Patents Assigned to Taipei Medical University
  • Supports for cell culture and cell sheet detachment and methods for cell sheet detachment
    Patent number: 9546349
    Abstract: The invention creates a support for cell culture and cell sheet detachment which has a substrate, whose surface is coated with a conjugate having a disulfide bond-containing amino acid as a spacer and a biopolymer enhancing cell attachment, migration or differentation. Unexpectedly, after being seeded on the support, the cells grow to form one or more layers of cell sheets and the cell sheets can be easily detached from the support by adding a reductant to cleave the disulfide bond. Accordingly, the invention provides a simple and non-toxic method for detachment of cell sheets.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: January 17, 2017
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: How Tseng, Jeng-Kuen Tsai, Keng-Liang Ou, Po-Nien Chen
  • Type of anion-containing calcium phosphate compound for dental remineralization
    Patent number: 9539445
    Abstract: The invention provides an anion-containing calcium phosphate compound, composition and dental patch comprising the same and their use in remineralizing teeth. The anion-containing calcium phosphate compound has the following formula: (Ca+2)x(anion?a)y(PO4?3)z wherein 2x=(a*y+3z); a is an integer of 1 to 3; and each of x, y and z is not 0.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: January 10, 2017
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: Jen-Chang Yang, Nai-Chia Teng, Chien-Chung Chen, Sheng-Yang Lee, Chen-Feng Ma, Dian-Yu Ji
  • Method and device for enhancing a directional migration of stem cells
    Patent number: 9382530
    Abstract: The invention provides a method of enhancing a directional migration of stem cells, comprising providing one or more stem cell(s) and irradiating the stem cells with an effective energy of green light thereby enhancing stem cell directionally migrating, wherein the orientation of migration of stem cells is opposite to the green light source. Also provided is a stem cell treated by the method of the invention and a device for enhancing a directional migration of stem cells.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: July 5, 2016
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventor: Jennifer Hui-Chun Ho
  • Thermosensitive injectable hydrogel for drug delivery
    Patent number: 9364545
    Abstract: The invention develops a developed a thermosensitive injectable hydrogel based on HA and a copolymer of polyethylene oxide (PEO) and polypropylene oxide (PPO), which has a gel formation temperature from 30° C. to 37° C. The thermosensitive injectable hydrogel of the invention provides a potential drug delivery system that can increase therapeutic efficacy of the drug.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: June 14, 2016
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: Hua-Jing Jhan, Hsiu-O Ho, Ming-Thau Sheu, Shing Chuan Shen, Yuan Soon Ho, Jun-Jen Liu
  • Use of members of IL-10 cytokine family
    Patent number: 9314504
    Abstract: The invention relates to a novel use of the members of the IL-10 cytokine family in wound healing. Particularly, the invention relates to the use of the member of the IL-10 cytokine family in the promotion of the proliferation and the migration of keratinocyte cells in wound healing.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 19, 2016
    Assignees: TAIPEI MEDICAL UNIVERSITY, CHI MEI MEDICAL CENTER
    Inventors: Ching-Hsi Hsing, Ching Hua Yeh, Li-Yun Wang, Ding Ping Sun
  • Method of high-throughput sorting of high expression cell and cells sorted therefrom
    Patent number: 9315815
    Abstract: The invention provides a method of high-throughput sorting of high expression protein-producing cell, which utilizes linking a protein and a transmembrane domain with a self-processing cleavage site and regulating the secretion of the protein or expression of protein on the cell membrane by adding self-processing cleavage enzyme inhibitor. Then, the high expression cell line can be high-throughput sorted by a detection technique. The invention also provides a recombinant nucleotide sequence and a vector used in the method and a cell sorted by the method.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: April 19, 2016
    Assignee: Taipei Medical University
    Inventors: Kuo-Hsiang Chuang, Tian-Lu Cheng, I-Shiuan Chiang, Yuan-Chin Hsieh
  • Use of indolyl and indolinyl hydroxamates for treating heart failure of neuronal injury
    Patent number: 9296692
    Abstract: Novel use of small molecules, particularly indolyl and indolinyl hydroxamates is disclosed herein. The indolyl and indolinyl hydroxamates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating a patient suffering from heart failure or neuronal injury.
