Patents Assigned to Taipei Medical University
  • Patent number: 11427544
    Abstract: Disclosed is hydroxamic acid compounds of Formula (I) set forth herein. Also disclosed are a pharmaceutical composition containing such a compound and a method of using the compound for treating a condition associated with histone deacetylase 6.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: August 30, 2022
    Assignees: TAIPEI MEDICAL UNIVERSITY, NATIONAL TAIWAN UNIVERSITY
    Inventors: Che-Ming Teng, Jing-Ping Liou, Shiow-Lin Pan, Chia-Ron Yang
  • Patent number: 11426346
    Abstract: A lutein-containing ophthalmic composition, wherein the ophthalmic composition is mainly consisting of a natural anti-inflammatory substance, a substance with increasing liquid viscosity, and an artificial tear. The substance with increasing liquid viscosity could apply the ophthalmic composition to elongate the retention time on the ocular surface, thereby increasing the retention time of anti-inflammatory substance on the ocular surface for treating dry eye syndrome and inhibiting ocular surface inflammation.
    Type: Grant
    Filed: October 13, 2019
    Date of Patent: August 30, 2022
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: Ching-Li Tseng, I-Chan Lin, Yi-Zhou Chen, Yu-Lun Chuang, Cheng-Han Tsai, Zhi-Yu Chen
  • Patent number: 11427935
    Abstract: A passive intermittent rotating assembly can automatically adjust a part of a cleaning material when the cleaning material cleans a spinning jet each time and that can stably operate in a high-voltage environment. The passive intermittent rotating assembly includes a plurality of first abutment members and second abutment members being arranged respectively at an inner side and outer side of the main wheel along the circumferential direction, and being separated from each other to form gaps for a push portion of a push member to pass through. Each of the first abutment members includes a first inner-side abutment portion and a first outer-side abutment portion provided for abutting against the push portion. Each of the second abutment members includes a second inner-side abutment portion and a second outer-side abutment portion provided for abutting against the push portion.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: August 30, 2022
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventor: How Tseng
  • Publication number: 20220251043
    Abstract: Disclosed herein are hydroxamic acid compounds. Also disclosed is a method of using the hydroxamic acid compounds for treating a condition associated with histone deacetylase 6.
    Type: Application
    Filed: July 22, 2020
    Publication date: August 11, 2022
    Applicant: Taipei Medical University
    Inventors: Shiow-Lin PAN, Chia-Ron YANG, Han-Li HUANG, Huang-Ju TU, Jing-Ping LIOU
  • Publication number: 20220192594
    Abstract: A device includes an angiography module, a phototherapy module, a carrier including an optical filter and accommodating the angiography module and the phototherapy module, and a control unit controlling operation of the angiography module and the phototherapy module. The angiography module includes infrared LEDs emitting infrared light through the optical filter to irradiate a limb of a subject, and an infrared sensor sensing a part of the infrared light reflected off the limb to generate a result, based on which the control unit generates an angiogram. The phototherapy module emits infrared light through the optical filter to irradiate the limb for phototherapy.
    Type: Application
    Filed: April 15, 2021
    Publication date: June 23, 2022
    Applicant: Taipei Medical University
    Inventor: Jian-Chiun Liou
  • Patent number: 11365200
    Abstract: The invention relates to compounds for treating and/or preventing obesity and obesity-related disorders. Particularly, the invention provides chromanone derivatives used as ATF3 inducer and for treating and/or preventing obesity and obesity-related disorders such as heart disease, hypertension, hyperlipidemia and diabetes.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: June 21, 2022
    Assignees: TAIPEI MEDICAL UNIVERSITY, NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE, MINISTRY OF HEALTH AND WELFARE, ACADEMIA SINICA, BUDDHIST TZU CHI MEDICAL FOUNDATION
    Inventors: Heng Lin, Ming-jaw Don, Ching-feng Cheng, Jing-jy Cheng, Wen-shan Li, Hui-chen Ku, Hsiao-fen Li, Hsi-hsien Chen, W J Huang
  • Patent number: 11351400
    Abstract: A biological object image-capturing and treatment system includes a micro detection and treatment device. The micro detection and treatment device includes a plurality of signal transmitting and receiving elements arranged as an array, wherein adjacent at least two signal transmitting and receiving elements transmit signals or receive signals during different periods. When performing an image-capturing procedure, at least one signal transmitting and receiving element transmits a first power signal and, when performing a treatment procedure, at least one signal transmitting and receiving element transmits a second power signal, wherein a power of the first power signal is different from a power of the second power signal.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: June 7, 2022
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventor: Jian-Chiun Liou
  • Patent number: 11320427
    Abstract: The invention provides a tandemly repeated protein comprising at least two repeats of an amino acid sequence of an antibody binding protein or a fragment thereof and a cell having the repeats expressed on the membrane thereof, which can be used in immunoassay to improve detection sensitivity and detection limit.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: May 3, 2022
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: Kuo-Hsiang Chuang, Yi-Jou Chen, Michael Chen
  • Publication number: 20220122246
    Abstract: The present disclosure provides an operating method of a dopamine transporter check system, and the operation method includes steps as follows. A scan image of a subject's brain is obtained from a scan machine, and the scan image is a three-dimensional image. The scan image is aligned to a standard brain space to obtain a standardized scan image. Intensity normalization is performed on the standardized scan image. The standardized scan image after the intensity normalization is converted into a two-dimensional image. A plurality of image data are got from at least one region of interest in the two-dimensional image, and the at least one region of interest includes a left caudate, a left putamen, a right caudate and a right putamen. A dopamine neuron loss degree measurement and evaluation model based on the image data is established through a transfer learning.
