Patents Assigned to Technion Research and Development Foundation
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Publication number: 20220161275Abstract: A method of electroporation of a biological object, comprises: introducing a carrier particle into a medium containing the biological object; applying a first electric field to the medium to induce trapping of the biological object by the carrier particle; and varying at least one parameter of the first electric field so as to induce electroporation of the biological object.Type: ApplicationFiled: March 17, 2020Publication date: May 26, 2022Applicant: Technion Research & Development Foundation LimitedInventors: Gilad YOSSIFON, Yue WUE, Sinwook PARK
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Publication number: 20220155243Abstract: A microwave device comprises: a cavity containing a crystal having paramagnetic defects, and being responsive to light; a magnetic field source for applying magnetic field to the cavity and the crystal; and a light source for generating a pump light beam directed to the crystal and having a frequency selected to induce inversion of spin energy levels of the crystal.Type: ApplicationFiled: November 18, 2021Publication date: May 19, 2022Applicant: Technion Research & Development Foundation LimitedInventors: Aharon BLANK, Alexander SHERMAN
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Patent number: 11318418Abstract: Provided herein is forward osmosis-based water purification process, that includes contacting a solution of a soluble draw agent with a dehydrated insoluble draw agent, separating the now hydrated insoluble draw agent from the now concentrated draw solution, and exerting a stimulus on the hydrated insoluble draw agent for extracting water therefrom, thereby regenerating a dehydrated insoluble draw agent, wherein the osmotic concentration (osmolality) of the insoluble draw agent is greater than the osmotic concentration of the diluted draw solution, and the insoluble draw agent is impermeable to the soluble draw agent.Type: GrantFiled: October 24, 2018Date of Patent: May 3, 2022Assignee: Technion Research & Development Foundation LimitedInventors: Alexander Kraytsberg, Yair Ein-Eli
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Patent number: 11299822Abstract: A method of producing a microtube is provided. The method comprising co-electrospinning two polymeric solutions through co-axial capillaries to thereby produce the microtube, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution. Also provided are electrospun microtubes.Type: GrantFiled: March 1, 2017Date of Patent: April 12, 2022Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Eyal Zussman, Yael Dror, Wael Salalha, Ron Avrahami
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Patent number: 11301397Abstract: A computing device, comprising at least one peripheral computing component, electrically connected to each of a plurality of hardware processors; wherein at least one of the plurality of hardware processors is adapted to executing a code for: configuring the at least one peripheral computing component to access at least one first memory location in a first memory component electrically coupled with a first hardware processor of the plurality of hardware processors via a first electrical connection between the peripheral computing component and the first hardware processor; and configuring the at least one peripheral computing component to access at least one second memory location in a second memory component electrically coupled with a second hardware processor of the plurality of hardware processors via a second electrical connection between the peripheral computing component and the second hardware processor; and wherein the first hardware processor is not the second hardware processor.Type: GrantFiled: April 24, 2019Date of Patent: April 12, 2022Assignee: Technion Research & Development Foundation LimitedInventors: Dan Tsafrir, Igor Smolyar
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Patent number: 11291515Abstract: A compact robotic device for driving movement of two or more elongate surgical tools configured for a telescopic arrangement when said two or more elongate surgical tools are at least partially received within said device, the device comprising: a housing comprising walls which define an inner volume including at least two inner pathways for accommodating the two or more elongate surgical tools; the housing encasing: a plurality of motors, and two or more tool actuation assemblies configured at a position of each of the two or more inner pathways; the actuation assemblies driven by the plurality of motors and configured to operably contact an elongate surgical tool at least partially received in the inner pathway to at least one of advance, retract and/or roll said elongate surgical tool.Type: GrantFiled: April 19, 2021Date of Patent: April 5, 2022Assignees: Microbot Medical Ltd., Technion Research & Development Foundation LimitedInventors: Simon Sharon, Idan Boader, Evgeny Kofman, Moshe Shoham, Eran Cohen, Eyal Morag
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Patent number: 11292986Abstract: This invention is directed to intramolecular crosslinked polymer chains, commonly known also as single-chain polymer nanoparticles (SCPNs), with high resistance to mechanochemical bond scission and to uses thereof in solution.Type: GrantFiled: January 29, 2017Date of Patent: April 5, 2022Assignee: Technion Research & Development Foundation LimitedInventor: Charles Eliezer Diesendruck
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Patent number: 11292746Abstract: Disclosed is a ceramic composition comprising a plurality of at least semi-coherent particles with an average diameter ranging from 1 nm to 50 nm included within a matrix, wherein the matrix comprises one metal carbonate salt, metal oxide or metalloid oxide, the particles and the matrix share at least one metal element and the metal element is 10% to 80% of the total content of said matrix, and the composition has a lattice mismatch of less than 5%. Disclosed are also an article and methods for making the ceramic composition of the present invention.Type: GrantFiled: November 20, 2018Date of Patent: April 5, 2022Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Boaz Pokroy, Iryna Polishchuk
