Patents Assigned to Sysmex Corporation
  • Publication number: 20230265210
    Abstract: Disclosed is a method for improving affinity of an antibody for an antigen, comprising, in an unmodified antibody, improving affinity for an antigen as compared to the unmodified antibody, by changing 74th, 76th and 77th amino acid residues of a light chain defined by Kabat method to charged amino acid residues.
    Type: Application
    Filed: March 24, 2023
    Publication date: August 24, 2023
    Applicant: SYSMEX CORPORATION
    Inventors: Shingo MAETA, Atsushi Fukunaga, Reema Bajaj
  • Publication number: 20230258545
    Abstract: Automation of analysis of cells contained in different types of specimens collected from different organs or sites is enabled. This sample preparation method is a method for preparing a sample for analyzing cells contained in a specimen, and includes: obtaining a dispersion condition corresponding to the type of the specimen; and dispersing the cells aggregated and contained in the specimen, according to the obtained dispersion condition.
    Type: Application
    Filed: April 28, 2023
    Publication date: August 17, 2023
    Applicant: SYSMEX CORPORATION
    Inventors: Hiroaki INOKUCHI, Toshikuni SUGANUMA, Kei SHIRASUNA
  • Patent number: 11725062
    Abstract: Disclosed is a method for improving affinity of an antibody for an antigen, comprising, in an unmodified antibody, improving affinity for an antigen as compared to the unmodified antibody, by changing 3rd, 5th and 9th amino acid residues of a light chain defined by Kabat method to charged amino acid residues.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: August 15, 2023
    Assignee: SYSMEX CORPORATION
    Inventors: Shingo Maeta, Atsushi Fukunaga, Reema Bajaj
  • Patent number: 11726028
    Abstract: Disclosed is a container rack configured to hold a plurality of containers, the container rack configured to be installed in a rack installation portion of a specimen analysis device, the container rack comprising: a holding portion including a plurality of holding holes through which body portions of the containers pass and which hold head portions of the containers; and a leg portion configured to support the holding portion, the leg portion provided from the holding portion to below the containers held in the holding holes, wherein the leg portion is configured such that the containers in the holding holes are exposed in a bottom view, and wherein the container rack is configured such that when the container rack is installed in the rack installation portion of the specimen analysis device, movement of the containers held in the holding holes is restricted by the rack installation portion.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: August 15, 2023
    Assignee: SYSMEX CORPORATION
    Inventors: Kenji Yoshimura, Masaki Shiba
  • Patent number: 11719706
    Abstract: Disclosed is a method for measuring a biomarker in a biological sample of the IPAF patient, wherein the biomarker comprises at least one selected from the group consisting of CXCL9 and CXCL10, and a measurement result of the biomarker is used as an index for determining treatment responsiveness to anti-inflammatory therapy.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: August 8, 2023
    Assignees: SAPPORO MEDICAL UNIVERSITY, SYSMEX CORPORATION
    Inventors: Masami Kameda, Mitsuo Otsuka, Takehiro Hasegawa
  • Patent number: 11714043
    Abstract: A specimen analysis system includes: a measurement data acquisition unit that acquires measurement data of particles obtained from a flow cytometer measuring the particles contained in a measurement specimen prepared by adding a reagent to a sample; an output mode information acquisition unit that acquires output mode information indicating an output form of the measurement data; and an output unit configured to output the measurement data in the output form in accordance with the output mode information.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: August 1, 2023
    Assignee: SYSMEX CORPORATION
    Inventors: Tomohiro Tsuji, Hiroo Tatsutani
  • Publication number: 20230228866
    Abstract: Disclosed is a method for improving affinity of an antibody for an antigen, comprising, in an unmodified antibody, improving affinity for an antigen as compared to the unmodified antibody, by changing 77th, 79th and 81st amino acid residues of a light chain defined by Kabat method to charged amino acid residues.
    Type: Application
    Filed: January 20, 2023
    Publication date: July 20, 2023
    Applicant: SYSMEX CORPORATION
    Inventors: Shingo MAETA, Atsushi Fukunaga, Reema Bajaj
  • Publication number: 20230228781
    Abstract: Disclosed is a container transfer method for transferring a container from a container holder capable of holding a plurality of containers, by using a holding section capable of performing an opening/closing operation, vertical movement, and horizontal movement. The method includes: moving the holding section downward to a position lower than a head portion of the container, at a position where the container is not held in a plan view; horizontally moving the holding section in an opened state, toward a target container on the container holder; after the horizontal movement of the holding section to the target container, closing the holding section with respect to the target container; and moving upward the holding section in a closed state.
    Type: Application
    Filed: January 6, 2023
    Publication date: July 20, 2023
    Applicant: Sysmex Corporation
    Inventors: Hidetaka HAYAMA, Yuichiro OHMAE, Yuji WAKAMIYA, Tomohiro KUROIWA
  • Publication number: 20230228779
    Abstract: Disclosed is a specimen transfer device connected to a rack transportation path of a specimen testing system, and the specimen transfer device includes: an ascending/descending mechanism configured to move a rack between a first ascending/descending position at which the rack in a first tier is disposed, and a second ascending/descending position at which the rack in a second tier is disposed; a container transfer mechanism configured to transfer a specimen container, to a second rack disposed in the second tier, from a first rack moved by the ascending/descending mechanism from the first ascending/descending position to the second ascending/descending position; a rack waiting region disposed in the first tier and configured to cause the rack to stay in a waiting state between the first ascending/descending position and a carrying-out position to the rack transportation path; and a first transportation mechanism configured to transport the first rack moved by the ascending/descending mechanism from the second
    Type: Application
    Filed: January 6, 2023
    Publication date: July 20, 2023
    Applicant: Sysmex Corporation
    Inventors: Hidetaka HAYAMA, Toshiki SATO, Yuichiro OHMAE
  • Publication number: 20230228780
    Abstract: Disclosed is a specimen testing system that includes: a specimen rearrangement unit configured to transfer a specimen container held in a first rack to a second rack; a specimen processing unit configured to process a specimen in the specimen container held in the second rack; a specimen storage unit configured to transfer the specimen container having been processed by the specimen processing unit from the second rack to a specimen container storage instrument for storage; a transportation unit configured to transport the second rack among the specimen rearrangement unit, the specimen processing unit, and the specimen storage unit; and a transportation control unit programmed to control the transportation unit. The transportation control unit is programmed to control bidirectional transportation of the second rack between the specimen rearrangement unit and the specimen storage unit.
    Type: Application
    Filed: January 6, 2023
    Publication date: July 20, 2023
    Applicant: Sysmex Corporation
    Inventors: Hidetaka HAYAMA, Yuichiro OHMAE, Toshiki SATO, Hiroyuki TSUJI
  • Publication number: 20230227578
    Abstract: Disclosed is a method for improving affinity of an antibody for an antigen, comprising, in an unmodified antibody, improving affinity for an antigen as compared to the unmodified antibody, by changing 18th, 20th and 22nd amino acid residues of a light chain defined by Kabat method to charged amino acid residues.
    Type: Application
    Filed: January 20, 2023
    Publication date: July 20, 2023
    Applicant: SYSMEX CORPORATION
    Inventors: Shingo MAETA, Atsushi Fukunaga, Reema Bajaj
  • Publication number: 20230227579
    Abstract: Disclosed is a method for improving affinity of an antibody for an antigen, comprising, in an unmodified antibody, improving affinity for an antigen as compared to the unmodified antibody, by changing 17th, 18th and 20th amino acid residues of a light chain defined by Kabat method to charged amino acid residues.
    Type: Application
    Filed: January 20, 2023
    Publication date: July 20, 2023
    Applicant: SYSMEX CORPORATION
    Inventors: Shingo MAETA, Atsushi Fukunaga, Reema Bajaj
  • Patent number: 11703441
    Abstract: Disclosed is a method for assisting prediction of onset of cerebral infarction, based on the number of red blood cells contained in a blood sample collected from a subject, comprising the steps of: calculating an exponent value for the prediction from a first measured value indicating red blood cell count measured by electrical resistance measurement method and a second measured value indicating red blood cell count measured by optical measurement method, comparing the exponent value with a reference range, and suggesting that the subject develops cerebral infarction when the exponent value is outside the reference range.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: July 18, 2023
    Assignees: KAWASAKI GAKUEN Educational Foundation, THE UNIVERSITY OF TOKYO, SYSMEX CORPORATION
    Inventors: Hiromi Kataoka, Yutaka Yatomi, Akiko Masuda, Hironori Shimosaka, Hajimu Kawakami
  • Publication number: 20230221238
    Abstract: In a configuration for analyzing data of cells measured by a cell measuring apparatus, accuracy of cell classification is improved without requiring the cell measuring apparatus to have high information processing capability. A cell analysis method, using a cell analyzer for analyzing cells in accordance with an artificial intelligence algorithm, includes: obtaining the data regarding the cells measured by the cell measuring apparatus; analyzing the data to generate information regarding a cell type of each of the cells; and transmitting the information to the cell measuring apparatus.
    Type: Application
    Filed: March 17, 2023
    Publication date: July 13, 2023
    Applicant: SYSMEX CORPORATION
    Inventors: Shoichiro ASADA, Konobu KIMURA, Masamichi TANAKA, Kenichiro SUZUKI, Kohei NANGO
  • Publication number: 20230204614
    Abstract: In a dispensing system, a body is arranged outside a specimen processing cabinet, and in a state where a hand and a dispenser are inserted into the specimen processing cabinets, a specimen accommodated in a specimen container held by the hand is dispensed into a dispensing container by the dispenser.
    Type: Application
    Filed: May 27, 2021
    Publication date: June 29, 2023
    Applicants: KAWASAKI JUKOGYO KABUSHIKI KAISHA, SYSMEX CORPORATION
    Inventors: Noboru TAKAGI, Atsushi KAMEYAMA, Eiji YOSHIKUWA, Toshiyuki TSUJIMORI, Shogo KUBOTA, Satoshi OUCHI, Yukio IWASAKI, Yasuhiro KOUCHI, Soichi OUE, Hironori KOBAYASHI, Yutaka MAEDA, Takayuki KOSHIHARA
  • Publication number: 20230204613
    Abstract: Disclosed is a specimen analysis method for analyzing a specimen regarding a plurality of measurement items, the specimen analysis method comprising: measuring a first measurement item and a second measurement item on the basis of a measurement order; executing a process related to a time difference between a measurement of the first measurement item and a measurement of the second measurement item; and obtaining a calculation value from a measurement value of the first measurement item and a measurement value of the second measurement item.
    Type: Application
    Filed: December 16, 2022
    Publication date: June 29, 2023
    Applicant: Sysmex Corporation
    Inventors: Naoya Kameyama, Tomoyuki Nishida, Yasuhiro Takeuchi, Takayuki Arai, Masahiro Miura
  • Publication number: 20230204615
    Abstract: A sample measuring device reduces the frequency with which a user introduces a measurement aid into the sample measuring device is provided. A sample measuring method measures a sample using a container containing a measurement aid which is a solid. The sample measuring method includes loading a predetermined number of measurement aids into a container from a storage chamber in which a plurality of measurement aids are movably stored in a cartridge attached to a sample measuring device, dispensing the sample into the container, and measuring the sample in the container into which the measurement aid has been loaded.
    Type: Application
    Filed: December 23, 2022
    Publication date: June 29, 2023
    Applicant: SYSMEX CORPORATION
    Inventors: Kohei ODA, Hironori KATSUMI, Yoshinori NAKAMURA
  • Publication number: 20230203435
    Abstract: Disclosed is a method for producing an antibody, comprising culturing in a presence of a polyanionic compound an animal cell into which a gene encoding an antibody has been introduced whereby the animal cell produces the antibody, wherein the polyanionic compound is at least one selected from the group consisting of an anionic polysaccharide and an anionic polyamino acid, and the antibody is an antibody in which at least 3 amino acid residues of framework region 3 (FR3) are substituted each independently with an arginine residue or a lysine residue.
    Type: Application
    Filed: November 4, 2022
    Publication date: June 29, 2023
    Applicant: SYSMEX CORPORATION
    Inventors: Yuriko EGASHIRA, Atsushi FUKUNAGA
  • Patent number: 11685948
    Abstract: Disclosed is a method for sequencing a nucleotide sequence of a target nucleic acid. The method comprises: providing a pool of amplicons, wherein the pool of amplicons is prepared by attaching a unique identifier to the target nucleic acid, and amplifying by PCR the target nucleic acid to which the unique identifier is attached; and sequencing the amplicons comprising the unique identifier and the target nucleic acid. In the method, a nucleotide sequence of the unique identifier comprises both a random nucleotide (N) and a predetermined nucleotide.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: June 27, 2023
    Assignee: SYSMEX CORPORATION
    Inventor: Frank Holtrup
  • Publication number: 20230194410
    Abstract: Disclosed is a method for detecting an antigen-specific activated T cell comprising: acquiring first information on a particle size and second information on a T cell activation marker for a first measurement sample prepared by mixing in vitro a first specimen separated from a biological sample containing a T cell and an antigen-presenting cell and an antigen reagent containing a predetermined antigen, by measuring the first measurement sample with a flow cytometer; acquiring the first information and the second information for a second measurement sample prepared from a second specimen separated from the biological sample and not containing the antigen reagent, by measuring the second measurement sample with the flow cytometer; detecting a target particle in the first measurement sample based on the first information and the second information on the first measurement sample, and detecting a background particle in the second measurement sample based on the first information and the second information on the
    Type: Application
    Filed: December 12, 2022
    Publication date: June 22, 2023
    Applicant: SYSMEX CORPORATION
    Inventors: Toyoko KATAYAMA, Hitoshi UGA, Akio OHTA, Masaki TAJIMA, Naoko IKUTA