Patents Assigned to Systems S.p.A.
  • PROCESS FOR THE PREPARATION OF CARVEDILOL AND ITS ENANTIOMERS
    Publication number: 20120041044
    Abstract: The present invention relates to a process for the preparation of carvedilol as well as of the optically active R and S enantiomers thereof and of mixtures of these enantiomers and, more particularly, relates to an improved process for the preparation of carvedilol and its enantiomers characterized by the use of ethyl acetate as reaction solvent.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 16, 2012
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Elisenda Trepat Guixer, Anna Munoz Alvarez, Marta Pomares Marco, Francisco Marquillas Olondriz
  • PROCESS FOR PREPARING OLOPATADINE AND/OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
    Publication number: 20120016138
    Abstract: The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt.
    Type: Application
    Filed: February 1, 2010
    Publication date: January 19, 2012
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Alberto Guidi, Filippo Chiarello, Gianmauro Orru', Massimo Verzini, Livius Cotarca, Jean-Claude Kizirian, Elisenda Trepat Guixer, Francisco Marquillas Olondriz
  • Process for preparing nebivolol
    Patent number: 8084629
    Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: December 27, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto
  • PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE
    Publication number: 20110306794
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.
    Type: Application
    Filed: February 16, 2010
    Publication date: December 15, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • BLANK FOR PACKING SUBSTANTIALLY FLAT ARTICLES, A METHOD AND MACHINE FOR MAKING THE BLANK
    Publication number: 20110214402
    Abstract: The invention relates to a blank (1), a method and a machine (11) for realising the blank (1). The blank (1) is constituted by four lengths (5) which are consecutively joined to form a structure (2) or frame (6) which can be folded around one or more flat articles (4) or tiles to be packed. The machine (11) and the method for realising the blanks (1) include supplying identical panels of cardboard which are joined to constitute a continuous strip (10) and which are subsequently cut to correspond to lengths of sides of the tiles. Each length (5) is joined to a consecutive length (5) by deposits (7a) of glue.
    Type: Application
    Filed: April 29, 2011
    Publication date: September 8, 2011
    Applicant: SYSTEM S.P.A.
    Inventor: ANDREA TORO
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110207948
    Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity.
    Type: Application
    Filed: October 28, 2009
    Publication date: August 25, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Paolo Maragni, Ivan Michieletto, Raffaella Volpicelli, Giorgio Soriato, Johnny Foletto, Livius Cotarca, Massimo Verzini
  • PROCESS FOR PREPARING CINACALCET
    Publication number: 20110207965
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula (I) i.e. Cinacalcet and its intermediates of formulae (V), (Va) and (Vb).
    Type: Application
    Filed: October 16, 2009
    Publication date: August 25, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • Process for preparing Nebivolol
    Patent number: 8003810
    Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula, wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: August 23, 2011
    Assignee: Zach System S.p.A.
    Inventors: Elio Ullucci, Paolo Maragni, Livius Cotarca, Johnny Foletto
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110201831
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Application
    Filed: April 29, 2011
    Publication date: August 18, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella VOLPICELLI, Paolo MARAGNI, Livius COTARCA, Johnny FOLETTO, Franco MASSACCESI
  • Process for preparing nebivolol
    Patent number: 7999124
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: August 16, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
  • Process for the purification of gabapentin
    Patent number: 7989658
    Abstract: The present invention relates to a process for the purification of gabapentin. The process relates to the addition of hydrochloric acid to an aqueous solution or suspension of gabapentin, before, during or after the concentration step of that solution, and the subsequent slurry of the gabapentin by the addition of an alcoholic solvent. The so obtained gabapentin has an high purity degree and, in particular, is characterized by a low content of lactam.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: August 2, 2011
    Assignee: ZaCh System S.p.A.
