Patents Assigned to Sysmex Corporation
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Patent number: 9891210Abstract: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.Type: GrantFiled: July 8, 2014Date of Patent: February 13, 2018Assignee: SYSMEX CORPORATIONInventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi
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Patent number: 9885661Abstract: Disclosed is an analyte detection method for detecting an analyte contained in a biological sample, constituted by irradiating a light of a first peak wavelength on a complex containing an analyte and fluorescent substance which gives off light of a second peak wavelength of 450 nm or higher but not exceeding 900 nm when irradiated with light of the first wavelength of 190 nm or higher but not exceeding 350 nm, detecting the light of the second peak wavelength given off by the fluorescent substance when irradiated by light of the first peak wavelength, by a photodetector, wherein the photodetector has a quantum efficiency in the second peak wavelength that is two or more times the quantum efficiency in the first peak wavelength.Type: GrantFiled: October 7, 2014Date of Patent: February 6, 2018Assignee: SYSMEX CORPORATIONInventors: Ayato Tagawa, Hiroya Kirimura
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Publication number: 20180031588Abstract: A smear transporting apparatus transports a smear slide on which a sample is smeared to a smear-image capture apparatus. The smear transporting apparatus includes a smear-container transport part that transports a first smear container accommodating smear slides to a smear pickup position; a smear transfer part that picks a smear slide whose image is to be captured by the smear-image capture apparatus from the first smear container transported to the smear pickup position, transfers the smear slide to the smear-image capture apparatus, and places the smear slide whose image has been captured by the smear-image capture apparatus in a second smear container different from the first smear container; and a storage that stores the first smear container and the second smear container.Type: ApplicationFiled: July 28, 2017Publication date: February 1, 2018Applicant: SYSMEX CORPORATIONInventors: Takayuki NAKAJIMA, Katsuaki YAMAGUCHI, Tetsuya ODA, Seiya SHINABE, Mitsuo YAMASAKI, Hidetaka HAYAMA
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Publication number: 20180031454Abstract: A smear system includes smear preparing apparatus that prepares a smear slide and a smear transporting apparatus that transports the smear slide to a smear-image capture apparatus. The smear preparing apparatus includes: a smear preparation part that smeares a sample on a slide; and a smear arrangement part that places smear slides in a smear container. The smear transporting apparatus includes: a smear-container transport part that transports the smear container with the smear slides; an identification-information acquisition part that acquires identification information on whether image capturing by the smear-image capture apparatus is necessary, from each of the smear slides accommodated in the smear container positioned on a transport path of the smear-container transport part; and a smear transfer part that transfers the smear slide whose image is to be captured to the smear-image capture apparatus on the basis of the identification information acquired by the identification-information acquisition part.Type: ApplicationFiled: July 28, 2017Publication date: February 1, 2018Applicant: SYSMEX CORPORATIONInventors: Takayuki NAKAJIMA, Tetsuya ODA, Hiromi ONOMICHI, Kentaro TSURUMI, Seiya SHINABE
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Publication number: 20180031582Abstract: Disclosed is a method for measuring a clotting time, including the steps of: (A) mixing a blood sample, an activator, a phospholipid, and a nickel ion-forming compound to obtain a specimen; and (B) mixing the specimen obtained in step (A) with a calcium salt to prepare a measurement specimen and measuring the clotting time of the measurement specimen.Type: ApplicationFiled: July 26, 2016Publication date: February 1, 2018Applicants: SYSMEX CORPORATION, SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUENInventors: Osamu KUMANO, Haruki YAMAGUCHI, Takeshi SUZUKI, Masahiro IEKO
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Publication number: 20180031539Abstract: Disclosed is a method for determining the severity of hemophilia, the method including the steps of: coagulating a blood specimen to acquire a coagulation waveform; acquiring an average change rate of a coagulation rate from the coagulation waveform; and determining the severity of hemophilia in the blood specimen based on the average change rate of the coagulation rate.Type: ApplicationFiled: July 27, 2017Publication date: February 1, 2018Applicants: SYSMEX CORPORATION, PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITYInventors: Midori SHIMA, Keiji NOGAMI, Tomoko MATSUMOTO, Yuka TABUCHI, Nobuo ARAI
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Publication number: 20180024128Abstract: An immunoassay apparatus may include: a sample dispenser part that dispenses a sample into a first reaction container; a reagent dispenser part that dispenses, into the first reaction container,: a solid-phase reagent containing a solid-phase carrier; a labeled reagent; and a releasing reagent that releases, from the solid-phase carrier, an immune complex including a target substance and a labeled substance; a measurement part that measures a signal based on the labeled substance in the immune complex in a second reaction container; a container supply part that stores a plurality of reaction containers; a transfer part that transfers the first reaction container so that the sample dispenser part and the reagent dispenser part perform a dispensing operation to the first reaction container, and that transfers the second reaction container so that the immune complex dispended from the first reaction container is dispensed into the second container.Type: ApplicationFiled: September 29, 2017Publication date: January 25, 2018Applicant: SYSMEX CORPORATIONInventors: Toshiyuki SATO, Toshikatsu FUKUJU, Shuhei KANEKO, Atsushi AOKI, Tomohiro OKUZAKI, Yasuhiro TAKEUCHI, Yutaka KAWAMOTO
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Patent number: 9874511Abstract: An analyzer including a housing with a mutually adjacent first side and a second side, and an annular reagent holding part disposed within the housing is disclosed. An immunoassay method for measuring antigen or antibody of a measurement object contained in a sample and performed by the analyzer is also disclosed.Type: GrantFiled: March 26, 2015Date of Patent: January 23, 2018Assignee: SYSMEX CORPORATIONInventors: Toshikatsu Fukuju, Yusuke Matsumoto
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Publication number: 20180017480Abstract: A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.Type: ApplicationFiled: September 26, 2017Publication date: January 18, 2018Applicant: SYSMEX CORPORATIONInventors: Masakazu FUKUDA, Masamichi TANAKA, Yousuke TANAKA
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Patent number: 9869685Abstract: A sample analyzer including: a first reagent container holding unit; a second reagent container holding unit being arranged on one side of the first reagent container holding portion; a reagent information reading unit; and a control unit. The reagent information reading unit includes an electric wave emitting portion, which is arranged on the other side of the first reagent container holding unit, for emitting a plurality of electric waves having mutually differing reaching ranges, and the control unit controls the reagent information reading unit to switch the electric wave emitted from the electric wave emitting portion in accordance with a read target being the first electronic tag or the second electronic tag.Type: GrantFiled: March 18, 2011Date of Patent: January 16, 2018Assignee: Sysmex CorporationInventor: Kazutoshi Tokunaga
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Publication number: 20180011054Abstract: Provided is a method for detecting a test substance. In this method, metal is deposited or a complex containing a test substance and a metal particle is immobilized on a working electrode on an electrode substrate including the working electrode and a counter electrode. An oxidation potential is applied to the working electrode to generate metal ions, then a reduction potential is applied to a portion having an area smaller than an area of the portion to which an oxidation potential is applied in the working electrode to deposit metal on the surface of the portion to which the reduction potential is applied, and current, voltage or charge caused by the metal deposited is measured to detect metal ions or a test substance.Type: ApplicationFiled: July 18, 2017Publication date: January 11, 2018Applicant: SYSMEX CORPORATIONInventors: Nobuyasu HORI, Hiroya KIRIMURA, Yuzuru TAKAMURA, Miyuki CHIKAE
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Patent number: 9863872Abstract: A sample analyzer includes: a preparation unit configured to mix a sample with a reagent to prepare a measurement specimen; a measurement unit configured to irradiate the measurement specimen with light to acquire optical time series data; and a controller configured to divide the time series data acquired by the measurement unit into data segments, determine first regression lines respectively of the data segments, select the first regression line with the highest matching degree with the time series data, set as an analysis target region a region of the time series data matching with the selected first regression line among the time series data acquired by the measurement unit, determine a second regression line using the time series data included in the set analysis target region, and perform an analysis using the second regression line.Type: GrantFiled: March 24, 2016Date of Patent: January 9, 2018Assignee: SYSMEX CORPORATIONInventor: Naoto Koshimura
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Patent number: 9863964Abstract: Disclosed is a sample analyzer configured to analyze a concentration of a target material contained in a sample based on a value representing a slope of a regression line which is based on data values included in an interval from a start point to an endpoint. The start point is detected by a predetermined method and the endpoint is detected by a predetermined method.Type: GrantFiled: April 29, 2016Date of Patent: January 9, 2018Assignee: SYSMEX CORPORATIONInventor: Naoto Koshimura
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Publication number: 20180003707Abstract: Disclosed is a method for producing an antibody reagent for detecting a test substance in a sample by an immune complex transfer method. The method comprises the steps of: bringing an antibody solution comprising a labeled antibody capable of binding to the test substance into contact with a solid phase used in the immune complex transfer method; and separating the solid phase and the antibody solution to prepare the antibody reagent from the antibody solution.Type: ApplicationFiled: June 28, 2017Publication date: January 4, 2018Applicant: SYSMEX CORPORATIONInventors: Seiichi HASHIDA, Aya MORIMOTO, Toshihiro WATANABE, Takahiro YAMAGAITO
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Publication number: 20180003729Abstract: A sample measurement system may include: a measurement unit that measures a sample in a sample container; a transport unit that transports a rack that can hold sample containers, via the measurement unit; a collection unit that is detachably provided with a tray in which racks can be set, and that collects the rack transported from the measurement unit by the transport unit and sets the rack in the tray; a storage that stores sample identification information, rack identification information, and tray identification information in association with each other; an input part; a display part; and a controller that, in a condition in which the input part receives input of the sample identification information or the rack identification information, causes the display part to display the tray identification information stored in association with the inputted sample identification information or the inputted rack identification information.Type: ApplicationFiled: September 13, 2017Publication date: January 4, 2018Applicant: SYSMEX CORPORATIONInventors: Hiroo TATSUTANI, Yuichiro OHMAE
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Publication number: 20180002108Abstract: A sample measurement system includes: a measurement unit that measures a sample stored in a sample container; a transport unit that transports a rack capable of holding sample containers via the measurement unit; a first transport-in/transport-out unit and a second transport-in/transport-out unit in each of which racks can be set alongside in a first direction, and that send the set racks to be transported to the measurement unit and receive the racks transported from the measurement unit; and a controller that controls the first transport-in/transport-out unit and the second transport-in/transport-out unit so that the racks are sequentially sent from the first transport-in/transport-out unit and the second transport-in/transport-out unit. The first transport-in/transport-out unit and the second transport-in/transport-out unit are disposed alongside in a second direction crossing the first direction, and each send the racks from one side in the first direction, and receive the racks from the other side.Type: ApplicationFiled: September 14, 2017Publication date: January 4, 2018Applicant: SYSMEX CORPORATIONInventors: Hiroo TATSUTANI, Yuichiro OHMAE, Atsushi KUMAGAI
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Publication number: 20170370920Abstract: The present invention relates to a method for detecting an analyte in a sample, comprising the steps of: forming on each of carrier particles a complex containing a first capture substance capable of binding to an analyte, one molecule of the analyte, a second capture substance capable of binding to the analyte, and a catalyst; immobilizing a reaction product on each of the carrier particles by reacting the catalyst in the compolex with a substrate; and detecting the analyte by detecting the carrier particles on each of which the reaction product is immobilized.Type: ApplicationFiled: September 5, 2017Publication date: December 28, 2017Applicant: SYSMEX CORPORATIONInventors: Kenji AKAMA, Seigo SUZUKI, Kenta ODA, Kentaro SHIRAI, Hana KUMAMOTO
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Publication number: 20170363521Abstract: First and second racks each has fixed positions to hold sample tubes. First and second drawers slide into and out of the case, and that support the first and second racks, respectively. A tube set unit is provided in an area close to the first rack in the case. A tube transfer unit removes sample tubes from the first and second racks in the case and a controller that controls a transfer operation of the tube transfer unit. The first rack is supported by the first drawer such that the first rack leaves a transit location in the case behind the first drawer in the direction of the first drawer movement into the case. The controller controls the tube transfer unit to remove at least one sample tube from the second rack and transfers the tube to the tube set unit via a path traversing the transit location.Type: ApplicationFiled: June 29, 2017Publication date: December 21, 2017Applicant: SYSMEX CORPORATIONInventors: Takaaki NAGAI, Daigo FUKUMA, Mitsuo YAMASAKI, Noriyuki NAKANISHI, Syunsuke YAO, Tomonori OKAZAKI, Takahiro SAINO
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Patent number: 9845507Abstract: Provided herein are methods for the detection of genetic mutations associated with cancer, particularly in the KIT gene.Type: GrantFiled: September 30, 2014Date of Patent: December 19, 2017Assignee: SYSMEX CORPORATIONInventors: Johannes Fredebohm, Frank Diehl, Frank Holtrup, Daniel Mehnert
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Patent number: 9840535Abstract: Disclosed is a method of recovering a peptide, including: mixing a liquid sample containing a complex of peptide and protein in blood with a reagent containing a neutral amino acid, an acidic amino acid or both the neutral and acidic amino acids to liberate the peptide from the protein in blood; and recovering the liberated peptide.Type: GrantFiled: January 14, 2015Date of Patent: December 12, 2017Assignee: SYSMEX CORPORATIONInventor: Kana Kawasaki