Patents Assigned to Technion Research & Development
  • Patent number: 12293853
    Abstract: Provided herein are composite conductors, characterized by having copper deposits inside the bulk rather than on the outer surface of a non-metallic conductive porous matrix, such as CNT fabric, as well as a process for obtaining the same. The composite conductors provided herein are also characterized by a low specific weight and a high ampacity compared to metal conductors of similar size and shape.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: May 6, 2025
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Yair Ein-Eli, Neta Yitzhack, Nina Sezin, David Starosvetsky
  • Publication number: 20250136719
    Abstract: The present invention relates to an heparanase-binding and heparanase-neutralizing monoclonal antibody (IgG-1 mAb A54), including its epitope (HBD-II) and mode of interaction with heparanase, pharmaceutical composition comprising same, and uses thereof e.g. for inhibiting or treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, viral infection, diabetes and related complications. The present invention further provides combinatorial cancer therapies, comprising the heparanase-neutralizing mAb and an additional anti-cancer treatment such as chemotherapy or radiation.
    Type: Application
    Filed: September 25, 2024
    Publication date: May 1, 2025
    Applicants: Technion Research & Development Foundation Limited, Hadasit Medical Research Services and Development Ltd.
    Inventors: Israel Vlodavsky, Uri Barash
  • Publication number: 20250122854
    Abstract: A direct gaseous reformate injector that includes an inlet for receiving a gaseous reformate; a plunger; and an outward-opening valve that comprises a valve body and a needle that is movable, by the plunger, in relation to the valve body, between a (a) closed position in which the gaseous reformate is not outputted from the direct gaseous reformate injector, and (b) an open position in which the gaseous reformate is outputted from the direct gaseous reformate injector.
    Type: Application
    Filed: October 15, 2024
    Publication date: April 17, 2025
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Leonid Tartakovsky, Asher Netzer Lichinitzer
  • Publication number: 20250114351
    Abstract: A method of treating a disease or disorder for which an increase in immune cells in the brain is therapeutic in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which specifically binds and increases activity of a receptor selected from the group consisting of a 5HT2C receptor, a 5HT2A receptor and a 5HT2B receptor in the postcentral gyrus and/or the choroid plexus (CP) of the brain of the subject. Compositions for treating these diseases are also disclosed.
    Type: Application
    Filed: December 18, 2024
    Publication date: April 10, 2025
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Asya ROLLS, Dorit FARFARA, Ben KORIN, Hilla AZULAY-DEBBY, Shahar ARMON
  • Publication number: 20250101369
    Abstract: A method of preparing a composition comprising mycelium along with a cellulose and/or plurality of nanoparticles is described herein. The method comprises inoculating a liquid medium with fungus, the liquid medium comprising nutrients and the cellulose and/or nanoparticles. Further described herein are compositions comprising mycelium along with a cellulose and/or plurality of nanoparticles, as well as articles-of-manufacture comprising such a composition, wherein at least 10% of the cellulose and/or nanoparticles in the composition is incorporated within the mycelium. A method of enhancing fungal growth is also described, comprising contacting the fungus with a liquid medium comprising a polymer which comprises carboxylic acid groups.
    Type: Application
    Filed: December 9, 2024
    Publication date: March 27, 2025
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Noam ATTIAS, Jacob GROBMAN, Tiffany ABITBOL
  • Publication number: 20250086788
    Abstract: A method for quantitative magnetic resonance imaging (MRI), the method includes (a) receiving a sequence of MRI images of an in vivo tissue, by an image registration deep neural network (DNN) module that was trained, by a training process, to impose one or more MRI signal related physical constraints on a content of the sequence of MRI images; and (b) extracting one or more quantitative map from the sequence of MRI images.
    Type: Application
    Filed: August 14, 2024
    Publication date: March 13, 2025
    Applicants: Technion Research & Development Foundation Limited, MEDICAL RESEARCH & DEVELOPMENT FUND FOR HEALTH SERVICES, BNAI-ZION MEDICAL CENTER
    Inventors: Mordechay Pinchas Freiman, Eyal Hanania, Israe Cohen
  • Publication number: 20250051348
    Abstract: Mechanophoric compounds featuring one or more, or two or more, clickable group(s), which are capable of being coupled to naturally occurring, synthetic and/or metallic substrates via Click chemistry, method of preparing mechanophoric matrices using the mechanophoric compounds, and mechanophoric matrices obtainable thereby, and uses thereof for detecting force-induced damage in the matrices by a colorimetric change are provided.
    Type: Application
    Filed: August 13, 2024
    Publication date: February 13, 2025
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Joshua M. GROLMAN, Yifan LIAO, Hang ZHANG, Charles Eliezer DIESENDRUCK
  • Publication number: 20250027868
    Abstract: An atomic interferometer system comprises optical tweezers each configured to trap at least one atom therein, an atom source system configured to release atoms, and a controller configured to control the optical tweezers to trap at least one atom released by the atom source system in one of the tweezers, to spatially split a wave function of the trapped atom between at least two of the tweezers, and to at least partially recombine the split atomic wave function in at least one of the tweezers. The atomic interferometer system can also comprise a measuring system configured to measure wavefunction population in each of the tweezers and to display an output pertaining to the wavefunction populations.
    Type: Application
    Filed: July 17, 2024
    Publication date: January 23, 2025
    Applicant: Technion Research & Development Foundation Limited
    Inventor: Yoav SAGI
  • Patent number: 12201386
    Abstract: Systems and methods for performing minimally invasive surgical procedures, especially for removal of tumors, and especially for brain tumors, using a robotically inserted therapeutic probe, which first detects tumorous tissue on a pre-planned path through the patient's tissue, before performing therapeutic procedures on the tissue, such as ablation. This pre-treatment detection procedure is thus able to avoid the destruction of healthy tissue. This also ensures that the therapeutic process indicated in a preoperative surgical plan is only performed on tumorous tissue, without sole reliance on preoperative image indications. This is important for neurosurgical operations performed on the brain, since preoperative images may not be accurate due to brain shift occurring during the procedure. Detection can be performed optically or ultrasonically, and treatment by laser or RF ablation. The probe insertion can be performed at 90° to the insertion axis of the device, thus minimizing passage through healthy tissue.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: January 21, 2025
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Hadas Ziso, David Zarrouk, Moshe Shoham, Menashe Zaaroor
  • Patent number: 12186454
    Abstract: A scaffold comprising electrospun decellularized ECM of an organ, wherein the decellularized ECM has a similar protein composition to native ECM of the organ. Methods of generating same are also disclosed as well as uses of same.
    Type: Grant
    Filed: January 23, 2023
    Date of Patent: January 7, 2025
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Marcelle Machluf, Eyal Zussman, Limor Baruch
  • Patent number: 12189762
    Abstract: A system, a method and a computer program product for protecting a speculative execution processor from side channel attacks, are disclosed. The system comprises a processing circuitry which performs an execution of a code segment, in one time period and copies, in another time period, only a committed portion of the executed code segment into a memory component which is accessible to read actions by an external processing unit. The speculative instructions are stored in an internal cache memory which is not accessible to read actions by the external processing unit.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: January 7, 2025
    Assignee: Technion Research & Development Foundation Limited
    Inventor: Abraham Mendelson
  • Publication number: 20240425938
    Abstract: This disclosure relates to methods and compositions useful for detecting and monitoring low-frequency mutations. Methods and compositions described herein can be used to guide clinical decisions, for example, by informing on which antibiotics should be avoided, or conversely, which antibiotics should be actively used in the case of compounds that select against a specific type of resistance.
    Type: Application
    Filed: August 9, 2024
    Publication date: December 26, 2024
    Applicants: The Broad Institute, Inc., The Children's Medical Center Corporation, Technion Research & Development Foundation Limited
    Inventors: Gregory P. PRIEBE, Roy KISHONY, Hattie CHUNG, Matthew M. SCHAEFERS
  • Publication number: 20240415372
    Abstract: An assembly for driving linear movement and roll movement of an elongate surgical tool, comprising: an elongate shaft comprising a central lumen extending along the shaft long axis; the elongate shaft comprising a plurality of apertures extending across walls of the elongate shaft and into the central lumen; a set of wheels positioned opposing each other and aligned on two sides of the central lumen, the set of wheels at least partially extending through the apertures beyond the walls of the elongate shaft and into the central lumen to contact an elongate surgical tool received therein; the set of wheels being coupled to the elongate shaft and configured to rotate with the elongate shaft as a single unit when the elongate shaft is rotated about the shaft long axis.
    Type: Application
    Filed: August 23, 2024
    Publication date: December 19, 2024
    Applicants: Microbot Medical Ltd., Technion Research & Development Foundation Limited
    Inventors: Simon SHARON, Idan BOADER, Moshe SHOHAM, Eran COHEN, Eyal MORAG
  • Publication number: 20240408791
    Abstract: Disclosed is a method of fabricating a construction element. The method may include assembling a mold on a rotational casting machine; rotating the mold around at least two axes at a predetermined speed; providing a first portion of magnesium silico-phosphate cement (MSPC) mix, having an altered hardening rate, to the mold while rotating the mold until at least a portion of the mold's walls is covered by a first layer of the MSPC mix; and rotating the mold until the MSPC mix is hardened to a predetermined degree.
    Type: Application
    Filed: August 20, 2024
    Publication date: December 12, 2024
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Ryan POURATI, Pavel Larianovsky, Arnon Ben Tur, Jacob Grobman, Tom Shaked, Aaron Sprecher, Aharon Weissman, Bassam Masri
  • Patent number: 12163120
    Abstract: A method of preparing a composition comprising mycelium along with a cellulose and/or plurality of nanoparticles is described herein. The method comprises inoculating a liquid medium with fungus, the liquid medium comprising nutrients and the cellulose and/or nanoparticles. Further described herein are compositions comprising mycelium along with a cellulose and/or plurality of nanoparticles, as well as articles-of-manufacture comprising such a composition, wherein at least 10% of the cellulose and/or nanoparticles in the composition is incorporated within the mycelium. A method of enhancing fungal growth is also described, comprising contacting the fungus with a liquid medium comprising a polymer which comprises carboxylic acid groups.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: December 10, 2024
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Noam Attias, Jacob Grobman, Tiffany Abitbol
  • Publication number: 20240401517
    Abstract: A hybrid system, including a solid-oxide fuel cell (SOFC), an internal combustion engine (ICE), and a thermochemical recuperation (TCR) unit. The TCR unit is configured to: (i) receive waist heat from the ICE, (ii) receive a primary fuel, (iii) perform a waste heat recovery process to provide reformed fuel. The SOFC is configured to receive a first part of the reformed fuel and convert the first part of the reformed fuel to electrical work. The ICE is configured to receive a second part of the reformed fuel and convert the second part of the reformed fuel to mechanical work.
    Type: Application
    Filed: April 30, 2024
    Publication date: December 5, 2024
    Applicant: Technion Research & Development Foundation Limited
    Inventors: David Diskin, Leonid Tartakovsky
  • Publication number: 20240390283
    Abstract: Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.
    Type: Application
    Filed: August 5, 2024
    Publication date: November 28, 2024
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Marcelle MACHLUF, Tomer BRONSHTEIN
  • Publication number: 20240352484
    Abstract: Provided is reward system activation for therapeutic purposes. Accordingly there is provided a method of treating a disease in a subject in need thereof, the method comprising subjecting the subject to a treatment module which activates the reward system of the subject.
    Type: Application
    Filed: April 18, 2024
    Publication date: October 24, 2024
    Applicants: Technion Research & Development Foundation Limited, Rambam Med-Tech Ltd.
    Inventors: Asya ROLLS, Lior GEPSTEIN, Hedva HAYKIN, Hilla AZULAY-DEBBY
  • Publication number: 20240325437
    Abstract: A method of increasing proliferation of adaptive immune cells of a subject at least 65 years old is provided. The method comprising contacting the immune cells with an agent which increases the level of labile iron in the immune cells and/or reduces toxicity of hemoglobin, heme or a degradation product thereof, thereby increasing the proliferation of the adaptive immune cells of the subject.
    Type: Application
    Filed: March 28, 2024
    Publication date: October 3, 2024
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Noga RON-HAREL, David EZUZ
  • Patent number: 12102290
    Abstract: An assembly for driving linear movement and roll movement of an elongate surgical tool, comprising: an elongate shaft comprising a central lumen extending along the shaft long axis; the elongate shaft comprising a plurality of apertures extending across walls of the elongate shaft and into the central lumen; a set of wheels positioned opposing each other and aligned on two sides of the central lumen, the set of wheels at least partially extending through the apertures beyond the walls of the elongate shaft and into the central lumen to contact an elongate surgical tool received therein; the set of wheels being coupled to the elongate shaft and configured to rotate with the elongate shaft as a single unit when the elongate shaft is rotated about the shaft long axis.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: October 1, 2024
    Assignees: Microbot Medical Ltd., Technion Research & Development Foundation Limited
    Inventors: Simon Sharon, Idan Boader, Moshe Shoham, Eran Cohen, Eyal Morag