    Inventors: Takahiko Tokuda, Harutsugu Tatebe
  • Patent number: 11150253
    Abstract: Disclosed is a method for analyzing a blood specimen, including the steps of: coagulating a blood specimen in the presence of an activating agent for fibrinolytic system to acquire a coagulation waveform; and acquiring information about fibrinolytic capacity of the blood specimen based on the acquired coagulation waveform.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: October 19, 2021
    Assignees: SYSMEX CORPORATION, PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY
    Inventors: Midori Shima, Keiji Nogami, Tomoko Matsumoto, Sho Shinohara, Nobuo Arai
  • Publication number: 20210318240
    Abstract: Disclosed is a blood analyzer including: a first sample preparation unit configured to prepare, from a blood sample, a first measurement sample for measuring a red blood cell infected with malaria; a second sample preparation unit configured to prepare, from the blood sample, a second measurement sample for measuring intrinsic fluorescence of a red blood cell; a light source unit configured to apply light to the first and the second measurement samples; a detection unit configured to detect fluorescence and scattered light generated from the first measurement sample to which light has been applied, and detect intrinsic fluorescence generated from the second measurement sample to which light has been applied; and an information processing unit configured to generate information about malaria infection based on fluorescence and scattered light detected from the first measurement sample, and generate information about iron-deficiency anemia based on intrinsic fluorescence detected from the second measurement sam
    Type: Application
    Filed: April 12, 2021
    Publication date: October 14, 2021
    Applicants: SYSMEX CORPORATION, OSAKA UNIVERSITY
    Inventors: Takahiro TOUGAN, Yuji TOYA
  • Publication number: 20210318297
    Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.
    Type: Application
    Filed: June 24, 2021
    Publication date: October 14, 2021
    Applicant: SYSMEX CORPORATION
    Inventors: Kazuyoshi HORII, Tomoyuki NOSE, Takao FUJIWARA, Tatsuya KOSAKO
  • Patent number: 11143664
    Abstract: A sample processing method may include: removing a liquid component in a container housing a suspension containing a magnetic particle bound with an analyte, while causing magnetic adhesion of the magnetic particle in the container; discharging an elution liquid for releasing the analyte from the magnetic particle from a pipette into the container from which the liquid component has been removed so as to mix the magnetic particle and the elution liquid; moving, after discharging the elution liquid into the container, the pipette relative to and close to an inner wall of the container so as to collect a droplet attached to the inner wall onto an outer surface of the pipette; and moving a tip of the pipette to an accumulation area in which the elution liquid accumulates in the container so as to move the droplet collected on the outer surface of the pipette to the accumulation area.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: October 12, 2021
    Assignee: SYSMEX CORPORATION
    Inventor: Yuto Sasaki
  • Publication number: 20210312627
    Abstract: The present invention provides an image analysis method for generating data indicating a region of a cell nucleus in an image of a tissue or a cell. The image analysis method is a method for analyzing an image of a tissue or a cell using a deep learning algorithm of a neural network structure, and generates data indicating a region of a cell nucleus in an analysis target image by the deep learning algorithm by generating analysis data from the analysis target image including an analysis target tissue or cell, and inputting the analysis data in the deep learning algorithm.
    Type: Application
    Filed: June 21, 2021
    Publication date: October 7, 2021
    Applicant: SYSMEX CORPORATION
    Inventors: Yosuke Sekiguchi, Kazumi Hakamada, Yuki Aihara, Kohei Yamada, Kanako Masumoto, Krupali Jain
  • Publication number: 20210299680
    Abstract: A centrifuge according to one or more embodiments may include a rotor comprising a holder that holds a reaction container, the rotor swingably supporting the holder; a rotating shaft connected to the rotor; a drive that rotates the rotating shaft; and a temperature adjustment unit including a heat transfer surface provided in contact with or close to at least a part of the holder when the drive stops rotating the rotating shaft.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 30, 2021
    Applicant: SYSMEX CORPORATION
    Inventors: Ryutaro SHINYA, Kazuyuki IGUCHI
  • Publication number: 20210302285
    Abstract: A specimen preparation device may include: a reagent setting part in which reagent containers each containing a reagent are set; and a dispenser comprising a nozzle that aspirates a reagent from a reagent container and discharges the reagent into a reaction container. The reagent setting part may include a setting part main body that holds the reagent containers, a lid provided to cover the setting part main body from above and comprising first insertion holes formed in the lid, the first insertion holes allowing the nozzle to passing through, a shutter member comprising a second insertion hole formed in the shutter member, the second insertion hole allowing the nozzle to pass through, and a shutter drive that moves the shutter member between an opening position at which the first insertion holes are open via the second insertion hole and a closing position at which the first insertion holes are closed.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 30, 2021
    Applicant: SYSMEX CORPORATION
    Inventors: Ryutaro SHINYA, Keiichiro SHOHMI, Masaya IWAMI
  • Publication number: 20210301332
    Abstract: Disclosed is a method for determining a success or failure of a nucleic acid amplification comprising obtaining a measurement value corresponding to the amount of a nucleic acid amplified by a nucleic acid amplification reaction of a measurement sample containing the nucleic acid in a state in which the nucleic acid amplification reaction has reached a saturation state; and determining the success or failure of a nucleic acid amplification reaction based on the acquired measurement value.
    Type: Application
    Filed: March 12, 2021
    Publication date: September 30, 2021
    Applicant: SYSMEX CORPORATION
    Inventors: Kazuki ASAO, Kosuke YAMAGUCHI
  • Publication number: 20210302450
    Abstract: A centrifuge according to one or more embodiments may include: a rotor comprising a holder that holds a reaction container, the rotor swingably supporting the holder; a rotating shaft connected to the rotor; a drive that rotates the rotating shaft; and a restriction member configured to come into contact with the holder to restrict a tilt angle of the reaction container when the drive is rotating the rotating shaft.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 30, 2021
    Applicant: SYSMEX CORPORATION
    Inventor: Ryutaro SHINYA
  • Publication number: 20210302444
    Abstract: Disclosed is a method for measuring a blood coagulation activity, comprising: acquiring a parameter related to differentiation of a coagulation waveform in a blood specimen collected from a patient administered with (1) a polypeptide containing a sequence represented by SEQ ID NO: 1, or (2) a polypeptide containing a polypeptide having 95% or more identity with the sequence represented by SEQ ID NO: 1 and having an activity as a blood coagulation factor VIII; and acquiring an activity value of a blood coagulation factor VIII in the blood specimen based on the acquired parameter.
    Type: Application
    Filed: March 24, 2021
    Publication date: September 30, 2021
    Applicants: SYSMEX CORPORATION, KEIO UNIVERSITY, SOCIAL WELFARE ORGANIZATION SAISEIKAI IMPERIAL GIFT FOUNDATION, INC.
    Inventors: Sho SHINOHARA, Osamu KUMANO, Nobuo ARAI, Seiji MADOIWA, Yuta FUJIMORI
  • Publication number: 20210299683
    Abstract: Disclosed is a measurement apparatus including: a first setting base capable of having set thereon a plurality of first storage portions arranged in a first direction; a second setting base capable of having set thereon a second storage portion, the second setting base being disposed in a second direction crossing the first direction with respect to the first setting base; a holding body configured to hold the first setting base and to hold the second setting base; a drive unit configured to move the holding body in the first direction; a dispenser configured to move along a movement axis thereof in the second direction, to suction a liquid in the second storage portion and dispense the liquid into each first storage portion; a measurement unit configured to measure a mixture dispensed in the first storage portion; and a movement stopping unit.
    Type: Application
    Filed: March 23, 2021
    Publication date: September 30, 2021
    Applicant: SYSMEX CORPORATION
    Inventors: Tomoya HAYASHI, Shinya MURAKAMI