    Type: Grant
    Filed: September 15, 2012
    Date of Patent: March 29, 2016
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: Yi-Jen Chen, Kuo-Sheng Hung, Yu-Hsun Kao, Jing-Ping Liou, Pei-Wen Shan
  • Specific A1AT monoclonal antibodies for detection of endometriosis
    Patent number: 9229012
    Abstract: Provided herein are monoclonal antibodies with a high binding affinity to isoforms of alpha 1-antitrypsin (A1AT), hybridoma cells producing the same, and their uses in diagnosing and/or detecting endometriosis from a serum sample of a subject suspicious of having endometriosis or a subject under health examination.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: January 5, 2016
    Assignees: Taipei Medical University, Academia Sinica
    Inventors: Wei-Chung Yang, Hwei-Jiung Wang, Shui-Tsung Chen, Ken-Fen Lu, Ming-Chi Peng
  • METHOD FOR REVERSED MODELING OF A BIOMEDICAL MODEL
    Publication number: 20150360420
    Abstract: A method for reversed modeling of biomedical model of the present invention comprises at least the following steps: (a) Obtaining the data of a first model; (b) Transferring data of the first model into data of a second model which are applied to a rapid Prototyping machine; (c) Entering data of the second model into the rapid prototyping machine; (d) Laying model materials, coating adhesives and continuing sterilization by the rapid prototyping machine and stacking until a biomedical model is made; wherein sterilization is done during stacking medical model, therefore keeping the biomedical model sterile inside is achieved.
    Type: Application
    Filed: June 15, 2014
    Publication date: December 17, 2015
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Keng-Liang Ou, Yu-Hao Chan, Han-Yi Cheng
  • TOOTHBRUSH FOR PERIODONTAL CARE
    Publication number: 20150359322
    Abstract: A toothbrush for periodontal care, comprises: a grip for holding; a head, set on the front of the grip, extending forward from the front of the grip for a predetermined length and having a predetermined width, wherein the bottom surface of the head has many bristles; it is characterized in that: the predetermined length of the head is slightly shorter than the total length of any two adjacent teeth, and the predetermined width almost equals the width of the lower first molar, thereby easy horizontal brushing and straight picking are achieved.
    Type: Application
    Filed: June 15, 2014
    Publication date: December 17, 2015
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Tai-Jung Yeh, Keng-Liang Ou, Yu-Hao Chan, Han-Yi Cheng
  • METHOD FOR PRODUCTION OF DECELLULARIZED BIOLOGICAL MATERIAL AND THE DECELLULARIZED BIOLOGICAL MATERIAL PREPARED THEREFROM
    Publication number: 20150344842
    Abstract: The invention provides a method for decellularization of a biological material to obtain a decellularized biological material. Compared to untreated biological material, the content of DNA of the decellularized biological material of the invention decreases to a low level and there is no significant reduction of glycosaminoglycan and collagen. The invention also provides a decellularized biological material prepared from the method of the invention and a support comprising the decellularized biological material.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 3, 2015
    Applicant: Taipei Medical University
    Inventors: MING-THAU SHEU, HSIU-O HO, YING-CHEN CHEN
  • Method for the diagnosis of the presence of an ovarian cancer
    Patent number: 9200262
    Abstract: The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: December 1, 2015
    Assignees: TAIPEI MEDICAL UNIVERSITY, NATIONAL HEALTH RESEARCH INSTITUTE
    Inventors: Sy-Jye Leu, Neng-Yao Shih, Yi-Yuan Yang, Ko-Jiunn Liu, I-Jen Huang, Yuan-Soon Ho, Suparat Charoenfuprasert, Yu-Ching Lee
  • Electrostatic-assisted fiber spinning method and production of highly aligned and packed hollow fiber assembly and membrane
    Patent number: 9139935
    Abstract: The invention provides a highly aligned and closely packed hollow fiber assembly, wherein the assemblies of fibrous membrane has a width-to-fiber diameter ratio (W/d) larger than 10 and the orientation of the fibers is no larger than +/?10°. Also provided is an electrospinning process for the preparation of the fiber assembly of the invention and its applications.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: September 22, 2015
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: Chien-Chung Chen, Jen-Chang Yang, Jen-Chieh Lu, Sheng-Yang Lee
  • Electrospinning apparatus with a sideway motion device and a method of using the same
    Patent number: 9091007
    Abstract: The invention provides an electrospinning apparatus, which comprises one or more spinneret, a rotating collector disposed from the spinneret and configured to collect the fibers, and a sideway motion device disposed on or connected to the spinneret or the rotating collector and configured to propel or move the spinneret or the rotating collector, wherein the sideway motion device is controlled by a controlling unit for providing an angular speed (?) of the sideway motion with a formula: ?=tan?1 x/H wherein x is a parallel motion speed of the device and H is a vertical height between the spinneret and the rotating collector and wherein the angular speed (?) is in a range of about 1.0×10?4 to about 1.0 (°/sec). Also provided is the 2-D or 3-D membranes produced therefrom and a method of using the apparatus of the invention.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: July 28, 2015
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: Chien-Chung Chen, Jen-Chang Yang, Keng-Liang Ou, Chen-Yu Liu, Cherng-You Ke
  • Composite of amorphous calcium phosphate/calcium sulfate hemihydrate (CSH/ACP) for bone implantation and process for producing the same
    Patent number: 9056097
    Abstract: The invention provides a composite of ?-calcium sulfate (CS) hemihydrate/amorphous calcium phosphate (?-CSH/ACP), comprising ?-CSH and ACP at a weight ratio of about 10:90 to about 90:10. Particularly, the composite of the invention has a resorption period of 3-6 months. The invention also provides a one-pot process for producing ?-CSH/ACP composite of the invention. The one-pot process of the invention can produce ?-CSH and ACP in a single process and easily obtain ?-CSH/ACP composite.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: June 16, 2015
    Assignee: Taipei Medical University
    Inventors: Jen-Chang Yang, Sheng-Yang Lee, Duen-Cheng Wang, Haw-Ming Huang, Wei-Jen Chang, Malosi Poma, Hong-Da Wu, Dian-Yu Ji
  • Use of uraria in promoting osteogenesis or providing neuroprotection
    Patent number: 9044476
    Abstract: The invention provides a method for promoting osteogenesis, increasing bone mass or enhancing the rate of bone growth, which comprises administering to a subject an effective amount of Uraria, a part thereof or an extract thereof. Also provided are a method for treating and/or preventing osteoporosis and a method for providing neuroprotection, comprising administering to a subject an effective amount of Uraria, a part thereof or an extract thereof.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: June 2, 2015
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventor: Mei-Hsien Lee
  • METHOD OF HIGH-THROUGHPUT SORTING OF HIGH EXPRESSION CELL AND CELLS SORTED THEREFROM
    Publication number: 20150118693
    Abstract: The invention provides a method of high-throughput sorting of high expression protein-producing cell, which utilizes linking a protein and a transmembrane domain with a self-processing cleavage site and regulating the secretion of the protein or expression of protein on the cell membrane by adding self-processing cleavage enzyme inhibitor. Then, the high expression cell line can be high-throughput sorted by a detection technique. The invention also provides a recombinant nucleotide sequence and a vector used in the method and a cell sorted by the method.
    Type: Application
    Filed: April 28, 2014
    Publication date: April 30, 2015
    Applicant: Taipei Medical University
    Inventors: KUO-HSIANG CHUANG, TIAN-LU CHENG, I-SHIUAN CHIANG, YUAN-CHIN HSIEH
  • Sensor chip for screening topoisomerase inhibitor and screening method thereof
    Patent number: 9005922
    Abstract: The present invention discloses a sensor chip for screening a topoisomerase inhibitor and a screening method thereof. The sensor chip comprises topoisomerase I and a biochip. The topoisomerase I is immobilized on the biochip, and the topoisomerase I has DNA catalytic activity. This provides a rapid screening method for topoisomerase I inhibitors.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: April 14, 2015
    Assignee: Taipei Medical University
    Inventors: Chun-Mao Lin, Hsiang-Ping Tsai, Chwen-Ming Shih, Jau-Lang Hwang, Chi-Ming Lee
  • Method of identifying a candidate compound which may inhibit ?9-nAchR overexpression or estrogen receptor-dependent transcription in nicotine-derived-compound-induced breast cancer cells
    Patent number: 8980571
    Abstract: The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or ?9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that ?9-nAChR has an activating protein 1 (AP1)-binding site, that the ?9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the ?9-nAChR promoter at the AP1-binding site, indicating that ER-induced ?9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: March 17, 2015
    Assignee: Taipei Medical University
    Inventors: Chia-Hwa Lee, Ya-Chieh Chang, Ching-Shyang Chen, Shih-Hsin Tu, Ying-Jan Wang, Li-Ching Chen, Yu-Jia Chang, Po-Li Wei, Hui-Wen Chang, Chien-Hsi Chang, Ching-Shui Huang, Chih-Hsiung Wu, Yuan-Soon Ho
  • Use of Indolyl and Indolinyl Hydroxamates for Treating Heart Failure of Neuronal Injury
    Publication number: 20150065552
    Abstract: Novel use of small molecules, particularly indolyl and indolinyl hydroxamates is disclosed herein. The indolyl and indolinyl hydroxamates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating a patient suffering from heart failure or neuronal injury.
    Type: Application
    Filed: September 15, 2012
    Publication date: March 5, 2015
    Applicant: Taipei Medical University
    Inventors: Yi-Jen Chen, Kuo-Sheng Hung, Yu-Hsun Kao, Jing-Ping Liou, Pei-Wen Shan