Abstract: An indirectly heated phase change switch (IPCS) for radio frequency (RF) switching, comprises two RF ports and an RF path therebetween, a phase change material (PCM) located between the RF ports, an embedded heater separated from the PCM by a dielectric layer, the embedded heater configured to provide thermal actuation of the PCM to bring about phase changes between a crystalline state and an amorphous state to provide Ohmic switching, and a bias voltage on the IPCS across said RF path. The bias is provided during heating to improve the crystallization time.

Abstract: A method for making 3D nano-structure comprising at least two materials by spatially controlling the growth of the materials, is provided. Further, a method for making 3D nano-structure bound to a thermally labile substrate is provided. Composites, comprising a substrate bound to a 3D nano-structure, wherein the 3D nano-structure is arranged in a pattern are provided.

Abstract: Compositions and methods for treating a medical condition are provided. Accordingly, there is provided a composition comprising a polypeptide comprising a GnRH receptor binding protein and a polynucleotide coding a therapeutic agent, wherein said polypeptide is in association with said polynucleotide via a linker comprising a cleavage motif that can be cleaved by a proteolytic enzyme secreted by a cell expressing said GnRH receptor. Also provided is a nucleic acid construct comprising a nucleic acid sequence encoding a fusion protein comprising a DNA binding domain (DBD) of a transcription factor that binds a regulatory region of a gonadotropin gene attached to a chromatin modifying domain that represses transcription upon association with the DBD. Also provided are methods of use thereof.

Abstract: The invention provides compositions, kits and methods for depositing a composition comprising a plurality of magnetic particles, to a target site of a subject by delivering the composition via controlled inhalation to a region of the subject's respiratory tract and applying a magnetic field to a target site within the region of the subject's respiratory tract to capture the particles in said target site.

Abstract: The present invention is directed to a cyclic polypeptide having ubiquitin binding affinity (KD) of 0.1-100 nM. Further provided are methods for reducing deubiquitination activity of a cell, and for treating cancer in a subject in need thereof.

Abstract: A method of producing spherical particles is provided herein. Also provided are compositions generated thereby and uses thereof in disease diagnosis and treatment.

Abstract: Methods of diagnosing and/or monitoring tuberculosis (TB) in a subject by analyzing a test sample comprising at least one volatile organic compound (VOC) or semi-volatile organic compound (SVOC) emitted or excreted from the skin of the subject. The test sample can be analyzed by a sensing unit comprising nanomaterials- and/or polymer-based sensors. Further provided is a skin-mountable device comprising a fixing unit and said sensing unit. Also discloses a method of diagnosing and/or monitoring tuberculosis, comprising analyzing specific skin-emitted VOCs or SVOCs, which are indicative of tuberculosis in a subject.

Abstract: An objective lens system comprises a set of lenses, arranged along a common optical axis to form a back focal plane. The objective lens system also comprises an optical mask at the back focal plane, and a housing encapsulating the set of lenses and the optical mask.

Abstract: A method of expanding and maintaining human embryonic stem cells (ESCs) in an undifferentiated state by culturing the ESCs in a suspension culture under culturing conditions devoid of substrate adherence is provided. Also provided are a method of deriving ESC lines in the suspension culture and methods of generating lineage-specific cells from ESCs which were expanded in the suspension culture of the present invention.

Abstract: A system for generating cold plasma is presented, suitable for use in in-vivo treatment of biological tissue. The system comprising: a control unit connectable to an elongated member at a first proximal end of the elongated member. The elongated member comprises a plasma generating unit at a second distal end thereof and gas and electricity transmission channels extending from said first proximal end towards said plasma generating unit. The control unit comprises a gas supply unit configured to provide predetermined flow rate of selected gas composition through said gas transmission channel and a power supply unit configured to generate selected sequence of high-frequency electrical pulses, typically in mega Hertz range, directed through said electricity transmission channel, thereby providing power and gas of said selected composition to the plasma generating unit for generating cold plasma.

Abstract: A method for displacement of an electromagnetic mode (EM) conditioned on the state of an ancilla qubit, the method may include displacing, by applying a displacement operation, an EM mode whose frequencies are conditioned on the state of the ancilla qubit and are spaced apart by a frequency difference, by providing a displacement signal having a bandwidth that exceeds the frequency difference and has a zero amplitude at one or more of the frequencies of the electromagnetic mode which are defined by the displacement operation not to be displaced and a non-zero amplitude at one or more frequencies of the mode which are defined by the displacement operation to be displaced.

Abstract: Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.

Abstract: A method of fabricating a light emitting device, comprises mixing a first solution containing a polymeric component with a second solution containing quantum-confinement structures, to provide a solution mixture, and dispensing the solution mixture to form a fiber. The fiber is allow to be self-drawn such that at least one section of the fiber has a reduced diameter relative to another section.

Abstract: A dendrimer including a ring core moiety, a paramagnetic group, a linking moiety and a branching moiety for continuously probing and quantifying an analyte is provided together with methods, kits and devices for performing sensitive, accurate and durable measurements.

Abstract: One of the main obstacles of securing industrial control systems is the lack of an appropriate security model that is both implementable by vendors and addresses the inherent security and usability issues needed by organizations. Current solutions such as device passwords and IPSec lack scalable key management infrastructure and fine granularity access control mechanisms. A security model for industrial control systems that supports organizational level authorizations and authentication requirements, while hiding the low-level details (e.g., keys and passwords) from the users is disclosed. It also enables easy addition and removal of PLCs, engineering station, HMI devices and users, and assigning permission to them. A major advantage is its support for hybrid ICS systems, characterized by co-existence of legacy devices and new devices, while using the same protocol. Devices may communicate therein either natively, or by a connected converter.

Abstract: A system and method for ensuring safe and tolerable insertion of a needle into a subject's body according to a preplanned or continuously monitored sequence of insertion steps. The system comprises a gripping device for gripping the needle in order to perform robotic insertion steps, yet for releasing the grip between such insertion steps, until the next insertion step is initiated. Thereby, the robot has full control of the needle during insertion steps, but does not constrain the needle between insertions, such that movement of the subject can cause neither damage nor discomfort. The gripping and insertion steps may be coordinated to keep in synchronization with the subject's breathing cycles, such that the insertion steps may be performed in the same segment of each cycle of motion of the subject's chest. The gripper can either fully disconnect from the needle, or can partially disconnect but constrain motion within limits.

Abstract: An energy storage and retrieval system including an air chamber, a first air compressor operating with Heat Transfer Liquid (HTL-compressor) connected to the air chamber, a second turbine, operating with Heat Transfer Liquid (HTL-turbine) connected to the air chamber, accepting compressed air from the air chamber and producing work. Related apparatus and methods are also described.

Abstract: An energy converter unit and X-ray source system are presented. The energy converter unit comprises a multilayered crystal structure having a selected layers' arrangement comprising at least first and second of layers of at least first and second material compositions. The layers-arrangement is formed of a pattern of n1 layers of said first layer type and n2 layers of said second layer type generating a selected lattice periodicity of said layers. The lattice periodicity is selected such that said multilayered crystal structure responds to the charged particle beam of predetermined parameters by coherent emission of X-ray radiation having selected spectral content and emission direction.

Abstract: A method for estimating parameters of a model that is non-linear and is more complex than a log-linear model, the method may include feeding measured observations and sampling coordinates of the measured observations to a machine learning process; and processing the measured observations and the sampling coordinates of the measured observations, by the machine learning process, to provide an estimate of the parameters of the model; wherein the model is indicative of a relationship between the measured observations and the sampling coordinates.

Abstract: A method comprising: generating a parametrized three-dimensional (3D) body surface model on a training set comprising a plurality of 3D scans of subjects, wherein at least some of said 3D scans are of subjects having a skeletal deformity; receiving one or more target 3D scans of a target subject; optimizing said body surface model with respect to said one or more target 3D scans to calculate a target body surface model of said target subject; training a skeletal estimation model on a training set comprising: (i) body surface models of a plurality of subjects, and (ii) skeletal landmarks sets of said plurality of subjects; and applying said trained skeletal estimation model to said calculated target body surface model of said target subject, to estimate a skeletal shape of said target subject.