Abstract: A method for sequence-specifically detecting a nucleic acid molecule. The method requires: a) contacting in an absence of an electric field, a mixture of nucleic acid molecules with a base pairing hybridizing molecule (BPHM) having a sequence of interest in a first solution and obtaining a hybrid consisting the nucleic acid molecule and the BPHM; b) introducing the first solution from step (a) into an ITP system, the ITP system comprises a second solution of high effective mobility leading electrolyte (LE) ions and a third solution of low effective mobility trailing electrolyte (TE); and c) applying the electric field across the second solution and the third solution. The hybrid focus at the sharp LE-TE interface in the ITP system. The TE has a higher mobility than the BPHM and the TE has a lower mobility than the hybrid. Sequence-specifically the detecting nucleic acid molecule by a signal from a label.
Type:
Grant
Filed:
March 27, 2017
Date of Patent:
May 28, 2019
Assignee:
Technion Research and Development Foundation Limited
Abstract: Provided is an electrode including conductive particles, which sediment under gravitational force and a liquid fluidizing medium flowing through the electrode, in which the conductive particles are suspended and optionally further including conductive particles, which do not sediment under gravitational force when the fluidizing medium flows in the electrode. Further provided are electrochemical devices and energy storage systems including the electrode.
Type:
Application
Filed:
July 10, 2017
Publication date:
May 23, 2019
Applicant:
Technion Research and Development Foundation Limited
Inventors:
Hagai COHEN, Ilya LOIFERMAN, Matthew SUSS
Abstract: According to an embodiment of the invention there is provided a device and method. The device may include a pure memristive logic gate, wherein the pure memristive logic gate consists essentially of at least one input memristive device and an output memristive device that is coupled to and differs from the at least one memristive device; wherein the pure memristive device is controlled by a single control voltage.
Type:
Grant
Filed:
June 14, 2017
Date of Patent:
May 7, 2019
Assignee:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
Inventors:
Shahar Kvatinsky, Dmitry Belousov, Slavik Liman, Nimrod Wald, Guy Satat
Abstract: Provided is a formulation including an agriculturally acceptable carrier and liposomes including a lipid membrane and an intraliposomal aqueous core. The liposome has a diameter in the range of between 100 nm to 300 nm and the lipid membrane includes at least one liposome forming phospholipid. The lipid membrane may include two or more phospholipids. At least one of the two or more phospholipids may be a liposome forming lipid. Further, at least one of the two or more phospholipids may be characterized by one or more of the following features: (a) it has an unsaturated lipid tail; (b) it includes a polar head group; (c) it includes an acidic head group. Further provided are methods of using the formulation for agricultural treatment and kits for preparing and using such formulations.
Type:
Application
Filed:
March 8, 2017
Publication date:
April 4, 2019
Applicant:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
Abstract: A system comprising: a handheld mobile device comprising: a projector unit configured to project an image; a camera; and a prism configured to reflect the image projected by the projector such that the camera can capture the projected image.
Type:
Grant
Filed:
April 7, 2015
Date of Patent:
March 5, 2019
Assignee:
Technion Research and Development Foundation Limited
Abstract: An apparatus for pad printing includes a printing pad (12). A textured transfer member (13) is configured to be pressed alternately by the printing pad (12) against an ink carrier (17) and against a substrate (24) so as to transfer an ink pattern to the substrate.
Type:
Grant
Filed:
August 24, 2014
Date of Patent:
February 12, 2019
Assignee:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
Abstract: A method that uses at least one hardware processor for receiving a three-dimensional model of an object, receiving an audio sequence embodied as a digital file that comprises a musical composition, generating a video frame sequence, and synthesizing the audio sequence and the video frame sequence into an audiovisual clip. The three-dimensional model is embodied as a digital file that comprises a representation of the object. The generating step comprises computing a caricature of the object by applying a computerized caricaturization algorithm to the three-dimensional model. The computing has scaling gradient fields of surface coordinates of the three-dimensional model by a function of a Gaussian curvature of the surface, and finding a regular surface whose gradient fields fit the scaled gradient fields.