    Type: Application
    Filed: December 9, 2020
    Publication date: April 21, 2022
    Applicant: Taipei Medical University (TMU)
    Inventors: Syu-Jyun Peng, Hsin-Yung Chen, Ya-Ju Tsai
  • Patent number: 11282197
    Abstract: The present disclosure provides an operating method of a system for analyzing brain tissue based on computerized tomographic imaging, and the operation method includes steps as follows. A computed tomography image of a subject is aligned to a predetermined standard brain space image, to obtain a first normalized test computed tomography image. A voxel contrast of the first normalized test computed tomography image is enhanced to obtain an enhanced first normalized test computed tomography image. The enhanced first normalized test computed tomography image is aligned to an average computed tomographic image of a control group to obtain a second normalized test computed tomography image. An analysis based on the second normalized test computed tomography image and a plurality of computerized tomographic images of the control group is performed to obtain a t-score map.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: March 22, 2022
    Assignees: National Central University, Taipei Medical University (TMU)
    Inventors: Syu-Jyun Peng, Yu-Wei Chen, Jing-Yu Yang, Jang-Zern Tsai, Kuo-Wei Wang, Yeh-Lin Kuo
  • Patent number: 11278523
    Abstract: The invention relates to the use of Indoline derivatives, and their effective dose in the prevention and/or treatment of fibrosis diseases. The compound can effectively prevent and/or treat a fibrosis disease without cytotoxicity or genotoxicity.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: March 22, 2022
    Assignee: Taipei Medical University
    Inventors: Chien Huang Lin, Jing-Ping Liou, Shiow-Lin Pan, Che-Ming Teng
  • Patent number: 11246499
    Abstract: A far-infrared emitters with physiological signal detection and method of operating the same is disclosed. A far-infrared beam module is switched on and generates far-infrared beam irradiating to a human body when a control unit starting up a microwave detecting module detecting physiological signal of the human body. The control unit is switched off when the time that the far-infrared beam irradiating on the human body reach a presetting period of time, thereby achieving the purpose of energy conservation.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: February 15, 2022
    Assignees: NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY, TAIPEI MEDICAL UNIVERSITY
    Inventors: San-Liang Lee, Chao-Hsiung Tseng, Ling-Hsiu Hung, Yung-Ho Hsu, Cheng-Hsien Chen
  • Patent number: 11238591
    Abstract: A medical image processing system includes a memory and a processor coupled to each other. The processor accesses and executes instructions which memory stores to perform the following: obtaining a plurality of brain MR images corresponding to a subject, wherein the brain MR images corresponds to a subject brain space; accessing a DBS targets atlas corresponding to a specific stimulation area; transforming the DBS targets atlas from a MNI brain space to the subject brain space based on a DARTEL algorithm; marking at least one coordinate having a largest Voxel value in the brain MR images based on the transformed DBS targets atlas; and storing the brain MR images being targeted with the at least one coordinate into a predetermined format corresponding to a guiding device so that the guiding device displays the brain MR images being targeted with the at least one coordinate for guidance in DBS procedure.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: February 1, 2022
    Assignees: Taipei Medical University (TMU), Kaohsiung Chang Gung Memorial Hospital
    Inventors: Syu-Jyun Peng, Fu-Yuan Shih
  • Patent number: 11229375
    Abstract: The invention relates to a method for determining ischemic status. The method comprises acquiring magnetic resonance diffusion tensor matrices and obtaining a relative decrease of diffusion magnitude due to the ischemic status from the magnetic resonance diffusion tensor matrices. The invention also relates to a method for assessing stroke onset time. The method comprises acquiring magnetic resonance diffusion tensor matrices and obtaining a relative decrease of pure anisotropy due to stroke from the magnetic resonance diffusion tensor matrices.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: January 25, 2022
    Assignee: Taipei Medical University
    Inventors: Cheng-Yu Chen, Hsiao-Wen Chung, Duen-Pang Kuo, Chia-Feng Lu, Yu-Chieh Jill Kao
  • Patent number: 11220734
    Abstract: A magnesium-based bulk metallic glass composite includes a magnesium-based bulk metallic glass composite comprising a magnesium-based material and a TiZr alloy.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: January 11, 2022
    Assignees: NATIONAL CENTRAL UNIVERSITY, TAIPEI MEDICAL UNIVERSITY
    Inventors: Chih-Hwa Chen, Shian-Ching Jang, Hsiang-Ho Chen, Lau-Yuen Woo, Erh-Yuan Chuang
  • Patent number: 11185386
    Abstract: A smart marking system for a surgical video and a method thereof are disclosed. The image recognition is performed for each surgical video to generate object information corresponding to each surgical video. The object information is used as feature data of the surgical video corresponding thereto. After a video to be analyzed is loaded, eigenvalue analysis and statistics are performed according to the video to be analyzed and all the feature data to calculate a similarity rate between the video to be analyzed and each surgical video. A surgical name corresponding to the surgical video with the highest similarity rate is selected to mark as a surgical name corresponding to the video to be analyzed. The video to be analyzed and the surgical name corresponding thereto are stored in a database as the surgical video. Thus, the efficiency of marking the surgical videos is improved.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: November 30, 2021
    Assignee: Taipei Medical University
    Inventors: Wei Min Liu, Yu Chieh Lee, Yi Ta Shen
  • Patent number: 11181597
    Abstract: The present disclosure provides an operating method of an automatic analysis system on magnetic resonance imaging (MRI), which includes steps as follows. Images are received from of the subject's brain from the MRI machine. Contrast-enhanced T1-weighted images and T2-weighted images are obtained from the images, and the pre-processing is performed on the images. The ratio of T2-weighted images to contrast-enhanced T1-weighted images is calculated to generate contrast-enhanced images. The unsupervised clustering is performed on the region of interest in the contrast-enhanced image to separate a cystic part and a non-cystic part so as to calculate the feature parameters. After radiosurgery is performed on the brain tumor corresponding to the region of interest, the volume change of the tumor is analyzed. The linear regression analysis of the feature parameters and the volume change of the tumor is performed for prognostic evaluation.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: November 23, 2021
    Assignees: Taipei Medical University (TMU), TAIPEI VETERANS GENERAL HOSPITAL
    Inventors: Syu-Jyun Peng, Chih-Ying Huang, Cheng-Chia Lee, Huai-Che Yang, Hsiu-Mei Wu
  • Patent number: 11155552
    Abstract: The present invention provides RUT analogs with various biological activities. In particular, the biological activities comprise anti-inflammatory activity, vasodilator effects, migration/invasion-suppressive activities, ability against damage due to remodeling between the epithelium and endothelium, collagen deposition and cardiac fibrosis suppress, Snail protein inhibitory effect, etc., which may improve cardiac, vasodilation, and lung functions. The RUT analogs disclosed herein also exhibit a lower cytotoxicity comparing to RUT.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: October 26, 2021
    Assignees: TAIPEI MEDICAL UNIVERSITY, NATIONAL TAIPEI UNIVERSITY OF TECHNOLOGY
    Inventors: Chun-Mao Lin, Chi-Ming Lee, Chi Wang, Sheng-Tung Huang, Jiun-An Gu, Tin-An Rau
  • Publication number: 20210285028
    Abstract: Disclosed is a method and a device for determining whether a sample contains ampicillin-resistant (AMP-R) non-typhoid Salmonella (NTS). The method comprises detecting, in the sample, the presence of a combination of certain genes or their gene products, wherein the presence of said combination indicates the sample contains AMP-R NTS.
    Type: Application
    Filed: May 21, 2019
    Publication date: September 16, 2021
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Shiuh-Bin FANG, Wei-Chiao CHANG, Wan-Hsuan CHOU, Ke-Chuan WANG
  • Patent number: 11066378
    Abstract: The present invention develops a series of methyl caffeate derivatives having biological activity in anti-angiogenesis. The present invention suggests that the compounds of the invention possess inhibiting angiogenesis through regulation of VEGF/VEGFR-2 and its downstream signaling cascades in the vascular endothelial cells (VECs).
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: July 20, 2021
    Assignees: Taipei Medical University, China Medical University
    Inventors: Chieh-Hsi Wu, Yueh-Hsiung Kuo, Chun-Hsu Pan