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Patent number: 11294205Abstract: Disclosed herein is a device comprised of: i) at least one substrate; (ii) a ceiling; (iii) one or more flow channels disposed between said substrate and said ceiling and configured to contain an actuation liquid; and (iv) one or more recesses distributed throughout at least said substrate and open to said flow channel and configured to contain a fluid; wherein 50% to 80% of the flow channel liquid-substrate interface, interfaces with said fluid within said recesses; and (v) at least one heating element, configured to heat one or more portions of the actuation liquid and generate a pressure and/or temperature gradient within said actuation liquid. Systems and uses of the device are further disclosed.Type: GrantFiled: March 22, 2018Date of Patent: April 5, 2022Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Valeri Frumkin, Moran Bercovici, Shimon Rubin, Carmel Rotschild
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Patent number: 11291705Abstract: Provided are methods of selecting a treatment for a cancer in a subject in need thereof, by analyzing activity of Yes associated protein 1 (YAP) in cancer cells of the subject, and methods of treating cancer using a therapeutically effective amount of an caspase-3 inhibitor. Also provided are methods of improving wound healing by administering a wound healing effective amount of a caspase-3 activator.Type: GrantFiled: October 13, 2017Date of Patent: April 5, 2022Assignee: Technion Research & Development Foundation LimitedInventors: Yaron Fuchs, Yahav Yosefzon, Despina Soteriou
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Publication number: 20220096161Abstract: A robotic device for performing intracranial procedures, comprising a baseplate for mounting on the subject's skull and a rotatable base element rotating on the baseplate. The rotatable base element has a central opening through which a cannulated needle can protrude such that it can rotate around an axis perpendicular to the baseplate. This cannulated needle is robotically controlled to provide motion into and out of the subject's skull. A flexible needle is disposed coaxially within the cannulated needle, and it is controlled to move into and out of a non-axial aperture in the distal part of the cannulated needle. Coordinated control of the insertion motion of the cannulated and flexible needles, and rotation of the combined cannulated/flexible needle assembly enables access to be obtained to a volume of a region of the brain having lateral dimensions substantially larger than the width of the cannulated needle.Type: ApplicationFiled: December 13, 2021Publication date: March 31, 2022Applicant: Technion Research & Development Foundation LimitedInventors: David ZARROUK, Moshe SHOHAM, Menashe ZAAROOR, Hadas ZISO
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Publication number: 20220091097Abstract: The present invention provides a vapor-permeable flexible sensing platform unit comprising: a first porous membrane, wherein said membrane is substantially flexible and hydrophobic; and a volatile organic compounds (VOCs) sensor disposed on said membrane, the VOCs sensor comprising an electrode array and a conducting polymer porous film being in electric contact with said electrode array, wherein the VOCs sensor is insensitive to lateral strain. Further provided are a method of preparation of said platform unit and a lift-off, float-on (LOFO) method for the preparation of protonically doped polyaniline (PANI) thin films.Type: ApplicationFiled: December 2, 2021Publication date: March 24, 2022Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITEDInventors: Hossam HAICK, Weiwei Wu
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Patent number: 11283244Abstract: A topological laser system is described. The laser system comprises an array of optical elements arranged in an array and coupled between them such that the array is configured for supporting one or more topological modes. The plurality of optical elements comprises optical elements carrying gain material configured for emitting optical radiation in response to pumping energy. The laser system further comprises a pumping unit configured to provide pumping of a group of the optical elements of the array within at least a portion of the spatial region corresponding with said topological mode; and at least one output port optically coupled to one or more of the optical elements associated with said topological mode. The at least one output ports is configured for extracting a portion of light intensity from said laser system.Type: GrantFiled: March 29, 2018Date of Patent: March 22, 2022Assignees: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION, LTD., THE UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.Inventors: Mordechai Segev, Gal Harari, Demetrios N. Christodoulides, Miguel Angel Bandres Motola
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Patent number: 11279643Abstract: Provided is a novel Nanofiltration-DiaNanofiltration (NF-DiaNF) system and method for extracting divalent ions from saline water (e.g., seawater) to produce solutions rich in divalent ions (in particular Mg2+, Ca2+ and SO42?), while minimizing the concentrations of undesirable species (e.g., Cl?, Br?, B and Na+). The solutions may be added to water (e.g., desalinated, soft, drinking or irrigation water) to enrich the water with divalent ions, thereby improving its quality.Type: GrantFiled: March 30, 2017Date of Patent: March 22, 2022Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Ori Lahav, Liat Birnhack, Paz Nativ, Oded Nir