Type:
Grant
Filed:
October 10, 2017
Date of Patent:
December 4, 2018
Assignee:
Technion Research and Development Foundation Limited
Inventors:
Matan Sela, Yonathan Aflalo, Ron Kimmel
Abstract: The present invention is directed to methods and kits useful for diagnosis and/or prognosis of urothelial cancer in a subject. The present invention further relates to methods of assessing severity of cancer and methods of determining efficacy of a treatment for cancer. The methods and kits of the invention comprise determining the levels of semaphorin 3A in a biological sample of a subject.
Type:
Grant
Filed:
December 2, 2014
Date of Patent:
November 27, 2018
Assignees:
The Fund for Medical Research, Development of Infrastructure and Health Services—Bnai Zion Medical Center, Technion Research and Development Foundation Limited
Inventors:
Zahava Vadasz, Sarel Halachmi, Jacob Rubinstein, Ofer Nativ, Elias Toubi
Abstract: A multifunctional dielectric gradient metasurface optical device has a layer of nanoscale dielectric gradient metasurface optical antenna elements deposited on a substrate layer, arranged with spatially varying orientations, shapes, or sizes in the plane of the device such that the optical device has a spatially varying optical phase response capable of optical wavefront shaping. The spatially varying optical phase response is a spatial interleaving of multiple distinct phase profiles corresponding to multiple optical sub-elements, thereby providing multifunctional wavefront shaping in the single optical element.
Type:
Grant
Filed:
January 29, 2017
Date of Patent:
November 13, 2018
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Technion Research and Development Foundation Limited
Inventors:
Dianmin Lin, Mark L. Brongersma, Erez Hasman, Pieter G. Kik, Aaron L. Holsteen
Abstract: An orthogonal frequency division multiplexing (OFDM) transmitter that includes an encoder, an interleaver, a symbol processor; and a transmission module; wherein the encoder is configured to encode a superframe to provide an encoded superframe; wherein the encoded superframe comprises a sequence of encoded frames; wherein the interleaver is configured to allocate multiple frequency sub-bands to each encoded frame of the encoded superframe by assigning adjacent frequency sub-bands to successive symbols of each encoded frame; wherein the symbol processor is configured to generate, for each encoded frame and according to the assignment of the multiple frequency sub-bands, an intermediate set of symbols; and wherein the transmission module is configured to transmit simultaneously, for each encoded frame, OFDM symbols that represents the intermediate set of symbols.
Type:
Grant
Filed:
October 30, 2017
Date of Patent:
October 30, 2018
Assignee:
Technion Research and Development Foundation LTD.
Inventors:
Moshe Nazarathy, Amitay Bar, Aviv Shalom, Igor Tselniker
Abstract: The present invention provides an electronic nose device based on chemically sensitive field effect transistors. In particular, the sensors of the electronic nose device are composed of non-oxidized, functionalized silicon nanowires which can detect volatile organic compounds with very high sensitivity. Methods of use in diagnosing diseases including various types of cancer are disclosed.
Type:
Grant
Filed:
July 24, 2008
Date of Patent:
July 3, 2018
Assignee:
Technion Research and Development Foundation Ltd.
Abstract: A fiber-reinforced hydrogel composite is provided. The composite includes a hydrogel and a fibrous component containing a plurality of fibers. Length of each of the plurality of fibers is less than about 1,000 ?m. A method of preparing a fiber-reinforced hydrogel composite is also provided. The method includes coating a hydrogel precursor solution on a substrate to form a hydrogel precursor film, depositing the plurality of fibers onto the hydrogel precursor film, and allowing the hydrogel precursor film to form a hydrogel film, thereby forming the fiber-reinforced hydrogel composite. A scaffold containing the fiber-reinforced composite, and a tissue repair method using the fiber-reinforced composite are also provided.
Type:
Grant
Filed:
May 15, 2013
Date of Patent:
April 24, 2018
Assignees:
National University of Singapore, Technion Research and Development Foundation LTD
Abstract: The present invention provides a system including: a protein having a domain that binds a membranal component; an inlet for sample flow, an Isotachophoresis (ITP) system and a flow generating means connected or coupled to the aqueous parts of the ITP. The invention also provides a method for detecting and or sorting cells with this system.
Type:
Grant
Filed:
November 28, 2014
Date of Patent:
February 6, 2018
Assignee:
Technion Research and Development Foundation Limited
Abstract: Computerized, audio-based caricature exaggeration which includes: receiving a three-dimensional model of an object; receiving an audio sequence; generating a video frame sequence, said generating comprising computing a caricature of the object, wherein (a) the computing is with a different exaggeration factor for each of multiple ones of the video frames, and (b) the different exaggeration factor is based on one or more parameters of the audio sequence; and synthesizing the audio sequence and the video frame sequence into an audiovisual clip.
Type:
Grant
Filed:
April 7, 2015
Date of Patent:
November 14, 2017
Assignee:
Technion Research and Development Foundation Limited
Inventors:
Matan Sela, Yonathan Aflalo, Ron Kimmel
Abstract: The present invention provides a semiconductor crystal comprising a semiconductor material having a tuned band gap energy, and methods for preparation thereof. More particularly, the invention provides a semiconductor crystal comprising a semiconductor material and amino acid molecules, peptides, or a combination thereof, incorporated within the crystal lattice, wherein the amino acid molecules, peptides, or combination thereof tune the band gap energy of the semiconductor material.
Type:
Grant
Filed:
September 29, 2014
Date of Patent:
September 26, 2017
Assignee:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
Abstract: A device that may include a narrowband filter that is arranged to pass radiation within a main signal waveband in which a muzzle flash is expected to include energy above a first energy threshold; a first single photon avalanche diode (SPAD) arranged to detect photons of the main signal waveband during different points in time and to output first digital detection signals representative of the photons of the main signal waveband; and a signal processor that is arranged to receive the first digital detection signals and to detect, in response to at least the first digital detection signals, the muzzle flash.
Type:
Grant
Filed:
April 10, 2014
Date of Patent:
September 12, 2017
Assignee:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION, LTD.
Abstract: A device, comprising: an array of cells, wherein the cells are arranged in columns and rows; wherein each cell comprises a memristive device; an interfacing circuit that is coupled to each cell of the array of cells; wherein the interfacing circuit is arranged to: receive or generate first variables and second variables; generate memristive device input signals that once provided to memristive devices of the array will cause a change in a state variable of each of the memristive devices of the cells of the array, wherein the change in the state variable of each of the memristive devices of the cells of array reflects a product of one of the first variables and one of the second variables; provide the memristive device input signals to memristive devices of the array; and receive output signals that are a function of at least products of the first variables and the second variables.
Type:
Grant
Filed:
March 19, 2014
Date of Patent:
September 5, 2017
Assignee:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
Inventors:
Dotan Di Castro, Daniel Soudry, Shahar Kvatinsky, Asaf Gal, Avinoam Kolodny
Abstract: A fiber optical superconducting nanowire detector with increased detector efficiency, fabricated directly on the tip of the input optical fiber. The fabrication on the tip of the fiber allows precise alignment of the detector to the fiber core, where the field mode is maximal. This construction maximizes the coupling efficiency to close to unity, without the need for complex alignment procedures, such as the need to align the input fiber with a previously fabricated device. The device includes a high-Q optical cavity, such that any photon entering the device will be reflected to and fro within the cavity numerous times, thereby increasing its chances of absorption by the nanowire structure. This is achieved by using dedicated cavity mirrors with very high reflectivity, with the meander nanowire structure contained within the cavity between the end mirrors, such that photons impinge on the nanowire structure with every traverse of the cavity.
Type:
Grant
Filed:
December 23, 2012
Date of Patent:
August 8, 2017
Assignee:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED