Abstract: Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are according to Formula 1501: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, PD, RA, RB, RC, L, M and Z are as described herein.

Abstract: Method of designing a tire for the steered axle of a heavy goods vehicle, having a nominal sidewall height F, having a tread in the new state having a maximum total width Lo for maximum contact with the ground and provided with at least four circumferential grooves each extending between the tread surface and a groove bottom, these grooves delimiting three intermediate ribs and two edge ribs axially bounding the tread, each edge rib having two lateral walls, one of which, known as the internal lateral wall, having a height PREp measured with respect to the bottom of the groove delimiting the edge rib, this internal lateral wall having, when viewed in section on a plane containing the axis of rotation, an inclination DEp, each edge rib having a width LEp greater than the width of each of the intermediate ribs, by iteratively determining values for the dimensions LEp, PREp and DEp that satisfy the following relationship: P(LEp, DEp, PREp)<1.105769231×F, with P(LEp, DEp, PREp)=?303.528?2.00675×LEp+10.

Abstract: A tread for passenger-vehicle tire having radially on the outside a running surface and comprising a plurality of elements, at least certain of these elements being provided with at least one incision delimited by two opposite faces, this incision consisting of a succession of thin sections and of thick sections placed in an alternating manner, the thin sections being inclined at an angle A equal to no more than 40 degrees, this angle being measured relative to a direction perpendicular to the running surface of the tread and passing through the points of the incision on the running surface of the tread, the thick sections forming an angle B of between 60 degrees and 120 degrees with a direction perpendicular to the running surface of the tread, and the thin sections having a width e less than the width E of the thick sections, the width of the thin sections being such that, when they go through the contact patch, the walls delimiting said thin sections are in contact, and the width of the thick sections bein

Abstract: The present invention provides a method for producing nanoparticles, which comprises maintaining a minute space of 1 mm or less between two processing surfaces capable of approaching to and separating from each other and being rotating relative to each other, allowing the minute space maintained between the two processing surfaces to serve as a flow path of a processed fluid thereby forming a forced thin film of the processed fluid and separating nanoparticles in the forced thin film.

Abstract: An apparatus and method for evaluating the ability of a tire to clean its tread is provided. For example, an apparatus (100) and method for evaluating the ability of a tire to eject materials such as e.g., mud from its tread during use is provided. Samples (10) of a subject test pattern are rotated at predetermined rpm profile. A camera (170) captures the effect of centrifugal forces on the materials during rotation, which in turn may be used to compare how differences in tread patterns impact the ejection of materials (15) from the tread during use.

Abstract: A desaturation detection circuit for use between the desaturation detection input of an optocoupler and the output of a power switching device, the desaturation detection circuit comprising: a threshold setting element having an input and an output, the input for connection to the output of a power switching device via one or more diode(s), the threshold setting element being arranged to set a threshold voltage at the input at which the threshold setting element will provide an output at the output of the threshold setting element when the input voltage is exceeded, and a detector having an input connected to the output of the threshold setting element and an output connectable to a desaturation detection input of an optocoupler, the detector being arranged to detect an output at the output of the threshold setting element and in response to provide a control signal at the output of the detector for the desaturation detection input to trigger a desaturation routine in the optocoupler.

Abstract: A method for protecting a tire against punctures includes: providing a self-sealing layer; providing an anti-tack layer that includes particles having a shape factor higher than 5; forming a tire such that the self-sealing layer is built into the tire during manufacture of the tire; and applying the anti-tack layer a radially internal surface of the self-sealing layer.

Abstract: Run-flat tires having a sidewall support that is manufactured from particular rubber composition. These compositions are based upon a cross-linkable elastomer composition having, per 100 parts by weight of rubber, a polybutadiene rubber having a Mooney viscosity of between 55 and 85 and a low-surface area, high-structure carbon black. An additional second rubber component may also be included in the elastomer composition. The low-surface area, high-structure carbon black may be characterized as having a nitrogen surface area of between 15 m2/g and 25 m2/g and a COAN of between 65 ml/100 g and 85 ml/100 g.

Abstract: The invention discloses an insulation component and a molding process for the same. The insulation component comprises an inner insulation foam layer and a layer, manufactured by reaction injection molding, of seamless stiff polymer material surrounding the inner insulation foam layer. The insulation component of the invention is made by reaction injection molding. Since the insulation component of this invention is made by forming a seamless stiff polymer material layer surrounding the inner insulation foam layer via reaction injection-molding, the sealing is good, a pre-assembled component is not required, the producing process is simple and the production cost is low.

Abstract: A pneumatic tire tread capable of mitigating air column resonance and maintaining drainage performance while ensuring that the flexible fences are abraded to a similar extent to the tread portion is formed from a rubber composition, and has a tread portion in which at least one primary groove is formed and multiple flexible fences is formed in the primary groove; the flexible fences are formed from at least a rubber composition for fences that is different from the rubber composition for the tread portion; the rubber composition for fences of the flexible fences has an abrasion index that is more than or equal to twice the abrasion index of the rubber composition of the tread portion; and the rubber composition for fences comprises a filler composition that is based on (a) a diene elastomer, (b) a reinforcing filler which is less than 50 phr; (c) a plasticizing system, and (d) a vulcanizing system.

Abstract: Tire comprising a carcass reinforcement and two beads, each comprising at least one annular reinforcing structure, a bead filler and an outer strip made from a rubber composition having an elastic modulus G? of less than or equal to 15 MPa and a viscous modulus G? such that G? [MPa]?0.2·G? [MPa]?0.2 MPa, wherein the bead filler has a thickness E(r) perpendicular to the carcass reinforcement with the bead filler, r denoting the distance from the radially innermost point of the annular reinforcing structure, wherein the assembly formed by the bead filler and the outer strip has a thickness ET(r), wherein the thickness ET(r) changes such that, in the range of distances r comprised between 25 and 45% of the height H of the tire, the variation in thickness is less than or equal to ?0.25 mm/mm over at least 4% of the height H, wherein, for all the points of which the distance r is greater than 10% and less than 35% of the height H, the ratio E(r)/ET(r) is greater than 0.3 and less than or 0.

Abstract: A pneumatic tire tread capable of mitigating air column resonance and maintaining drainage performance while ensuring that the flexible fences are abraded to a similar extent to the tread portion is formed from a rubber composition, and has a tread portion in which a primary groove is formed and multiple flexible fences is formed in the primary groove; the flexible fences are formed from at least a rubber composition for fences that is different from the rubber composition for the tread portion; the rubber composition for fences of the flexible fences has an abrasion index that is more than or equal to twice the abrasion index of the rubber composition of the tread portion; and the rubber composition for fences comprises a filler composition that is based on (a) a diene elastomer, (b) a filler A, which is more than 50 phr of filler A in which the filler particles are nanoparticles having an average grain size (by weight average) smaller than 500 nm; and (c) a filler B, which is more than 50 phr of filler B in

Abstract: The lining for a mold for vulcanizing a tire, comprises at least one network of cords and of sipe blades for molding a corresponding network of grooves and of cuts in the tread. The network of cords and of blades comprises at least one node between two cords. Each cord of the network overmolds at least the edge of a blade.

Abstract: The present invention provides structures on the tread of a tire that improve the evacuation of mud, soil and the like. In particular, different tread features are provided that may improve the evacuation of mud, soil and the like by themselves or by strategically combining them. These different tread features may be tested to see how they affect mud evacuation at different rotational speeds by a test apparatus that mimics the performance of a tire. For example, a tread that has offset shoulder tread blocks, which shows good mud evacuation at lower speeds, may be combined with shoulder grooves with pockets that show good mud evacuation at intermediate speeds to see if this combination provides a solution that has the lowest change of speed necessary to evacuate 50-87% of the mud found in the grooves.

Abstract: Apparatus for preventing output of an input signal is disclosed. The apparatus comprises a signal control unit comprising a signal buffering unit having an input and an output, the signal buffering unit arranged to receive an input signal and pass the input signal to the output when the signal buffering unit is powered, wherein a negative power supply terminal of the signal buffering unit is arranged to be supplied by a first power source having a voltage. The signal control unit also comprises a boost circuit arranged to boost the voltage of the first power source to a boosted voltage higher than the voltage of the first power source and supply either the voltage of the first power source or the boosted voltage to a positive power supply terminal of the signal buffering unit.

Abstract: Segmented mold for molding and vulcanizing a tire of given diameter (DS), having a width (L) and a diameter (J) at the interconnect point (E), comprising shells and segments collaborating to withstand the internal pressure and remain in the closed position without assistance from additional components, in which mold each segment comprises at its lateral edges a projection extending radially inwards, which projection is equipped with a lip extending axially towards the inside of the mold and having an inclined frustoconical surface of given angle (?) with respect to the axis (XX?) of the mold such that the extensions of the line of each frustoconical surface on a meridian plane intercept on the radially internal side of the segment concerned, and in which mold each shell comprises a projection extending radially outwards and provided with a lip having a frustoconical surface inclined by the same angle ? with respect to the axis XX? of the mold.

Abstract: Disclosed are specific antibodies against the protein Trio, their method of production, and their use in in vitro cancer prognostic method. Also described are the antigens enabling production of the antibodies.