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Publication number: 20220073865Abstract: A method of preparing a composition comprising mycelium along with a cellulose and/or plurality of nanoparticles is described herein. The method comprises inoculating a liquid medium with fungus, the liquid medium comprising nutrients and the cellulose and/or nanoparticles. Further described herein are compositions comprising mycelium along with a cellulose and/or plurality of nanoparticles, as well as articles-of-manufacture comprising such a composition, wherein at least 10% of the cellulose and/or nanoparticles in the composition is incorporated within the mycelium. A method of enhancing fungal growth is also described, comprising contacting the fungus with a liquid medium comprising a polymer which comprises carboxylic acid groups.Type: ApplicationFiled: September 10, 2021Publication date: March 10, 2022Applicants: Technion Research & Development Foundation Limited, RISE Innventia ABInventors: Noam ATTIAS, Jacob GROBMAN, Tiffany ABITBOL
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Publication number: 20220075669Abstract: A method for non-blocking multithreading, the method may include (a) providing, during a deep neural network (DNN) calculation iteration, to a shared computational resource, input information units related to multiple DNN threads; (b) determining whether to reduce a numerical precision of one or more DNN calculations related to at least one of the multiple DNN threads, and (c) executing, based on the determining, DNN calculations on at least some of the input information units to provide one or more results of the DNN processing.Type: ApplicationFiled: September 8, 2021Publication date: March 10, 2022Applicant: Technion Research and Development Foundation Ltd.Inventors: Gil SHOMRON, Uri WEISER
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Publication number: 20220071723Abstract: An assembly for driving linear movement and roll movement of an elongate surgical tool, comprising: an elongate shaft comprising a central lumen extending along the shaft long axis; the elongate shaft comprising a plurality of apertures extending across walls of the elongate shaft and into the central lumen; a set of wheels positioned opposing each other and aligned on two sides of the central lumen, the set of wheels at least partially extending through the apertures beyond the walls of the elongate shaft and into the central lumen to contact an elongate surgical tool received therein; the set of wheels being coupled to the elongate shaft and configured to rotate with the elongate shaft as a single unit when the elongate shaft is rotated about the shaft long axis.Type: ApplicationFiled: November 15, 2021Publication date: March 10, 2022Applicants: Microbot Medical Ltd., Technion Research & Development Foundation LimitedInventors: Simon SHARON, Idan BOADER, Moshe SHOHAM, Eran COHEN, Eyal MORAG
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Patent number: 11270432Abstract: A method for inspecting a three dimensional structure of a microscopic scale of a sample, the method may include obtaining an image of the three dimensional structure; obtaining a reference image of a reference three dimensional structure, the reference three dimensional structure and the three dimensional structure are ideally identical to each other; wherein each one of the image and the reference image was generated using optics that includes a phase mask, wherein the phase mask virtually expands a depth of field of the optics by encoding depth information over a depth range that exceeds the depth of field; generating a difference image that represents a difference between the image and the reference image; determining, based on the difference image, whether there is at least one defect in the three dimensional structure; wherein when determining that there is the at least one defect then providing a depth of the at least one defect.Type: GrantFiled: August 24, 2020Date of Patent: March 8, 2022Assignees: Applied Materials Israel Ltd., TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Haim Feldman, Yoav Shechtman
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Patent number: 11262358Abstract: Provided are methods of predicting responsiveness of a subject having an inflammatory bowel disease (IBD) to a tumor necrosis factor (TNF)-alpha inhibitor, by analyzing a frequency of at least one subpopulation of immune cells in a tissue biopsy of the subject. Also provided are methods of selecting a treatment for a subject and kits for determining responsiveness of the subject to treatment with a TNF-alpha inhibitor.Type: GrantFiled: April 6, 2017Date of Patent: March 1, 2022Assignees: Technion Research & Development Foundation Limited, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Shai S. Shen-Orr, Elina Starovetsky, Naama Maimon, Purvesh Khatri, Renaud Gaujoux, Francesco Vallania
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Publication number: 20220056406Abstract: Provided is an isolated population of human pluripotent stem cells comprising at least 50% human pluripotent stem cells characterized by an OCT4+/TRA1-60?/TRA1-81?/SSEA1+/SSEA4? expression signature, and novel methods of generating and maintaining same in a pluripotent, undifferentiated state a suspension culture devoid of cell clumps. Also provided are novel culture media, cell cultures and methods for culturing pluripotent stem cells in a suspension culture or a two-dimensional culture system while maintaining the cells in a proliferative, pluripotent and undifferentiated state. The novel culture media comprise interleukin 11 (IL11) and Ciliary Neurotrophic Factor (CNTF); bFGF at a concentration of at least 50 ng/ml and an IL6RIL6 chimera; or an animal contaminant-free serum replacement and an IL6RIL6 chimera. Also provided are methods for generating lineage-specific cells from the pluripotent stem cells.Type: ApplicationFiled: November 10, 2021Publication date: February 24, 2022Applicant: Technion Research & Development Foundation LimitedInventors: Michal AMIT, Joseph ITSKOVITZ-ELDOR