Abstract: A machine for covering articles with sheets of plastic material. The machine includes a device suitable for cutting and sealing the sheets that cooperate with a work plane and a guide suitable for arranging a roll of a continuous sheet of plastic material in a suitable position for unrolling subsequent portions of the continuous sheet and the positioning thereof on the work plane.
Abstract: The present invention relates to a process for the preparation of clopidogrel and, more particularly, to an improved process for the preparation of clopidogrel hydrogen sulfate crystalline Form I by addition of dilute sulfuric acid to a solution of clopidogrel free base in butyl acetate.
Type:
Application
Filed:
June 11, 2009
Publication date:
May 19, 2011
Applicant:
ZACH SYSTEM S.P.A.
Inventors:
Giorgio Soriato, Roberto Brescello, Daniele Urbani, Livius Cotarca
Abstract: A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (?)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia.
Abstract: A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (?)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia.
Abstract: A method and system for automatically extracting relations between concepts included in electronic text is described. Aspects the exemplary embodiment include a semantic network comprising a plurality of lemmas that are grouped into synsets representing concepts, each of the synsets having a corresponding sense, and a plurality of links connected between the synsets that represent semantic relations between the synsets.
Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a di-astereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
Type:
Application
Filed:
March 16, 2009
Publication date:
January 27, 2011
Applicant:
ZACH SYSTEM S.P.A.
Inventors:
Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto
Abstract: The present invention refers to a system for detecting obstacles for vehicles, comprising at least one sensor able to transmit a detection signal and to receive an echo signal reflected off at least one obstacle, means of parametric evaluation of said received echo signal which comprise means of comparison between at least two successive echo signals for the determination of a reference echo signal able to define the position of at least one fixed obstacle with respect to said at least one sensor.
Abstract: The invention relates to a blank (1), a method and a machine (11) for realising the blank (1). The blank (1) is constituted by four lengths (5) which are consecutively joined to form a structure (2) or frame (6) which can be folded around one or more flat articles (4) or tiles to be packed. The machine (11) and the method for realising the blanks (1) include supplying identical panels of cardboard which are joined to constitute a continuous strip (10) and which are subsequently cut to correspond to lengths of sides of the tiles. Each length (5) is joined to a consecutive length (5) by deposits (7a) of glue.
Abstract: A process for series connection of two photovoltaic cells (1a, 1b) in series, comprising following stages: predisposing a first photovoltaic cell (1a) and a second photovoltaic cell (1b), both of a type comprising a photosensitive semiconductor layer (2) provided with front contacts (3a, 3b) and back contacts (4) arranged on opposite surfaces of the cell; partially superposing the two photovoltaic cells (1a, 1b), causing at least a partial superposing of the back contact (4) of the first photovoltaic cell (1a) on the front contact (3a, 3b) of the second photovoltaic cell (1b) and consequently establishing an electrical contact between the back contact (4) and the front contact (3a, 3b).
Abstract: The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of ?, -diaminocarbonyl-?,?-pentamethylene glutarimide.
Type:
Grant
Filed:
June 22, 2005
Date of Patent:
July 20, 2010
Assignee:
Zach System S.P.A.
Inventors:
Marco Villa, Maurizio Paiocchi, Katiuscia Arrighi, Francesco Corcella, Vincenzo Cannata, Giorgio Soriato, Massimo Verzini
Abstract: Circuit for the generation of two symmetrical buses of tension with respect to the negative of the feeding tension, comprising supply means able to supply a power step-up circuit comprising an inductor, a switch, a diode and a condenser, an LC filter being arranged in cascade to said power step-up circuit, a pair of switches with relevant re-circulation diodes being connected in cascade to said LC filter, whose peculiar aspect is that said supply means comprise a single supply source, and a circuit branch consisting of a condenser and a diode connected in series the one to the other and in parallel to said switch and said condenser of said power step-up circuit, a further inductor with diode in series being connected between the anode end of said circuit branch diode and a condenser connected symmetrically with respect to the condenser of said power step-up circuit.
Abstract: A photovoltaic module (1) comprises a plurality of photovoltaic cells (100), electrically interconnected to define a photo-active surface (2). The photovoltaic cells (100) being closed between a front covering layer (3a) and a back covering layer (3b) which are electrically insulating, the front covering layer (3a) being frontally covered by a frontal covering element (4) having a mechanical protection function for the photovoltaic cells (100). The back covering layer (3b) being posteriorly supported by a support element, the support element being a ceramic slab of a limited thickness.
Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula, wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol.
Type:
Application
Filed:
November 23, 2007
Publication date:
March 25, 2010
Applicant:
ZACH SYSTEM S.P.A.
Inventors:
Elio Ullucci, Paolo Maragni, Livius Cotarca, Johnny Foletto
Abstract: The present invention relates to a process for the preparation of levetiracetam and, more particularly, to an improved process for the preparation of levetiracetam characterized by a crystallization-induced dynamic resolution of a diastereoisomeric mixture of an (±)-alpha-ethyl-2-oxo-1-pyrrolidine acetamide derivative.
Type:
Application
Filed:
July 20, 2007
Publication date:
March 25, 2010
Applicant:
ZACH SYSTEM S.P.A.
Inventors:
Massimiliano FORCATO, Ivan MICHIELETTO, Paolo MARAGNI, Franco MASSACCESI, Livius COTARCA
Abstract: The present invention relates to a process for the preparation of Nebivolol and, more particularly, to an improved method of synthesizing 6-fluoro chroman epoxides of formula (I) key intermediates in preparing nebivolol.
Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
Type:
Application
Filed:
November 23, 2007
Publication date:
March 4, 2010
Applicant:
ZACH SYSTEM S.P.A.
Inventors:
Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
Abstract: A process for the preparation of 1,1-cyclohexanediacetic acid monoamide comprising the amination of 1,1-cyclohexanediacetic acid anhydride by reaction with aqueous NH3 at a temperature lower than 30° C. by using a NH3/anhydride molar ratio lower than 3, and the product precipitation through the acidification of the reaction mixture; a precipitation process of 1,1-cyclohexanediacetic acid monoamide; and a process for the synthesis of gabapentin comprising the above preparation of 1,1-cyclohexanediacetic acid monoamide, the Hofmann transposition of the same monoamide, the purification of a gabapentin salt and the crystallization from organic solvent.
Type:
Application
Filed:
March 9, 2009
Publication date:
December 31, 2009
Applicant:
ZACH SYSTEM S.p.A.
Inventors:
Katiuscia ARRIGHI, Vincenzo CANNATA, Francesco CORCELLA, Gaetano MARCHIORO, Andrea NICOLI, Maurizio PAIOCCHI, Marco VILLA
Abstract: The present invention relates to a process for the purification of gabapentin. The process relates to the addition of hydrochloric acid to an aqueous solution or suspension of gabapentin, before, during or after the concentration step of that solution, and the subsequent slurry of the gabapentin by the addition of an alcoholic solvent. The so obtained gabapentin has an high purity degree and, in particular, is characterized by a low content of lactam.
Type:
Application
Filed:
December 15, 2005
Publication date:
November 26, 2009
Applicant:
ZACH SYSTEM S.P.A.
Inventors:
Roberto Giovanetti, Andrea Nicoli, Livius Cotarca
Abstract: A process for resolving dorzolamide trans racemate, which comprises reacting said racemate with (1S)-(+)-10-camphorsulfonic acid so obtaining the (4S,6S) enantiomer by selectively precipitating and recovering the camphorsulfonic acid salt thereof (dorzolamide camphorsulfonate), and neutralizing dorzolamide camphorsulfonate to obtain dorzolamide.
Type:
Application
Filed:
April 16, 2007
Publication date:
November 5, 2009
Applicant:
ZACH SYSTEM S.P.A.
Inventors:
Paolo Maragni, Ivan Michieletto, Livius Cotarca