    Inventors: Roberto Giovanetti, Andrea Nicoli, Livius Cotarca
  • METHOD AND SYSTEM FOR AUTOMATICALLY IDENTIFYING RELATED CONTENT TO AN ELECTRONIC TEXT
    Publication number: 20110145250
    Abstract: The exemplary embodiments provide methods and systems for automatically identifying content related to an electronic text. Aspects of exemplary embodiments include linking topic categories, psychological states, demographic profiles, and additional content using one or more databases; in response to receiving content of an electronic text, analyzing by a software component executing on a computer the content and assigning one or more of topic categories to the content; automatically identifying at least one the psychological states of a user caused by the content and the demographic profiles whose members would be interested in the content that are linked to the one or more topic categories assigned to the content; and presenting a portion of the additional content that is linked to at least one of the identified demographic profiles and the psychological states.
    Type: Application
    Filed: December 14, 2009
    Publication date: June 16, 2011
    Applicant: EXPERT SYSTEM S.P.A.
    Inventor: Stefano Spaggiari
  • Process for preparing nebivolol
    Patent number: 7960572
    Abstract: The present invention relates to a process for the preparation of Nebivolol and, more particularly, to an improved method of synthesizing 6-fluoro chroman epoxides of formula (I) key intermediates in preparing nebivolol.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: June 14, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto
  • Machine for covering various types of articles
    Patent number: 7954303
    Abstract: A machine for covering articles with sheets of plastic material. The machine includes a device suitable for cutting and sealing the sheets that cooperate with a work plane and a guide suitable for arranging a roll of a continuous sheet of plastic material in a suitable position for unrolling subsequent portions of the continuous sheet and the positioning thereof on the work plane.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: June 7, 2011
    Assignee: Colibri' System S.p.A.
    Inventor: Aldo Farneti
  • Blank for packing substantially flat articles, a method and machine for making the blank
    Patent number: 7954304
    Abstract: The invention relates to a blank (1), a method and a machine (11) for realising the blank (1). The blank (1) is constituted by four lengths (5) which are consecutively joined to form a structure (2) or frame (6) which can be folded around one or more flat articles (4) or tiles to be packed. The machine (11) and the method for realising the blanks (1) include supplying identical panels of cardboard which are joined to constitute a continuous strip (10) and which are subsequently cut to correspond to lengths of sides of the tiles. Each length (5) is joined to a consecutive length (5) by deposits (7a) of glue.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: June 7, 2011
    Assignee: System S.p.A.
    Inventor: Andrea Toro
  • PROCESS FOR THE PREPARATION OF CLOPIDOGREL HYDROGEN SULFATE CRYSTALLINE FORM I
    Publication number: 20110118467
    Abstract: The present invention relates to a process for the preparation of clopidogrel and, more particularly, to an improved process for the preparation of clopidogrel hydrogen sulfate crystalline Form I by addition of dilute sulfuric acid to a solution of clopidogrel free base in butyl acetate.
    Type: Application
    Filed: June 11, 2009
    Publication date: May 19, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Giorgio Soriato, Roberto Brescello, Daniele Urbani, Livius Cotarca
  • Process for the preparation of levetiracetam
    Patent number: 7939676
    Abstract: A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (?)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: May 10, 2011
    Assignee: Zach System S.p.A.
    Inventors: Corrado Colli, Massimiliano Forcato, Livius Cotarca
  • Process for the preparation of Levetiracetam
    Publication number: 20110065932
    Abstract: A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (?)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia.
    Type: Application
    Filed: September 17, 2009
    Publication date: March 17, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Corrado Colli, Massimiliano Forcato, Livius Cotarca
  • Method and system for automatically extracting relations between concepts included in text
    Patent number: 7899666
    Abstract: A method and system for automatically extracting relations between concepts included in electronic text is described. Aspects the exemplary embodiment include a semantic network comprising a plurality of lemmas that are grouped into synsets representing concepts, each of the synsets having a corresponding sense, and a plurality of links connected between the synsets that represent semantic relations between the synsets.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: March 1, 2011
    Assignee: Expert System S.p.A.
    Inventor: Marco Varone
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110021793
    Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a di-astereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
    Type: Application
    Filed: March 16, 2009
    Publication date: January 27, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto