Patents Assigned to Sysmex Corporation
  • Urine analysis system, image capturing apparatus, urine analysis method
    Patent number: 11499908
    Abstract: A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: November 15, 2022
    Assignee: SYSMEX CORPORATION
    Inventors: Masakazu Fukuda, Masamichi Tanaka, Yousuke Tanaka
  • SMEAR STAINING APPARATUS, SMEAR PREPARING APPARATUS, AND SMEAR STAINING METHOD
    Publication number: 20220357248
    Abstract: A smear staining apparatus may include: a chamber part in which glass slides can be placed and that is configured to contain a staining solution for staining a smear on each of the glass slides; a cover part that covers the chamber part from above and comprises an insertion hole through which the glass slides are transported to the chamber part; and a transport part that transports the glass slides to the chamber part through the insertion hole.
    Type: Application
    Filed: July 21, 2022
    Publication date: November 10, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Takaaki NAGAI, Noriyuki NAKANISHI, Seiya SHINABE, Tetsuya ODA, Mitsuo YAMASAKI, Hiroyuki KOGA
  • Transport system, sample analyzer, sample rack, and transport regulation method
    Patent number: 11493524
    Abstract: A transport system includes a sample rack configured to hold a sample and comprising a notch; a rack storage unit in which the sample rack is stored; a transport path arranged to transport the sample rack moved from the rack storage unit; and a regulating member configured to regulate movement of the sample rack from the rack storage unit toward the transport path, wherein the regulating member is provided at a position corresponding to the notch provided in the sample rack, and enters an interior of the sample rack from the notch and abuts an interior wall of the sample rack as the sample rack moves from the rack storage unit toward the transport path.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: November 8, 2022
    Assignee: SYSMEX CORPORATION
    Inventor: Kohei Oda
  • Reagent for determination of coagulation time, production method therefor, reagent kit, and method for determination of coagulation time
    Patent number: 11486885
    Abstract: Disclosed is a reagent for determination of activated partial thromboplastin time, comprising: a phosphatidylcholine (PC); a phosphatidylserine (PS); and a phosphatidylethanolamine (PE), wherein a concentration ratio of the PS relative to the PC is not less than 0.16 and not more than 0.25, and a concentration of the PS is not less than 7 ?g/mL and not more than 13 ?g/mL.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: November 1, 2022
    Assignee: SYSMEX CORPORATION
    Inventors: Kohei Akatsuchi, Takahiko Bandou, Naoki Yamamoto, Masako Aki
  • Method for measuring cholesterol uptake capacity of lipoproteins
    Patent number: 11486875
    Abstract: The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. The present invention also relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. The present invention further relates to a tagged cholesterol which can be used in the method and the reagent kit.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: November 1, 2022
    Assignee: SYSMEX CORPORATION
    Inventors: Keiko Yoshikawa, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Miwa, Takuya Kubo
  • Measurement method, measuring apparatus, program, and method for obtaining and displaying qualitative determination result
    Patent number: 11486877
    Abstract: Disclosed is a measurement method for measuring a test substance contained in a biological sample based on a predetermined measurement principle, comprising acquiring a first measured value of the test substance using a first measurement reagent, and operating the first measured value to an arithmetic value when measured using a second measurement reagent different from the first measurement reagent, by using arithmetic information designed to make a first cut-off value for the measured value obtained using the first measurement reagent correspond to a second cut-off value for a measured value obtained using the second measurement reagent.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: November 1, 2022
    Assignee: SYSMEX CORPORATION
    Inventors: Mamoru Ashida, Motonari Daito, Tetsuro Morinaga
  • Chemiluminescence measurement apparatus
    Patent number: 11480525
    Abstract: Disclosed is a chemiluminescence measurement apparatus that includes: a support member configured to support a cartridge for measuring a test substance contained in a specimen by chemiluminescence measurement; a motor configured to rotate the support member so as to rotate the cartridge such that a process required for the chemiluminescence measurement proceeds in the cartridge; and a light receiver configured to receive light generated by chemiluminescence in the cartridge that is supported by the support member rotated by the motor. The cartridge supported by the support member and a light receiving surface of the light receiver are disposed inside a dark space surrounded by a light-shielding portion, and the motor is disposed outside the dark space.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: October 25, 2022
    Assignee: SYSMEX CORPORATION
    Inventors: Sayuri Tomoda, Tomoyuki Nose, Noriaki Sasaki, Kazuyoshi Horii
  • ELECTRODE, METHOD FOR MANUFACTURING ELECTRODE, ION SENSOR, IN-VIVO COMPONENT MEASURING DEVICE, AND IN-VIVO COMPONENT MEASURING METHOD
    Publication number: 20220334077
    Abstract: An electrode with higher potential stability for repeated use and/or long-term use in an ion sensor is provided. The electrode includes an internal solid layer containing a metal oxide and a solid electrolyte and an electrode material.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 20, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Kenichi UCHIYAMA, Junko KOJIMA
  • Sample analyzing method and sample analyzer
    Patent number: 11473130
    Abstract: A sample analyzing method includes: denaturing DNA by heating a measurement specimen; bleaching the measurement specimen to inhibit autofluorescence from the measurement specimen; binding a fluorescent dye to a test substance in the measurement specimen; and capturing an image of fluorescence originated from the fluorescent dye by irradiating the measurement specimen with light. The DNA denaturation treatment is performed before the bleaching.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: October 18, 2022
    Assignee: SYSMEX CORPORATION
    Inventors: Takuya Kubo, Shigeki Iwanaga
  • Method for concentrating extracellular vesicles
    Patent number: 11467073
    Abstract: Disclosed is a method for concentrating extracellular vesicles, comprising preparing a mixture comprising a first fraction and a second fraction by mixing a liquid sample comprising extracellular vesicles, a polysaccharide, and a polyether having an average molecular weight of 20,000 or less, wherein the first fraction comprises a higher concentration of extracellular vesicles than the second fraction, and the first fraction comprises a higher concentration of extracellular vesicles than the liquid sample.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: October 11, 2022
    Assignee: SYSMEX CORPORATION
    Inventors: Koya Yamawaki, Yuki Aihara
  • QUALITY CONTROL METHOD OF SPECIMEN ANALYSIS SYSTEM AND SPECIMEN ANALYSIS SYSTEM
    Publication number: 20220308076
    Abstract: A quality control method of a specimen analysis system according to one or more embodiments is disclosed. The quality control method may include cooling and storing a quality control material comprising a cell of known concentration; heating the cooled and stored quality control material; transporting the heated quality control material to an analyzer; and measuring the quality control material by the analyzer.
    Type: Application
    Filed: March 3, 2022
    Publication date: September 29, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Yuji WAKAMIYA, Toru UEMURA, Yuichiro OHMAE, Hidetaka HAYAMA
  • METHOD FOR DETERMINING ONSET RISK OF CARDIOVASCULAR DISEASE IN SUBJECT, AND METHOD FOR DETERMINING VASCULAR CALCIFICATION IN SUBJECT
    Publication number: 20220308057
    Abstract: Disclosed is a method of determining onset risk of cardiovascular disease in a subject, the method comprising: capturing, on a solid phase, an extracellular vesicle derived from a blood sample collected from the subject; and measuring alkaline phosphatase activity of the extracellular vesicle, a measured result of the alkaline phosphatase activity being directed for use as an index of the onset risk of cardiovascular disease in the subject.
    Type: Application
    Filed: February 18, 2022
    Publication date: September 29, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Maria KIRIYAMA, Eiya TAMADA, Elnaz NAKHAEI, Mami ONISHI
  • REAGENT FOR DETECTING TARGET SUBSTANCE CONTAINING SUGAR CHAIN, DETECTION METHOD, CARRIER USED IN DETECTION OF TARGET SUBSTANCE CONTAINING SUGAR CHAIN, AND METHOD FOR MANUFACTURING SAID CARRIER
    Publication number: 20220299502
    Abstract: The present invention relates to a method for detecting a target substance that is useful for detection of a glycoprotein and the like comprising a specific sugar chain, a reagent for detecting a target substance, a carrier and a method for manufacturing the carrier.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 22, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Chikayuki TSURUNO, Shinya NAGAI, Minako TERAO, Chika MIZUTA, Takuya KYOUTOU
  • ANALYSIS METHOD, ANALYSIS DEVICE, ANALYSIS SYSTEM, AND ANALYSIS PROGRAM FOR ANALYZING A BLEEDING TENDENCY OF A SUBJECT
    Publication number: 20220299534
    Abstract: PROBLEM: According to the present invention, a patient who experiences severe bleeding is detected based on a value obtained by a common coagulation test. SOLUTION: The present invention is an analysis method for analyzing the bleeding tendency of a subject, and the problem is resolved by this analysis method which includes obtaining a time-series data set of a coagulation reaction of a blood sample collected from the subject; obtaining, based on the time-series data set, a maximum speed arrival time until a coagulation reaction speed is maximized or a maximum acceleration arrival time until a coagulation reaction acceleration is maximized, and a reference time in the coagulation reaction; obtaining a value based on the maximum speed arrival time or the maximum acceleration arrival time, and the reference time; and outputting the value or information relating to the bleeding tendency based on the value.
    Type: Application
    Filed: March 18, 2022
    Publication date: September 22, 2022
    Applicant: SYSMEX CORPORATION
    Inventor: Satomi NISHIKAWA
  • METHOD FOR ACQUIRING INFORMATION ON SPINAL MUSCULAR ATROPHY
    Publication number: 20220291204
    Abstract: Disclosed is a method for acquiring information on spinal muscular atrophy, comprising acquiring a fluorescence image of a nucleated cell in a measurement sample, wherein the measurement sample is a sample prepared from a blood specimen obtained from a subject, an SMN protein in the nucleated cell is labeled with a first fluorescent dye, and a predetermined nuclear protein in the nucleated cell is labeled with a second fluorescent dye, acquiring an intracellular distance between a first bright spot corresponding to the first fluorescent dye and a second bright spot corresponding to the second fluorescent dye in the fluorescence image, and acquiring a value regarding a number of nucleated cells in which the intracellular distance is equal to or less than a first threshold value, wherein the value is an indicator of spinal muscular atrophy affection.
    Type: Application
    Filed: March 11, 2022
    Publication date: September 15, 2022
    Applicants: TOKYO WOMEN'S MEDICAL UNIVERSITY, SYSMEX CORPORATION
    Inventors: Kayoko SAITO, Noriko Otsuki, Takanori Maekawa
  • ANALYSIS METHOD AND ANALYZER
    Publication number: 20220292855
    Abstract: Disclosed is an analysis method for a specimen using an analyzer connected to a host computer, the analysis method including: obtaining, with respect to each of a plurality of cells contained in the specimen, feature data of the cell; generating classification information in which each of the cells is classified into a plurality of cell types, by analyzing the feature data with use of an artificial intelligence algorithm and performing classifying; generating a measurement result of the specimen on the basis of the classification information; displaying, on a display part of the analyzer, the measurement result and at least a part of the classification information; and transmitting, to the host computer, output data that includes the measurement result and in which at least a part of the classification information has been removed.
    Type: Application
    Filed: March 10, 2022
    Publication date: September 15, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Shoichiro Asada, Konobu Kimura, Masamichi Tanaka, Kenichiro Suzuki
  • ANALYSIS METHOD AND ANALYZER
    Publication number: 20220291199
    Abstract: Disclosed is an analysis method for analyzing a specimen containing cells, the analysis method including: applying light to a measurement sample prepared from the specimen and detecting light generated from cells; obtaining, with respect to each of a plurality of cells contained in the specimen, feature data of the cell on the basis of the detected light; analyzing the feature data with use of an artificial intelligence algorithm, thereby classifying each of the cells into a plurality of cell types; and displaying information based on a result of the classifying.
    Type: Application
    Filed: March 10, 2022
    Publication date: September 15, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Shoichiro Asada, Konobu Kimura, Masamichi Tanaka, Kenichiro Suzuki
  • ANALYSIS METHOD AND ANALYZER
    Publication number: 20220291200
    Abstract: Disclosed is an analysis method for analyzing a specimen containing cells, the analysis method including: applying light to a measurement sample prepared from the specimen and detecting light generated from cells; obtaining, with respect to each of a plurality of cells contained in the specimen, feature data of the cell on the basis of the detected light; analyzing the feature data with use of an artificial intelligence algorithm, thereby classifying each of the cells into a plurality of cell types; and generating result data including a result of the classifying of each of the cells into the plurality of cell types.
    Type: Application
    Filed: March 10, 2022
    Publication date: September 15, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Shoichiro Asada, Konobu Kimura, Masamichi Tanaka, Kenichiro Suzuki
  • QUALITY CONTROL METHOD OF SPECIMEN ANALYSIS SYSTEM AND SPECIMEN ANALYSIS SYSTEM
    Publication number: 20220283194
    Abstract: A quality control method of a specimen analysis system is disclosed, including: receiving a setting of a quality control measurement condition from a user; determining at least one quality control specimen to be used for quality control measurement from among a plurality of the quality control specimens stored in a storage, according to the quality control measurement condition and information on the quality control specimens that are stored in the storage section; taking out the determined quality control specimen from the storage; transporting the determined quality control specimen to a measurement unit; and measuring the transported quality control specimen by the measurement unit.
    Type: Application
    Filed: March 3, 2022
    Publication date: September 8, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Yuji WAKAMIYA, Toru UEMURA, Yuichiro OHMAE, Hidetaka HAYAMA
  • METHOD FOR CONTROLLING SPECIMEN ANALYSIS SYSTEM AND SPECIMEN ANALYSIS SYSTEM
    Publication number: 20220283196
    Abstract: A method for controlling a specimen analysis system including at least one measurement unit according to one or more embodiments is disclosed. The method may include automatically starting at least one measurement unit according to a schedule registered by a user; automatically supplying a quality control specimen to the measurement unit that is automatically started; and measuring the quality control specimen by the measurement unit.
    Type: Application
    Filed: March 3, 2022
    Publication date: September 8, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Yuji WAKAMIYA, Toru UEMURA, Yuichiro OHMAE, Hidetaka HAYAMA