Patents Assigned to Technion Research & Development
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Patent number: 12293853Abstract: Provided herein are composite conductors, characterized by having copper deposits inside the bulk rather than on the outer surface of a non-metallic conductive porous matrix, such as CNT fabric, as well as a process for obtaining the same. The composite conductors provided herein are also characterized by a low specific weight and a high ampacity compared to metal conductors of similar size and shape.Type: GrantFiled: May 14, 2020Date of Patent: May 6, 2025Assignee: Technion Research & Development Foundation LimitedInventors: Yair Ein-Eli, Neta Yitzhack, Nina Sezin, David Starosvetsky
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Publication number: 20250136719Abstract: The present invention relates to an heparanase-binding and heparanase-neutralizing monoclonal antibody (IgG-1 mAb A54), including its epitope (HBD-II) and mode of interaction with heparanase, pharmaceutical composition comprising same, and uses thereof e.g. for inhibiting or treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, viral infection, diabetes and related complications. The present invention further provides combinatorial cancer therapies, comprising the heparanase-neutralizing mAb and an additional anti-cancer treatment such as chemotherapy or radiation.Type: ApplicationFiled: September 25, 2024Publication date: May 1, 2025Applicants: Technion Research & Development Foundation Limited, Hadasit Medical Research Services and Development Ltd.Inventors: Israel Vlodavsky, Uri Barash
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Publication number: 20250122854Abstract: A direct gaseous reformate injector that includes an inlet for receiving a gaseous reformate; a plunger; and an outward-opening valve that comprises a valve body and a needle that is movable, by the plunger, in relation to the valve body, between a (a) closed position in which the gaseous reformate is not outputted from the direct gaseous reformate injector, and (b) an open position in which the gaseous reformate is outputted from the direct gaseous reformate injector.Type: ApplicationFiled: October 15, 2024Publication date: April 17, 2025Applicant: Technion Research & Development Foundation LimitedInventors: Leonid Tartakovsky, Asher Netzer Lichinitzer
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Publication number: 20250114351Abstract: A method of treating a disease or disorder for which an increase in immune cells in the brain is therapeutic in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which specifically binds and increases activity of a receptor selected from the group consisting of a 5HT2C receptor, a 5HT2A receptor and a 5HT2B receptor in the postcentral gyrus and/or the choroid plexus (CP) of the brain of the subject. Compositions for treating these diseases are also disclosed.Type: ApplicationFiled: December 18, 2024Publication date: April 10, 2025Applicant: Technion Research & Development Foundation LimitedInventors: Asya ROLLS, Dorit FARFARA, Ben KORIN, Hilla AZULAY-DEBBY, Shahar ARMON
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Publication number: 20250101369Abstract: A method of preparing a composition comprising mycelium along with a cellulose and/or plurality of nanoparticles is described herein. The method comprises inoculating a liquid medium with fungus, the liquid medium comprising nutrients and the cellulose and/or nanoparticles. Further described herein are compositions comprising mycelium along with a cellulose and/or plurality of nanoparticles, as well as articles-of-manufacture comprising such a composition, wherein at least 10% of the cellulose and/or nanoparticles in the composition is incorporated within the mycelium. A method of enhancing fungal growth is also described, comprising contacting the fungus with a liquid medium comprising a polymer which comprises carboxylic acid groups.Type: ApplicationFiled: December 9, 2024Publication date: March 27, 2025Applicant: Technion Research & Development Foundation LimitedInventors: Noam ATTIAS, Jacob GROBMAN, Tiffany ABITBOL
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Publication number: 20250086788Abstract: A method for quantitative magnetic resonance imaging (MRI), the method includes (a) receiving a sequence of MRI images of an in vivo tissue, by an image registration deep neural network (DNN) module that was trained, by a training process, to impose one or more MRI signal related physical constraints on a content of the sequence of MRI images; and (b) extracting one or more quantitative map from the sequence of MRI images.Type: ApplicationFiled: August 14, 2024Publication date: March 13, 2025Applicants: Technion Research & Development Foundation Limited, MEDICAL RESEARCH & DEVELOPMENT FUND FOR HEALTH SERVICES, BNAI-ZION MEDICAL CENTERInventors: Mordechay Pinchas Freiman, Eyal Hanania, Israe Cohen
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Publication number: 20250051348Abstract: Mechanophoric compounds featuring one or more, or two or more, clickable group(s), which are capable of being coupled to naturally occurring, synthetic and/or metallic substrates via Click chemistry, method of preparing mechanophoric matrices using the mechanophoric compounds, and mechanophoric matrices obtainable thereby, and uses thereof for detecting force-induced damage in the matrices by a colorimetric change are provided.Type: ApplicationFiled: August 13, 2024Publication date: February 13, 2025Applicant: Technion Research & Development Foundation LimitedInventors: Joshua M. GROLMAN, Yifan LIAO, Hang ZHANG, Charles Eliezer DIESENDRUCK
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Publication number: 20250027868Abstract: An atomic interferometer system comprises optical tweezers each configured to trap at least one atom therein, an atom source system configured to release atoms, and a controller configured to control the optical tweezers to trap at least one atom released by the atom source system in one of the tweezers, to spatially split a wave function of the trapped atom between at least two of the tweezers, and to at least partially recombine the split atomic wave function in at least one of the tweezers. The atomic interferometer system can also comprise a measuring system configured to measure wavefunction population in each of the tweezers and to display an output pertaining to the wavefunction populations.Type: ApplicationFiled: July 17, 2024Publication date: January 23, 2025Applicant: Technion Research & Development Foundation LimitedInventor: Yoav SAGI
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Patent number: 12201386Abstract: Systems and methods for performing minimally invasive surgical procedures, especially for removal of tumors, and especially for brain tumors, using a robotically inserted therapeutic probe, which first detects tumorous tissue on a pre-planned path through the patient's tissue, before performing therapeutic procedures on the tissue, such as ablation. This pre-treatment detection procedure is thus able to avoid the destruction of healthy tissue. This also ensures that the therapeutic process indicated in a preoperative surgical plan is only performed on tumorous tissue, without sole reliance on preoperative image indications. This is important for neurosurgical operations performed on the brain, since preoperative images may not be accurate due to brain shift occurring during the procedure. Detection can be performed optically or ultrasonically, and treatment by laser or RF ablation. The probe insertion can be performed at 90° to the insertion axis of the device, thus minimizing passage through healthy tissue.Type: GrantFiled: September 6, 2018Date of Patent: January 21, 2025Assignee: Technion Research & Development Foundation LimitedInventors: Hadas Ziso, David Zarrouk, Moshe Shoham, Menashe Zaaroor
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Patent number: 12186454Abstract: A scaffold comprising electrospun decellularized ECM of an organ, wherein the decellularized ECM has a similar protein composition to native ECM of the organ. Methods of generating same are also disclosed as well as uses of same.Type: GrantFiled: January 23, 2023Date of Patent: January 7, 2025Assignee: Technion Research & Development Foundation LimitedInventors: Marcelle Machluf, Eyal Zussman, Limor Baruch
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Patent number: 12189762Abstract: A system, a method and a computer program product for protecting a speculative execution processor from side channel attacks, are disclosed. The system comprises a processing circuitry which performs an execution of a code segment, in one time period and copies, in another time period, only a committed portion of the executed code segment into a memory component which is accessible to read actions by an external processing unit. The speculative instructions are stored in an internal cache memory which is not accessible to read actions by the external processing unit.Type: GrantFiled: June 19, 2020Date of Patent: January 7, 2025Assignee: Technion Research & Development Foundation LimitedInventor: Abraham Mendelson
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Publication number: 20240425938Abstract: This disclosure relates to methods and compositions useful for detecting and monitoring low-frequency mutations. Methods and compositions described herein can be used to guide clinical decisions, for example, by informing on which antibiotics should be avoided, or conversely, which antibiotics should be actively used in the case of compounds that select against a specific type of resistance.Type: ApplicationFiled: August 9, 2024Publication date: December 26, 2024Applicants: The Broad Institute, Inc., The Children's Medical Center Corporation, Technion Research & Development Foundation LimitedInventors: Gregory P. PRIEBE, Roy KISHONY, Hattie CHUNG, Matthew M. SCHAEFERS
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Publication number: 20240415372Abstract: An assembly for driving linear movement and roll movement of an elongate surgical tool, comprising: an elongate shaft comprising a central lumen extending along the shaft long axis; the elongate shaft comprising a plurality of apertures extending across walls of the elongate shaft and into the central lumen; a set of wheels positioned opposing each other and aligned on two sides of the central lumen, the set of wheels at least partially extending through the apertures beyond the walls of the elongate shaft and into the central lumen to contact an elongate surgical tool received therein; the set of wheels being coupled to the elongate shaft and configured to rotate with the elongate shaft as a single unit when the elongate shaft is rotated about the shaft long axis.Type: ApplicationFiled: August 23, 2024Publication date: December 19, 2024Applicants: Microbot Medical Ltd., Technion Research & Development Foundation LimitedInventors: Simon SHARON, Idan BOADER, Moshe SHOHAM, Eran COHEN, Eyal MORAG
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Publication number: 20240408791Abstract: Disclosed is a method of fabricating a construction element. The method may include assembling a mold on a rotational casting machine; rotating the mold around at least two axes at a predetermined speed; providing a first portion of magnesium silico-phosphate cement (MSPC) mix, having an altered hardening rate, to the mold while rotating the mold until at least a portion of the mold's walls is covered by a first layer of the MSPC mix; and rotating the mold until the MSPC mix is hardened to a predetermined degree.Type: ApplicationFiled: August 20, 2024Publication date: December 12, 2024Applicant: Technion Research & Development Foundation LimitedInventors: Ryan POURATI, Pavel Larianovsky, Arnon Ben Tur, Jacob Grobman, Tom Shaked, Aaron Sprecher, Aharon Weissman, Bassam Masri
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Patent number: 12163120Abstract: A method of preparing a composition comprising mycelium along with a cellulose and/or plurality of nanoparticles is described herein. The method comprises inoculating a liquid medium with fungus, the liquid medium comprising nutrients and the cellulose and/or nanoparticles. Further described herein are compositions comprising mycelium along with a cellulose and/or plurality of nanoparticles, as well as articles-of-manufacture comprising such a composition, wherein at least 10% of the cellulose and/or nanoparticles in the composition is incorporated within the mycelium. A method of enhancing fungal growth is also described, comprising contacting the fungus with a liquid medium comprising a polymer which comprises carboxylic acid groups.Type: GrantFiled: September 10, 2021Date of Patent: December 10, 2024Assignee: Technion Research & Development Foundation LimitedInventors: Noam Attias, Jacob Grobman, Tiffany Abitbol
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Publication number: 20240401517Abstract: A hybrid system, including a solid-oxide fuel cell (SOFC), an internal combustion engine (ICE), and a thermochemical recuperation (TCR) unit. The TCR unit is configured to: (i) receive waist heat from the ICE, (ii) receive a primary fuel, (iii) perform a waste heat recovery process to provide reformed fuel. The SOFC is configured to receive a first part of the reformed fuel and convert the first part of the reformed fuel to electrical work. The ICE is configured to receive a second part of the reformed fuel and convert the second part of the reformed fuel to mechanical work.Type: ApplicationFiled: April 30, 2024Publication date: December 5, 2024Applicant: Technion Research & Development Foundation LimitedInventors: David Diskin, Leonid Tartakovsky
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Publication number: 20240390283Abstract: Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.Type: ApplicationFiled: August 5, 2024Publication date: November 28, 2024Applicant: Technion Research & Development Foundation LimitedInventors: Marcelle MACHLUF, Tomer BRONSHTEIN
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Publication number: 20240352484Abstract: Provided is reward system activation for therapeutic purposes. Accordingly there is provided a method of treating a disease in a subject in need thereof, the method comprising subjecting the subject to a treatment module which activates the reward system of the subject.Type: ApplicationFiled: April 18, 2024Publication date: October 24, 2024Applicants: Technion Research & Development Foundation Limited, Rambam Med-Tech Ltd.Inventors: Asya ROLLS, Lior GEPSTEIN, Hedva HAYKIN, Hilla AZULAY-DEBBY
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Publication number: 20240325437Abstract: A method of increasing proliferation of adaptive immune cells of a subject at least 65 years old is provided. The method comprising contacting the immune cells with an agent which increases the level of labile iron in the immune cells and/or reduces toxicity of hemoglobin, heme or a degradation product thereof, thereby increasing the proliferation of the adaptive immune cells of the subject.Type: ApplicationFiled: March 28, 2024Publication date: October 3, 2024Applicant: Technion Research & Development Foundation LimitedInventors: Noga RON-HAREL, David EZUZ
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Patent number: 12102290Abstract: An assembly for driving linear movement and roll movement of an elongate surgical tool, comprising: an elongate shaft comprising a central lumen extending along the shaft long axis; the elongate shaft comprising a plurality of apertures extending across walls of the elongate shaft and into the central lumen; a set of wheels positioned opposing each other and aligned on two sides of the central lumen, the set of wheels at least partially extending through the apertures beyond the walls of the elongate shaft and into the central lumen to contact an elongate surgical tool received therein; the set of wheels being coupled to the elongate shaft and configured to rotate with the elongate shaft as a single unit when the elongate shaft is rotated about the shaft long axis.Type: GrantFiled: November 15, 2021Date of Patent: October 1, 2024Assignees: Microbot Medical Ltd., Technion Research & Development Foundation LimitedInventors: Simon Sharon, Idan Boader, Moshe Shoham, Eran Cohen, Eyal Morag